Experimental validation and identification of ferroptosis-associated biomarkers for diagnostic and therapeutic targeting in hearing loss by Chenyang Yuan, Tianyu Ma, Mengting Liu, Li Jiang, Gongrui Tang, Qi Hu, Tianhong Zhang

“…The Lasso and SVM-RFE models were applied to reduce the gene set, identifying model genes. Biological functions, pathways, and gene-drug associations related to these model genes were analyzed. …”
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Identification of mitophagy and ferroptosis-related hub genes associated with intracerebral haemorrhage through bioinformatics analysis by Yan Wang, Rufeng Wang, Jianzhong Zhu, Ling Chen

“…Enrichment analysis elucidated functions. Hub genes were selected via STRING, MCODE, and MCC algorithms in Cytoscape. miRNAs targeting hubs were predicted using miRWalk 3.0, forming a miRNA-hub gene network. …”
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Single cell sequencing and computational findings reveal anti-estrogen receptor-positive breast cancer roles of formononetin by Bihui Li, Shuangxi Li, Ruihan Li, Menzhen Li, Zhaoquan Huang

“…Further network pharmacology analysis highlighted the importance of formononetin targets in biological functions and signaling pathways related to immune and inflammatory responses, metastatic ability, metabolism, cell proliferation, and gland development in different ER-positive breast cancer cell types. …”
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Pterostilbene-isothiocyanate conjugate suppresses growth of prostate cancer cells irrespective of androgen receptor status. by Kumar Nikhil, Shruti Sharan, Ajanta Chakraborty, Partha Roy

“…The present study focused on analyzing the role of pterostilbene (PTER)-isothiocyanate (ITC) conjugate--a novel class of hybrid compound synthesized by appending an ITC moiety on PTER backbone--in regulating the functions of androgen receptor (AR), thereby causing apoptosis of PCa cells. …”
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Good Brexit, Bad Brexit: Evaluation Through Metaphoric Conceptualizations in British Media by Nelly Tincheva

“…However, as the present paper suggests, Rosch’s ‘levels’ in prototypology can be seen as functioning through conceptual metonymy. That, in its turn, combined with the all-pervasive cognitive mechanism of spreading activation (first introduced into linguistics by de Beaugrande and Dressler in 1981) suggests all semantic levels can be co-activated in the process of metaphorization, regardless of which level is currently being highlighted and drawn on. …”
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Dynamic Complexity of Positive and Negative Affect in NSSI – A Daily Diary Study by Michaela Bruckbauer-Schwed, Tim Kaiser, Marc Keglevic, Anton-Rupert Laireiter

“…[Background] Non-suicidal self-injury (NSSI) is a major health problem. Functionally, it is related to affect instability and increased affective intensity. …”
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Integrative analysis of ceRNA networks and immune cell infiltration in thyroid cancer for enhanced diagnostic and prognostic insights by Chang Lv, Huazhe Wu, Dejun Yin, Wei Fang, Liming Zhou

“…Gene Ontology and KEGG pathway analyses elucidated the biological functions and pathways of these genes. A ceRNA network was constructed, highlighting the interactions between 32 lncRNAs, 18 miRNAs, and 56 mRNAs. …”
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Numerical and analytical investigation of vapor flows in a flat plate heat pipe: Effects of length ratio and Reynolds number by M. Johari, H.A. Hoshyar, D.D. Ganji

“…Additionally, this research presents a powerful method for solving non-linear ordinary differential equations, offering significant time savings and enabling predictive functions. …”
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HCMV-infected cells maintain efficient nucleotide excision repair of the viral genome while abrogating repair of the host genome. by John M O'Dowd, Anamaria G Zavala, Celeste J Brown, Toshio Mori, Elizabeth A Fortunato

“…Our data confirm that NER functions in HCMV-infected cells and almost exclusively repairs the viral genome to the detriment of the host's genome.…”
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Bioinformatics-based analysis of the relationship between STC1 expression and immune infiltration in gastric cancer by Weijun Ma, Xiaoli Ma, Yaoqi Li

“…Gene Set Enrichment Analysis (GSEA) was also conducted to explore potential functions of STC1 in GC.ResultsSTC1 expression was significantly higher in GC tissues and independently predicted poor overall survival. …”
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An insulin-sensitive Drosophila insulin-like receptor mutant remodels methionine metabolism to extend lifespan. by Marc Tatar, Wenjing Zheng, Shweta Yadav, Rochele Yamamoto, Noelle Curtis-Joseph, Shengxi Li, Lin Wang, Andrey A Parkhitko

