Only Another Adjective, or Finally a New Functional Post-Ideological Subtype? A Conceptual Analysis of Valence Populism by Michal Aleš

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Protocol for CRISPR-mediated deletion of cis-regulatory element in murine Th17 cells for in vivo assessment of effector function by Xiancai Zhong, Hongmin Wu, Guanpeng Wang, Zuoming Sun

“…Here, we present a protocol for CRISPR-mediated deletion of a CRE in murine Th17 cells for in vivo assessment of effector function in EAE. We describe steps for dual U6gRNA construction, preparation of retroviruses, viral delivery, and Th17 differentiation. …”
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Long-term persistence of functional thymic epithelial progenitor cells in vivo under conditions of low FOXN1 expression. by Xin Jin, Craig S Nowell, Svetlana Ulyanchenko, Frances H Stenhouse, C Clare Blackburn

“…Normal thymus function reflects interactions between developing T-cells and several thymic stroma cell types. …”
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AI-Driven Integration of Deep Learning With Lung Imaging, Functional Analysis, and Blood Gas Metrics for Perioperative Hypoxemia Prediction by Kecheng Huang, Chujun Wu, Rongpeng Pi, Jieyu Fang

“… This viewpoint article explores the transformative role of artificial intelligence (AI) in predicting perioperative hypoxemia through the integration of deep learning with multimodal clinical data, including lung imaging, pulmonary function tests, and arterial blood gas (ABG) analysis. …”
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A loss of function screen of identified genome-wide association study Loci reveals new genes controlling hematopoiesis. by Ewa Bielczyk-Maczyńska, Jovana Serbanovic-Canic, Lauren Ferreira, Nicole Soranzo, Derek L Stemple, Willem H Ouwehand, Ana Cvejic

“…Using the from-GWAS-to-function strategy we have not only identified a series of genes that represent novel regulators of thrombopoiesis and hematopoiesis, but this work also represents, to our knowledge, the first example of a functional genetic screening strategy that is a critical step toward obtaining biologically relevant functional data from GWA study for blood cell traits.…”
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The adjuvant effects of high-molecule-weight polysaccharides purified from Antrodia cinnamomea on dendritic cell function and DNA vaccines. by Chi-Chen Lin, I-Hong Pan, Yi-Rong Li, Yi-Gen Pan, Ming-Kuem Lin, Yi-Huang Lu, Hsin-Chieh Wu, Ching-Liang Chu

“…However, research addressing the function of AC in enhancing immunity is rare. The aim of the present study is to investigate the active components and the mechanism involved in the immunostimulatory effect of AC. …”
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Functional analysis of type II chalcone isomerase (CHI) genes in regulating soybean (Glycine max L.) nodule formation by Xinyue Wang, Jingwen Li, Yuxue Zhou, Jinhao Zhang, Le Wang, Yajing Liu, Xuguang Yang, Hongshuang Han, Qingyu Wang, Ying Wang

“…However, overexpression of GmCHI1B1 significantly increased the content of glycitein but not daidzein, genistein content implied that homologous genes exhibit functional differentiation. These results provide a reference for subsequent studies on improving nitrogen fixation in soybeans and providing functional genes for the improvement of new varieties.…”
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The effect of high intensity interval and continues training on cardiac stem cells function and myocardial regeneration capacity in male rats by AREZOO ESKANDARI SHAHRABI, rahman sori, siroos chobineh, zohre mazaheri tirani

“…The aim of this study was the effect of high intensity interval and continues training on cardiac stem cells function and myocardial regeneration capacity in male rats.Methods: Twenty-four Vistar male rats (365.6±13.3 g, 6-8 month) were divided into three groups HIIT (high intensity) continuous and control. …”
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Adult ADHD, Comorbidities and Impact on Functionality in a Population of Individuals with Personality Disorders – DSM IV and DSM 5 Perspectives by Laura Aelenei, Dan Prelipceanu

“…The overall severity and the impact on functionality as assessed with the presence of hospitalizations and the WFIRS scale show a signifi cant importance in differentiating the intensity of ADHD symptomatology.…”
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FAM20B Gain-of-Function Blocks the Synthesis of Glycosaminoglycan Chains of Proteoglycans and Inhibits Proliferation and Migration of Glioblastoma Cells by Lydia Barré, Irfan Shaukat, Mohamed Ouzzine

“…Here, we demonstrated that <i>FAM20B</i> gain-of-function decreased, in a dose dependent manner, the synthesis of both CS- and HS-attached PGs. …”
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Patient-derived iPSCs link elevated mitochondrial respiratory complex I function to osteosarcoma in Rothmund-Thomson syndrome. by Brittany E Jewell, An Xu, Dandan Zhu, Mo-Fan Huang, Linchao Lu, Mo Liu, Erica L Underwood, Jun Hyoung Park, Huihui Fan, Julian A Gingold, Ruoji Zhou, Jian Tu, Zijun Huo, Ying Liu, Weidong Jin, Yi-Hung Chen, Yitian Xu, Shu-Hsia Chen, Nino Rainusso, Nathaniel K Berg, Danielle A Bazer, Christopher Vellano, Philip Jones, Holger K Eltzschig, Zhongming Zhao, Benny Abraham Kaipparettu, Ruiying Zhao, Lisa L Wang, Dung-Fang Lee

