Advancing Enzyme-Based Detoxification Prediction with ToxZyme: An Ensemble Machine Learning Approach by Kashif Iqbal Sahibzada, Shumaila Shahid, Mohsina Akhter, Muhammad Faisal, Reham A. Abd El Rahman, Muhammad Imran, Yangyong Lv, Dongqing Wei, Yuansen Hu

“…The aaccurate prediction of enzymes with environment detoxification functions is crucial, not only to achieve a better understanding of bioremediation strategies, but also to alleviate environmental pollution. …”
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Comprehensive transcriptomic profiling reveals molecular characteristics and biomarkers associated with risk stratification in papillary thyroid carcinoma by Congcong Yan, Chen Zheng, Jiaxing Luo, Xue Wu, Xinyu Meng, Chaoyue Lv, Shurong Shen, Meng Zhou, Ouchen Wang

“…Comparative transcriptional profiling analysis revealed two functionally distinct patterns of gene dysregulation between the risk subtypes. …”
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Numerical Modeling of Renal Ionic Equilibrium for Implantable Kidney Applications by Saleh Massoud, Ayham Darwich, Ebrahim Ismaiel

“… The human kidney is one of the most important organs in the human body; it performs many functions and has a great impact on the work of the rest of the organs. …”
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Gene2role: a role-based gene embedding method for comparative analysis of signed gene regulatory networks by Xin Zeng, Shu Liu, Bowen Liu, Weihang Zhang, Wanzhe Xu, Fujio Toriumi, Kenta Nakai

“…Abstract Background Understanding the dynamics of gene regulatory networks (GRNs) across various cellular states is crucial for deciphering the underlying mechanisms governing cell behavior and functionality. However, current comparative analytical methods, which often focus on simple topological information such as the degree of genes, are limited in their ability to fully capture the similarities and differences among the complex GRNs. …”
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Distinct horizontal gene transfer potential of extracellular vesicles versus viral-like particles in marine habitats by Steven J. Biller, M. Gray Ryan, Jasmine Li, Andrew Burger, John M. Eppley, Thomas Hackl, Edward F. DeLong

“…Fractionated EV-enriched and VLP-enriched subpopulations contain diverse DNA from the surrounding microbial community, but differ in their capacity and encoded functions. The sequences carried by both particle types are enriched in mobile genetic elements (MGEs) as compared with other cellular chromosomal regions, and we highlight how this property enables novel MGE discovery. …”
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A role of pigment epithelium-derived factor in zinc-mediated mechanism of neurodegeneration in glaucoma by Dmitry V. Chistyakov, Anatolii S. Belousov, Marina P. Shevelyova, Elena N. Iomdina, Viktoriia E. Baksheeva, Natalia G. Shebardina, Anastasia M. Moysenovich, Timofey K. Bulgakov, Sergey Yu. Petrov, Mikhail L. Shishkin, Sanchay S. Tulush, Veronika V. Tiulina, Ekaterina I. Pogodina, Olga S. Gancharova, Olga M. Filippova, Alexey V. Baldin, Sergey V. Goriainov, Arina I. Nikolskaya, Arthur O. Zalevsky, Andrei A. Deviatkin, Alisa A. Vologzhannikova, Neonila V. Gorokhovets, Ekaterina A. Litus, Sergey V. Komarov, François Devred, Marina G. Sergeeva, Alexey V. Mishin, Sergey S. Bukhdruker, Lijie Wu, Evandro A. Araujo, Andrey A. Zamyatnin, Ivan I. Senin, Dmitry V. Zinchenko, Philipp O. Tsvetkov, Valentin I. Borshchevskiy, Sergei E. Permyakov, Evgeni Yu. Zernii

