The SV40 virus enhancer functions as a somatic hypermutation-targeting element with potential tumorigenic activity by Filip Šenigl, Anni I. Soikkeli, Salomé Prost, David G. Schatz, Martina Slavková, Jiří Hejnar, Jukka Alinikula

Get full text

Restorative effects of camellia oil on the skin-barrier function in a model of DNCB-induced atopic dermatitis by Shicheng Jiao, Lijun Deng, Mu Niu, Jie Yang

Get full text

Protective Role of AMPK against PINK1B9 Flies’ Neurodegeneration with Improved Mitochondrial Function by Guoliang Xiang, Xueyi Wen, Wenjing Wang, Tianchan Peng, Jiazhen Wang, Qinghua Li, Junfang Teng, Ying Cui

“…Mitochondrial dysfunction in PINK1B9 flies has been ameliorated with increased ATP level, restored mitochondrial morphology in muscle, and increased NDUFS3 protein expression. Conclusively, AMPK overexpression could partially rescue the PD flies via improving PINK1B9 flies’ mitochondrial function.…”
Get full text

Blockade of immunosuppressive cytokines restores NK cell antiviral function in chronic hepatitis B virus infection. by Dimitra Peppa, Lorenzo Micco, Alia Javaid, Patrick T F Kennedy, Anna Schurich, Claire Dunn, Celeste Pallant, Gidon Ellis, Pooja Khanna, Geoffrey Dusheiko, Richard J Gilson, Mala K Maini

“…We found that, in contrast to their upregulated TRAIL expression and maintenance of cytolytic function, NK cells had a markedly impaired capacity to produce IFN-γ in CHB. …”
Get full text

4-Octyl Itaconate Modulates Dendritic Cells Function and Tumor Immunity via NRF2 Activation by Zhu B, Zhu L, Ge Z, Zheng S, Dai X, Feng D, Tan L, Sha P, Yao Y

“…The protein level of NRF2 in BMDCs was analyzed by Western blot.Results: Treatment with 4OI represses DC maturation and function. Specifically, 4OI-treated DCs exhibited impaired phenotypic and functional maturation, characterized by decreased expression of co-stimulatory molecules CD40, CD80, and CD86, as well as lower levels of pro-inflammatory cytokines IL-12, IL-6, TNF-α and IL-1β. …”
Get full text

Downregulation of AdipoR1 in the hippocampus impairs synaptic function and structure and causes depression-like behavior by Peilin Zhu, Yanmin Luo, Yue Li, Jing Tang, Li Liu, Yuhui Deng, Jing Li, Lin Jiang, Wenyu Yang, Qian Xiao, Shun Wang, Yuning Zhou, Fenglei Chao, Lei Zhang, Chunni Zhou, Yong Tang, Xin Liang

“…Adiponectin, an adipokine, crosses the blood‒brain barrier to function in specific brain regions. Previous studies have suggested that the downregulation of adiponectin signaling is involved in the occurrence of depression. …”
Get full text

Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function. by Wenbo Tang, Matthew Kowgier, Daan W Loth, María Soler Artigas, Bonnie R Joubert, Emily Hodge, Sina A Gharib, Albert V Smith, Ingo Ruczinski, Vilmundur Gudnason, Rasika A Mathias, Tamara B Harris, Nadia N Hansel, Lenore J Launer, Kathleen C Barnes, Joyanna G Hansen, Eva Albrecht, Melinda C Aldrich, Michael Allerhand, R Graham Barr, Guy G Brusselle, David J Couper, Ivan Curjuric, Gail Davies, Ian J Deary, Josée Dupuis, Tove Fall, Millennia Foy, Nora Franceschini, Wei Gao, Sven Gläser, Xiangjun Gu, Dana B Hancock, Joachim Heinrich, Albert Hofman, Medea Imboden, Erik Ingelsson, Alan James, Stefan Karrasch, Beate Koch, Stephen B Kritchevsky, Ashish Kumar, Lies Lahousse, Guo Li, Lars Lind, Cecilia Lindgren, Yongmei Liu, Kurt Lohman, Thomas Lumley, Wendy L McArdle, Bernd Meibohm, Andrew P Morris, Alanna C Morrison, Bill Musk, Kari E North, Lyle J Palmer, Nicole M Probst-Hensch, Bruce M Psaty, Fernando Rivadeneira, Jerome I Rotter, Holger Schulz, Lewis J Smith, Akshay Sood, John M Starr, David P Strachan, Alexander Teumer, André G Uitterlinden, Henry Völzke, Arend Voorman, Louise V Wain, Martin T Wells, Jemma B Wilk, O Dale Williams, Susan R Heckbert, Bruno H Stricker, Stephanie J London, Myriam Fornage, Martin D Tobin, George T O'Connor, Ian P Hall, Patricia A Cassano

