Association between serum tricosanoic acid and cognitive function in older adults: findings from the NHANES and GEO databases by Ti Yang, Yue Zhang, Zeen Cai, Ying Wang, Shengqiong Deng

“…Population-level analysis (NHANES, n = 1,127) confirmed higher serum C23:0 associated with better cognitive function.DiscussionThis study provides strong evidence for frontal cortex-specific reduced C23:0 in AD and highlights its potential as a serum cognitive marker.…”
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ABHD6 loss-of-function in mesoaccumbens postsynaptic but not presynaptic neurons prevents diet-induced obesity in male mice by David Lau, Stephanie Tobin, Horia Pribiag, Shingo Nakajima, Alexandre Fisette, Dominique Matthys, Anna Kristyna Franco Flores, Marie-Line Peyot, S. R. Murthy Madiraju, Marc Prentki, David Stellwagen, Thierry Alquier, Stephanie Fulton

“…Together, these results reveal functional specificity of pre- and post-synaptic mesoaccumbens neuronal ABHD6 to differentially control energy balance and propose ABHD6 inhibition as a potential anti-obesity tool.…”
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Comparison of reproductive performance and functional analysis of spermatogenesis factors between domestic yak and semi-wild blood yak by Xin Pang, Yangyang Pan, Meng Wang, Shantong Qiu, Yulong He, Yuchun Ren, Tianjun Yu, Sijiu Yu, Yan Cui

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Heterogeneous virus classification using a functional deep learning model based on transmission electron microscopy images by Niloy Sikder, Md. Al-Masrur Khan, Anupam Kumar Bairagi, Mehedi Masud, Jun Jiat Tiang, Abdullah-Al Nahid

“…The methodology of this study includes two coherent image processing techniques to reduce the noise present in raw microscopy images and a functional Convolutional Neural Network (CNN) model for classification. …”
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Characterization of CsWRKY29 and CsWRKY37 transcription factors and their functional roles in cold tolerance of tea plant by Huijuan Zhao, Ali Inayat Mallano, Fangdong Li, Penghui Li, Qiong Wu, Yanli Wang, Yunze Li, Naveed Ahmad, Wei Tong, Yeyun Li, Zhengzhu Zhang, Enhua Xia

“…Additionally, the functional roles of two genes, CsWRKY29 and CsWRKY37, were examined under cold stress; and the silencing of these genes resulted in tea plant phenotypes susceptible to cold stress. …”
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Driving Innovation Through Regulatory Design and Corporate Behaviour: A Case Study of Functional Food Industry in Japan by Keigo Sato, Kota Kodama, Shintaro Sengoku

“…This study addresses the critical need for innovation in the healthcare sector, particularly in Japan’s functional food industry, amid rising chronic diseases and healthcare costs. …”
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SUMOylation substrate encoding genes as prognostic biomarkers in pancreatic ductal adenocarcinoma with functional assessment of SAF-B2 by Xiangjun Wang, Chuanxin Yang, Yangming Liu, Jian Wang

“…SUMOylation, a reversible post-translational modification, plays a critical role in tumor progression, yet its prognostic significance in PDAC remains unclear.MethodsWe assessed SUMOylation expression patterns and function in PDAC using Western blot and the SUMOylation inhibitor TAK-981. …”
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On the treatment of connecting conditions and the choice of admissible functions in energy method to investigate band gap characteristics of periodic beams by Yuta KONNO, Takahiro TOMIOKA

“…Three treatments to express a unit cell and three admissible functions are tested. Calculated dispersion curves are compared with those obtained by the differential quadrature method (DQM), which is widely used in band gap research. …”
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Evolutionary dynamics of Orchid DL paralogs: gene duplication, functional divergence, and expression patterns across Orchid subfamilies by Francesca Lucibelli, Angela Carfora, Annette Becker, Katrin Ehlers, Serena Aceto

“…Sequence comparison and expression analyses uncovered potential pseudogenization events affecting DL2 paralogs of Vanilloideae and Cypripedioideae, while in the most recent subfamily Epidendroideae, differential expression of DL2 in inner perianth tissues suggests the possible acquisition of a new function in the development of the lip callus. …”
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Effect of enhanced early life nutrition on the molecular regulation of anterior pituitary function in Holstein Friesian bull calves by K. Keogh, S. Coen, P. Lonergan, S. Fair, D. A. Kenny

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Vibration characteristics of axially loaded tapered Timoshenko beams made of functionally graded materials by the power series method by M. Soltani

