Early secretory antigen target of 6-kDa of Mycobacterium tuberculosis inhibits macrophage apoptosis and host defense via TLR2 by Lin Zhang, Fang Fang, Danrui Liu, Geman Xia, Tong Feng, Jingzhu Lv, Jinying Qi, Tengteng Li, Hui Liu, Tao Xu, Fengjiao Wu, Chuanwang Song, Wei Li, Xiaojing Wang, Xianyou Chang, Hongtao Wang, Ting Wang, Zhongqing Qian

“…In parallel, our in silico analysis of differentially expressed genes in dendritic cells (DCs) infected with Bacille Calmette-Guérin (BCG) strains, with or without the region of difference-1 (RD1) gene, strongly suggests that ESAT-6, located within the RD1 region, modulates host defense functions and apoptosis in DCs during BCG infection. …”
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Combining single-cell analysis and molecular docking techniques to construct a prognostic model for colon adenocarcinoma and uncovering inhibin subunit βb as a novel therapeutic ta... by Qinqing Wu, Qinqing Wu, Lu Ye, Yuwei Wu, Mengyu Zhao, Mengyu Zhao, Jiaxin Lu, Yanping Yu, Yanping Yu, Yixiao Niu, Yixiao Niu, Luxiao Zhang, Peijun Zuo, Peijun Zuo

“…Finally, we used gene knockout techniques to silence the key gene INHBB and explored its biological functions in vitro.ResultsIn our study, by analyzing the expression differences of ARGs, we successfully classified patients with COAD. …”
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An Integrated Approach Utilizing Single-Cell and Bulk RNA-Sequencing for the Identification of a Mitophagy-Associated Genes Signature: Implications for Prognostication and Therapeu... by Yuke Zhang, Li Ding, Zhijin Zhang, Liliang Shen, Yadong Guo, Wentao Zhang, Yang Yu, Zhuoran Gu, Ji Liu, Aimaitiaji Kadier, Jiang Geng, Shiyu Mao, Xudong Yao

“…Furthermore, the cellular functions of the genes of interest were verified in vitro. …”
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Identification of RAD51AP1 as a key gene in hepatitis B virus-associated hepatocellular carcinoma by Meiling Wan, Yonghong Wang, Xiaoling Liu, Yaling Li, Cunliang Deng, Changfeng Sun

“…Then, in vitro experiments including CCK-8 assay, wound healing, and Transwell assay were performed to explore the functions and mechanisms. Results: RAD51AP1 was identified as a specific key gene linked to the progression of HBV-associated HCC. …”
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Polyphenolic Metabolites and Antioxidant Activities of Alpinia katsumadai Hayata. and Its Adulterants by DING Shuxian, YANG Qing, WANG Qinglong, WANG Zhunian, YUAN Langxing, FENG Shixiu,LIU Mengting, YIN Haiquan, ZHANG Aling, WANG Maoyuan

“…Schum. contained more unique polyphenolic substances, whose composition and functions warrant further investigation. This study provides theoretical guidance for the selection of high-quality Chinese medicinal materials and the development of related products.…”
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Validation of the European Oncology toolkit for the self-assessment of Quality of Life (EUonQoL-Kit) in cancer patients and survivors: study protocol of a pan European survey by G. Apolone, M. Costantini, L. Caselli, N. Bos, A. Caraceni, G. Ciliberto, N. Couespel, M. Ferrer, M. Groenvold, S. Kaasa, C. Lombardo, R. Pietrobon, G. Pravettoni, A. Sirven, H. Vachon, G. Velikova, O. Garin, A. Gilbert, A. Machiavelli, C. Marzorati, R. Miceli, M. Pe, MA. Petersen, A. Tanzilli, F. van Schelven, C. Dantas, I Minnée-van Braak, L. Pinnavaia, C. Brunelli