“…Type I and II mutants overlap in many pathways but also produce distinct transcriptomic profiles that include differences in innate immune and reproductive functions. In metabolomic analyses, the KID mutant dInr353 reprograms methionine metabolism in a way that phenocopies dietary methionine restriction, in contrast to canonical mutants which are characterized by upregulation of the transsulfuration pathway. …”
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A novel 5-protein kinase risk signature for predicting glioma prognosis and immunotherapy responsiveness by Senbin Wu, Qiaohong Li, Lilan Huang, Hong Li, Ying Ma

“…These dysregulated kinases were enriched in biological functions and signaling pathways related to glioma progression. …”
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SEMIOLOGICAL MEANS OF SCIENTIFIC AND PEDAGOGICAL COGNITION by Victoria V. Dobrova

“…The methodological basis of the study is the research techiques of pedagogical semiology and cognitive linguistics: content analysis, system-structural analysis, comparative analysis, method of interpretation, which allows to understand more deeply the functioning of the language of pedagogical science, to form and convey pedagogical meanings, to fix pedagogical phenomena in the language. …”
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Genomic Exploration of Nonalcoholic Fatty Liver Disease: Insights From Gene Expression and Variation in Morbidly Obese Individuals by Tamadher Abbas Rafaa, Safa Abbas Khudhair, Zahraa Yassen Mohammed, Ahmed AbdulJabbar Suleiman

“…Moreover, this study identified AKR1D1, LIPC, UGT2B17, DGAT2, and SERPINE1 implicated in metabolic, immune, and lipid functions while being overexpressed in both hepatocyte cells among obese patients identified and validated through Liver Cell Atlas, highlighting their pivotal role in the pathogenesis of the disease in obese patients through perturbed hepatocytes. …”
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Identification of kidney renal clear cell carcinoma prognosis based on gene expression and clinical information by Xiong Zou, Xi Chen, Jianjun Yang, Yanfeng Li

“…A number of high-risk genes related to KIRC prognosis were screened out, and these genes were mainly involved in immune-related functions such as lymphocyte migration. At the same time, we combined TCGA and GEO to find four genes (BASP1, CCL8, FCGR1B, FKBP11) for determining the risk stratification of KIRC, and constructed a model for clinicians to assess KIRC prognosis based on gene expression and clinical information. qPCR confirmed that BASP1, FCGR1B, and FKBP11 were significantly upregulated in KIRC compared to adjacent normal tissues, whereas CCL8 showed no significant differential expression between KIRC and paracancerous tissues.ConclusionOur study has the potential to assist clinicians assess KIRC prognosis and modify more appropriate personalized treatment for KIRC patients in a timely manner.…”
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Pancancer analysis of DNA damage repair gene mutations and their impact on immune regulatory gene expression by Kanchana Yadav, Trishala Das, Andrew M. Lynn

“…These genes were clustered and categorized using Metascape, an integrative bioinformatics tool that applies enrichment-based analysis to group functionally related genes into clusters. The clustered genes were further validated through a literature review and the GeneCards database. …”
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Comparative genomics search for losses of long-established genes on the human lineage. by Jingchun Zhu, J Zachary Sanborn, Mark Diekhans, Craig B Lowe, Tom H Pringle, David Haussler

“…Therefore, it enables us to find genes that were inactivated long after their birth, which were likely to have evolved nonredundant biological functions before being inactivated. The method was used to look for gene losses along the human lineage during the approximately 75 million years (My) since the common ancestor of primates and rodents (the euarchontoglire crown group). …”
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De novo transcriptome assembly and discovery of drought-responsive genes in white spruce (Picea glauca). by Zoé Ribeyre, Claire Depardieu, Julien Prunier, Gervais Pelletier, Geneviève J Parent, John Mackay, Arnaud Droit, Jean Bousquet, Philippe Nolet, Christian Messier

“…Many transcripts that had predicted functions associated with photosynthesis, cell wall organization, and water transport were down-regulated under drought conditions, while transcripts linked to abscisic acid response and defense response were up-regulated. …”
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Development of the global energy sector based on the innovative principles of the "green" economy by A. A. Ter-Grigoryants, E. V. Sokolenko, A. E. Gerasimova

“…The interpretation of the concept of “green” economy from the perspective of an innovative product is given; its structure and main functions are studied; the role of scientific and technological progress in the use of clean energy is determined. …”
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ABCG1 and ABCG4 Suppress γ-Secretase Activity and Amyloid β Production. by Osamu Sano, Maki Tsujita, Yuji Shimizu, Reiko Kato, Aya Kobayashi, Noriyuki Kioka, Alan T Remaley, Makoto Michikawa, Kazumitsu Ueda, Michinori Matsuo

“…In contrast, secreted Aβ levels increased in differentiated SH-SY5Y neuron-like cells in which ABCG1 and ABCG4 were suppressed. …”
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