High-selective HDAC6 inhibitor alleviates bone marrow fibrosis through inhibiting collagen formation and extracellular matrix deposition by Chiao-Hsu Ke, Mao-En Huang, Hsin-Yi Wu, Chao-Wu Yu, Shuei-Liong Lin, Shau-Ping Lin, Shu-Han Yu, Chih-Hung Huang, Chen-Si Lin

“…Abstract Bone marrow fibrosis (BMF) impairs normal hematopoietic functions in patients. The overactivation of the TGF-β signaling pathway is regarded as one of the offenders causing disease progression. …”
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Practical considerations for DNA sensing using Faradaic electrochemical impedance spectroscopy on ENIG PCB electrodes by Shruti Ahuja, Avani Kulkarni, Richa Pandey, Kiran Kondabagil, Siddharth Tallur

“…Our approach employs ENIG PCB electrodes functionalized with thiolated single-stranded DNA probes targeting the uidA gene of E. coli. …”
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Revealing the significance of tissue-resident memory T cells in lung adenocarcinoma through bioinformatic analysis and experimental validation by Zhuoqi Li, Mei Tian, Yuanhui Yang, Yuanyuan Wang, Lu Zhang, Fujing Huang, Xiao Wen, Xiaoshu Yin, Xiaoyan Lin, Xiaoyan Lin, Yuan Tian

“…PurposeTo investigate the functions of lung TRM cells in the development and treatment of lung adenocarcinoma (LUAD).MethodsR-language bioinformatics analysis was applied to obtain differentially expressed (DE) lung TRM cell-specific genes and a related prognostic signature, which were further validated using external datasets, immunohistochemical staining images, and biological experiments.ResultsA total of 130 DE lung TRM cell-specific genes were identified, 14 of which were involved in the prognostic signature, including SLC16A3, ARHGAP11A, PTTG1, DTL, GPRIN1, EXO1, GAPDH, TYMS, DAPK2, CCL20, HLA-DQA1, ADAM12, ALOX5AP and OASL. …”
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Increased organic fertilizer significantly increases leaf nitrogen and phosphorus but not carbon content in a tropical tea plantation by Jing-li Lu, Ying Wang, Di Li, Qiu Yang, Yamin Jiang, Peng Wang, Tianyan Su, Geming Li, Qian Shi, Huai Yang, Wenjie Liu, Mengyang Fang

“…Abstract Carbon (C), nitrogen (N), and phosphorus (P) are essential elements for plant growth and metabolism, with their stoichiometry playing a pivotal role in ecosystem functioning. In tea plantations, fertilization strongly influences the balance of these elements. …”
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Protective Effect of Low-molecular-weight Fucoidan on Lead-induced Oxidative Damage in HepG2 Cells Based on Cellular Metabolomics by Fan YU, Na LI, Yingying GUO, Xinyue DAI, Wenjia ZHU, Lin YAO, Yanhua JIANG, Lianzhu WANG

“…Enrichment analysis of key metabolites regulated by F1 indicated that F1 primarily influenced several metabolic pathways involved in redox functions, such as D-glutamine and D-glutamate metabolism; alanine, aspartate, and glutamate metabolism; selenium compound metabolism; and arginine biosynthesis. …”
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New genomic resources inform transcriptomic responses to heavy metal toxins in the common Eastern bumble bee Bombus impatiens by Amy L. Toth, Christopher D. R. Wyatt, Rick E. Masonbrink, Katherine S. Geist, Ryan Fortune, Sarah B. Scott, Emeline Favreau, Sandra M. Rehan, Seirian Sumner, Mary M. Gardiner, Frances S. Sivakoff

“…RNA sequencing of heavy metal exposed workers revealed 603 brain and 34 fat body differentially expressed genes. In the brain, differentially expressed genes had biological functions related to chaperone activity and protein folding. …”
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The impact of aztreonam–clavulanic acid exposure on gene expression and mutant selection using a multidrug-resistant E. coli by Tongtong Lin, Jiayuan Zhang, Shuo Diao, Jinke Yan, Kexin Zhang, Jichao Cao, Junyi Huang, Yaohai Wang, Zhihua Lv, Xiaopeng Shen, Sherwin K. B. Sy, Michael Lynch, Hongan Long, Mingming Yu