“…Psychometric analyses will encompass exploratory and confirmatory factor analyses (measurement model and structural validity), Cronbach's alpha (internal consistency), intraclass correlation coefficient (test–retest reliability), Pearson/Spearman correlation (concurrent validity), comparison of group scores (construct validity), and Differential Item Functioning (cross-country item equivalence). …”
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Characterization and Expression Analysis of the Sterol C-5 Desaturase Gene <i>PcERG3</i> in the Mycobiont of the Lichen <i>Peltigera canina</i> Under Abiotic Stresses by Moatasem A. Swid, Milana V. Koulintchenko, Alfred O. Onele, Ilya Y. Leksin, Daniya F. Rakhmatullina, Ekaterina I. Galeeva, Julia N. Valitova, Farida V. Minibayeva, Richard P. Beckett

“…., <i>Penicillium</i>. The differential expression of <i>PcERG3</i> in response to temperature stress, a dehydration/rehydration cycle, and heavy metal exposure suggests that it plays a crucial role in maintaining the balance between more and less saturated sterols and, more generally, in membrane functioning. …”
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Prognostic gene expression and microRNA profiling signatures and genetic alterations in primary testicular diffuse large B-cell lymphoma by Wenyu Shi, Zijun Y. Xu-Monette, Youchao Jia, Alexandar Tzankov, Heounjeong Go, Ling Li, Maurilio Ponzoni, Yafei Wang, Qiongli Zhai, Anamarija M. Perry, Shi Wang, Xiaoxiao Wang, April Chiu, Mina L. Xu, Carlo Visco, Karen Dybkaer, Henry Withers, Mark Long, Alyssa F. Yuan, Yi Miao, Everardo Macias, Dehong Wu, Wen Shuai, Bangchen Wang, Jianyong Li, Govind Bhagat, Youli Zu, Zenggang Pan, William Choi, Santiago Montes-Moreno, Weina Chen, J. Han van Krieken, Michael B. Møller, Xinfang Yu, Benjamin M. Parsons, Shanxiang Zhang, Eric D. Hsi, Aliyah R. Sohani, Jeremy S. Abramson, Andrés J. M. Ferreri, Bing Xu, Yong Li, Ken H. Young

“…The TLT subtype featured upregulation of genes functioning in DNA damage response, DNA repair, chromatin remodeling, the cell cycle, and the nucleus, and was associated with significantly poorer patient survival and higher frequencies of MYD88 mutations, multiple CNVs, MCD subtype, bulk tumors, and elderly patients in the PT-DLBCL cohort. …”
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Altered expression and potential role of N6-methyladenosine mRNA methylation in abdominal aortic aneurysm mouse model by Julin Wang, Tianyu Miao, Yanyun Wang, Tiehao Wang, Zhangyu He, Fei Xiong, Ding Yuan, Qiang Guo, Yi Yang, Zhichen Tang, Bin Huang, Jichun Zhao

“…This study aimed to explore the expression profile, potential functions and regulated mechanism of m6A RNA methylation in the abdominal aortic aneurysm mice model. …”
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STAT2/SLC27A3/PINK1-Mediated Mitophagy Remodeling Lipid Metabolism Contributes to Pazopanib Resistance in Clear Cell Renal Cell Carcinoma by Dingheng Lu, Yuxiao Li, Xinyang Niu, Jiazhu Sun, Weitao Zhan, Yuchen Shi, Kai Yu, Suyuelin Huang, Xiaoyan Liu, Liping Xie, Xueyou Ma, Ben Liu

“…The differential expression of SLC27A3 and its effect on drug resistance of ccRCC tumor were detected in vitro and in vivo. …”
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Development of Professional Competencies in IT-specialists by Anatolii V. Karpov, Aleksandr A. Karpov, Sergei O. Prisyazhnyuk

“…This means that it includes the formation and development not only of those determinants that have internal localization in relation to it as a system, but also of those that have extrasystemic localization. They, being functionally included, “embedded” in it, constitute one of the levels of its subjective determinants: the level of meta-competencies, which is formed by the soft-skills category. …”
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Comparative Effect of Breast Milk and Infant Formulae on Neonatal Gut Microbiome within Katsina Metropolis by Usman, A., Abdulkadir, B., Lawal, B., Isah, M. B.

