S100A9 as a promising therapeutic target for diabetic foot ulcers by Renhui Wan, Shuo Fang, Xingxing Zhang, Weiyi Zhou, Xiaoyan Bi, Le Yuan, Qian Lv, Yan Song, Wei Tang, Yongquan Shi, Tuo Li, Sihan Zhou, Xiuyuan Hao

“…Enrichment analysis was conducted to screen for critical gene functions and pathways. A protein interaction network was constructed to identify node genes corresponding to key proteins. …”
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The Sensitive Genes for Cervical Cancer: Two-Sample Mendelian Randomization with Experimental Validation by Zhang R, Chai S, Chen Q, Lai J, Cai C

“…Finally, we further validated the functions of the selected target genes in cervical cancer cells and analyzed their Gene Set Enrichment Analysis (GSEA) results, drug sensitivity, and prognostic value.Results: We identified 2,801 upregulated and 1,646 downregulated DEGs. …”
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Integration of proteomics and metabolomics analysis investigate mechanism of As-induced immune injury in rat spleen by Xiaoqian Ran, Xi Yan, Guanwei Ma, Zhiyuan Liang, Hongbin Zhuang, Xiaoxiao Tang, Xiaolu Chen, Xueshan Cao, Xukun Liu, Yuhan Huang, Yi Wang, Xinglai Zhang, Peng Luo, Liming Shen

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Substantial Heritability Underlies Fairness Norm Adaptation Capability and its Neural Basis by Yuening Jin, Dang Zheng, Ruolei Gu, Qingchen Fan, Martin Dietz, Changshuo Wang, Xinying Li, Jie Chen, Yuanyuan Hu, Yuan Zhou

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Detecting Sleep Apnea with Smart-tech: Scientific Breakthrough or Overhyped Technology? by Aleksandra Głowacka, Paulina Grzeszczuk, Iwona Skorulska, Agnieszka Kalisz, Marta Ignatiuk-Chilkiewicz, Weronika Grywińska, Julia Kozakiewicz, Kamil Kościelecki, Klaudia Mączewska, Patrycja Długozima

“…Sleep disorders can severely impair cognitive functions such as concentration and memory, while also leading to chronic fatigue and emotional instability. …”
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Identification and characterization of early human photoreceptor states and cell-state-specific retinoblastoma-related features by Dominic WH Shayler, Kevin Stachelek, Linda Cambier, Sunhye Lee, Jinlun Bai, Bhavana Bhat, Mark W Reid, Daniel J Weisenberger, Jennifer G Aparicio, Yeha Kim, Mitali Singh, Maxwell Bay, Matthew E Thornton, Eamon K Doyle, Zachary Fouladian, Stephan G Erberich, Brendan H Grubbs, Michael A Bonaguidi, Cheryl Mae Craft, Hardeep P Singh, David Cobrinik

“…Beyond the cell state characterizations, full-length scRNA-seq revealed that both L/M cone and rod precursors co-expressed NRL and THRB RNAs yet differentially expressed functionally antagonistic NRL isoforms and prematurely terminated THRB transcripts. …”
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Infection of human induced pluripotent stem cells by an oncogenic herpesvirus by Jiaojiao Fan, Zhen Lin, Huiliang Zhang, Lu Dai, Zhiqiang Qin

“…Transcriptomic analysis revealed significant changes in global cellular gene expression in KSHV-infected hiPSCs as well as lytically induced cells.ConclusionOur findings demonstrate hiPSCs as a powerful tool to explore the potential impacts of KSHV infection on stem cell functions and virus pathogenesis in stem cell differentiated cells.…”
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Inhibition of EETosis with an anti-citrullinated histone antibody: a novel therapeutic approach for eosinophilic inflammatory disorders by Eline Zwiers, Daphne Montizaan, Annemarie Kip, Kelsy Waaijenberg, Paul S. Fichtinger, Sameer K. Mathur, Yuki Fujioka, Shigeharu Ueki, Helmuth van Es, Renato G. S. Chirivi, Eric Meldrum, Maarten van der Linden

“…CIT-013 potently inhibits release of EETs (half-maximal inhibitory concentration of 2.5 nM) without inhibiting other eosinophil functions such as degranulation, adhesion, superoxide production and induction of chemokine expression. …”
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<i>MECP2</i> mRNA Profile in Brain Tissues from a Rett Syndrome Patient and Three Human Controls: Mutated Allele Preferential Transcription and In Situ RNA Mapping by Martina Mietto, Silvia Montanari, Maria Sofia Falzarano, Elisa Manzati, Paola Rimessi, Marina Fabris, Rita Selvatici, Francesca Gualandi, Marcella Neri, Fernanda Fortunato, Miryam Rosa Stella Foti, Stefania Bigoni, Marco Gessi, Marcella Vacca, Silvia Torelli, Joussef Hayek, Alessandra Ferlini

“…This study reports the <i>MECP2</i> transcript representation in a post-mortem RTT brain and, for the first time, the in situ <i>MECP2</i> transcript localization in a human control brain, offering insights into how specific <i>MECP2</i> mutations may differentially impact neuronal functions. We suggest these findings are crucial for developing RNA-based therapies for Rett syndrome.…”
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Translation, cross-cultural adaptation, and validation of the Norwegian version of the Keratoconus Outcomes Research Questionnaire by Eilin Lundanes, Svein Magne Roten, Helle Kristine Falkenberg, Lena Leren, Vibeke Sundling