“…The findings highlight how this particular antibiotic combination suppresses virulence genes, disrupts bacterial regulatory systems, and interferes with cellular functions critical for resistance. Moreover, the study lays the groundwork for understanding antibiotic resistance development in the treatment of multi-drug resistant infections through in vitro studies, offering insights that could inform future strategies in clinical settings. …”
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Genome-wide identification of the regulatory network of mitogen-activated protein kinase signaling cascades gene families in Hevea Brasiliensis by Xiaojuan Huang, Manman Sun, Xiaoyu Du, Lin Quan, Jinquan Chao, Xiaomin Deng, Hongze Liao

“…Furthermore, expression profiling analysis based on public transcriptomic data revealed that these genes were differentially expressed in various tissues and differentially regulated in response to different stresses. …”
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An In-Person and Online Intervention for Parkinson Disease (UPGRADE-PD): Protocol for a Patient-Centered and Culturally Tailored 3-Arm Crossover Trial by Michail Elpidoforou, Irene Grimani, Marianna Papadopoulou, Nikolaos Papagiannakis, Anastasia Bougea, Athina-Maria Simitsi, Evangelos Sfikas, Ioanna Alexandratou, Ioanna Alefanti, Roubina Antonelou, Christos Koros, Ioanna Mavroyianni, Chrysa Chrysovitsanou, Leonidas Stefanis, Daphne Bakalidou

“…Assessments will be performed face-to-face at baseline and at the end of each study period and will include quality of life, fatigue, depressive symptoms, stress, anxiety, sarcopenia, frailty, balance, cognitive functions, movement and nonmovement PD symptoms, and BMI. …”
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Positive feedback regulation between RpoS and BosR in the Lyme disease pathogen by Sajith Raghunandanan, Raj Priya, Gaofeng Lin, Fuad Alanazi, Andrew Zoss, Elise Warren, Philip Stewart, X. Frank Yang

“…Our recent studies have shown that the homolog of Fur/PerR repressor/activator BosR functions as an RNA-binding protein that controls the rpoS mRNA stability. …”
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Transcriptome-Wide Analysis of N6-Methyladenosine-Modified Long Noncoding RNAs in Particulate Matter-Induced Lung Injury by Yingying Zeng, Guiping Zhu, Wenjun Peng, Hui Cai, Chong Lu, Ling Ye, Meiling Jin, Jian Wang

“…We use bioinformatic tools to analyze the potential functions and pathways of these m⁶A-modified lncRNAs, revealing their involvement in regulating inflammation, immune response, and metabolism-related pathways. …”
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Exploring the Potential Regulatory Mechanisms of Mitophagy in Ischemic Cardiomyopathy by Li Z, Kong J, Xi S, Jin Z, Yang F, Zhu Z, Liu L

“…Then, an intersection was taken between MSRGs and the differentially expressed genes (DEGs) obtained from the differential expression analysis to obtain DE-MSRGs. …”
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Gene signatures associated with exosomes as diagnostic markers of postpartum depression and their role in immune infiltration by Jianbo He, Hong Chen, Kaiming Duan, Kaiming Duan, Sikandaier Wushouer, Xiaowei Wang, Yaxuan Li, Xingang Qin

“…Exosomes significantly contribute to the pathogenesis, identification, treatment outcome determination, and intervention of PPD. However, the functions of exosome-related genes (ERGs) in PPD remain to be fully elucidated. …”
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Genome-Wide Identification of the <i>DOG1</i> Gene Family in Pepper (<i>Capsicum annuum</i>) and Its Expression Profiles During Seed Germination by Zhichao Zhao, Jingbo Sun, Feng Zhang, Chunjuan Dong

