A nicotinamide metabolism-related gene signature for predicting immunotherapy response and prognosis in lung adenocarcinoma patients by Meng Wang, Wei Li, Fang Zhou, Zheng Wang, Xiaoteng Jia, Xingpeng Han

“…Background Nicotinamide (NAM) metabolism fulfills crucial functions in tumor progression. The present study aims to establish a NAM metabolism-correlated gene (NMRG) signature to assess the immunotherapy response and prognosis of lung adenocarcinoma (LUAD). …”
Get full text

PCCNN: A CNN classification model integrating EEG time-frequency features for stroke classification by Teng Wang, Fenglian Li, Jia Yang, Wenhui Jia, Fengyun Hu

“…DWT extracts multi-scale wavelet coefficients from stroke-related frequency bands, while EMD decomposes EEG signals into intrinsic mode functions (IMFs), representing narrowband oscillation components. …”
Get full text

Comparative analysis of WC1.1+ and WC1.2+ γδ T cell subset responses from cattle naturally infected with Mycobacterium bovis to repeat stimulation with mycobacterial antigens. by Alia Parveen, Sajad A Bhat, Mahmoud Elnaggar, Kieran G Meade

“…In conclusion, while WC1.1+ and WC1.2+ γδ T cells exhibit a conserved inflammatory response to PPDb, differences in anti-inflammatory and antimicrobial gene expression between these cell subsets provide new insights into their effector functions in response to mycobacterial antigens.…”
Get full text

Towards a Universal Security Framework for Darknet Suppression: Conceptual Foundations and Future Prospects by Cheng HUANG, Jianwei DING, Jiapeng ZHAO, Zhouguo CHEN, Jinqiao SHI

“…This involves constructing a small flow sampling model based on self-similarity associations and a darknet traffic identification and service classification model using Gaussian kernel functions and multimodal optimization. This method enables precise, real-time identification and classification of darknet traffic. 3) Introducing a multi-network full-time domain connection prediction and relationship mapping method based on behavioral invariance. …”
Get full text

CsrA-mediated regulation of a virulence switch in Acinetobacter baumannii by Raja Singh, María Pérez-Varela, Jennifer M. Colquhoun, Carsten Kröger, Fergal J. Hamrock, Ali Shaibah, Ellen L. Neidle, Philip N. Rather

“…ABSTRACT CsrA is an RNA binding protein that functions as a global regulator in bacteria. We demonstrate that, in Acinetobacter baumannii, CsrA acts as a positive regulator of the switch from virulent (VIR-O) to avirulent (AV-T) subpopulations. …”
Get full text

Comparing the psychometric evidence of the Depression, Anxiety, and Stress Scale-21 (DASS-21) between Spanish and Chinese primary schoolteachers: insights from classical test theor... by Xu Wang, Cui-Hong Cao, Xiao-Ling Liao, Xing-Yong Jiang, Mark D. Griffiths, I-Hua Chen, Chung-Ying Lin, Olga Malas

“…SEM demonstrated the DASS-21’s concurrent validity with emotional exhaustion, with consistent findings across both samples. After excluding Differential Item Functioning (DIF) items, strict measurement invariance between Spanish and Chinese teachers was achieved, as verified by multi-group CFA. …”
Get full text

Small Extracellular Vesicle (sEV) Uptake from Lung Adenocarcinoma and Squamous Cell Carcinoma Alters T-Cell Cytokine Expression and Modulates Protein Profiles in sEV Biogenesis by Hafiza Padinharayil, Jinsu Varghese, Pulikkottil Raphael Varghese, Cornelia M. Wilson, Alex George

“…Gene Ontology (GO) analysis of these DAPs highlighted processes such as sEV biogenesis, metabolic pathways, and regulatory functions, with ADC sEVs influencing NAD metabolism, ECM binding, and oxidoreductase activity, while SCC sEVs affected mRNA stability, amino acid metabolism, and cadherin binding. …”
Get full text

Integrated genome and transcriptome analysis reveals pathogenic mechanisms of Calonectria eucalypti in Eucalyptus leaf blight by QianLi Liu, GuoQing Li, YuHua Liang, Yan Lin, KaiDong Liu, ZhenChi Huang, ShanNi Cao, FeiFei Liu

“…Comparative genomics revealed 60 expanded gene families and eight species-specific clusters in C. eucalypti, predominantly enriched in virulence-associated functions such as transferase activity, sporulation, and host adhesion. …”
Get full text

Ghrelin Immunoreactive Cell Amounts in the Abomasum in 4-Month-Old Calves by Feeding Different Amounts of Prebiotics and New Synbiotics by Astra Arne, Aija Ilgaza, Liga Astra Kalnina

“…In the gastrointestinal system, ghrelin affects multiple functions, including secretion of gastric acid, gastric motility, and pancreatic protein output. …”
Get full text

Integrative analysis of multi-omics data identified PLG as key gene related to Anoikis resistance and immune phenotypes in hepatocellular carcinoma by Xueyan Wang, Lei Gao, Haiyuan Li, Yanling Ma, Bofang Wang, Baohong Gu, Xuemei Li, Lin Xiang, Yuping Bai, Chenhui Ma, Hao Chen

“…Furthermore, we present compelling experimental evidence that PLG functions as a significant tumor promoter, suggesting its potential as a target for the formulation of tailored therapeutic strategies for HCC.…”
Get full text

