Alterations in neutrophil mRNA profiles in multiple sclerosis and identification of candidate genes for further investigation by Huining Zhang, Huining Zhang, Huining Zhang, Ruoyi Guo, Ruoyi Guo, Ruoyi Guo, Yusen Han, Yusen Han, Yusen Han, Zhichao Yao, Zhichao Yao, Zhichao Yao, Moyuan Quan, Moyuan Quan, Moyuan Quan, Bin Li, Bin Li, Bin Li, Li Guo, Li Guo, Li Guo

“…These results lay the groundwork for future studies exploring therapeutic strategies targeting neutrophil functions in MS.…”
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Integrating machine learning models with multi-omics analysis to decipher the prognostic significance of mitotic catastrophe heterogeneity in bladder cancer by Haojie Dai, Zijie Yu, You Zhao, Ke Jiang, Zhenyu Hang, Xin Huang, Hongxiang Ma, Li Wang, Zihao Li, Ming Wu, Jun Fan, Weiping Luo, Chao Qin, Weiwen Zhou, Jun Nie

“…In addition, we explored the ceRNA axis containing upstream non-coding RNAs after detailed analysis of pathway activation, immunoregulation, and methylation functions of the core genes. Finally, we performed drug screening and molecular docking experiments based on the core gene in the DSigDB database. …”
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Distinct 5-methylcytosine profiles of LncRNA in breast cancer brain metastasis by Song Wang, Jianran Guo, Xinmiao Xian, Min Li, Anqi Zhang, Yujiao Liu, Yifei Zhang, Shen Chen, Guohao Gu, Xuehua Zhang, Dong Yan, Meng An, Li Pan, Bo Fu

“…Enrichment pathway analyses were through Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) to predict the potential functions of m5C in BCBM. Results The MeRIP-seq analysis identified 23,934 m5C peaks in BCBM and 21,236 m5C in BC. …”
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Research on the effect of LAMP1 in the development and progression of ccRCC and its potential mechanism with LC3C-mediated autophagy by Xiongbao Wang, Xiongbao Wang, Xiongbao Wang, Liang Fang, Liang Fang, Lixiang Xiao, Guangxin Zhong, Minghao Han, Bingshen Wang, Juchao Ren, Yuanwei Zang, Yuanwei Zang

“…BackgroundLysomembrane-associated protein 1 (LAMP1), known to exhibit differential expression in various tumor types and play a crucial role in the development of tumors. …”
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The effect of the administration form of antibiotic therapy on the gut microbiome in patients with infected diabetic foot ulcers - DFIATIM trial by Chahrazed Mekadim, Jakub Mrazek, Kateřina Olša Fliegerová, Hana Sechovcová, Tiziana Maria Mahayri, Radka Jarošíková, Jitka Husáková, Veronika Wosková, Petr Tůma, Jan Polák, Dominika Sojáková, Andrea Němcová, Michal Dubský, Vladimíra Fejfarová

“…Conclusion The present study reported alterations in gut microbiota composition and functionality and provided the bacterial markers as well as potential metabolic signatures associated with each administration mode in patients with iDFUs, which may be used as a reference set for future studies of the effect of antibiotics administration on the gut microbiome of patients with iDFUs. …”
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The cold immunological landscape of ATM-deficient cancers by Fresia Pareja, Stephen Morris, Sonali Sinha, Lorenzo Galluzzi, Fatemeh Derakhshan, Jennifer Ma, Jorge Reis-Filho, Nadeem Riaz, Shu Yazaki, Victor Ng, Ardijana Novaj, Yingjei Zhu, Xin Pei, Jeremy Setton, Flavie Naulin, Manuel Beltrán-Visiedo, Ethan Shin, Ana Leda F Longhini, Rui Gardner, Kevin Ma, Anne Roulston, Maria Koehler, Simon Powell, Ezra Rosen, Atif Khan