“…Notably, PEDF secretion is enhanced in both glaucoma and retinal cell models in response to zinc stress; however, zinc binding negatively affects axogenic, differentiative and prosurvival functions of PEDF by suppressing its ability to activate receptor PEDF-R/PNPLA2. …”
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Landscape analysis of m6A modification reveals the dysfunction of bone metabolism in osteoporosis mice by Lifeng Zheng, Chao Lan, Xinyue Gao, An Zhu, Yaoqing Chen, Jinluan Lin, Sunjie Yan, Ximei Shen

“…Numerous studies have underscored the crucial functions of m6A regulators in OP. This study aimed to explore the relationship between OP and RNA m6A methylation, investigating its underlying mechanisms through comprehensive bioinformatic analysis and experimental validation. …”
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Influence of Lactobacillus plantarum and cellulase on fermentation quality and microbial community in mixed silage of Solanum rostratum and alfalfa by Yuyu Li, Yuyu Li, Hua Wang, Hua Wang, Yandong Zhang, Yu Ji, Yu Ji, Lizhu Guo, Lizhu Guo, Lifen Hao, Lifen Hao, Kejian Lin, Kejian Lin

“…The use of additives increased the abundance of Lactobacillus and Weissella, which was related to the improvement of the quality of mixed silage and the degradation of total alkaloids. Differential microbial functions were mainly carbohydrate metabolism, biosynthesis of secondary metabolites and carbon metabolism.ConclusionThe application of additives and mixed silage provides a new idea for the feed utilization of S. rostratum.…”
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Optimization of the Raman spectroscopic method for crystal orientation and residual stress of aluminum oxide by Miaoxia Xie, Chengyu Xiang, Xueliang Zeng, Xuesu Zhang, Linjie Zhang, Jiangtao Xiong

“…A half-wavelength plate was set in the common light path to simultaneously alter the polarization directions of both incident laser and scattered Raman signals, and the distribution functions of the polarized Raman scattering intensity about the polarization rotation angle and the crystal orientation angle were deduced. …”
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Sex Differences in Brain Transcriptomes of Juvenile Cynomolgus Macaques by Nadia Kabbej, Frederick J. Ashby, Alberto Riva, Paul D. Gamlin, Ronald J. Mandel, Aishwarya Kunta, Courtney J. Rouse, Coy D. Heldermon

“…Results: We identified target genes in the temporal lobe, ventral midbrain, and cerebellum with functions in translation, immunity, behavior, and neurological disorders that exhibited statistically significant sexually divergent expression. …”
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SIRT3 Inhibits Cell Proliferation of Nonsmall Cell Lung Carcinoma by Inducing ROS Production by Ze Yu, Hongtao Liao, Guanhuai Wu, Ying Liu, Guoqiang Zhang, Liang Xiao, Shuibo Yang, Jia Liu, Guocai Yang

“…Conclusions Overall, our findings suggested that SIRT3 functions as a tumor suppressor that can suppress the progression of NSCLC via stimulating ROS production.…”
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The abscisic acid signaling negative regulator OsPP2C68 confers drought and salinity tolerance to rice by Beilei Wang, Yuping Luo, Binxia Zhong, Han Xu, Fengping Wang, Wen Li, Meiqi Lin, Juan Chen, Liangbi Chen, Manzhong Liang, Xiaojun Dai

“…However, a comprehensive understanding of the functions of individual members of rice PP2CA gene families remains limited. …”
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MicroRNAs in Pancreatic Cancer: Involvement in Carcinogenesis and Potential Use for Diagnosis and Prognosis by Tereza Halkova, Romana Cuperkova, Marek Minarik, Lucie Benesova

“…This review summarizes the recent reports describing functions of miRNAs in cellular processes underlying pancreatic cancerogenesis and their utility in diagnosis, survival prognosis, and therapy.…”
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Identification through a transcriptomic approach of candidate genes involved in the adaptation of the cyst nematode Globodera pallida to the potato resistance factor GpaV vrn by Océane Lechevalier, Kévin Gazengel, Magali Esquibet, Sylvain Fournet, Eric Grenier, Stéphanie Daval, Josselin Montarry

