THE IMPACT OF THIRD-GENERATION BETA-BLOCKER ANTIHYPERTENSIVE TREATMENT ON ENDOTHELIAL FUNCTION AND THE PROTHROMBOTIC STATUS. EFFECTS OF SMOKING by G. P. Vyssoulis, A. G. Marinakis, K. A. Aznaouridis, E. A. Karpanou, A. N. Arapogianni, D. V. Cokkinos, C. I. Stefanadis

“…The effect of vasodilating β-blockers on endothelial function and prothrombotic state has not been investigated. …”
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The dual-function of HSP70 in immune response and tumor immunity: from molecular regulation to therapeutic innovations by Beining Zhang, Ruiqun Qi, Ruiqun Qi

“…In recent years, studies have revealed that HSP70 has dual functions in immune regulation: on the one hand, it enhances immune responses by activating non-specific immunity (such as Toll-like receptor 2/4 (TLR2/4) signaling pathways) and specific immunity (such as cross-presentation of antigens, T helper 1 (Th1)/T helper 17 (Th17) differentiation); on the other hand, it inhibits excessive immune reactions by inducing the differentiation of regulatory T cells (Treg) and promoting the secretion of anti-inflammatory factors [such as interleukin-10 (IL-10)]. …”
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Specialization of the brain for language in children with Fragile X Syndrome: a functional Near Infrared Spectroscopy study by Elizabeth Smith, Kelli C. Dominick, Lauren M. Schmitt, Ernest V. Pedapati, Craig A. Erickson

“…We report results of a functional Near Infrared Spectroscopy (fNIRS) study of responses to speech and nonspeech sounds in the auditory cortex in a sample of 2- to 10-year-old children with FXS and typically developing controls (FXS n = 23, TDC n = 15, mean age = 6.44 and 7.07 years, respectively). …”
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Defining the end of puberty in boys: INSL3 and the acute determinants of adult Leydig-cell functional capacity by Bilal Tulumcu, Richard Ivell, Waleed Alhujaili, Ravinder Anand-Ivell

“…Leydig-cell functional capacity reflects the total number and differentiation status of the Leydig-cell population within an individual and can be assessed by measuring in blood the constitutive Leydig-cell hormone insulin-like peptide 3 (INSL3). …”
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Hspa13 Deficiency Impaired Marginal Zone B Cells Regulatory Function and Contributed to Lupus Pathogenesis by Chen Xing, Haoran Cui, Ge Li, Xiaoling Liu, Kun Liu, Qing Wen, Xin Huang, Renxi Wang, Lun Song

“…However, the molecular basis underlying the role of Hspa13 in regulating Bregs function and lupus pathogenesis remains unclear. In this study, Bregs display higher Hspa13 expression than IL‐10− B cells. …”
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3D collagen nanofiber scaffold with adipose derived stem cells for functional adipose tissue regeneration by Liping Zhang, Yueguang Xue, Delu Mu, Siyi Chen, Guangmin Wu, Zitong Yang, Yizhu Chen, Hu Xu, Li Zhu, Jiandong Wang

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A Convergent Legendre Spectral Collocation Method for the Variable-Order Fractional-Functional Optimal Control Problems by Zahra Pirouzeh, Mohammad Hadi Noori Skandari, Kameleh Nassiri Pirbazari

“…In this paper, a numerical method is applied to approximate the solution of variable-order fractional-functional optimal control problems. The variable-order fractional derivative is described in the type III Caputo sense. …”
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CXCR4 is a response gene for parathyroid hormone which affects osteoblast and osteoclast function in vitro by Beatriz Larraz-Prieto, Louise Hjorth Lind, Jacob Bastholm Olesen, Asim Azfer, Morten Svarer Hansen, Morten Frost, Abbas Jafari, Stuart H. Ralston, Kent Søe, Nerea Alonso

“…Conclusion: Our results suggest that CXCR4 is a responsive gene to TPTD treatment, involved in the regulation of osteoblast and osteoclast generation and function. Further in vivo studies are required to confirm this role, and to determine whether pharmacological strategies targeting CXCR4 could potentially improve the treatment outcome for osteoporotic patients. …”
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Direct conversion of urine-derived cells into functional motor neuron-like cells by defined transcription factors by Hiroaki Nagai, Masayo Saito, Hidehisa Iwata