“…Background Mutations in genes encoding DNA repair factors, which facilitate mismatch repair, homologous recombination, or DNA polymerase functions, are known to enhance tumor immunogenicity. …”
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A personal sensing technology enabled service versus a digital psychoeducation control for primary care patients with depression and anxiety: a pilot randomized controlled trial by Colleen Stiles-Shields, Karen M. Reyes, Tanvi Lakhtakia, Shannon R. Smith, Olga E. Barnas, Elizabeth L. Gray, Charles J. Krause, Kaylee P. Kruzan, Mary J. Kwasny, Zara Mir, Sameer Panjwani, Steven K. Rothschild, Lisa Sánchez-Johnsen, Nathan W. Winquist, Emily G. Lattie, Nicholas B. Allen, Madhu Reddy, David C. Mohr

“…Adjusting for baseline differences and randomization strata, TES participants reported a greater change in a quality of life rating of Physical Functioning (PedsQL) across time (p = .018). TES participants also reported higher levels of engagement and demonstrated higher app usage. …”
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Comparative transcriptomics of atrazine-tolerant and sensitive alfalfa varieties under atrazine stress by Yingao Li, Chunyang Dong, Zeshan Zulfiqar, Haojie Wang, Jiading Lu, Xiaoxia Zhang, Jun Li, Yinghua Shi, Chengzhang Wang, Xiaoyan Zhu, Hao Sun

“…Conclusions The tolerant variety JN5010 shows improved tolerance to atrazine stress by maintaining stable gene expression and precise regulation in various pathways, such as antioxidant processes, signaling, photosynthesis, and toxin removal. This differential gene expression helps JN5010 maintain stability in its functions under stress, demonstrating better adaptability. …”
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Entrectinib can induce nerve cell damage by inhibiting PI3K-AKT and TGF-β signaling pathways by Qingshan Tang, Jiachen Dong, Feng Zhang, Dan Zhao, Qi Yang, Jiayu Wen, Yuhao Sun, Jifu Wei, Zhixian Liu

“…Next, transcriptome sequencing technology was performed to identify differentially expressed genes (DEGs). Gene ontology (GO), kyoto encyclopedia of genes and genomes (KEGG) analysis and gene set enrichment analysis (GSEA) were applied to predict the potential functions of DEGs. …”
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Microbial diversity and composition in the gut microbiome of patients during systemic inflammatory response syndrome: can we use gut bacteria as potential biomarkers to characteriz... by Rafaela Ramalho Guerra, Rafaela Ramalho Guerra, Rafaela Ramalho Guerra, Patricia da Silva Fernandes, Otávio von Ameln Lovison, Otávio von Ameln Lovison, Giovanna de Ross Forni, Giovanna de Ross Forni, Gabriel Silva de Oliveira, Luana Cristina Viana, Dariane Castro Pereira, William Latosinski Matos, William Latosinski Matos, Miriane Melo Silveira Moretti, Fabiana Zempulski Volpato, Luciana Giordani, Luciana Giordani, Patricia Orlandi Barth, Patricia Orlandi Barth, Tarsila Vieceli, Diego Rodrigues Falci, Márcio Manozzo Boniatti, Afonso Luís Barth, Afonso Luís Barth, Afonso Luís Barth, Andreza Francisco Martins, Andreza Francisco Martins, Andreza Francisco Martins, Andreza Francisco Martins

“…In sepsis, the loss of taxa involved in key metabolic functions, as short-chain fatty acid production, reflects dysbiosis and may contribute to worse outcomes. …”
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VALIDATION OF LONG-TERM HANDLING AND STORAGE CONDITIONS FOR HEMATOPOIETIC STEM CELL PRODUCTS FOR AUTOLOGOUS TRANSPLANTS by Ahmed Al Bahrani

“…The inclusion of in-vitro assays as part of functionality testing could further enhance the quality assessment of stored PBHSCs products.…”
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Multidimensional bioinformatics analysis reveals the potential carcinogenic role of acrylamide in colorectal cancer by Xiaopeng Yu, Junjie Niu, Jinyang Hu

