Computational fluid dynamics-multibody system dynamics bidirectional coupling calculation and flow-induced vibration evaluation of a high-speed pantograph-catenary system by Zhuojun Li, ChunJiang Chen, Huapu Song, Gang Yang, Jun Yang, Huadong Yao, Jiqiang Niu

“…This study proposes a bidirectional coupling method for the pantograph based on overset grids. The user-defined functions (UDF) in Fluent enable real-time data exchange between aerodynamic forces and structural displacements. …”
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PDK1 promotes epithelial ovarian cancer progression by upregulating BGN by Zhang Lei, Yan Lina, Fu Xin, Tao Ziqi, Liu Shuna, Li Rong, Wang Ting, Mao Yepeng, Shang Wenwen, Gong Mi, Jia Xuemei, Wang Fang

“…In conclusion, PDK1 functions as an oncogene, facilitating EOC progression by upregulating BGN and activating the NF-κB pathway. …”
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CircRALGPS2 modulates chicken follicle development through promotion of granulosa cell apoptosis and autophagy via the miR-200a-3p/TGFβ2/SMAD pathway by Haorong He, Xinghong Yu, Can Cui, Yao Zhang, Zhuanjian Li, Shunshun Han, Huadong Yin

“…Moreover, we demonstrated that circRALGPS2 functions as a molecular sponge for miR-200a-3p, revealing that miR-200a-3p and circRALGPS2 exert antagonistic effects on GC autophagy and apoptosis. …”
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Machine learning identifies KRT8 dysregulation and endothelial remodeling in Moyamoya disease by Zhiguang Han, Jialong Yuan, Zhenyu Zhou, Yutong Liu, Chengxu Lei, Xun Ye, Yuanli Zhao, Shihao He

“…Key genes were identified through differential analysis and WGCNA. The functions of potential biomarkers were explored by methods such as correlation analysis, KEGG analysis, PPI network, and tube formation experiments. …”
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A triterpene-enriched natural extract from Eucalyptus tereticornis modulates the expression of genes involved in adipogenesis, lipolysis, and extracellular matrix remodeling in a p... by Sergio Acin, Alejandro Mejia-Garcia, Geysson Javier Fernandez, Norman Balcazar

“…To conduct clustering analysis, the normalized counts of each gene and applied k-means clustering were standardized.Results The combination of molecules in the natural extract has an additive or synergic effect that increases the number of genes regulated associated with the biological functionality of differentiating adipocytes, with UAL playing a central role. …”
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Diagnosis and rational treatment of painful diabetic peripheral neuropathy: an interdisciplinary expert consensus by Gagik R. Galstyan, Elena G. Starostina, Nikolay N. Yakhno, Irina V. Gurieva, Maxim V. Churyukanov, Igor A. Strokov, Alla Y. Tokmakova, Mikhail L. Kukushkin, Anatoly I. Martynov, Marina V. Shestakova

“…Diabetic peripheral neuropathy is a common chronic complication of diabetes mellitus, significantly impairing well-being, quality of life and functioning of patients. The prevalence of diabetic peripheral neuropathy in the Russian Federation ranges from 0.1% to 67.2% in type 1 and from 0.1 to 42.4% in type 2 diabetes mellitus. …”
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The Swimming Performance and Transcriptomic Insights Into Diverse Gene Regulation in Grass Carp Brain Under Water Velocity Stress by Mian Adnan Kakakhel, Nishita Narwal, Alam Khan, Majid Rasta, Liming Liu, Ihsan Ali, Yujiao Wu, Shi Xiaotao

“…Additionally, brain samples were collected for transcriptomic analysis, which revealed that differentially expressed genes (DEGs) were functionally annotated revealing key pathways associated with changed behavior patterns. …”
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The superiority of feasible solutions-moth flame optimizer using valve point loading by Mohammad Khurshed Alam, Herwan Sulaiman, Asma Ferdowsi, Md Shaoran Sayem, Md Mahfuzer Akter Ringku, Md. Foysal

“…The MFO, Grey Wolf Optimizer (GWO), Success-history-based Parameter Adaptation Technique of Differential Evolution - Superiority of Feasible Solutions (SHADE-SF), and Superiority of Feasible Solutions-Moth Flame Optimizer (SF-MFO) algorithms are applied to address the OPF problem with two objective functions: (1) reducing energy production costs and (2) minimizing power losses. …”
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APOA1 promotes tumor proliferation and migration and may be a potential pan-cancer biomarker and immunotherapy target by Peiyi Xu, Qiuyan Zhang, Jing Zhai, Pu Chen, Xueting Deng, Lin Miao, Xiuhua Zhang

“…In addition, in vitro CCK-8 and transwell migration and invasion assays were performed to determine the biological functions of APOA1 in gastric cancer (GC) cells. Results: The pan-cancer analysis showed that APOA1 is differentially expressed in different cancer types and significantly correlated with tumor stages. …”
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Transcriptomic network underlying physiological alterations in the stem of Myricaria laxiflora in response to waterlogging stress by Linbao Li, Yang Su, Weibo Xiang, Guiyun Huang, Qianyan Liang, Bicheng Dun, Haibo Zhang, Zhiqiang Xiao, Liwen Qiu, Jun Zhang, Di Wu