“…Deletion of four items (AL3, AL3b, AL12, AL15) improved dimensionality of the “Activity limitations” subscale. Differential item functioning was present in two items (AL4 and AL6). …”
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Reduced avoidance behaviour in Daphnia magna due to agrochemical-induced vulnerability by María Eugenia López-Valcárcel, Ana del Arco, Cristiano V.M. Araújo, Gema Parra

“…Additionally, agrochemically induced vulnerability and its effect on avoidance behaviour may affect ecosystem functioning through the altered spatial distribution of zooplankton populations.…”
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Identification of key biomarkers of the glomerulus in focal segmental glomerulosclerosis and their relationship with immune cell infiltration based on WGCNA and the LASSO algorithm by Yun Xia Zhang, Juan Lv, Jun Yuan Bai, XiaoWei Pu, En Lai Dai

“…The analysis of the infiltration of 28 immune cells and their correlation with the key biomarkers were performed.Results A total of 1474 DEGs were identified. Their functions were mostly related to immune-related diseases and signaling pathways. …”
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The immune-related gene CD5 is a prognostic biomarker associated with the tumor microenvironment of breast cancer by Yi Zhao, Hengheng Zhang, Wenwen Wang, Guoshuang Shen, Miaozhou Wang, Zhen Liu, Jiuda Zhao, Jinming Li

“…The tumor microenvironment (TME) plays an important role in this process, but the functions of immune components and stromal components in the TME require further elucidation. …”
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Adjusting for seasonal harvest bias in the lactation index for white‐tailed deer management by Kamen L. Campbell, Bronson K. Strickland, Stephen Demarais, Phillip D. Jones, Guiming Wang, Chad M. Dacus, Christopher Cook, W. Matt Knox

“…For each population, we calculated distance of mean female harvest date from median parturition date, and included linear, quadratic, and cubic functions of mean harvest day as potential explanatory variables. …”
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Proteome profiling of human lung epithelial cells unveils distinct patterns of protein expression in response to SARS-CoV-2 ORF3a by Apoorva, Astha Shukla, Atul Kumar, Saurabh Singh, Sunit K. Singh

“…These proteins may play a role in modulating the host's cellular immune functions in response to SARS-CoV-2 ORF3a. Taken together, the present study demonstrates key proteins involved in ORF3a-mediated dampened immune response in human lung epithelial cells, which may facilitate viral replication. …”
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A ceRNA network mediated by LINC00475 in papillary thyroid carcinoma by Yang Yarong, Hua Wenjuan, Zeng Mei, Yu Liling, Zhang Baijun, Wen Liming

“…This study aimed to find out the functions and mechanism of lncRNA LINC00475 in PTC. …”
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Development of 4T1 breast cancer mouse model system for preclinical carbonic anhydrase IX studies by Zane Kalniņa, Ilva Liekniņa, Svetlana Koteloviča, Ramona Petrovska, Gediminas Žvinys, Agne Petrosiute, Asta Zubrienė, Matīss Toms Laugalis, Vendija Skeltona, Juris Jansons, Madara Kreishmane, Edita Čapkauskaitė, Daumantas Matulis, Kaspars Tārs

“…The generated cell lines were validated for CAIX production and characterised functionally in vitro and in vivo after orthotopic implantation in syngeneic BALB/c mice. …”
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Metabolomic insights into the prebiotic and metabolic regulatory properties of ellagic acid and urolithins on probiotic-like bacteria in vitro by Yang Yang, Ke Wang, Jia-Chi Chiou, Danyue Zhao

“…Overall, this study provides in-depth understanding on how dietary polyphenols with prebiotic properties regulate the growth and metabolic functions of probiotic-like bacteria.…”
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Omics-Based Interaction Analysis Reveals Interplay of Chemical Pollutant (Ozone) and Photoradiation (UVSSR) Stressors in Skin Damage by Hong Zhang, Yiying Dong, Xue Xiao, Xiao Cui, Xuelan Gu

“…Omics-based interaction framework (OBIF) analysis showed that most interactive genes following ozone and UVSSR exposure displayed a cooperative effect and had functions related to the skin barrier; these genes with synergistic effects were enriched in biological pathways such as the chronic inflammatory response and the apoptotic signaling pathway. …”
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Soluble β-Amyloid Oligomers Selectively Upregulate TRPC3 in Excitatory Neurons via Calcineurin-Coupled NFAT by Zhengjun Wang, Dongyi Ding, Jiaxing Wang, Ling Chen, Qingming Dong, Moumita Khamrai, Yuyang Zhou, Akihiro Ishii, Kazuko Sakata, Wei Li, Jianyang Du, Thirumalini Vaithianathan, Fu-Ming Zhou, Francesca-Fang Liao

“…The selective downregulation of the <i>Trpc6</i> gene induced synaptotoxicity, while no significant effect was observed from the Trpc3-targeting siRNA, suggesting potentially differential roles of TRPC3 and 6 in modulating the synaptic morphology and functions. …”
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