“…<h4>Methods</h4>We performed GWAS of the rate of change in forced expiratory volume in the first second (FEV1) in 14 longitudinal, population-based cohort studies comprising 27,249 adults of European ancestry using linear mixed effects model and combined cohort-specific results using fixed effect meta-analysis to identify novel genetic loci associated with longitudinal change in lung function. Gene expression analyses were subsequently performed for identified genetic loci. …”
Get full text

Integrative Genomic and Functional Approaches Identify FUOM as a Key Driver and Therapeutic Target in Cervical Cancer by Wenzhi Jiao, Shanshan Liu, Jianwei Shi, Minmin Yu

“…Methods MR analysis identified eQTL‐related genes with significant causal associations with cervical cancer. Functional enrichment and Gene Set Variation Analysis (GSVA) revealed their involvement in key pathways. scRNA‐seq explored cell‐specific expression patterns and immune cell infiltration in the tumor microenvironment (TME). …”
Get full text

The Impact of Fucoidan Extracts on Heat-Stress-Induced Loss of In Vitro Fast-Twitch Muscle Function in Mice by Samantha T. C. Kucewicz, Stefan Piantella, Jarrod E. Church, Caroline J. Taylor, Chris van der Poel

“…Functional analysis was complemented with gene analysis and the C2C12 myoblast heat-stress assay. …”
Get full text

Enhancement of memory and emotional functions by long-term ingestion of protease-treated porcine liver extract in mice by Taiga Kurihara, Masanori Sasanuma, Masahiro Kato, Toshio Inoue, Naoko Okada, Teruki Shirayama, Yusuke Tanikawa, Taiki Kawahara, Kazuhiro Sohya, Hiroki Yasuda, Yoshikazu Matsuda, Takeshi Uemura

“…Collectively, these results suggest that PLDP induces changes in gene expression associated with brain function, potentially contributing to the enhancement of cognitive function and psychological health. …”
Get full text

Structural and functional roles of conserved residues of human papillomavirus (HPV) E2 protein and biological consequences by Sean Fletcher, Esther E. Biswas-Fiss, Subhasis B. Biswas

“…While its core functions are conserved, variations within the E2 protein are thought to contribute to the differential oncogenic potential among HPV types, though the structural basis for this remains incompletely understood. …”
Get full text

Deep functional measurements of Fragile X syndrome human neurons reveal multiparametric electrophysiological disease phenotype by James J. Fink, Nathaniel Delaney-Busch, Ryan Dawes, Evanthia Nanou, Christopher Folts, Karthiayani Harikrishnan, Chris Hempel, Hansini Upadhyay, Trinh Nguyen, Himali Shroff, David Stoppel, Steven J. Ryan, Jane Jacques, Jennifer Grooms, Elizabeth Berry-Kravis, Mark F. Bear, Luis A. Williams, David Gerber, Mark Bunnage, Brinley Furey, Graham T. Dempsey

“…This neurophysiological phenotype was optimized and validated into a high throughput assay based on the amount of FMRP re-expression and the number of healthy neurons in a mosaic network necessary for functional rescue. …”
Get full text

Functional Investigation of a Novel PIWIL4 Mutation in Nonobstructive Azoospermia During the First Wave of Spermatogenesis by Xiayu Wang, Qian Du, Wanqian Li, Zhongyu Zou, Chikun Wang, Yan Zhou, Zhibin Hu, Yayun Gu, Feng Li