“…Herein, a transcriptomics approach was used to disentangle the mechanisms by which G. pallida adapts to the plant resistant factor GpaV vrn , and to elucidate the functions involved in this adaptation. Results Differential gene expression analysis between virulent and avirulent lineages originating from experimental evolution experiments identified candidate genes involved in the adaptation to GpaV vrn . …”
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Water level monitoring by using magnetic optical sensor by Jonatan Daniel Morales Arrieta, Jesus Vargas Ortiz, Jesús Patricio Ordaz Oliver, Juan Carlos González Islas, Omar Samperio Vázquez

“…The proposed float system solves the common problems of corrosion and calcareous sinter, optimizing the functionality of the device for long-term applications. …”
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I engage in physical activity while operating a wheelchair.: a systematic review of stroke patients by Moch Yunus, Ronal Surya Aditya, Nurul Ihsan, Mohd Jamil, Arief Darmawan, Anita Sulistyorini, Nanang Tri Wahyudi, Fesya Khaifa Nurzahra, Abdullah Saleh Alruwaili, Daifallah M. Al Razeeni, Reem Iafi Almutairi

“…Wheelchair users employ many strategies to improve their functioning abilities.   Keyword: Sitting Position, Stroke, Wheelchairs, Delivery of Health Care   …”
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Prevalence of Personality Disorders among Males and Females between the Ages of 15 and 65 in Yazd in 2017 by Nastaran Ahmadi, Parvaneh Rashidpour, Mohammadreza Mohammadi, Javad Aardeshirpay, Hosein Abouzari, Masoud Mirzaei, Amir Houshang Mehrparvar, Fatemeh Rismanian Yazdi, Mohammadhadi Farahzadi

“…Background: Personality disorder is a type of mental disorder in which a rigid and unhealthy pattern of thinking, functioning, and behaving may be seen. A person with a personality disorder has trouble perceiving and relating to situations and people. …”
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Identification and assessment of hub genes and miRNAs coregulatory associated with immune infiltrations and drug interactions in latent tuberculosis based on MicroarrayData analysi... by PhongSon Dinh, ChauMyThanh Tran, ThiPhuongHoai Dinh, Hai-Anh Ha, Aigul Utegenova, Awais Ali, Abdulaziz Alamri

“…The predicted key genes involved in the transition from latent to active TB, including PLEKHG1, CLPB, DOK4, IL1β, and TLR3, are primarily associated with multicellular organism processes, stimulus-response, GPCR ligand binding, and immune functions. Finally, we screened Celastrol and Cefaclor Anhydrous targeting IL1β as potent anti-inflammatory drug to reduce the inflammation due to TB. …”
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Single‐Molecule Multi‐Channel Conductance Assisted by Through‐Space Conjugation by Shaoxin Song, Jinshi Li, Yi Xiong, Ben Zhong Tang, Zujin Zhao

“…ABSTRACT Molecular electronics has emerged and evolved within the context of the miniaturization of silicon‐based microchips, with the purpose to achieve conducting functions by integrating individual molecules into circuits through a “bottom‐up” approach, but the exploration of intrinsic physical phenomena and operational principles is still in the infancy stage. …”
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Study on the peak shaving operation of cascade hydropower stations based on the plant-wide optimal curve by Fengshuo Liu, Kui Huang, Xuanyu Shi, Longqing Zhao, Yangxin Yu, Xueshan Ai, Xiang Fu

“…This study proposes a novel method to enhance RES and hydropower utilization through: 1) Establishing a plant-wide optimal output-water level-outflow relationship curve based on the output-head-flow relationship and the flow-head loss and outflow-tailwater level relationship curves for each unit; 2) Developing a short-term peak shaving model for cascaded hydropower stations that incorporates wind and PV power which defines minimum coefficient of variation of residual load as objective functions, and improving discrete differential dynamic programming successive approximation (DDDPSA) method to solve it; 3) Analyzing the peak shaving capacity of the cascade hydropower station by varying water consumption for power generation. …”
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