Interpretable graph Kolmogorov–Arnold networks for multi-cancer classification and biomarker identification using multi-omics data by Fadi Alharbi, Nishant Budhiraja, Aleksandar Vakanski, Boyu Zhang, Murtada K. Elbashir, Harshith Guduru, Mohanad Mohammed

“…The model architecture is based on the Kolmogorov–Arnold theorem principle and uses trainable univariate functions to enhance interpretability and feature analysis. …”
Get full text

Sequential simulation of regeneration-specific microenvironments using scaffolds loaded with nanoplatelet vesicles enhances bone regeneration by Wenshuai Li, Qichen Shen, Tong Tong, Hongsen Tian, Xiaowei Lian, Haoli Wang, Ke Yang, Zhanqiu Dai, Yijun Li, Xianhua Chen, Qingqing Wang, Dan Yang, Feng Wang, Feng Hao, Linfeng Wang

“…In vitro, the NPVs regulated lipid metabolism in bone marrow mesenchymal stem cells (BMSCs), reprogramed the fate of BMSCs by activating the PI3K/AKT and MAPK/ERK positive feedback pathways, and increased BMSC functions, including proliferation, migration and proangiogenic potential. …”
Get full text

Enhancing structural health monitoring with machine learning for accurate prediction of retrofitting effects by A. Presno Vélez, M. Z. Fernández Muñiz, J. L. Fernández Martínez

“…Ensuring long-term functionality was vital to prevent accidents, economic losses, and service interruptions. …”
Get full text

Structural mechanism of CB1R binding to peripheral and biased inverse agonists by Punita Kumari, Szabolcs Dvorácskó, Michael D. Enos, Karthik Ramesh, Darrix Lim, Sergio A. Hassan, George Kunos, Resat Cinar, Malliga R. Iyer, Daniel M. Rosenbaum

“…These structures reveal how these compounds retain high affinity and specificity for CB1R’s hydrophobic orthosteric site despite incorporating polar functionalities that lead to peripheral restriction. Further, the structure of the MRI-1891 complex along with accompanying molecular dynamics simulations shows how differential engagement with transmembrane helices and the proximal N-terminus can propagate through the receptor to contribute to biased inhibition of β-arrestin signaling.…”
Get full text

From acute tubular injury to tubular repair and chronic kidney diseases – KIM-1 as a promising biomarker for predicting renal tubular pathology by Ping L. Zhang, Ming-Lin Liu

“…Functionally, KIM-1 aids proximal tubules in clearing apoptotic cells and moderating inflammatory responses, thereby helping to prevent excessive immune activation during the early stages of injury. …”
Get full text

Exploring the roles of ncRNAs in prostate cancer via the PI3K/AKT/mTOR signaling pathway by Rongwang Guo, Liji Shi, Yonghui Chen, Canling Lin, Weihua Yin

“…In this paper, we summarize the types of ncRNAs that are associated with the PAM pathway in PCa cells as well as the functions and clinical roles of these ncRNAs in PCa. …”
Get full text

Role of microRNAs in Osteosarcopenic Obesity/Adiposity: A Scoping Review by Mariantonia Braile, Adriano Braile, Chiara Greggi, Virginia Veronica Visconti, Giuseppe Toro, Maria Consiglia Trotta, Gianluca Conza, Umberto Tarantino

“…<b>Background:</b> Osteosarcopenic obesity (OSO) syndrome, also defined as osteosarcopenic adiposity (OSA), is characterized by the concurrent loss of bone and muscle mass, accompanied by excess fat, leading to reduced functionality and metabolic imbalances. Recent studies have highlighted the role of microRNAs (miRNAs) in the pathophysiology of OSO/OSA, showing differential expression in individuals with osteosarcopenia and obesity. …”
Get full text

Combined analysis of metabolomics and transcriptomics reveals the effects of sugar treatment on postharvest strawberry fruit quality by Zihui Zhang, Riru Tian, Junyi Wan, Yan Wang, He Li

“…These findings elucidate molecular responses to exogenous sugar treatment and offer a foundation for further investigation of gene functions in postharvest fruit quality regulation.…”
Get full text

Designing Innovative Digital Solutions in the Cultural Heritage and Tourism Industry: Best Practices for an Immersive User Experience by Vito Del Vecchio, Mariangela Lazoi, Claudio Marche, Christos Mettouris, Mario Montagud, Giorgia Specchia, Mostafa Z. Ali

“…This study presents the findings of a survey-based analysis conducted among 122 CH and tourism professionals, focusing on the most relevant features, services, and functionalities that such platforms should integrate. …”
Get full text

Pea-Protein-Stabilized Emulsion as a High-Performance Cryoprotectant in Frozen Dough: Effects on the Storage Stability and Baking Performance by Diming Li, Youqing Shi, Zhihan Ouyang, Yongxin Teng, Boru Chen, Yingying Chen, Yufan Luo, Nan Zhang, Nandan Kumar, Yonghui Li, Bin Li, Xiangwei Zhu

