Novel cuproptosis metabolism-related molecular clusters and diagnostic signature for Alzheimer’s disease by Fang Jia, Wanhong Han, Shuangqi Gao, Jianwei Huang, Wujie Zhao, Zhenwei Lu, Wenpeng Zhao, Zhangyu Li, Zhanxiang Wang, Ying Guo

“…The GSEA, PPI network, GO, KEGG, and correlation analysis were conducted to explore the biological functions of DECRGs. Molecular clusters were performed using unsupervised cluster analysis. …”
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Transcriptomic analysis of rat prefrontal cortex following chronic stress induced by social isolation – Relevance to psychiatric and neurodevelopmental illness, and implications fo... by Jen-Yin Goh, Patricia Rueda, Joy Taylor, Alex Rathbone, Daniel Scott, Christopher J. Langmead, Kevin C.F. Fone, Gregory D. Stewart, Madeleine V. King

“…To provide insight into the relevance of this manipulation for studying human illness, we compared differentially expressed genes (DEGs) and enriched biological functions against datasets involving post-mortem frontal cortical tissue from patients with psychiatric and neurodevelopmental illnesses. …”
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Insights into the mechanisms of serplulimab: a distinctive anti-PD-1 monoclonal antibody, in combination with a TIGIT or LAG3 inhibitor in preclinical tumor immunotherapy studies by Yizhou Zhang, Ruicheng Wei, Ge Song, Xinyi Yang, Mengli Zhang, Wei Liu, Aiying Xiong, Xuehan Zhang, Qianhao Li, Wan-Jen Yang, Chencheng Han, Rui Liu, Chen Hu, Qingyu Wang, Jun Zhu, Yongqiang Shan

“…We characterized the differences between serplulimab with approved PD-1/PD-L1 inhibitors (pembrolizumab and nivolumab) in terms of their binding features and functions in vitro and anti-tumor activity in vivo. …”
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Berberine in the treatment of radiation-induced skin injury: insights from proteomics and network pharmacology by Jie Zou, Jie Zou, Xia-Juan Xiao, Ping Zhang, Xing-Zi Huang, Jing Wang, Chun-Qin Tao, Xiao-Lan Ou, Gong Chen, Ting-Hao He, Long Yang, Biao Huang, Dao-Jiang Yu, Dao-Jiang Yu, Yu Zhao

“…A protein-protein interaction (PPI) network was then constructed, and core targets were screened with the Cytoscape plug-in. Molecular functions and pathways were analyzed through GO and KEGG pathway enrichment analyses. …”
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Development of a PROM to measure patient-centredness in chronic care consultations in primary care by Anne Holm, Anna Bernhardt Lyhnebeck, Sussi Friis Buhl, Kristine Bissenbakker, Jette Kolding Kristensen, Anne Møller, Anders Prior, Zaza Kamper-Jørgensen, Sidsel Böcher, Mads Aage Toft Kristensen, Asger Waagepetersen, Anders Hye Dalsgaard, Volkert Siersma, Ann Dorrit Guassora, John Brandt Brodersen, on behalf MM600 trial group

“…Few items demonstrated differential item functioning concerning variables such as age, sex, and education. …”
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Development of a Caco-2-based intestinal mucosal model to study intestinal barrier properties and bacteria–mucus interactions by Evelien Floor, Jinyi Su, Maitrayee Chatterjee, Elise S. Kuipers, Noortje IJssennagger, Faranak Heidari, Laura Giordano, Richard W. Wubbolts, Silvia M. Mihăilă, Daphne A. C. Stapels, Yvonne Vercoulen, Karin Strijbis

“…This novel in vitro intestinal model can facilitate studies into mucus and epithelial barrier functions and in-depth molecular characterization of pathogenic and commensal microbe–mucus interactions.…”
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Hamilton Rating Scale for Anxiety: exploring validity with robust measures of classical theory parameters and a rating scale model in university students by Md Dilshad Manzar, Faizan Z. Kashoo, Mohammed Salahuddin, Dejene Nureye, Habtamu Acho Addo, Seithikurippu R. Pandi-Perumal, Amir H. Pakpour, Ahmed S. Bahammam