“…A total of 8714 genes in the stem of M. laxiflora were identified as differentially expressed genes (DEGs) under waterlogging stress, which could be assigned into two different subgroups with distinct gene expression patterns and biological functions. …”
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Salmonella-induced SIRT1 and SIRT3 are crucial for maintaining the metabolic switch in bacteria and host for successful pathogenesis by Dipasree Hajra, Raju S Rajmani, Ayushi Devendrasingh Chaudhary, Shashi Kumar Gupta, Dipshikha Chakravortty

“…Alongside, governing immunological functions by modulating p65 NF-κB acetylation, SIRT1, and SIRT3 also skew Salmonella-induced host metabolic switch by regulating the acetylation status of HIF-1α and PDHA1. …”
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Integration of ATAC-seq and RNA-seq reveals signal regulation during post-molt and inter-molt stages in muscle of Eriocheir sinensis by Bin Wang, Bin Wang, Jingjing Li, Mingzhi Zhang, Mingzhi Zhang, Anqi Li, Zhentao Song, Zhentao Song, Zhen He, Zhen He, Ruiqi Zhang, Ruiqi Zhang, Tong Hao, Tong Hao, Jinsheng Sun, Jinsheng Sun

“…Further protein structure analysis and RT-qPCR validation confirmed five GPCR genes related to molting process, in which four genes (GRM7, FMRFaR, mth2, gpr161) are active during the post-molt stage and one gene (moody) functions during the inter-molt stage.DiscussionThese findings highlight the key regulatory proteins and pathways involved in E. sinensis muscle during molting and also offer foundational data for studying the mechanisms of molting and discontinuous growth in crustaceans.…”
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Antitumor effects of natural killer cells derived from gene-engineered human-induced pluripotent stem cells on hepatocellular carcinoma by Mayuna Nakamura, Yuka Tanaka, Keishi Hakoda, Masahiro Ohira, Tsuyoshi Kobayashi, Kenji Kurachi, Kouichi Tamura, Hideki Ohdan

“…Our data suggest that eNK cells, whose functions have been enhanced by genetic engineering, have the potential to improve HCC treatment.…”
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Upregulation of Peripheral Blood NLRP3 and IL‐18 in Patients With Acute Kidney Injury in Sepsis and Its Clinical Significance by Jing Zhou, Yibin Ye, Zhipeng Chen, Yong Liu, Baozheng Wu, Haiping Huang

“…KEGG and GO analysis were used to identify enriched molecular functions and pathways. The study included 62 SA patients admitted to the Department of Intensive Care Medicine of our hospital from February 2021 to June 2022, including 34 non‐AKI cases and 28 AKI cases, and 25 healthy volunteers were used as the control group. …”
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Defective biogenesis of human mitochondrial ribosomes causes sensorineural deafness by Chao Chen, Wenqi Shan, Min-Xin Guan

“…Especially, hair cell-like cells differentiated from patients-derived iPSCs harboring both m.1555A > G and TRMU c.28G > T mutations displayed greater defects in the morphology and functions than those in cells bearing only m.1555A > G mutation and these defects were restored by genetic correction of TRMU c.28G > T mutation. …”
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Music therapy as a preventive intervention for postpartum depression: modulation of synaptic plasticity, oxidative stress, and inflammation in a mouse model by Qiang Fu, Rui Qiu, Tongtong Yao, Liming Liu, Yaobo Li, Xiaodong Li, Wen Qi, Yuewen Chen, Yong Cheng

“…Abstract Postpartum depression (PPD) significantly impacts women’s mental health and social functioning, yet effective therapies remain limited. …”
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BandFocusNet: A Lightweight Model for Motor Imagery Classification of a Supernumerary Thumb in Virtual Reality by Haneen Alsuradi, Joseph Hong, Alireza Sarmadi, Robert Volcic, Hanan Salam, S. Farokh Atashzar, Farshad Khorrami, Mohamad Eid

“…A promising control strategy for supernumerary effectors involves utilizing electroencephalography (EEG) through motor imagery (MI) functions. In this work, we investigate whether MI activity associated with a supernumerary effector could be reliably differentiated from that of a natural one, thus addressing the concern of concurrency. …”
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Investigating hydrocarbon potential utilizing isopach maps in the paleo-environment of the external Fars region, Zagros fold-thrust belt by Mina Farzaneh, Zahra Maleki, Mehran Arian, Mohammad Ali Ganjavian, Pooria Kianoush

“…Notably, the findings reveal that the Nezamabad Fault functions as a significant basement fault, actively controlling hydrocarbon distribution during geological epochs. …”
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Impact of amber powdered waste on the processability and properties of PCL-based materials by Cláudia A.B. dos Santos, Bartłomiej Kryszak, Michał Grzymajło, Łukasz J. Wilk, Patrycja Szymczyk-Ziółkowska, Adam Junka, Aleksandra Ujćič, Konrad Szustakiewicz

“…Amber powdered waste from the jewelry industry appears to be a promising sustainable filler and compatibilizer for PCL, while also potentially adding biological functionalities.…”
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Parabacteroides goldsteinii mitigates the lipopolysaccharide-induced inflammatory response in IPEC-J2 cells by Junjie Zhang, Anjian Li, Yang He, Taozong Guo, Yixuan Ge, Hongbin Pan, Cuilian Dong

“…GO analysis was used to annotate the functions of the DEGs, and the results showed that biological regulation, cellular anatomical entity, and binding were dominant. …”
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