Murine mesenchymal stem cells exhibit a restricted repertoire of functional chemokine receptors: comparison with human. by Giselle Chamberlain, Karina Wright, Antal Rot, Brian Ashton, Jim Middleton

“…Mesenchymal stem cells (MSCs) are non-haematopoeitic, stromal cells that are capable of differentiating into mesenchymal tissues such as bone and cartilage. …”
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Functional genomics of trypanotolerant and trypanosusceptible cattle infected with Trypanosoma congolense across multiple time points and tissues. by Gillian P McHugo, James A Ward, John A Browne, Grace M O'Gorman, Kieran G Meade, Emmeline W Hill, Thomas J Hall, David E MacHugh

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Prediction of depression in individuals at high familial risk of mood disorders using functional magnetic resonance imaging. by Heather C Whalley, Jessika E Sussmann, Liana Romaniuk, Tiffany Stewart, Martina Papmeyer, Emma Sprooten, Suzanna Hackett, Jeremy Hall, Stephen M Lawrie, Andrew M McIntosh

“…<h4>Methods</h4>We studied 98 young unaffected individuals at high familial risk of BD and 58 healthy controls using functional Magnetic Resonance Imaging (fMRI) scans and a task involving executive and language processing. …”
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Comparison of Two Different OCT Systems: Retina Layer Segmentation and Impact on Structure-Function Analysis in Glaucoma by Livia M. Brandao, Anna A. Ledolter, Andreas Schötzau, Anja M. Palmowski-Wolfe

“…To compare two different spectral-domain optical coherence tomography (OCT) systems in regard to full macular thickness (MT) and ganglion cell layer-inner plexiform layer (GCIPL) measures and in regard to structure-function correlation when compared to standard automated perimetry (SAP). …”
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Comparative Analysis of Functional Adaptations to Vivifrail Intervention Between Higher- and Lower-Fitness Healthy Older Adults by Fang-Ru Lee, Yu-Jui Li, Chia-Yu Tang, Chang-Chi Lai, Hsia-Ling Tai, Szu-Kai Fu

“…This study evaluated the differential effects of an advanced Vivifrail D-level exercise intervention on arterial stiffness, functional fitness, and body composition in robust older women with varying baseline fitness levels. …”
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Family history, inflammation, and cerebellum in major depression: a combined VBM and dynamic functional connectivity study by Jianyue Pang, Jiaying Xu, Long Chen, Huimin Teng, Chenxiao Su, Zhiyuan Zhang, Lingyun Gao, Rui Zhang, Gang Liu, Yuan Chen, Jin He, Yajing Pang, Hengfen Li

“…Voxel-based morphometry (VBM) and sliding-window dynamic functional connectivity (dFC) analyses were performed, and inflammatory biomarkers (C-reactive protein (CRP) and interleukin-6 (IL-6)) were detected. …”
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A temporally restricted function of the dopamine receptor Dop1R2 during memory formation by Jenifer C Kaldun, Emanuele Calia, Ganesh Chinmai Bangalore Mukunda, Cornelia Fritsch, Nikita Komarov, Simon G Sprecher

“…Dopamine acts through multiple receptors and controls an intricate signaling network to regulate different tasks. While the diverse functions of dopamine are intensely studied, the interplay and role of the distinct dopamine receptors to regulate different processes is less well understood. …”
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Functional screening reveals genetic dependencies and diverging cell cycle control in atypical teratoid rhabdoid tumors by Daniel J. Merk, Foteini Tsiami, Sophie Hirsch, Bianca Walter, Lara A. Haeusser, Jens D. Maile, Aaron Stahl, Mohamed A. Jarboui, Anna Lechado-Terradas, Franziska Klose, Sepideh Babaei, Jakob Admard, Nicolas Casadei, Cristiana Roggia, Michael Spohn, Jens Schittenhelm, Stephan Singer, Ulrich Schüller, Federica Piccioni, Nicole S. Persky, Manfred Claassen, Marcos Tatagiba, Philipp J. Kahle, David E. Root, Markus Templin, Ghazaleh Tabatabai

“…Results We here use a functional genomics approach to identify genetic dependencies in ATRT, validate selected hits using a functionally instructed small molecule drug library, and observe preferential activity in ATRT cells without subgroup-specific selectivity. …”
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Cloning and function analysis of ZmICE1a, a contributor to the melioration of maize kernel traits by Yifei Xiao, Liang Tu, Yulin Jiang, Pengfei Liu, Xiangyang Guo, Angui Wang, Yunfang Zhu, Xuefeng Lu, Zehui Chen, Xun Wu

“…Gene mining and clarification of relevant gene functions associated with kernel traits is beneficial for breeding high-yield maize varieties. …”
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CACNA1A loss-of-function affects neurogenesis in human iPSC-derived neural models by Ilaria Musante, Davide Cangelosi, Lorenzo Muzzi, Fanny Jaudon, Marco Di Duca, Sara Guerrisi, Francesca Antonini, Yeraldin Chiquinquira Castillo De Spelorzi, Lorenzo A. Cingolani, Federico Zara, Paolo Scudieri