“…Four threshold estimates (τi1, τi2, τi3 and τi4) for each item were ordered as expected. Differential item functions showed item-level measurement invariance for all the 14 HRSA items across gender for both uniform and non-uniform estimates. …”
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Staphylococcus aureus induces mitophagy via the HDAC11/IL10 pathway to sustain intracellular survival by Yaji Yang, Haotian Zhou, Feilong Li, Yanhao Zhang, Jianye Yang, Yidong Shen, Ning Hu, Quanming Zou, Leilei Qin, Hao Zeng, Wei Huang

“…Although macrophages play a vital role as innate immune cells, the mechanisms by which S. aureus survives within them and suppresses host immune functions remain incompletely understood. Methods This study employed confocal microscopy, flow cytometry, ELISA, and siRNA technology to assess the survival capacity of S. aureus within macrophages and the impact of inflammatory cytokines on its persistence. …”
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Garlic Extracts Nanoliposome as an Enhancer of Bioavailability of ABA and Thiamine Content and as an Antifungal Agent Against <i>Fusarium oxysporum</i> f. sp. <i>pisi</i> Infecting... by Barbara Kutasy, Géza Hegedűs, Márta Kiniczky, József Péter Pallos, Ágnes Nagy, István Pócsi, Klaudia Pákozdi, Máté Kállai, Csaba Weingart, Katalin Andor, Bettina Kovács, Eszter Virág

“…Furthermore, the absence of <i>Fusarium</i> infection in the treated small-plot field cultures suggests that the tested garlic extracts formulation functions as a promising preventive biostimulant against plant fungal diseases.…”
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Evaluating PFAS-Induced modulation of peripheral blood mononuclear cells (PBMCs) immune response to SARS-CoV-2 spike in COVID-19 Vaccinees by Humblenoble Stembridge Ayuk, Arkadiusz Pierzchalski, Tamara Tal, Oddvar Myhre, Birgitte Lindeman, Nicola Margareta Smith, Violeta Stojanovska, Ana Claudia Zenclussen

“…The persistent nature of the environmental contaminants per- and polyfluoroalkyl substances (PFAS) has recently received considerable attention, particularly because of their adverse effects on immune system functionality in the context of vaccine responses to infectious diseases. …”
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Chlorophyllase (PsCLH1) and light-harvesting chlorophyll a/b binding protein 1 (PsLhcb1) and PsLhcb5 maintain petal greenness in Paeonia suffruticosa ‘Lv Mu Yin Yu’ by Qing Hao, Tongtong Li, Gaojie Lu, Shuo Wang, Zhen Li, Cancan Gu, Fan Kong, Qingyan Shu, Yang Li

“…Based on comparative transcriptomes, differentially expressed genes (DEGs) were identified, among which three were functionally characterized through overexpression in tobacco plants or silencing in ‘LMYY’ petals. …”
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Multi-omics dissection of MAPK-driven senescence unveils therapeutic vulnerabilities in KIAA1549::BRAF-fusion pediatric low-grade glioma models by Romain Sigaud, Anja Stefanski, Florian Selt, Daniela Kocher, Diren Usta, Daniel Picard, Isabel Büdenbender, Marc Remke, Stefan M. Pfister, David T. W. Jones, Tilman Brummer, Olaf Witt, Till Milde

“…Trametinib treatment inhibited MAPK activity, OIS and SASP signatures across all omics levels, functionally underscored by reduced sensitivity towards senolytic drugs. …”
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The bacterial microbiome of symbiotic and menthol-bleached polyps of long-term aquarium-reared Galaxea fascicularis by Puntin, Giulia, Wong, Jane C. Y., Röthig, Till, Baker, David M., Sweet, Michael, Ziegler, Maren

“…While understanding coral functioning is essential to guide conservation efforts, research is challenged by the complex nature of corals. …”
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Associations between an inflammatory diet index and nonunion: a prospective study of 172,839 UK biobank participants by Jiemao Su, Wenxuan Fan, Keyu Kong, Yifan Wang, Zanjing Zhai, Jingwei Zhang, Minghao Jin, Yansong Qi, Yongsheng Xu