NUTRITCIOGENETICS AND RISK FACTORS OF CARDIOVASCULAR DISEASE: ASSOCIATED RESEARCH IN EASTERN SIBERIA POPULATIONS by T. A. Bairova, V. V. Dolgikh, L. I. Kolesnikova, O. A. Pervushina

“…We evaluated clinically, functionally and genetically healthy and hypertensive (having essential arterial hypertension) adolescents and compared the results. …”
Get full text

«Implantation window» disturbance in patients with hyperplastic processes of endometrium by O. I. Parnytska

“…Successful implantation requires a functionally normal embryo at the blastocyst stage and receptive endometrium, while the communication between them is also vital. …”
Get full text

Dietary inclusion of Hermetia illucens larvae meal modifies caecal microbiota diversity and composition in barbary partridges (Alectoris barbara) by Elie Atallah, Tiziana Maria Mahayri, Jakub Mrázek, Fulvia Bovera, Giovanni Piccolo, Kateřina Olša Fliegerová, Giuseppe Moniello

“…Several of these taxa are associated with gut health, fiber fermentation, and metabolic functions, indicating a biological importance of the observed microbial shifts. …”
Get full text

The Role of Plant Evolutionary History in Shaping the Variation in Specific Leaf Area Across China by Minyue Si, Caiyi Zhang, Chunzhu Xiang, Mingxia Jiang, Linwei Guo, Junjiong Shao

“…ABSTRACT Specific leaf area (SLA, leaf area per unit leaf dry mass) occupies a central position in both community assembly and ecosystem functioning. Although SLA has significant phylogenetic signals, how and to what extent the evolutionary history influences the variation in SLA remain poorly understood. …”
Get full text

Extracellular vesicles from melatonin-preconditioned mesenchymal stromal cells protect human umbilical vein endothelial cells against hypoxia/reoxygenation detected by UHPLC-QE-MS/... by Liwei Cai, Qian Ma, Danli Zhuo, Qingcheng Chen, Yiming Zhuang, Shengkun Yuan, Xin Lu, Changyi Zhang, Yu Zhou

“…Melatonin (MT), however, not only exerts a significant protective effect in the treatment of cardiovascular diseases but also enhances biological functions of MSCs through pretreatment. Therefore, in the current study, we sought to determine whether MT improves the paracrine effect of MSCs through pretreatment. …”
Get full text

Reactive Oxygen Species: A Double-Edged Sword in the Modulation of Cancer Signaling Pathway Dynamics by Manisha Nigam, Bajrang Punia, Deen Bandhu Dimri, Abhay Prakash Mishra, Andrei-Flavius Radu, Gabriela Bungau

“…By systematically integrating data on ROS source-specific functions and redox-sensitive signaling pathways, the complex interplay between ROS concentration, localization, and persistence is elucidated, revealing how these factors dictate the paradoxical support of tumor progression or induction of cancer cell death. …”
Get full text

Identification of signature genes and subtypes for heart failure diagnosis based on machine learning by Yanlong Zhang, Yanming Fan, Fei Cheng, Dan Chen, Hualong Zhang

“…In addition, we assessed the different subtypes of heart failure through unsupervised clustering, and investigations were conducted on the differences in the immunological microenvironment, improved functions, and pathways among these subtypes. Finally, a comprehensive analysis of the expression profile, prognostic value, and genetic and epigenetic alterations of four potential diagnostic candidate genes was performed based on The Cancer Genome Atlas pan-cancer database.ResultsA total of 295 differential genes were identified in the HF dataset, and intersected with the blue module gene with the highest correlation to HF identified by weighted correlation network analysis (r = 0.72, p = 1.3 × 10−43), resulting in a total of 114 key HF genes. …”
Get full text

Effectiveness of Digital Health Interventions on Sedentary Behavior Among Patients With Chronic Diseases: Systematic Review and Meta-Analysis by Yan Zhang, Fei Wan Ngai, Qingling Yang, Yao Jie Xie

“…Phone, web, and activity trackers were 3 digital technologies adopted in the interventions and they were used in combination in most studies (18/26, 69.2%). The functions included facilitating self-monitoring of SB, reminding interruption of long undisturbed sitting, and promoting goal attainment. …”
Get full text

The Histidine-25-Arginine Mutation in the Rice MACPF Protein OsCAD1 Induces Cell Death and Activates Defense Responses in the Lesion Mimic Mutant spl17 by Dongsheng Tian, Yanchang Luo, Shuye Jiang, Yuejing Gui, Raji Mohan, Ignatius Ren Kai Phang, In-Cheol Jang, Zhongchao Yin

“…Transcriptome analyses, including RNA-Seq and Gene Set Enrichment Analysis (GSEA), indicate that differentially expressed genes (DEGs) in spl17 are enriched in catalytic activity, metabolic processes, and membrane functions. …”
Get full text

Novel insights from comprehensive analysis: The role of cuproptosis and peripheral immune infiltration in Alzheimer's disease. by Jing Wang, Zi-Wen Yu, Qi Liu, Jing-Xun Wu, Yi-Dan Zhang, Hui-Juan Wan, Min Bi, Nai-An Xiao, Kun-Mu Zheng, Bin Jiang

“…<h4>Results</h4>19 DECAGs were found in AD and the key biological processes and molecular functions associated with AD were further determined. …”
Get full text