RNA Sequencing Identifies Novel Signaling Pathways and Potential Drug Target Genes Induced by FOSL1 in Glioma Progression and Stemness by Guo S, Sidhu R, Ramar V, Guo AA, Wang G, Liu M

“…Notably, 8 upregulated (ITGA5, SDC1, PHLDB2, TNFRSF8, ADAM8, TLR7, STEAP3, and POU3F2) and 4 downregulated (IFIT1, FBXO16, ARL3, and BEX1) genes were identified, with implications for glioblastoma prognosis.Conclusion: This transcriptome investigation emphasizes the diverse functions of FOSL1 in different biological processes and signaling networks during the shift from proneural to mesenchymal state in glioblastoma.Keywords: glioma, RNA sequencing, FOSL1, NF-κB, glioma stem cells, signaling pathways…”
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Validation using item response theory, and assessment of sensitivity to change of the Hypoglycemia Awareness Questionnaire in patients with type 2 diabetes treated with insulin by Julieth Patricia García‐Lugo, Ana Julia Carrillo Algarra, Fabio Alexander Sierra‐Matamoros, Sandra Milena Hernández‐Zambrano, Diana Cristina Henao‐Carrillo

“…A partial credit model was used for validation using item response theory, infit, and outfit statistics were calculated, person‐item map and item characteristic curves were plotted, and differential item functioning was assessed. Results The study included 502 participants, the mean age at diagnosis of diabetes was 47.8 ± 13.9 years, the median time with the diagnosis was 15 years (IQR: 9–22), and the mean HbA1c 71 ± 27.3 mmol/mL (8.6 ± 2.5%), 48.6% had Glomerular Filtration Rate >60 mL/min/min2. …”
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Features of personal resources of psychological safety of students of different levels of education in a tense social environment by I.A. Baeva, I.V. Kondakova, M.-E.-L.S. Sokolova, Yu.S. Stepanova

“…At the same time, there is a need for effective functioning in it, which requires maintaining a state of psychological safety, which determines resistance to negative environmental impacts. …”
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Genotyping peculiarities of wheat photosynthesis light induction and productivity under the drought effect by Dmytro Kiriziy, Volodymyr Morgun

“…At the same time, the vast majority of works devoted to the problems of photosynthetic apparatus functioning under unstable light conditions do not take into account an adverse impact on photosynthesis of such a common stressor as drought. …”
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Identification of resistance sources and genomic regions regulating Septoria tritici blotch resistance in South Asian bread wheat germplasm by Manjeet Kumar, Xinyao He, Sudhir Navathe, Umesh Kamble, Madhu Patial, Pawan Kumar Singh

“…Many of these QTNs could differentiate the mapping panel into resistant versus susceptible groups and were linked to candidate genes related to disease resistance functions within linkage disequilibrium blocks. …”
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Realising the Benefits of Sports and Physical Activity: The Human Capital Model (Materializando los beneficios del deporte y la actividad física: El modelo de capital humano) by Richard Bailey, Ed Cope, Daniel Parnell

“…Despite the fact that physical activity is universally acknowledged to be an important part of healthy functioning and well being, the full scope of its value is rarely appreciated.  …”
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Effective Diabetic Retinopathy Classification With Siamese Neural Network: A Strategy for Small Dataset Challenges by Maria Tariq, Vasile Palade, Yingliang Ma

“…Furthermore, we conduct an in-depth analysis of hyperparameter optimisation, specifically investigating different pair selection techniques, loss functions, and distance layers to thoroughly evaluate their impact on the performance of the model. …”
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TGFβ-signaling in Squamous Cell Carcinoma Occurring in Recessive Dystrophic Epidermolysis Bullosa by Julia Knaup, Christina Gruber, Barbara Krammer, Verena Ziegler, Johann Bauer, Thomas Verwanger

“…Methods: We applied cDNA arrays comprising 9738 human expressed sequence tags (EST) with various functions. Selected results were verified by Real-time RT PCR. …”
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Simulation of Vertical Movements of Seawater in Stratified Reservoirs by N. V. Kudinov, A. A. Filina, A. V. Nikitina, D. V. Bondarenko, I. F. Razveeva

“…This is open-source software that provides not only the redefinition of empirical dependences (as algebraic functions), but also the connection of external simulating modules to display dependences algorithmically.Discussion and Conclusion. …”
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Ashbya gossypii as a versatile platform to produce sabinene from agro-industrial wastes by Gloria Muñoz-Fernández, Javier-Fernando Montero-Bullón, José Luis Martínez, Rubén M. Buey, Alberto Jiménez

“…Conclusions Engineered A. gossypii strains serve as a suitable platform for assessing plant terpene synthase functionality and substrate selectivity in vivo, which are crucial to understand monoterpene bioproduction. …”
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X-Linked Autism Type 9 Caused by a Hemizygote Pathogenic Variant in the TMLHE Gene: Etiological Diagnosis in an Adult Male with Moderate Intellectual Disability by Verhoeven WM, Pfundt R, Engelke UF, Kluijtmans LA, Egger JI

