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15141
Altered oral health and microbiota in drug-free patients with schizophrenia
Published 2025-03-01“…Key discriminative taxa were found in LEfSe analysis, including the phyla Fusobacteriota, Firmicutes, and Actinobacteriota. The differential taxa and microbial functions showed a strong correlation with clinical oral conditions. …”
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15142
NKD1 enhances colon cancer progression by inhibiting the autophagic degradation of MYC
Published 2025-07-01“…Moreover, NKD1 activated the expression of MYC downstream target genes through MYC. Functionally, the PPARδ/NKD1/MYC signaling pathway increased colon cancer cells’ proliferation, migration and angiogenesis capabilities. …”
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15143
Poly(ADP-ribose)polymerase 2 is zinc-dependent enzyme and nucleosome reorganizer
Published 2025-06-01“…Auto(poly-ADP-ribosylation) activity of PARP2 is enhanced by Mg2+ ions and modulated by Zn2+ ions: suppressed or enhanced depending on the occupancy of two functionally different zinc binding sites. The data suggest that transient changes in concentration of cations can differentially modulate PARP2 activity, local chromatin structure and the DNA damage response. …”
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15144
Metaheuristic Optimization for Robust RSSD-Based UAV Localization with Position Uncertainty
Published 2025-02-01“…However, potential collisions and other issues can disrupt communication and hinder functionality in real-world applications. Therefore, accurate localization of UAVs is crucial. …”
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15145
Categorización de los materiales didácticos para la enseñanza de los seres vivos en los antiguos gabinetes y laboratorios
Published 2019-06-01“…We study the genesis, manufacturing characteristics, functionality and didactical use of these materials. …”
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15146
Cytoplasmic connexin43-microtubule interactions promote glioblastoma stem-like cell maintenance and tumorigenicity
Published 2025-05-01“…These cells have the capacity to self-renew and differentiate and as such, GSCs participate in tumor recurrence following treatment. …”
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15147
Screening and validation of tsRNAs associated with lung adenocarcinoma
Published 2025-01-01“…In vitro cell proliferation, migration, and invasion assays were performed to investigate the biological functions of tRF-19-69M8LOJX in lung adenocarcinoma cells.Results Compared with the normal tissues, tRF-19-69M8LOJX was up-regulated in lung adenocarcinoma tissues (log2FC=4.28, FDR<0.05). …”
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15148
Comprehensive analysis of long non-coding RNA and mRNA expression patterns during seminiferous tubules maturation in Guanzhong dairy goats
Published 2025-02-01“…However, the expression patterns and functions of these molecules across different developmental stages of dairy goat seminiferous tubules remain poorly understood. …”
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15149
Transcriptomic analysis of non-leukemic cell subsets in azacytidine-responsive AML highlights pathways associated with adhesion, platelet aggregation, and angiogenesis in mice and...
Published 2025-05-01“…Transcriptional analysis of AZA-treated samples revealed decreased cell type scores for suppressive subsets and increased pathway scores for T and B cell functions. Comparisons of gene ontology annotations enriched from genes differentially regulated by AZA in human and mouse blood samples revealed overlap in numerous biological pathways including adhesion, thrombosis, and angiogenesis. …”
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15150
Non-invasive urinary proteomic biomarkers for prognostic assessment in sepsis
Published 2025-07-01“…KEGG and GO analyses were conducted to investigate the possible functions of these proteins. Feature variables were selected from the differentially expressed proteins using the Least Absolute Shrinkage and Selection Operator (LASSO) and the random forest algorithms and by determining whether their proteins had an area under the curve (AUC) greater than 0.8. …”
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15151
Role of Fcγ receptors in HER2-targeted breast cancer therapy
Published 2022-01-01“…Polymorphisms in FcγRIIIa and FcγRIIa generate variants that bind to the Fc portion of antibodies with different affinities. This results in differential FcγR-mediated activities associated with differential therapeutic outcomes across multiple clinical settings, from early stage to metastatic disease, in patients with HER2+ breast cancer treated with the anti-HER2 mAb trastuzumab. …”
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15152
Bioinformatics-based identification of CTSS, DOK2, and ENTPD1 as potential blood biomarkers of schizophrenia
Published 2025-02-01“…Subsequently, we performed Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses on these DEGs to elucidate their biological functions and related pathways. Furthermore, we constructed a protein-protein interaction (PPI) network of the differentially expressed genes to identify key genes and matched them with their target microRNAs (miRNAs). …”
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15153
Characterization of Immune-Related circRNAs and mRNAs in Human Chronic Atrophic Gastritis
Published 2024-11-01“…Exploring immune-related circular RNAs (circRNAs) could provide insights for potential diagnostic and therapeutic strategies.Methods: Samples from 40 patients with CAG and non-CAG (CNAG) underwent high-throughput sequencing, and EdgeR analysis identified differentially expressed circRNAs and mRNAs. Gene Ontology (GO) analysis elucidated biological functions, while Immune Cell Abundance Identifier (ImmuCellAI) estimated immune cell abundance. …”
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15154
KLF6-mediated recruitment of the p300 complex enhances H3K23su and cooperatively upregulates SEMA3C with FOSL2 to drive 5-FU resistance in colon cancer cells
Published 2025-03-01“…Abstract Histone lysine succinylation, an emerging epigenetic marker, has been implicated in diverse cellular functions, yet its role in cancer drug resistance is not well understood. …”
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15155
Study of the psychometric properties of the HLS-EU-12 questionnaire in rural Bangladesh.
Published 2025-01-01“…The analysis was focused on differential item functioning (DIF) across gender and age, targeting, multidimensionality, response dependency, and item categorization.…”
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15156
Synergistic interaction between wheat streak mosaic virus and Triticum mosaic virus modulates wheat transcriptome to favor disease severity
Published 2025-01-01“…A total of 31,754 differentially expressed wheat genes were identified among all comparisons. …”
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15157
CircRNA-miRNA-mRNA regulatory network in high-altitude hypobaric hypoxia-induced hearing impairment and hearing acclimatization
Published 2025-03-01“…The DEmRNAs in this network were functionally annotated using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses based on Metascape. …”
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15158
Identifying Therapeutic Targets and Potential Drugs for Diabetic Retinopathy: Focus on Oxidative Stress and Immune Infiltration
Published 2025-02-01“…Single-gene Gene Set Enrichment Analysis (GSEA) identified biological functions, while nomograms and ROC curves assessed diagnostic potential. …”
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15159
Exosomal lncRNA profiles in patients with HFrEF: Evidence for KLF3-AS1 as a novel diagnostic biomarker
Published 2025-08-01“…Exosomal KLF3-AS1 had an area under the ROC curve of 0.861. Functionally, KLF3-AS1 overexpression reduced Ang II-induced cardiac hypertrophy in vitro. …”
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15160
Effects of laminarin on antioxidant capacity and non-specific immunity of spotted sea bass (Lateolabrax maculatus)
Published 2025-03-01“…As a prebiotic, laminarin has functions such as antioxidant and improving the body's immunity. …”
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