Downstream metabolites of (+)-cis-12-oxo-phytodienoic acid function as noncanonical bioactive jasmonates in Arabidopsis thaliana by Minoru Ueda, Rina Saito, Yuho Nishizato, Tsumugi Kitajima, Nobuki Kato

“…These downstream metabolites function independently of the JA-Ile-COI1-JAZ-MYCs canonical jasmonate signaling module, and their electrophilic α, β-unsaturated carbonyl functionalities are essential for their bioactivity. …”
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The somonym component baş ‘head’ in the phraseology and proverbs of the Dobrujan Tatars and the Volga Tatars (functional-semantic analysis) by Fyaridya I. Tagirova, Ilgamiya I. Sabitova

“…The work uses the method of functional-semantic analysis, as well as the analysis of phraseological units of the compared languages for the similarity of the plan of internal semantic content and the plan of lexical expression. …”
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The long noncoding RNA FRILAIR regulates strawberry fruit ripening by functioning as a noncanonical target mimic. by Yajun Tang, Zhipeng Qu, Jiajun Lei, Reqing He, David L Adelson, Youlin Zhu, Zhenbiao Yang, Dong Wang

“…Long noncoding RNAs (lncRNAs) are emerging as important regulators in plant development, but few of them have been functionally characterized in fruit ripening. Here, we have identified 25,613 lncRNAs from strawberry ripening fruits based on RNA-seq data from poly(A)-depleted libraries and rRNA-depleted libraries, most of which exhibited distinct temporal expression patterns. …”
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Integrating transcriptomic and metabolomic analyses to characterize the potential function of SLC1A5 in thyroid cancer by Fengling Shan, Lan Wang, Xinyu Lu, Meihong Zhou, Zi Wang, Jingjing Lou, Xingdang Liu

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Overexpression of Chromosome 21 miRNAs May Affect Mitochondrial Function in the Hearts of Down Syndrome Fetuses by Antonella Izzo, Rosanna Manco, Tiziana de Cristofaro, Ferdinando Bonfiglio, Rita Cicatiello, Nunzia Mollo, Marco De Martino, Rita Genesio, Mariastella Zannini, Anna Conti, Lucio Nitsch

“…Also miRNAs might play important roles in the cardiac phenotype as they are highly expressed in the heart and regulate cardiac development. …”
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Genome-wide association study and subsequent functional analysis reveal regulatory mechanism underlying piglet diarrhea by Dong Chen, Qi Shen, Rui Huang, Zhenjian Zhao, Yang Yu, Shengdi Cui, Junge Wang, Ziyang Chen, Pingxian Wu, Guoqing Tang

“…Through this process, we identified 308 single nucleotide polymorphisms (SNPs) and annotated 151 candidate genes. Extensive functional validation and systematic analysis were performed on key candidate genes KSR1, SKAP1, SLC35F6, and OR12. …”
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Metformin Activation of Sirtuin 3 Signaling Regulates Mitochondrial Function Improves Diabetes-Associated Cognitive Impairment by An JF, Su H, Zhang CQ, Wang XT, Zhang GQ, Fu LY, Xu YN, Tao L, Shen XC

“…Subsequently, DACD mice were administered MET for 2 months. The expression levels of proteins related to mitochondrial function were analyzed using immunohistochemical staining, immunofluorescence double staining, qRT-PCR, and Western blot. …”
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Distinct effects of IL-18 on the engraftment and function of human effector CD8 T cells and regulatory T cells. by Richard G Carroll, Carmine Carpenito, Xiaochuan Shan, Gwenn Danet-Desnoyers, Ronghua Liu, Shuguang Jiang, Steven M Albelda, Tatiana Golovina, George Coukos, James L Riley, Zdenka L Jonak, Carl H June

“…We investigated the effects of human IL-18 on the engraftment and function of human T cell subsets in xenograft mouse models. …”
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Targeting CD93 on monocytes revitalizes antitumor immunity by enhancing the function and infiltration of CD8+ T cells by Yan Wu, Da Jiang, Xing-Chen Liu, Yong-Hao Ruan, Limin Zheng, Aiqi Huang, Bai-Xi Zhu, Jiangling Gong

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A decellularized flowable placental connective tissue matrix supports cellular functions of human tenocytes in vitro by Yong Mao, Nikita John, Nicole M. Protzman, Adam Kuehn, Desiree Long, Raja Sivalenka, Radoslaw A. Junka, Anna Gosiewska, Robert J. Hariri, Stephen A. Brigido

