Danshenol B alleviates central post-stroke pain by regulating the PIK3CG/NLRP3 signaling pathway by Panyang Li, Linna Yu, Jinzhong Yao, Tingting Zhao, Sen Zhao

“…Notably, simultaneous overexpression of NLRP3 attenuated the analgesic effects induced by PIK3CG knockdown, further confirming that NLRP3 functions downstream of PIK3CG in mediating CPSP. Conclusions Danshenol B alleviates CPSP in mice by suppressing the PIK3CG/NLRP3 signaling pathway, elucidating its analgesic mechanism and highlighting its potential as a novel therapeutic candidate for CPSP.…”
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Virocell resource manipulation under nutrient limitation by Morgan M. Lindback, Cristina Howard-Varona, Jane Fudyma, Malak Tfaily, Matthew B. Sullivan, Melissa B. Duhaime

“…ABSTRACT Virus-infected cells, called virocells, impact host metabolic functions, resources, and ecosystem processes, but the effects of nutrient limitation remain less well understood. …”
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Screening and analysis of programmed cell death related genes and targeted drugs in sepsis by Juanjuan Song, Kairui Ren, Yi Wang, Dexin Zhang, Lin Sun, Zhiqiang Tang, Lili Zhang, Ying Deng

“…Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were conducted to elucidate the functions of the DEGs. PCD-related genes were cross-referenced with the identified DEGs. …”
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Interactions among Merlin, Arkadia, and SKOR2 mediate NF2-associated human Schwann cell proliferation by Pei-Ciao Tang, Seyoung Um, Anderson B. Mayfield, Olena R. Bracho, Christian Del Castillo, Christine T. Dinh, Derek M. Dykxhoorn, Xue Zhong Liu

“…Although the exactly molecular mechanism mediating NF2-driven schwannomatosis is not fully understood, it is known that defective Merlin protein functionality leads to abnormal cell proliferation. Methods Herein, we utilized a human induced pluripotent stem cell (hiPSC)-based Schwann cell (SC) model to investigate the role of Merlin in human SCs. …”
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Integrative analyses of 16S rDNA sequencing and serum metabolomics demonstrate significant roles for the oral microbiota and serum metabolites in post-kidney transplant diabetes me... by Chao Liu, Sheng Chao, Lei Jia, Qizhen Yang, Qian Chen, Yulin Niu

“…Furthermore, clinical indicators in PTDM patients, such as creatinine, cystatin C, and urea, showed a significant association with the differential oral microbiota and serum metabolites. Dysbiosis in the oral microbiota of the PTDM patients was associated with changes in the serum metabolites and alterations in their functions. …”
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Exploring potential methylation markers for ovarian cancer from cervical scraping samples by Ju-Yin Lien, Lu Ann Hii, Po-Hsuan Su, Lin-Yu Chen, Kuo-Chang Wen, Hung-Cheng Lai, Yu-Chao Wang

“…Furthermore, an over-representation analysis was conducted to explore the functions associated with genes mapped from differentially methylated positions (DMPs) in comparisons between normal and tumor samples, as well as between benign and malignant samples. …”
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Vegetation Monitoring of Palm Trees in an Oasis Environment (Boudenib, Morocco) Using Automatic Processing of Medium-Resolution Remotely Sensed Data by Kaoutar Badioui, Ann Van Griensven, Boud Verbeiren

“…TREX has various applications, but the main functionality is to provide an automatic processing of PROBA-V satellite images into time series of NDVI and LAI, used in vegetation monitoring of user-defined points of interest. …”
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Stimulator of Interferon Genes (STING)-Type I Interferon Signaling: Bridging Immunity and Pain by Ti-Chuan Chiu, Yu-Yu Li, Chia-Hung Yu, Kuo-Chuan Hung, Chin-Chen Chu, Ping-Hsun Feng, Ping-Heng Tan

“…Interferons (IFNs) are cytokines with diverse functions, possessing antiviral, antiproliferative, and immunomodulatory effects. …”
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Item-level measurement properties of the pediatric awareness and sensory motor assessment in children with medical complexity by Brooke Mulrenin, Bryant A. Seamon, Carrie Cormack, Kimberly Lane Kascak, Cynthia Dodds

“…Person misfit did not degrade item measures or model statistics. Differential item functioning (DIF) was noted for the three easiest items on specific days. …”
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Genome-Wide Identification and Expression Analysis of PkNRT Gene Family in Korean Pine (<i>Pinus koraiensis</i>) by Xinyu Zhao, Haibo Wu, Boyang Li, Pengyang Wang, Peng Zhang, Hailong Shen, Jianfei Yang

“…These findings would provide a theoretical foundation for further investigations into the functions of <i>PkNRTs</i> in Korean pine.…”
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Psychometric evaluation of the Chinese version of the Patient Self-Advocacy Scale using classical test theory and item response theory by Jialu Cui, Jing Wang, Ailin Yue, Jiayan Cao, Zhijie Zhang, Baoxin Shi

