Extracellular vesicles (EVs) in seminal plasma of buffalo bulls possess spermatozoa specific fertility associated proteins and enzymes by Rakesh Kumar, Mir Ahmad, Bala Subramaniam, Ankit Pal, Aditya Patel, Shiva Shiva, Vitika Chauhan, Seema Karanwal, Mukesh Bhakat, Tirtha K. Datta

“…The identified proteins were strongly related to sperm functions. Thus, the present study supports that buffalo seminal EVs possess vital fertility-associated proteins and enzymes, which could be important markers for assessing buffalo bull fertility. …”
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Proteomic Analysis of the Effects of Shenzhu Tiaopi Granules on Model Rats with Type 2 Diabetes Mellitus by Zhao JD, Fang ZH

“…Jin-Dong Zhao,1– 3 Zhao-Hui Fang1– 3 1Department of Endocrinology Two, the First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui Province, 230031, People’s Republic of China; 2Center for Xin’an Medicine and Modernization of Traditional Chinese Medicine of IHM, the First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui Province, 230012, People’s Republic of China; 3Diabetes Institute, Anhui Academy Chinese Medicine, Hefei, 230012, People’s Republic of ChinaCorrespondence: Zhao-Hui Fang, Department of Endocrinology Two, the First Affiliated Hospital of Anhui University of Chinese Medicine, 117 Meishan Road, Hefei, Anhui Province, 230031, People’s Republic of China, Email fangzhaohui1111@163.comBackground: Shenzhu Tiaopi granule (STG) has antidiabetic functions. Data-independent acquisition proteomic technology is an integral part of systems biology. …”
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Elucidating the role of PPARG inhibition in enhancing MERS virus immune response: A network pharmacology and computational drug discovery by Ahmed M. Hassan, Leena H. Bajrai, Azzah S. Alharbi, Meshari M. Alhamdan, Vivek Dhar Dwivedi, Esam I. Azhar

“…Methods: Two gene expression datasets (GSE81909 and GSE100504) were analyzed to identify differentially expressed genes (DEGs) using GEO2R. Furthermore, gene ontology (GO), pathway enrichment analysis, and protein-protein interaction (PPI) network were performed to understand the gene’s functions. …”
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Exploring the role of ferroptosis in pemphigus: identification of diagnostic markers and regulatory mechanisms by Jing Mao, Jianping Lan, Zheyu Zhuang, Ying Chen, Ying Chen, Yushan Ou, Xinhong Su, Xueting Zeng, Fuchen Huang, Zequn Tong, Xiaoqing Lv, Xiaoqing Lv, Xiaoqing Lv, Hui Ke, Zhenlan Wu, Ying Zou, Bo Cheng, Bo Cheng, Bo Cheng, Chao Ji, Chao Ji, Chao Ji, Ting Gong

“…This study aims to investigate the expression patterns and potential biological functions of ferroptosis-related genes in pemphigus, as well as their regulatory mechanisms.MethodsTo achieve this, skin samples from five pemphigus patients and five healthy controls were collected from Fujian Medical University Union Hospital. …”
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Causal estimation of the relationship between reproductive performance and the fecal bacteriome in cattle by Yutaka Taguchi, Haruki Yamano, Yudai Inabu, Hirokuni Miyamoto, Koki Hayasaki, Noriyuki Maeda, Yoshiro Kanmera, Seiji Yamasaki, Noboru Ota, Kenji Mukawa, Atsushi Kurotani, Shigeharu Moriya, Teruno Nakaguma, Chitose Ishii, Makiko Matsuura, Tetsuji Etoh, Yuji Shiotsuka, Ryoichi Fujino, Motoaki Udagawa, Satoshi Wada, Jun Kikuchi, Hiroshi Ohno, Hideyuki Takahashi

