Functional Divergence of Plant‐Derived Thaumatin‐Like Protein Genes in Two Closely Related Whitefly Species by Yuan Hu, Cheng Gong, Zezhong Yang, Haolin Han, Tian Tian, Xin Yang, Wen Xie, Shaoli Wang, Qingjun Wu, Xuguo Zhou, Ted C. J. Turlings, Zhaojiang Guo, Youjun Zhang

“…These findings reveal an as‐yet undescribed scenario of cross‐species functional differentiation of horizontally transferred genes and suggest that the HGT‐mediated evolutionary novelty can contribute to ecotypic divergence and even speciation.…”
Get full text

Identification of a functional vitamin D response element in the promoter of goose anti-Müllerian hormone gene by Rong Chen, Chen Chen, Yifei Qin, Jie Liu, Mingming Lei, Huanxi Zhu, Zhendan Shi

“…These results suggest that vitamin D3 downregulates AMH mRNA expression via a functional VDRE that binds the VDR/RXR heterodimer in goose ovarian prehierarchical follicles. …”
Get full text

Respiratory long COVID in aged hamsters features impaired lung function post-exercise with bronchiolization and fibrosis by Laura Heydemann, Małgorzata Ciurkiewicz, Theresa Störk, Isabel Zdora, Kirsten Hülskötter, Katharina Manuela Gregor, Lukas Mathias Michaely, Wencke Reineking, Tom Schreiner, Georg Beythien, Asisa Volz, Tamara Tuchel, Christian Meyer zu Natrup, Lisa-Marie Schünemann, Sabrina Clever, Timo Henneck, Maren von Köckritz-Blickwede, Dirk Schaudien, Karl Rohn, Klaus Schughart, Robert Geffers, Mika K. Kaneko, Yukinari Kato, Carina Gross, Georgios Amanakis, Andreas Pavlou, Wolfgang Baumgärtner, Federico Armando

“…This study aimed to characterize the trajectory of lung regeneration over 112 days in the male hamster model by combining morphological, transcriptomic and functional readouts. We demonstrate that in the acute phase, SARS-CoV-2 Delta-infected, male, aged hamsters show a severe impairment of lung function at rest. …”
Get full text

An active shrinkage and antioxidative hydrogel with biomimetic mechanics functions modulates inflammation and fibrosis to promote skin regeneration by Tao Zhang, Xin-Cao Zhong, Zi-Xuan Feng, Xiao-Ying Lin, Chun-Ye Chen, Xiao-Wei Wang, Kai Guo, Yi Wang, Jun Chen, Yong-Zhong Du, Ze-Ming Zhuang, Yong Wang, Wei-Qiang Tan

“…To these, we developed an active shrinkage and antioxidative hydrogel with biomimetic mechanical functions (P&G@LMs) to reshape the healing microenvironment and effectively promote skin regeneration. …”
Get full text

Store‐operated calcium entry controls innate and adaptive immune cell function in inflammatory bowel disease by Marilena Letizia, Yin‐Hu Wang, Ulrike Kaufmann, Lorenz Gerbeth, Annegret Sand, Max Brunkhorst, Patrick Weidner, Jörn Felix Ziegler, Chotima Böttcher, Stephan Schlickeiser, Camila Fernández, Megumi Yamashita, Kenneth Stauderman, Katherine Sun, Désirée Kunkel, Murali Prakriya, IBDome Researchers, Ashley Sanders, Britta Siegmund, Stefan Feske, Carl Weidinger

“…We observed that the pharmacologic inhibition of SOCE attenuated the production of proinflammatory cytokines including IL‐2, IL‐4, IL‐6, IL‐17A, TNF, and IFNγ by human colonic T cells and ILCs, reduced the production of IL‐6 by B cells and the production of IFNγ by myeloid cells, but had no effect on the viability, differentiation, and function of intestinal epithelial cells. …”
Get full text

Processing demands modulate the activities and functional connectivity patterns of the posterior (VWFA-1) and anterior (VWFA-2) VWFA by Aqian Li, Chuansheng Chen, Xiaoyan Wu, Yuan Feng, Jingyu Yang, Xiaoxue Feng, Rui Hu, Leilei Mei

“…Nevertheless, it is still unclear how the functional connectivity pattern of the VWFA is regulated by processing demands induced by experimental tasks, and whether processing demands differentially regulate the posterior (VWFA-1) and anterior (VWFA-2) subregions of the VWFA. …”
Get full text

Diversity and Functional Differences in Soil Bacterial Communities in Wind–Water Erosion Crisscross Region Driven by Microbial Agents by Tao Kong, Tong Liu, Zhihui Gan, Xin Jin, Lin Xiao

“…Microbial treatments differentially influence soil bacterial communities and functions. …”
Get full text

Sarcopenic obesity is attenuated by E-syt1 inhibition via improving skeletal muscle mitochondrial function by Chao Song, Wu Zheng, Guoming Liu, Yiyang Xu, Zhibo Deng, Yu Xiu, Rongsheng Zhang, Linhai Yang, Yifei Zhang, Guoyu Yu, Yibin Su, Jun Luo, Bingwei He, Jie Xu, Hanhao Dai

“…To investigate the regulatory role of E-syt1 in muscle metabolism, we performed in vivo and in vitro experiments through E-syt1 loss- and gain-of-function on muscle physiology. When E-syt1 is overexpressed in vitro, myoblast proliferation, differentiation, mitochondrial respiration, biogenesis, and mitochondrial dynamics are impaired, which were alleviated by the silence of E-syt1. …”
Get full text