Get full text

TET1 functions as a tumor suppressor in lung adenocarcinoma through epigenetic remodeling and immune modulation by Abdur Rahim, Brian L. Ruis, Andrew T. Rajczewski, Monica E. Kruk, Natalia Y. Tretyakova

“…Results In the present study, we employed genetic approaches to directly address the function of TET1 protein in lung adenocarcinoma. We found that overexpression (OE) of TET1 in human lung adenocarcinoma (H441, H1975) cells decreased their proliferation and inhibited colony formation, cell migration, and 3D spheroid tumorigenesis. …”
Get full text

Extremely low-frequency electromagnetic fields facilitate proliferation and functional differentiation in spinal neural stem cells by Wenxu Tang, Dan He, Xiaofei Li, Yi Feng, Yue Xu, Jiawei Hu, Wei Xu, Lei Xue

“…Abstract Traumatic spinal cord injury (SCI), typically resulting from direct mechanical damage to the spine, often leads to disruption of neural signaling and axonal conduction, severely impairing nervous system function. In rodent models of SCI, neural stem cell (NSC) transplantation has demonstrated significant potential in restoring motor function and enhancing neural repair. …”
Get full text

Doxorubicin loaded polylactide nanoparticles functionalized histamine promote apoptosis of human gastric cancer cells AGS by Patrycja Jaroniek, Marek Brzeziński, Magdalena Chmiela, Weronika Gonciarz

Get full text

Evidence for a Role of the Long Non-Coding RNA ITGB2-AS1 in Eosinophil Differentiation and Functions by Timothée Fettrelet, Aref Hosseini, Jacqueline Wyss, Joanna Boros-Majewska, Darko Stojkov, Shida Yousefi, Hans-Uwe Simon

“…Although long non-coding RNAs (lncRNAs) are known to be involved in eosinophilic conditions, their specific expression and functions within eosinophils have not been thoroughly investigated, largely due to the reliance on tissue homogenates. …”
Get full text

Melatonin Improves Salt Tolerance in Tomato Seedlings by Enhancing Photosystem II Functionality and Calvin Cycle Activity by Xianjun Chen, Bi Chen, Yao Jiang, Jianwei Zhang, Mingjie Liu, Qin Yang, Huiying Liu

“…This study investigated the regulatory role of exogenous melatonin (MT) on photosynthetic performance under salt stress by determining chlorophyll content, chlorophyll a fluorescence parameters, Calvin cycle enzyme activities, and related gene expression. Results showed that salt stress significantly reduced chlorophyll content and impaired photosystem II (PSII) functionality, as evidenced by the increased minimum fluorescence (<i>F</i>_o) and decreased maximum quantum efficiency of PSII (<i>F</i>_v/<i>F</i>_m) and effective PSII quantum yield (<i>Φ</i>_PSII). …”
Get full text

Phylogenetic and functional analysis of MYB genes unraveling its role involved in anthocyanin biosynthesis in H macrophylla by Yingying Liao, Wenwen Zhao, Yu Wang, Sumeiqi Zhao, Shiqin Gu, Chao Zhang, Jiqing Peng, Song Sheng, Sen Wang

“…Predominantly, MYB proteins were localized within the nucleus, although some were also detected in other organelles, indicating a multifaceted role in cellular function. Phylogenetic analysis established that 13 MYB genes from H. macrophylla can be categorized into five distinct subfamilies based on the classifications observed in Arabidopsis thaliana, suggesting their involvement in the biosynthetic pathways of anthocyanins and proanthocyanidins. …”
Get full text

Effects of dietary protein sources and levels on uric acid metabolism, renal function, and inflammatory responses in goslings by Yuanjing Chen, Zhengfeng Yang, Guoqiang Su, Ning Li, Haiming Yang, Zhiyue Wang, Zhiyue Wang

“…Dietary protein plays a crucial role in poultry nutrition, influencing nitrogen metabolism, renal function, and immune responses. This study investigated the effects of dietary protein source (plant-based vs. animal-based) and level (14.5, 18.5, and 22.5%) on serum biochemical parameters, renal metabolic markers, inflammatory cytokines, and gene expression in Jiangnan White goslings from day 1 to day 30 of age. …”
Get full text