“…Study’s Novelty Excerpt • This study provides novel insights into the differential impacts of breast milk and infant formula on the neonatal gut microbiome in Katsina metropolis, an area with limited existing research on this subject…”
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Identification, Classification of the MIKC-Type MADS-Box Gene Family, and Expression Analysis of Female and Male Flower Buds in Walnut (<i>Juglans regia,</i> Juglandaceae) by Caihua Guo, Olumide Phillip Fesobi, Zhongrong Zhang, Xing Yuan, Haochang Zhao, Shaowen Quan, Jianxin Niu

“…In summary, our results provide valuable information for further biological functions research on MIKC-type MADS-box genes in walnut, such as flower organ development, and lays a solid foundation for future studies.…”
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Comparative study of lysine acetylation in Vesicomyidae clam Archivesica marissinica and the manila clam Ruditapes philippinarum: adaptation mechanisms in cold seep environments by Xue Kong, Wei Wang, Sunan Chen, Manzong Song, Ying Zhi, Yuefeng Cai, Haibin Zhang, Xin Shen

“…The findings present many potential proteins for further exploration of acetylation functions in cold seep clams and other deep-sea mollusks.…”
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Maternal loss of mouse Nlrp2 alters the transcriptome and DNA methylome in GV oocytes and impairs zygotic genome activation in embryos by Zahra Anvar, Michael D. Jochum, Imen Chakchouk, Momal Sharif, Hannah Demond, Alvin K. To, Daniel C. Kraushaar, Ying-Wooi Wan, Michael C. Mari, Simon Andrews, Gavin Kelsey, Ignatia B. Van den Veyver

“…Maternal inactivation of genes encoding SCMC proteins has been linked to infertility and subfertility in mice and humans, but the underlying molecular mechanisms for the diverse functions of SCMC proteins, and specifically the role of NLRP2, are incompletely understood. …”
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Integrated Multi-Level Investigation of Friend Leukemia Integration 1 Transcription Factor as a Novel Immune-Inflammatory Biomarker in Rheumatoid Arthritis: Bridging Bioinformatics... by Zhang M, Wan L, Fang H, Zhang X, Wang S, Li F, Yan D

“…Receiver operating characteristic analysis and gene-set enrichment analysis-KEGG were conducted to elucidate the biological functions of these target genes. Finally, cellular experiments were performed to validate FLI1’s regulatory effects on its target genes and its impact on synovial cell viability and apoptosis in RA.Results: FLI1 was upregulated in RA. …”
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Time-Course Renal and Pulmonary Injury Analysis and Bioinformatics Screening of Core Pathogenic Genes and Immune Cell Infiltration Patterns in a Sepsis by Apizi A, Li J, Kamilijiang P, Yang CB, Wang ZK, Chai RF, Yu ZX

“…Gene Ontology enrichment analysis revealed that differentially expressed genes were predominantly enriched in biological processes, molecular functions, cellular components, and the hematopoietic cell lineage pathway. …”
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AFF3 is a Prognostic Biomarker Correlated with Immune Infiltrates in Triple-Negative Breast Cancer by Jing Chen, Bing Tan, Wei Zhuang, Tenghua Yu, Jianglong Li, Chongwu He

“…This study aims to examine the prognostic value and immune-related functions of AFF3 in TNBC. Methods: In the Gene Expression Omnibus (GEO) database, differentially expressed genes (DEGs) were identified from three datasets associated with TNBC. …”
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Heme Oxygenase-1 Modulates Macrophage Polarization Through Endothelial Exosomal miR-184-3p and Reduces Sepsis-Induce Lung Injury by Chen W, Zhang Y, Chen J, Dong S, Wu X, Wu Y, Du Z, Yang Y, Gong L, Yu J

“…Heme oxygenase-1 (HO-1), an early stress-responsive enzyme with inherent protective functions, has been implicated in acute lung injury (ALI) mitigation. …”
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Epidemiological Situation on Tularemia in the far Eastern Federal District (2000-2017) by T. N. Demidova, V. P Popov, T. V. Mikhailova, A. S. Cemichin, Y. S. Podobedova

“…The purpose of this work is to identify the main patterns of functioning and epidemic manifestations of natural foci of tularemia in the far Eastern Federal district (far Eastern Federal district) on the basis of long-term monitoring and using various research methods.Results, The analysis of the epizootic state and epidemic manifestation of natural foci of tularemia in the territory of the far Eastern Federal district for 2000-2017 shows that the main regularities of the epidemic process remain in the natural foci of this infection. …”
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