“…Herein, induced motor neuron-like cells (iMNs) were generated from UDCs by transducing transcription factors involved in motor neuron (MN) differentiation. iMNs exhibited neuronal morphology, upregulation of pan-neuron and MN markers, and MN functionality, including spontaneous calcium oscillation and bungarotoxin-positive neuromuscular junction formation, when co-cultured with myotubes. …”
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On the improvement of schizophrenia detection with optical coherence tomography data using deep neural networks and aggregation functions by Paweł Karczmarek, Małgorzata Plechawska-Wójcik, Adam Kiersztyn, Adam Domagała, Agnieszka Wolinska, Steven M. Silverstein, Kamil Jonak, Paweł Krukow

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Engineered extracellular vesicles with sequential cell recruitment and osteogenic functions to effectively promote senescent bone repair by Lei Qi, Jing Wang, Jinge Yan, Weidong Jiang, Weiwen Ge, Xin Fang, Xudong Wang, Steve GF Shen, Lu Liu, Lei Zhang

“…To further validate its function, Gelatin methacryloyl (GelMA) hydrogel was used as a carrier to construct the Apt-376b-EV@GelMA delivery system. …”
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Climatic Adaptability Changes in Leaf Functional Traits of Old <i>Pinus tabulaeformis</i> in Loess Plateau by Yuting Lei, Zimao Feng, Zhong Zhao

“…A systematic examination of leaf functional traits, environmental determinants, and adaptive regulation strategies in old <i>Pinus tabuliformis</i> was conducted in the Loess Plateau region. …”
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The predicted target gene validation, function, and prognosis studies of miRNA-22 in colorectal cancer tissue by Bo Li, Bai Li, Hongyan Sun, Haishan Zhang

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Protocol to derive postganglionic parasympathetic neurons using human pluripotent stem cells for electrophysiological and functional assessment by Christina James, Hsueh-Fu Wu, Jennifer Art, Archie Patel, Nadja Zeltner

“…We describe steps for human pluripotent stem cell replating, neural crest replating, cryobanking, and parasympathetic neuron differentiation. We then detail procedures for functional assays via multielectrode array (MEA) analysis.For complete details on the use and execution of this protocol, please refer to Wu et al.1 : Publisher’s note: Undertaking any experimental protocol requires adherence to local institutional guidelines for laboratory safety and ethics.…”
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Biorecognition-Based Nanodiagnostics: Maltotriose-Functionalized Magnetic Nanoparticles for Targeted Magnetic Resonance Imaging of Bacterial Infections by Junshan Wan, Chuqiang Yin, Xiaotong Chen, Keying Wu, Chonghui Zhang, Yu Zhou, Yugong Feng, Jing Chang, Ting Wang

“…Leveraging the selective bacterial uptake of maltotriose via the maltodextrin transport pathway, we engineered maltotriose-functionalized magnetic nanoparticles (Malt-MNPs) as a novel MRI contrast agent. …”
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Functional and structural features of the retina, fixation characteristics and their correlations with visual acuity in nystagmus and amblyopia of various origins by V. V. Neroev, E. P. Tarutta, R. R. Khubieva, A. V. Apaev

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PRDM16 functions as a co-repressor in the BMP pathway to suppress neural stem cell proliferation by Li He, Jiayu Wen, Qi Dai

“…When Prdm16 is lost, the SMAD complex relocates to nearby genomic regions, leading to abnormal upregulation of BMP target genes. This function of PRDM16 is also required for the specification of choroid plexus (ChP) epithelial cells. …”
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Integrative Genomic and Functional Approaches Identify FUOM as a Key Driver and Therapeutic Target in Cervical Cancer by Wenzhi Jiao, Shanshan Liu, Jianwei Shi, Minmin Yu

“…Objective This study integrates Mendelian randomization (MR) and single‐cell RNA sequencing (scRNA‐seq) to identify causal eQTL‐related genes and explore their roles in tumorigenesis. Functional experiments were conducted to validate key findings. …”
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Construction of a multimodal esophageal cancer prognostic model with screening of key genes and investigation of their biological functions by Zhengsong Chang, Yiru Li, Mengyao Wang, Xin Zhang, Qiang Bai, Huan Luo, Pengyun Deng, Liping Yang, Xiaomei Li

“…Functional experiments and co-immunoprecipitation/transcriptomic sequencing explored biological roles and molecular networks. …”
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Restoration of Lost Functions in Students after Blast Traumatic Brain Injuries in the Process of Inclusive Physical Education by Oksana Blavt, Oleksandr Herasymenko

“…The purpose of the article is to determine the effectiveness of the developed program of inclusive physical education on the restoration of dynamic balance functions in students after blast traumatic brain injury. …”
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