“…The presence of I‐CTM also prevented the loss of tenocyte phenotype, attenuated the expression of pro‐inflammatory cytokines, growth factors, and MMP, and promoted the expression of antifibrotic growth factor, TGFβ3. …”
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Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse. by Tia DiTommaso, Lynelle K Jones, Denny L Cottle, WTSI Mouse Genetics Program, Anna-Karin Gerdin, Valerie E Vancollie, Fiona M Watt, Ramiro Ramirez-Solis, Allan Bradley, Karen P Steel, John P Sundberg, Jacqueline K White, Ian M Smyth

“…A total of 562 different mouse lines were subjected to a variety of tests assessing cutaneous expression, macroscopic clinical disease, histological change, hair follicle cycling, and aberrant marker expression. …”
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Identification and Functional Characterization of Glycosylation of Recombinant Human Platelet-Derived Growth Factor-BB in Pichia pastoris. by Mengmeng Dai, Changming Yu, Ting Fang, Ling Fu, Jing Wang, Jun Zhang, Jun Ren, Junjie Xu, Xiaopeng Zhang, Wei Chen

“…Yeast Pichia pastoris is a widely used system for heterologous protein expression. However, post-translational modifications, especially glycosylation, usually impede pharmaceutical application of recombinant proteins because of unexpected alterations in protein structure and function. …”
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Differential proteomics and functional research following gene therapy in a mouse model of Leber congenital amaurosis. by Qinxiang Zheng, Yueping Ren, Radouil Tzekov, Yuanping Zhang, Bo Chen, Jiangping Hou, Chunhui Zhao, Jiali Zhu, Ying Zhang, Xufeng Dai, Shan Ma, Jia Li, Jijing Pang, Jia Qu, Wensheng Li

“…Gene therapy in rd12 mice restored retinal function in treated eyes, which was demonstrated by electroretinography (ERG). …”
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Use of allele-specific FAIRE to determine functional regulatory polymorphism using large-scale genotyping arrays. by Andrew J P Smith, Philip Howard, Sonia Shah, Per Eriksson, Stefan Stender, Claudia Giambartolomei, Lasse Folkersen, Anne Tybjærg-Hansen, Meena Kumari, Jutta Palmen, Aroon D Hingorani, Philippa J Talmud, Steve E Humphries

“…As a step towards a high-throughput method to identify genome-wide, non-coding, functional regulatory variants, we describe the technique of allele-specific FAIRE, utilising large-scale genotyping technology (FAIRE-gen) to determine allelic effects on chromatin accessibility and regulatory potential. …”
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Spatial and functional profiles distinguish target sets of Parkinson’s disease and antipsychotic drugs with different clinical effects by Kalyani B. Karunakaran, Sanjeev Jain, Darius Widera, Graeme S. Cottrell

“…In summary, our study identified specific spatial and functional features that distinguish the target sets of PD and antipsychotic drugs with different clinical effects.…”
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Anapc5 and Anapc7 as genetic modifiers of KIF18A function in fertility and mitotic progression by Carleigh Nesbit, Whitney Martin, Anne Czechanski, Candice Byers, Narayanan Raghupathy, Ardian Ferraj, Jason Stumpff, Laura Reinholdt

“…Abstract The kinesin family member 18 A (KIF18A) is an essential regulator of microtubule dynamics and chromosome alignment during mitosis. Functional dependency on KIF18A varies by cell type and genetic context but the heritable factors that influence this dependency remain unknown. …”
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P13 | MORPHO-FUNCTIONAL DIFFERENCES IN THE GUT OF AGED MICE WITH THE POSSIBLE EFFECTS OF ANTI-INFLAMMATORY TREATMENTS

“…For these reasons, preserving the structural and functional integrity of the GI barrier is fundamental to control and prevent inflammation, which contributes to age-related diseases2. …”
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Cloning and functional analysis of transcription factor AaCMB1 on carotenoid accumulation in spathe of Anthurium andraeanum by Hong Luo, Chunfang Hu, Lulu Bai, Guangdong Wang

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Loss of Pleiotropic Regulatory Functions in Tannin1, the Sorghum Ortholog of Arabidopsis Master Regulator TTG1 by Anthony Schuh, Geoffrey P. Morris

“…Further, NILs had no visible difference in anthocyanin pigmentation, and no genes with known or expected function in flavonoid synthesis were differentially expressed. …”
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SS-31 Targets NOS2 to Enhance Osteogenic Differentiation in Aged BMSCs by Restoring Mitochondrial Function by Sen Duan, Qindong Zhang, Jinqiang Zhu, Jiaming Wang

“…In conclusion, the findings of this study highlight the therapeutic potential of SS-31 in reversing the age-related decline in BM-MSC function by specifically inhibiting NOS2 expression and restoring mitochondrial function. …”
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