“…Abstract CACNA1A encodes the pore-forming α1A subunit of the CaV2.1 calcium channel, whose altered function is associated with various neurological disorders, including forms of ataxia, epilepsy, and migraine. …”
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Evaluation of the polymorphism of the GDF9 and BMP15 genes and their relationship with the reproductive functions of sheep of different breeds by Z. K. Gadzhiev, E. S. Surzhikova, D. D. Evlagina, A. I. Surov, S. N. Shumaenko

“…Polymorphism is the result of evolutionary processes and is inherited, associated with biodiversity and modified by natural selection and functions to preserve various forms of population. …”
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Structural and functional roles of conserved residues of human papillomavirus (HPV) E2 protein and biological consequences by Sean Fletcher, Esther E. Biswas-Fiss, Subhasis B. Biswas

“…The HPV E2 protein is a central regulator of viral replication and oncogene expression, making it a critical determinant of HPV-associated malignancies. While its core functions are conserved, variations within the E2 protein are thought to contribute to the differential oncogenic potential among HPV types, though the structural basis for this remains incompletely understood. …”
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Complex Assessment of the Functional State of the Urinary System in Preclinical Studies. Part 2. Markers of Nephrotoxicity (Review) by M. V. Miroshnikov, K. T. Sultanova, M. N. Makarova, N. M. Faustova, S. O. Khan, E. A. Loseva

“…Having compared the prognostic significance of common biomarkers, the authors provided general recommendations for a comprehensive preclinical assessment of urinary system function, including laboratory investigations, instrument-based tests, and necropsy. …”
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SARS-CoV-2 infection impairs oculomotor functions: A longitudinal eye-tracking study by Xiaoting Duan, Zehao Huang, Shuai Zhang, Gancheng Zhu, Rong Wang, Zhiguo Wang

“…The current study used three eye-tracking tasks (free-viewing, fixation, and smooth pursuit) to assess the oculomotor functions of mild infected cases over six months with symptomatic SARS-CoV-2 infected volunteers. …”
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VgrG and PAAR Proteins Define Distinct Versions of a Functional Type VI Secretion System. by Francesca R Cianfanelli, Juliana Alcoforado Diniz, Manman Guo, Virginia De Cesare, Matthias Trost, Sarah J Coulthurst

“…The presence of at least one PAAR protein was found to be essential for T6SS function, consistent with designation as a 'core' T6SS component. …”
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Functional role of cell classes in monkey prefrontal cortex after learning a working memory task by Amirreza Asadi, Christos Constantinidis, Mohammad Reza Daliri

“…This study advances our understanding of the functional heterogeneity within the PFC and the specialized contributions of different neuronal subtypes to cognitive processes.…”
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Short-term impacts of TV viewing on executive functions in children with reading difficulties: an eye tracking study by Zahra Babaei, Sara Arian Namazi, Saeid Sadeghi

“…Abstract Background Studies have shown that watching fantastic TV programs immediately impacts typically developing children’s executive functions (EFs). TV program contents may have a different effect on children with reading difficulties (RDs) because of executive dysfunctions, which have not been studied yet. …”
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Viability Study of a Safe Method for Health to Prepare Cement Pastes with Simultaneous Nanometric Functional Additions by M. A. de la Rubia, E. de Lucas-Gil, E. Reyes, F. Rubio-Marcos, M. Torres-Carrasco, J. F. Fernández, A. Moragues

“…The use of a mixing method based on a novel dry dispersion procedure that enables a proper mixing of simultaneous nanometric functional additions while avoiding the health risks derived from the exposure to nanoparticles is reported and compared with a common manual mixing in this work. …”
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Father’s adolescent body silhouette is associated with offspring asthma, lung function and BMI through DNA methylation by Negusse Tadesse Kitaba, Toril Mørkve Østergaard, Marianne Lønnebotn, Simone Accordini, Francisco Gómez Real, Andrei Malinovschi, Anna Oudin, Bryndis Benediktsdottir, Francisco Javier Callejas González, Leopoldo Palacios Gómez, Mathias Holm, Nils Oskar Jõgi, Shyamali C. Dharmage, Svein Magne Skulstad, Vivi Schlünssen, Cecilie Svanes, John W. Holloway

“…We identified 2005 differentially methylated cytosine-phosphate-guanine (dmCpG) sites (FDR < 0.05), including dmCpGs associated with offspring asthma (119), lung function (178) and BMI (291). …”
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Histological, Transcriptomic, and Functional Analyses Reveal the Role of Gibberellin in Bulbil Development in <i>Lilium lancifolium</i> by Shanshan Du, Mengdi Wang, Jiahui Liang, Wenqiang Pan, Qianzi Sang, Yanfang Ma, Mengzhu Jin, Mingfang Zhang, Xiuhai Zhang, Yunpeng Du

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