“…These genes are functionally enriched in pathways governing immune response regulation and leukocyte activation.ConclusionThese findings propose that a moderately pro-inflammatory dietary pattern may confer protection against impaired bone healing, whereas both strongly anti-inflammatory and excessively pro-inflammatory diets were associated with compromised healing outcomes. …”
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Transcriptome analysis revealed that AcWRKY75 transcription factor reduced the resistance of kiwifruit to Pseudomonas syringae pv. actinidiae by Lixia Ye, Minmin Luo, Yafang Wang, Yafang Wang, Mengqi Yu, Mengqi Yu, Zhi Wang, Fuxi Bai, Xuan Luo, Li Li, Qiong Huang, Jue Peng, Qi Chen, Qinghong Chen, Lei Gao, Lei Zhang

“…Subcellular localization and transcriptional activity analysis confirmed that AcWRKY75 functions as a nucleus-located transcriptional activator. …”
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Aloe Emodin Alleviates Radiation‐Induced Heart Disease via Blocking P4HB Lactylation and Mitigating Kynurenine Metabolic Disruption by Fan Ouyang, Yaling Li, Haoming Wang, Xiangyang Liu, Xiaoli Tan, Genyuan Xie, Junfa Zeng, Gaofeng Zeng, Qiong Luo, Hong Zhou, Siming Chen, Kai Hou, Jinren Fang, Xia Zhang, Linlin Zhou, Yukun Li, Anbo Gao

“…Mechanistically, aloe emodin inhibits phosphorylated glycogen synthase kinase 3B (p‐GSK3B) transcription in the nucleus to repress the interaction of prostaglandin G/H synthase 2 (PTGS2) with SH3 domain of SH3 domain‐containing GRB2‐like protein B1 (SH3GLB1), thereby disrupting the functions of mitochondrial complexes and reducing SH3GLB1‐mediated mitoROS accumulation, eventually suppressing calcium‐binding and coiled‐coil domain‐containing protein 2 (NDP52)‐induced mitophagy. …”
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Construction of a novel radioresistance-related signature for prediction of prognosis, immune microenvironment and anti-tumour drug sensitivity in non-small cell lung cancer by Yanliang Chen, Chan Zhou, Xiaoqiao Zhang, Min Chen, Meifang Wang, Lisha Zhang, Yanhui Chen, Litao Huang, Junjun Sun, Dandan Wang, Yong Chen

“…Then, Immune landscape and drug sensitivity were evaluated. The biological functions exerted by the key gene LBH were verified by in vitro experiments.Results Ninety-nine RRRGs were screened by intersecting the results of DEGs and WGCNA, then 11 hub RRRGs associated with survival were identified using machine learning algorithms (LASSO and RSF). …”
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Explore the potential mechanism of Huachansu injection against osteosarcoma via metabolomics, network pharmacology and bioinformatics by Jingjing Meng, Xiangqi Zhang, Danfeng Xiang, Hanlu Liang, Shuai Zhao, Lingyan Xu, Jiao Yang, JunJun Chen, Jingxian Zhang, Yonglong Han

“…Abstract Aim Huachansu injection (HCSI) shows effective medicinal functions against osteosarcoma. This study aimed to reveal the underlying mechanisms of HCSI against osteosarcoma by integrating metabolomics, network pharmacology and bioinformatics. …”
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Culturally adapted developmental outcome measure for Aboriginal and Torres Strait Islander children: study protocol for the validation of the ASQ-STEPS by Patricia Eadie, Anita D’Aprano, Francesca Lami, Dan Cloney, Samantha Simpson, Cassie Boyle, Leah Lindrea-Morrison, Raelene Brunette, Emma Stubbs, Cuc Nguyen, Isabel Brookes

“…Classical and IRM fit statistics and differential item functioning will be employed to examine validity. …”
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TOM40 as a prognostic oncogene for oral squamous cell carcinoma prognosis by Lifei Deng, Hong Ran, Dunhui Yang, Zhen Wang, Peng Zhao, Hengjie Huang, Yongjin Wu, Peng Zhang

“…A network of genes co-expressed with TOM40 was constructed and functionally annotated by gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses. …”
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