“…Abstract Background The gut bacteriome influences host metabolic and physiological functions. However, its relationship with reproductive performance remains unclear. …”
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Identification of <i>AP2/ERF</i> Transcription Factors and Characterization of <i>AP2/ERF</i> Genes Related to Low-Temperature Stress Response and Fruit Development in Luffa by Jianting Liu, Haifeng Zhong, Chengjuan Cao, Yuqian Wang, Qianrong Zhang, Qingfang Wen, Haisheng Zhu, Zuliang Li

“…Our findings will help clarify the evolution of the luffa <i>AP2/ERF</i> family, while also providing valuable insights for future studies on AP2/ERF functions.…”
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Multiomics insights into BMI-related intratumoral microbiota in gastric cancer by Kang Liu, Zhengchen Jiang, Zhengchen Jiang, Yubo Ma, Ruihong Xia, Yingsong Zheng, Kailai Yin, Chuhong Pang, Li Yuan, Li Yuan, Xiangdong Cheng, Xiangdong Cheng, Zhuo Liu, Bo Zhang, Shi Wang

“…However, LEfSe analysis revealed 32 differential intratumoral microbiota between the LBMI and NLBMI groups. …”
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Copper Pyrithione Induces Hepatopancreatic Apoptosis and Metabolic Disruption in <i>Litopenaeus vannamei</i>: Integrated Transcriptomic, Metabolomic, and Histopathological Analysis by Jieyu Guo, Yang Yang, Siying Yu, Cairui Jiang, Xianbin Su, Yongfeng Zou, Hui Guo

“…A large number of differentially expressed genes (DEGs) were identified by transcriptomics analysis at 3 and 48 h, respectively. …”
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Deciphering molecular and cellular ex vivo responses to bispecific antibodies PD1-TIM3 and PD1-LAG3 in human tumors by Alfred Zippelius, Petra Herzig, Pratiksha Gulati, Christian Klein, Marta Trüb, Kirsten D Mertz, Robert Rosenberg, Viola Heinzelmann-Schwarz, Mark Wiese, Didier Lardinois, Pablo Umana, Marina Natoli, Klas Hatje, Fabian Junker, Zhiwen Jiang, Iakov I Davydov, Markus Germann, Daniel Marbach, Adrian Zwick, Patrick Weber, Stefan Seeber, Lothar Tietze, Laura Codarri-Deak, Henry Kao

“…Yet, the molecular and cellular mechanisms by which either receptor functions to mediate its inhibitory effects are still poorly understood. …”
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COGNITIVE SEMANTICS OF NOUNS IN DENUMERATIVE WORD FORMATION (BASED ON UKRAINIAN LANGUAGE) by Olha V. Kostryba

“…To mitigate mental-verbal dissonance, a verbalized slot within the frame structure of the word-form- ing nest has been established. This slot functions analogously to the “motivational sema” in motivation- al process. …”
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Results from AD-HEARING (ADherence to and adjustment of HEARING aids in clinical routine care as preventive dementia strategy): a prospective 6-month follow-up study on cognition a... by Michael Belz, Sebastian Gmeinwieser, Mona Abdel-Hamid, Mona Abdel-Hamid, Robert Kühler, Jenny Blum, Philipp Hessmann, Nicola Strenzke, Claudia Bartels

“…Hearing aid use might reduce this risk by preserving cognitive and psychological functions.ObjectiveThis study aims to investigate the influence of ARHL and hearing aid use on cognition and different aspects of psychological well-being.MethodsDuring 05/2021 and 05/2023, 31 subjects with audiometrically confirmed ARHL were included and 28 underwent follow-up 6 months later (final analysis sample). …”
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Interaction between the liver transcriptome and gut microbiota in mice during Toxoplasma gondii infection as identified by integrated transcriptomic and microbiome analysis by Yang Zou, He Ma, Xing Yang, Xin-Yu Wei, Chao Chen, Jing Jiang, Tao Jiang