“…Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed to elucidate gene functions, while clinical feature correlation analysis and single-sample gene set enrichment analysis (ssGSEA) were utilized to assess immune infiltration characteristics. …”
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In-vitro immunomodulatory efficacy of extracellular vesicles derived from TGF-β1/IFN-γ dual licensed human bone marrow mesenchymal stromal cells by Jiemin Wang, Seyedmohammad Moosavizadeh, Manon Jammes, Abbas Tabasi, Trung Bach, Aideen E. Ryan, Thomas Ritter

“…Transcriptomic analysis further revealed seven overlapping DEGs between IFN-γ– and TGF-β1–licensed MSCs, including both upregulated (GPR68, LIMK2, LIPG) and downregulated (EFNA5, PRKG1, DCLK1, TRIM2) genes, several of which are functionally implicated in EV-mediated immune regulation. …”
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Technology Effects and Child Health: Wellness Impact and Social Effects (TECHWISE): Protocol for a Prospective, Observational, Real-World Study by Scott H Kollins, Jessica Flannery, Karen Goetz, Samir Akre-Bhide

“…Following electronic consent (eConsent), participants and their caregivers will complete a range of baseline measures electronically, including assessments of psychiatric and social functioning, as well as measures of loneliness, digital stress, and disordered eating. …”
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Exploring the complex interplay between oral Fusobacterium nucleatum infection, periodontitis, and robust microRNA induction, including multiple known oncogenic miRNAs by Syam Jeepipalli, Aravindraja C, William Duncan, V. M. Krishna, Bikash Sahay, Edward K. L. Chan, L. Kesavalu

“…Recently, microRNAs have emerged as critical players in the interactions between host and microbes, and many host functions have been reported to be regulated by miRNAs during infection. …”
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o8G-modified circPLCE1 inhibits lung cancer progression via chaperone-mediated autophagy by Qingyun Zhao, Dunyu Cai, Haotian Xu, Yihong Gao, Ruirui Zhang, Xiaodong Zhou, Xingcai Chen, Sixian Chen, Jiaxi Wu, Wenyi Peng, Shengyi Yuan, Deqing Li, Gang Li, Aruo Nan

“…The biological functions of circPLCE1 in vivo and in vitro were clarified via establishing a circPLCE1 silencing/overexpression system. …”
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tRFAla-AGC-3-M8 attenuates neuroinflammation and neuronal damage in Alzheimer’s disease via the EphA7-ERK1/2-p70S6K signaling pathway by Zihao Deng, Yudi Li, Wenjun Chi, Wanzhou Zhang, Fangming Li, Li Ling

“…This study aimed to investigate specific tsRNAs associated with AD by performing RNA sequencing on the cortex of APP/PS1 transgenic mice and to explore the relationship between tsRNAs and their target genes within the Eph receptor family, thereby elucidating insights into the specific regulatory functions of these molecules. Methods Eight-month-old male C57BL/6 and APP/PS1 transgenic mice were used in the study. …”
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CD151 Promotes Cancer Progression in Triple-Negative Breast Cancer by Inducing EMT through the MAPK Signaling Pathway by Lv H, Zhang B, Weng X, Li Y, Deng C, Wang R, Shi L, Yin Y

“…However, the specific functions of CD151 in triple-negative breast cancer (TNBC) remain unclear. …”
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Association between full blood count and urine steroid metabolome in patients with adrenal masses by Natalia V. Vorokhobina, Valentina V. Kalugina, Ludmila I. Velikanova, Zulfiya R. Shafigullina, Ekaterina V. Malevanaya, Aleksandr A. Lisitsyn

“…Better understanding of the mechanisms that alter the functioning of the immune system would allow for the development of a patient-centered approach to the treatment of corticotropin-independent endogenous Cushing's syndrome (CS). …”
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Genome-Wide Identification of the HSP Gene Family in Penaeus japonicus and Their Expression Characteristics During Development Stages by Xueqiong BIAN, Xianyun REN, Junxia WANG, Shaoting JIA, Jianjun GUO, Kuangcheng ZHAO, Ping LIU, Jian LI, Jitao LI

“…Motif analysis showed that the hsp gene family was highly conserved; however, the functions of different families were quite different. …”
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