“…Taken together, these findings provide an extensive description of the <i>C. annuum DOG1</i> gene family and might facilitate further studies for elucidating their functions in seed germination.…”
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Specific gene expression signatures induced by the multiple oncogenic alterations that occur within the PTEN/PI3K/AKT pathway in lung cancer. by Carmela De Marco, Carmelo Laudanna, Nicola Rinaldo, Duarte Mendes Oliveira, Maria Ravo, Alessandro Weisz, Michele Ceccarelli, Elvira Caira, Antonia Rizzuto, Pietro Zoppoli, Donatella Malanga, Giuseppe Viglietto

“…Finally, we made use of Ingenuity Pathway Analysis (IPA) to investigate the relevant BioFunctions enriched by the costitutive activation of AKT1-, PI3K- or PTEN-dependent signalling in lung epithelial cells. …”
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Temperate Forest Soil Microbiomes and Their Assembly Processes are Modulated by the Interplay of Co‐Existing Tree Species Identity, Diversity and Their Mycorrhizal Type by Hafeez Ul Haq, Bala Singavarapu, Amelie Hauer, Nico Eisenhauer, Olga Ferlian, Helge Bruelheide, Tesfaye Wubet

“…ABSTRACT Recent studies have highlighted the significant role of tree species' mycorrhizal traits on forest soil microbial communities and their associated ecosystem functions. However, our understanding of how tree species richness in mono‐mycorrhizal (arbuscular mycorrhiza [AM] or ectomycorrhiza [EcM]) or mixed‐mycorrhizal (AM and EcM = AE) stands affects the rooting zone microbial community assembly processes remains limited. …”
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Altered Monocyte Populations and Activation Marker Expression in Children with Autism and Co-Occurring Gastrointestinal Symptoms by Rachel J. Moreno, Yasmin W. Azzam, Serena Eng, Destanie Rose, Paul Ashwood

“…In humans, circulating monocytes are often categorized into three subpopulations—classical, transitional (or “intermediate”), and nonclassical monocytes, which can vary in functions, including archetypal inflammatory and/or reparative functions, as well as their effector locations. …”
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Variations of five eIF4E genes across cassava accessions exhibiting tolerant and susceptible responses to cassava brown streak disease. by Shanshan Shi, Xiuchun Zhang, M Alejandra Mandel, Peng Zhang, Yuliang Zhang, Morag Ferguson, Teddy Amuge, Steve Rounsley, Zhixin Liu, Zhongguo Xiong

“…Both have a (+)-sense single-stranded RNA genome with a 5' covalently-linked viral protein, which functionally resembles the cap structure of mRNA, binds to eukaryotic translation initiation factor 4E (eIF4E) or its analogues, and then enable the translation of viral genomic RNA in host cells. …”
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A Fractional PDE-Based Model for Nerve Impulse Transport Solved Using a Conforming Virtual Element Method: Application to Prosthetic Implants by Zaffar Mehdi Dar, Chandru Muthusamy, Higinio Ramos

“…The main objective of this study is to present a fundamental mathematical model for nerve impulse transport, based on the underlying physical phenomena, with a straightforward application in describing the functionality of prosthetic devices. The governing equation of the resultant model is a two-dimensional nonlinear partial differential equation with a time-fractional derivative of order <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>α</mi><mo>∈</mo><mo>(</mo><mn>0</mn><mo>,</mo><mn>1</mn><mo>)</mo></mrow></semantics></math></inline-formula>. novel and effective numerical approach for solving this fractional-order problem is constructed based on the virtual element method. …”
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Strategic Approach to Monitoring the Risk Resilience and Financial security of Companies in the Passenger Air Transport Industry by A. A. Pushevskaya, N. A. Kazakova

“…AbsTRACTThe relevance of the study is due to the social significance of the Russian passenger air transportation industry, its high exposure to complex risks due to the sanctions policy of unfriendly countries, the turbulence and uncertainty of existing risk factors, the need for state regulation and control over the functioning of companies in the industry, as well as the lack of an effective system for monitoring its sustainable development. …”
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