“…Abstract:In the present article, a semi-analytical technique to investigate free bending vibration behavior of axially functionally graded non-prismatic Timoshenko beam subjected to a point force at both ends is developed based on the power series expansions. …”
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Discriminant analysis: peculiarities of impact of sports specialization on 3rd-year female students’ functional and motor fitness by Serhii Chernenko, Wladyslaw Jagiello, Olha Ivashchenko, Oleg Khudolii, Sviatoslava Pashkevich

“…The results of the following tests are most important for differentiated assessment of the state of motor and functional fitness at the first level: Romberg test (r = 0.662), 100-meter dash (r = 0.491), Push-ups (r = 0.491). …”
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Whole-Body Distribution of Leukemia and Functional Total Marrow Irradiation Based on FLT-PET and Dual-Energy CT by Taiki Magome PhD, Jerry Froelich MD, Shernan G. Holtan MD, Yutaka Takahashi PhD, Michael R. Verneris MD, Keenan Brown PhD, Kathryn Dusenbery MD, Jeffrey Wong MD, Susanta K. Hui PhD

“…The red marrow (RM) and yellow marrow (YM) of the BME were segmented from DECT using a basis material decomposition method. Functional total marrow irradiation (fTMI) treatment planning simulations were performed combining FLT-PET and DECT imaging to differentially target irradiation to the leukemia niche and the rest of the skeleton. …”
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Enterotoxigenic Escherichia coli heat-labile enterotoxin induces cell death and disrupts effector functions in porcine monocytes by Jinglin Ma, Hans Van der Weken, Leen Hermans, Matthias Dierick, Eric Cox, Bert Devriendt

“…Our results showed that STa did not affect the viability or effector functions of monocytes. LT, on the other hand, decreased the viability of monocytes. …”
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Mitigating functional fatigue of 3D-printed nickel-titanium shape memory alloy using hybridizing stabilizers by Ojo Philip Bodunde, Shiming Gao, Shuo Qu, Junhao Ding, Xu Song, Wei-Hsin Liao

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Exosomes derived let-7f-5p is a potential biomarker of SLE with anti-inflammatory function by Yi-jing Liu, Hai-bing Miao, Shu Lin, Zhen Chen

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Protective effect of interferon type I on barrier function of human airway epithelium during rhinovirus infections in vitro by Helena Boland, Adrian Endres, Ralf Kinscherf, Ralf Schubert, Beate Wilhelm, Hans Schwarzbach, Danny Jonigk, Peter Braubach, Gernot Rohde, Carla Bellinghausen

“…Taken together, these data demonstrate a beneficial effect of IFN-β in protecting epithelial barrier function in addition to its antiviral effects.…”
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Comparison of effects of p53 null and gain-of-function mutations on salivary tumors in MMTV-Hras transgenic mice. by Dadi Jiang, Catherine I Dumur, H Davis Massey, Viswanathan Ramakrishnan, Mark A Subler, Jolene J Windle

“…Some of these mutants appear to have acquired novel functions beyond merely losing wild-type functions. …”
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Formulation and evaluation of cetuximab functionalized phospholipid modified nanocrystals of paclitaxel for non-small cell lung cancer therapy by Manish Kumar, Pooja Goswami, Abhishek Jha, Manjit Manjit, Amol Parasram Satpute, Biplob Koch, Brahmeshwar Mishra

“…The findings of this study indicate the promising potential of the prepared cetuximab-functionalized phospholipid-coated paclitaxel nanocrystals in lung cancer therapy.…”
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Maps of open chromatin guide the functional follow-up of genome-wide association signals: application to hematological traits. by Dirk S Paul, James P Nisbet, Tsun-Po Yang, Stuart Meacham, Augusto Rendon, Katta Hautaviita, Jonna Tallila, Jacqui White, Marloes R Tijssen, Suthesh Sivapalaratnam, Hanneke Basart, Mieke D Trip, Cardiogenics Consortium, MuTHER Consortium, Berthold Göttgens, Nicole Soranzo, Willem H Ouwehand, Panos Deloukas

“…We showed that the two cell types exhibit distinct patterns of open chromatin and that cell-specific open chromatin can guide the finding of functional variants. We identified an open chromatin region at chromosome 7q22.3 in megakaryocytes but not erythroblasts, which harbors the common non-coding sequence variant rs342293 known to be associated with platelet volume and function. …”
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