“…Gene ontology (GO) enrichment analysis further revealed the stage-specific features of liver functionality. Specifically, during the acute stage of infection, pathways associated with inflammation were significantly enriched. …”
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Genome-Wide Identification of Heat Shock Transcription Factor Family and Key Members Response Analysis to Heat Stress in Loquat by Chaojun Deng, Yongping Chen, Weilin Wei, Xiuping Chen, Jimou Jiang

“…A promoter analysis retrieved thirty-three CAREs that were functionally relevant and connected to the expression of <i>HSF</i>s. …”
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Transcriptome analysis reveals the mechanism of mixed oligosaccharides in the response of rice seedlings to abiotic stresses by Yanan Xu, Yanan Xu, Yigang Yang, Yeran Bai, Makoto Saito, Wei Han, Yuanpei Zhang, Guohua Lv, Jiqing Song, Wenbo Bai

“…This coordinated gene expression was functionally associated with enhanced leaf photosynthesis capacity and mitigated oxidative damage through improved electron transport and reactive oxygen species scavenging mechanisms. …”
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B cell c-Maf signaling promotes tumor progression in animal models of pancreatic cancer and melanoma by Hong Li, Shu Li, Jun Yan, Yongling Ning, Hongying Hao, Qian Zhong, Chuanlin Ding, Xiaoling Hu, Kelly M McMasters

“…Additionally, tumor-specific antibodies (Abs) also exhibit antitumor and protumor functions dependent on the Ab isotype. Transcription factor c-Maf has been suggested to contribute to the regulation of IL-10 in Breg, but the role of B cell c-Maf signaling in antitumor immunity and regulating Ab responses remains unknown.Methods Conditional B cell c-Maf knockout (KO) and control mice were used to establish a KPC pancreatic cancer model and B16.F10 melanoma model. …”
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Analytical assessment of metagenomic workflows for pathogen detection with NIST RM 8376 and two sample matrices by Jason G. Kralj, Stephanie L. Servetas, Samuel P. Forry, Monique E. Hunter, Jennifer N. Dootz, Scott A. Jackson

“…Surprisingly, when we compared the linear response of the same taxa in the two different sample types, we found those functions to be the same, despite large differences in LODs. …”
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LC-MS/MS based metabolomics reveals the mechanism of skeletal muscle regeneration by Lei Yi, Kaiming Wang, Sui Liufu, Wenwu Chen, Bohe Chen, Xiaolin Liu, Caihong Liu, Jingwen Liu, Xin Xu, Haiming Ma

“…Temporal expression analysis revealed metabolites consistent with changes in the skeletal muscle regeneration process and found that these metabolite functions were mainly enriched in inhibiting inflammatory responses, alleviating myofibrillar lysis, and promoting muscle growth. …”
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“Opening the era”: to the 100th anniversary of establishing Soviet weekly magazine "Ogonyok" by A. V. Tantsevova

“…The purpose of the article is to reconstruct, on the basis of various historical sources, the history of the creation and functioning of the Soviet weekly Ogonyok in the first post-revolutionary decade, to consider its role and place in the system of Soviet periodicals.Materials and methods. …”
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LEGAL AND ECONOMIC PRINCIPLES OF THE FOREIGN POLICY OF INDEPENDENT AZERBAIJAN IN RELATION TO NEIGHBORING COUNTRIES by Katana Gafarova

“…The relationship between the economic and legal components in the content of the country's foreign policy activity is differentiated, where the economy acts as a means and functionality for the use of a certain set of resources for the production, sale, distribution and consumption of public goods, and the law ensures the structuring of all social phenomena according to certain rules of behaviour in terms of satisfying public and private interests in the context of building a compromise model of the relationship between them. …”
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CYFIP2: potential pancreatic cancer biomarker and immunotherapeutic target by Cong Xiao, Xiaojuan Zhang, Bobo Hou, Ping Wan, Zhenjun Cao, Xuefeng Rao

“…Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Set Variation Analysis (GSVA) were used to explore the multiple biological functions and regulatory pathways in which CYFIP2 co-expressed genes co-engage in pancreatic cancer. …”
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