“…The Wright map showed good matching between item difficulty and person ability. Differential item functioning (DIF) analysis revealed no significant differences across gender. …”
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Cyanoexosortase B is essential for motility, biofilm formation, and scytonemin production in a filamentous cyanobacterium by Gabriel A. Parrett, Daniel H. Haft, Maida Ruiz, Ferran Garcia-Pichel, Christopher C. Ebmeier, Douglas D. Risser

“…Given the abundance of putative PEP-CTERM proteins encoded in the N. punctiforme genome and the fact that this study only associates a fraction of them with biological functions, it seems likely that CrtB may play an important role in other biological processes in cyanobacteria.IMPORTANCEIn gram-negative bacteria, exosortases facilitate the trafficking of proteins to the exterior of the cell where they have been implicated in stabilizing the association of extracellular polymeric substances (EPS) with the cell surface to facilitate biofilm formation and flocculation, but the role of exosortases in cyanobacteria has not been explored. …”
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Identification of ZNF652 as a Diagnostic and Therapeutic Target in Osteoarthritis Using Machine Learning by Chen Y, Liang R, Zheng X, Fang D, Lu WW, Chen Y

“…Then a screening process was initiated to identify differentially expressed genes (DEGs). The DEGs were discerned using three distinct machine learning methods. …”
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Intervención estatal, transformaciones en los vínculos con el sector privado y crecimiento económico sectorial. El caso del sector de Software y Servicios Informáticos de la ciudad... by CARINA BORRASTERO

“…This led to changes which positioned Cordoba as one of the most important technological centers in the country: a significant increase in the local business network and employment in the sector, and the consolidation of a Provincial Government promotion model oriented to the differential development of this industry. We argue that the type of intervention undertaken by the Provincial Government, in its close association with a particularly dynamic economic sector, produced important changes at the structural level of the State, its specific functions, the nature of its relationship with the private sector and ways to institutionalize such links, progressively acquired a ‘structural’ character. …”
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Identification and Validation of Feature Genes Related to Mitochondrial Dysfunction and Oxidative Stress in Ulcerative Colitis by Wu Y, Tan Z, Lan Q, Liu Y, Liu C, He H, Zhang J, Dong W

“…Given their close association, it is crucial to clarify the molecular characteristics and biological functions of MD and OS-related genes in UC.Methods: Gene expression profiles, mitochondrial-related genes, and OS-related genes were obtained from the corresponding databases. …”
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Role of lysine acetylation-related genes in the diagnosis and prognosis of glioma by Min Zhou, Bing Wang, Richu Liang, Xinping Luan

“…Corresponding pathways and functions were analyzed between different groups. The difference of immune environment was compared. …”
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Identification and prognostic analysis of propionate metabolism-related genes in head and neck squamous cell carcinoma by Shitong Zhou, Shitong Zhou, Yu Jiang, Panhui Xiong, Zhongwan Li, Lifeng Jia, Wei Yuan, Xiufu Liao, Xiang An, Jie Hu, Rui Luo, Hailan Mo, Hongyan Fang, Yucheng Yang

“…Recent studies have suggested that propionate metabolism-related genes (PMRGs) may play key roles in tumor progression and immune regulation, yet their functions in HNSCC remain unclear.MethodsTranscriptomic data from 502 HNSCC tumor samples and 44 normal tissue samples were obtained from the UCSC Xena database as the training set. …”
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Effects of gintonin-enriched fraction on hippocampal gene expressions by Rami Lee, Na-Eun Lee, Sun-Hye Choi, Sung Min Nam, Hyoung-Chun Kim, Hyewhon Rhim, Ik-Hyun Cho, Sung-Hee Hwang, Seung-Yeol Nah

“…Conclusion: We found that GEF affects mouse hippocampal gene expressions, associated with memory, cognitive, anti-stress and anti-anxiety functions, and neurodegeneration at differential degree, that might explain the genetic bases of GEF-mediated neuroprotective effects.…”
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Smartwatch ECG and artificial intelligence in detecting acute coronary syndrome compared to traditional 12-lead ECG by Jina Choi, Joonghee Kim, Carmen Spaccarotella, Giovanni Esposito, Il-Young Oh, Youngjin Cho, Ciro Indolfi

“…Meanwhile, smartwatches offering ECG functionality have become widespread. This study evaluates the feasibility of an image-based ECG analysis artificial intelligence (AI) system with smartwatch-based multichannel, asynchronous ECG for diagnosing ACS. …”
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Identification of SNPs and Candidate Genes Associated with Growth Using GWAS and Transcriptome Analysis in Portuguese Oyster (<i>Magallana angulata</i>) by Jingyi Xie, Yue Ning, Yi Han, Caiyuan Su, Xiaoyan Zhou, Qisheng Wu, Xiang Guo, Jianfei Qi, Hui Ge, Yizou Ke, Mingyi Cai

“…By combining GWAS and comparative transcriptome analysis, a total of seven candidate genes were identified, with biological functions related to growth inhibition, stress response, cell cycle regulation, and immune defense. …”
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