“…Willem MA Verhoeven,1– 3 Rolph Pfundt,4,5 Udo FH Engelke,6 Leo AJ Kluijtmans,6 Jos IM Egger3– 5 1Department of Psychiatry, Erasmus University Medical Center, Rotterdam, The Netherlands; 2Centre for Consultation and Expertise, Utrecht, The Netherlands; 3Vincent van Gogh Centre of Excellence for Neuropsychiatry, Venray, The Netherlands; 4Department of Human Genetics, Radboud University Medical Centre, Nijmegen, The Netherlands; 5Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands; 6Department of Human Genetics, Translational Metabolic Laboratory, Radboud University Medical Centre, Nijmegen, The NetherlandsCorrespondence: Willem MA Verhoeven, Email wmaverhoeven@planet.nlIntroduction: Levocarnitine is essential for brain functioning and fatty acid metabolism and stems largely from dietary sources. …”
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AVPR1A RS3 and relationship maintenance processes in newlywed couples by Anastasia Makhanova, James K. McNulty, Lisa A. Eckel, Larissa Nikonova, Jennifer A. Bartz, Arial S. Bloshinsky, Elizabeth A. D. Hammock

“…Nevertheless, in offering a potential reconciliation between the discrepancies, we suggest that attending to relational phase may be critical to understanding the role of RS3 in couple functioning; AVPR1A RS3 variability may be differentially associated with pair bonding in the newlywed stage compared to established marriages.…”
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Integrative machine learning and bioinformatics analysis to identify cellular senescence-related genes and potential therapeutic targets in ulcerative colitis and colorectal cancer by Tianle Xue, Yunpeng Chen, Xiaomeng Li, Zhixiang Zhou, Qiyang Chen

“…In addition, immune cell infiltration, protein–protein interaction (PPI) networks, and drug enrichment analyses—including molecular docking—were performed to further elucidate the biological functions and therapeutic potentials of the identified genes.ResultsOur analysis revealed significant transcriptomic alterations in UC and CRC tissues, with the turquoise module demonstrating the strongest association with disease traits. …”
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Impact of synthetic and herbal dyes on photosynthesis and ROS scavenging enzyme activities in Spirodela polyrhiza by Vineet Soni, Upma Bhatt, Pooja Tailor, Reto J. Strasser

“…The results indicate that exposure to SCs severely disrupted PSII functionality, as evidenced by a drastic decline in the quantum yield of primary photochemistry (φPo), electron transport efficiency (φEo), and performance index (PIcs). …”
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New investigation on soliton solutions of two nonlinear PDEs in mathematical physics with a dynamical property: Bifurcation analysis by Hossain Md Dulal, Boulaaras Salah Mahmoud, Saeed Abdulkafi Mohammed, Gissy Hussain, Hossain Md Nur, Mamun Miah Md

“…The derived soliton solutions are articulated in terms of rational, trigonometric, and hyperbolic functions, each embodying the physical implications of the equations through meticulously specified parameters. …”
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Physical vulnerability of masonry building to the slow-moving landslide: insight from numerical simulation by Haojie Wang, Haojie Wang, Haojie Wang, Jiarui Mao, Jiarui Mao

“…Weibull functions were employed to fit vulnerability curves for masonry structures under four ground crack scenarios, revealing displacement thresholds of 22 cm, 26 cm, 27 cm, and 37 cm for complete structural vulnerability (V = 1) in each respective scenario. …”
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Expression profiles and potential roles of microRNAs in erythrocytes during the aging process by Liping Sun, Xiaofei Li, Xiaoxing Liang, Cuimi Duan, Fengxian Li, Yang Yu, Deqing Wang

“…A bioinformatics analysis identified the potential targets and biological functions of these miRNAs. The experiment of miR-22-3p in the human erythroblast cell line K562 confirmed its negative effects on PK levels. …”
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Hybrid Deep Neural Network Optimization with Particle Swarm and Grey Wolf Algorithms for Sunburst Attack Detection by Mohammad Almseidin, Amjad Gawanmeh, Maen Alzubi, Jamil Al-Sawwa, Ashraf S. Mashaleh, Mouhammd Alkasassbeh

“…The strength of DNNs is derived from their ability to model complex functions and to improve detection engines through deeper architecture. …”
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Multivariate evaluation method for the detection of pest infestations on plants via VOC analysis using gas chromatography mass spectrometry by Sarah Vermeeren, Markus Witzler, Ramona Makarow, Carsten Engelhard, Peter Kaul

“…For this reason, a multivariate evaluation method based on a self-written Python script, using principal component analysis (PCA) and linear discriminant analysis (LDA), was developed and tested for functionality using a dataset, which has been evaluated manually and has identified five specific markers (2,4-dimethyl-1-heptene, 3-carene, $$\alpha$$ -longipinene, cyclosativene, and copaene) for Anoplophora glabripennis (ALB) infestation on Acer trees. …”
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Epigenetic Regulation of Neutrophils in ARDS by Jordan E. Williams, Zannatul Mauya, Virginia Walkup, Shaquria Adderley, Colin Evans, Kiesha Wilson

“…Beyond their classical antimicrobial functions, neutrophils contribute to pulmonary injury via the release of reactive oxygen species, proteolytic enzymes, and neutrophil extracellular traps (NETs). …”
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