“…Compared with some of the well-recognized functionalities, such as textural improvers and flavor carriers, its cryoprotective behavior in frozen dough has not been extensively investigated. …”
Get full text

Silicon might mitigate nickel toxicity in maize roots via chelation, detoxification, and membrane transport by Olha Lakhneko, Ivana Fialová, Roderik Fiala, Mária Kopáčová, Andrej Kováč, Maksym Danchenko

“…Proposed mitigation mechanisms should be functionally validated in follow-up studies.…”
Get full text

Gaslike Social Motility: Optimization Algorithm with Application in Image Thresholding Segmentation by Oscar D. Sanchez, Luz M. Reyes, Arturo Valdivia-González, Alma Y. Alanis, Eduardo Rangel-Heras

“…Performance is assessed using 22 benchmark functions, demonstrating GSM’s competitiveness. Additionally, GSM’s efficiency in image thresholding segmentation is highlighted, as it achieves high-quality results with fewer iterations and particles compared to other methods.…”
Get full text

Dynamic interaction networks in a hierarchically organized tissue by Daniel C Kirouac, Caryn Ito, Elizabeth Csaszar, Aline Roch, Mei Yu, Edward A Sykes, Gary D Bader, Peter W Zandstra

“…We reconstruct a stem cell intracellular network, and identify PI3K, Raf, Akt, and PLC as functionally distinct signal integration nodes, linking extracellular, and intracellular signaling. …”
Get full text

IRF5 Is a Specific Marker of Inflammatory Macrophages In Vivo by Miriam Weiss, Katrina Blazek, Adam J. Byrne, Dany P. Perocheau, Irina A. Udalova

“…Macrophages are an integral part of the innate immune system and key players in pathogen clearance and tissue remodelling. Both functions are accomplished by a pivotal network of different macrophage subtypes, including proinflammatory M1 and anti-inflammatory M2 macrophages. …”
Get full text

Aspects of thermal radiation for the second law analysis of magnetized Darcy–Forchheimer movement of Maxwell nanomaterials with Arrhenius energy effects by Vinodkumar Reddy Mulinti, Malleswari Kakanuti, Ajithkumar Moorthi, Elkamchouchi Dalia H., Ali Farhan, Nath Jintu Mani, Khan Umair, Khashi’ie Najiyah Safwa

“…A system of highly non-linear ordinary differential equations is built using suitable similarity transformations. …”
Get full text

Free linear vibrations of a viscoelastic spherical shell with filler by Mirsaidov, Mirziyod Mirsaidovich, Safarov, Ismoil Ibrohimovich, Teshaev, Muhsin Khudoyberdiyevich, Eliboyev, Nurali Rajabaliyevich

“…The problem is reduced to finding those frequencies at which the system of motion equations has nonzero solutions in the class of infinitely differentiable functions. &nbsp;…”
Get full text

Temporal profiling of host transcriptome highlights time- and tissue-dependent Interferon pathway activation in NNV-infected European sea bass by Luca Peruzza, Giulia Dalla Rovere, Serena Ferraresso, Rafaella Franch, Daniela Bertotto, Francesco Pascoli, Gaia Bacchin, Anna Toffan, Luca Bargelloni

“…Results revealed substantial changes in gene expression over time, particularly for brain, with downregulation of genes involved in nervous system functions and upregulation of immune and inflammatory response genes from 24 to 48 hpi onwards, mostly associated with the interferon (IFN) response. …”
Get full text

GNPDA2 Gene Affects Adipogenesis and Alters the Transcriptome Profile of Human Adipose-Derived Mesenchymal Stem Cells by Lijun Wu, Feifei Ma, Xiaoyuan Zhao, Mei-Xian Zhang, Jianxin Wu, Jie Mi

“…GO term enrichment analysis indicated that most differentially expressed genes (DEGs) affected by deficiency of GNPDA2 have functions to lipid and glucose metabolism. …”
Get full text

Scream’s roughness grants privileged access to the brain during sleep by Guillaume Y. T. Legendre, Maëva Moyne, Judith Domínguez-Borràs, Samika Kumar, Virginie Sterpenich, Sophie Schwartz, Luc H. Arnal

“…Abstract During sleep, recognizing threatening signals is crucial to determine when to wake up and when to continue vital sleep functions. Screaming is perhaps the most efficient way for communicating danger at a distance or in conditions of limited visibility. …”
Get full text

Multi-criteria pressure sensors placement in water distribution networks using fuzzy TOPSIS by Mohammad Mehdi Riyahi, Carlo Giudicianni, Amin E. Bakhshipour, Ali Haghighi, Enrico Creaco

“…The BGDE considers sensitivity and entropy as objective functions, while the investment cost is taken into account as a constraint. …”
Get full text