“…RTS osteoblast metabolic assays demonstrated elevated mitochondrial respiratory complex I function, increased oxidative phosphorylation (OXPHOS), and increased ATP production. …”
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The crucial function of IDO1 in pulmonary fibrosis: From the perspective of mitochondrial fusion in lung fibroblasts and targeted molecular inhibition by Lei Wang, Shanchun Ge, Ye Zhang, Deqin Feng, Ting Zhu, Louqian Zhang, Chaofeng Zhang

“…We find that IDO1 is significantly upregulated in the fibrotic lungs of patients and mice, showing a positive correlation with genes characteristic of fibrosis. Functionally, IDO1 knockout inhibits lung fibroblast proliferation, differentiation, mitochondrial biogenesis, and mitochondrial oxidative phosphorylation. …”
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Caspase 3 exhibits a yeast metacaspase proteostasis function that protects mitochondria from toxic TDP43 aggregates by Steve Brunette, Anupam Sharma, Ryan Bell, Lawrence Puente, Lynn A Megeney

“…We demonstrate that human caspase 3 can functionally substitute for the ScMCA1 and limit protein aggregation in yeast, including TDP-43 inclusions. …”
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The Possibilities of Multiparametric Magnetic Resonance Imaging to Reflect Functional and Structural Graft Changes 1 Year After Kidney Transplantation by Andrejus Bura, Gintare Stonciute-Balniene, Laura Velickiene, Inga Arune Bumblyte, Ruta Vaiciuniene, Antanas Jankauskas

“…T1 mapping by magnetic resonance imaging (MRI) has emerged as a promising method to assess renal structure and function. This study aimed to determine the potential of MRI as a diagnostic tool for evaluating graft function and structural changes in kidney grafts 1 year after transplantation. …”
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A single-cell transcriptomic atlas of human lens epithelium: identification and functional insights into lens stem/progenitor cells by Yuzhou Gu, Lu Chen, Shuying Chen, Yuhao Wu, Shengjie Hao, Feiyin Sheng, Jiali Yuan, Zhenwei Qin, Di Wu, Yu Han, Zengying Yao, Zhijian Chen, I. Michael Wormstone, Yibo Yu, Junbin Qian, Qiuli Fu, Ke Yao

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Functional trait differences between alien and native plants under hydrological variability in the riparian zone of the Three Gorges Reservoir by Xuemei Yi, Yuanyang Huang, Yongsheng Shi, Jialing Ju, Jilong Chen, Shengjun Wu

“…Results revealed a non-linear, N-shaped relationship between species diversity and flooding intensity, with species richness and diversity indices negatively correlated with prolonged inundation. While overall functional differentiation did not significantly vary with flooding intensity, convergence in plant height traits was observed under moderate flooding, whereas stronger flooding led to increased trait divergence. …”
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Human neural stem cells directly programmed from peripheral blood show functional integration into the adult mouse brain by Lea Jessica Berg, Chung Ku Lee, Hideaki Matsumura, Anke Leinhaas, Rachel Konang, Ali H. Shaib, Pedro Royero, Julia Schlee, Chao Sheng, Heinz Beck, Martin Karl Schwarz, Nils Brose, Jeong Seop Rhee, Oliver Brüstle

“…However, little is known about the functionality of iNSC-derived neurons upon in vivo transplantation. …”
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Exploring the functional role of POU5F1 using CRISPR RNP electroporation of zygote (CRISPR-EZ) in buffaloes by Meeti Punetha, Dharmendra Kumar, Suman Choudhary, Sheetal Saini, Kamlesh Kumari Bajwa, Surabhi Sharma, Manu Mangal, P. S. Yadav, T. K. Datta

“…We developed an easy and straightforward protocol for gene editing, which could serve as a valuable method for studying the functional genomics of the buffalo embryos. …”
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Selective Glycopolymer Inhibitors of Galectin-3: Supportive Anti-Cancer Agents Protecting Monocytes and Preserving Interferon-Gamma Function by Filipová M, Tavares MR, Hovorková M, Heine V, Nekvasilová P, Křen V, Etrych T, Chytil P, Bojarová P

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Nurr1 deficiency impairs autophagy-lysosomal function through GBA-dependent transcriptional regulation in Parkinson’s disease pathogenesis by Cheng Cheng, Cheng Cheng, Huijia Yang, Lulu Tian, Yang Ni, Congcong Jia, Weidong Le, Qingshan Wang

“…Defective lysosomal function compromised lysosomal mediated autophagic vesicle clearance. …”
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