Impacts of Spartina alterniflora invasion on C-cycling functional genes and microbial communities in salt marsh wetlands during cold season by Xiaoling Zhang, Bin Ma, Qian Zhang, Qingjun Wang, Xiaodong Yang, Junxiang Fei, Shihong Zhang, Fan Zhang, Yuan Zhang, Shixiao Xu

“…Therefore, this study compared the differences in soil carbon cycling (C-cycling) functional genes between invaded and native areas during the cold season, as well as the changes in microbial communities involved in differential functional genes’ expression. …”
Get full text

Lactobacillus delbrueckii subsp. bulgaricus 2038 and Streptococcus thermophilus 1131 ameliorate barrier dysfunction in human induced pluripotent stem cell-derived crypt-villus stru... by Kyosuke Kobayashi, Yuri Imai, Yuka Shimizu, Isamu Ogawa, Isamu Ogawa, Takaaki Nakai, Yuri Mizuno, Yoshika Kaneda, Yumiko Watanabe-Yasuoka, Fuka Yamazaki, Junko Mochizuki, Toshihiro Sashihara, Tamihide Matsunaga, Tamihide Matsunaga, Takahiro Iwao, Takahiro Iwao

Subjects: Get full text

Dynamic optical soliton solutions of M-fractional modify unstable nonlinear Schrödinger equation via two analytic methods by Md. Mamunur Roshid, Mahtab Uddin, Salah Boulaaras, M.S. Osman

Subjects: Get full text

Spatial and functional profiles distinguish target sets of Parkinson’s disease and antipsychotic drugs with different clinical effects by Kalyani B. Karunakaran, Sanjeev Jain, Darius Widera, Graeme S. Cottrell

“…Although global brain expression patterns did not effectively differentiate between the targets of the two sets of APDs, they did differentiate the targets of the two PD drug sets. …”
Get full text

Loss of Pleiotropic Regulatory Functions in Tannin1, the Sorghum Ortholog of Arabidopsis Master Regulator TTG1 by Anthony Schuh, Geoffrey P. Morris

“…Further, NILs had no visible difference in anthocyanin pigmentation, and no genes with known or expected function in flavonoid synthesis were differentially expressed. …”
Get full text

Transplantation of derivative retinal organoids from chemically induced pluripotent stem cells restored visual function by Ning Zhao, Chang-Jun Zhang, Xiao Zhang, Wen Wang, Kangxin Jin, Zi-Bing Jin

“…We transplanted retinal photoreceptors from ROs into the subretinal space of retinal degeneration mouse models and the cells could integrate into the host retina, establish synaptic connections, and significantly improve the visual functions of the murine models. This proof-of-concept study for the first time demonstrated that CiPSCs could differentiate into ROs with a full spectrum of retinal cell types, and provided new insights into chemical approach-based retinal regeneration for degenerative diseases.…”
Get full text

Local Fractional Adomian Decomposition and Function Decomposition Methods for Laplace Equation within Local Fractional Operators by Sheng-Ping Yan, Hossein Jafari, Hassan Kamil Jassim

“…We perform a comparison between the local fractional Adomian decomposition and local fractional function decomposition methods applied to the Laplace equation. …”
Get full text

In Vitro Co-culture of Bacterial and Mammalian Cells to Investigate Effects of Potential Probiotics on Intestinal Barrier Function by Ajitpal Purba, Rachel Anderson, Dulantha Ulluwishewa

“…Human intestinal barrier function is crucial for health. Beneficial microbes, such as commensal gut bacteria and probiotics, are known to contribute to the regulation of this barrier function. …”
Get full text

Anapc5 and Anapc7 as genetic modifiers of KIF18A function in fertility and mitotic progression by Carleigh Nesbit, Whitney Martin, Anne Czechanski, Candice Byers, Narayanan Raghupathy, Ardian Ferraj, Jason Stumpff, Laura Reinholdt

“…Abstract The kinesin family member 18 A (KIF18A) is an essential regulator of microtubule dynamics and chromosome alignment during mitosis. Functional dependency on KIF18A varies by cell type and genetic context but the heritable factors that influence this dependency remain unknown. …”
Get full text

Existence of Periodic Solutions in a Discrete Predator-Prey System with Beddington-DeAngelis Functional Responses by Changjin Xu, Maoxin Liao

“…A discrete predator-prey model with Holling II and Beddington-DeAngelis functional responses is investigated. With the aid of differential equations with piecewise constant arguments, a discrete version of continuous nonautonomous delayed predator-prey model with Beddington-DeAngelis functional responses is proposed. …”
Get full text

Associations of Pet Ownership with Wheezing and Lung Function in Childhood: Findings from a UK Birth Cohort. by Simon M Collin, Raquel Granell, Carri Westgarth, Jane Murray, Elizabeth S Paul, Jonathan A C Sterne, A John Henderson

“…Pet ownership was not associated with lung function at age 8 years, with the exception of positive associations of rodent and bird ownership with better lung function.…”
Get full text

The Optimal Quadrature Formula of Approximate Calculation of Curvilinear Integral of First Kind for Some Classes of Functions and Curves by K. Tukhliev

“…Nikolskiy sense for approximate calculation of curvilinear integrals of first kind on the class of differentiable functions, the second gradient norm of which in Lp (1 ≤ p < ∞) is bounded along the curve by which the curvilinear integral is calculated. …”
Get full text