Point mutations of the mitochondrial chaperone TRAP1 affect its functions and pro-neoplastic activity by Claudio Laquatra, Alessia Magro, Federica Guarra, Matteo Lambrughi, Lavinia Ferrone, Giulio Fracasso, Melissa Bacchin, Martina La Spina, Elisabetta Moroni, Elena Papaleo, Giorgio Colombo, Andrea Rasola

“…Changes in these parameters influence TRAP1 functions, as revealed by their effects on the activity of the TRAP1 interactor succinate dehydrogenase (SDH). …”
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An approximate solution of multi-term fractional telegraph equation with quadratic B-spline basis functions by Ebimene James Mamadu, Henrietta Ify Ojarikre, Daniel Chinedu Iweobodo, Joseph Nwaka Onyeoghane, Jude Chukwuyem Nwankwo, Ebikonbo-Owei Anthony Mamadu, Jonathan Tsetimi, Ignatius Nkonyeasua Njoseh

“…The Galerkin Method (GM)is one of the most popular techniques for the solution of Partial Differential Equations (PDEs), and it uses the idea of mapping a solution onto a set of basis functions and then seeking the residual error through minimization. …”
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Smart fiber with overprinted patterns to function as chip-like multi-threshold logic switch circuit by Xiaofei Wei, Rui Li, Siwei Xiang, Long Qin, Xinxin Luo, Jie Xue, Xing Fan

“…Abstract There is a growing demand for precise health management, capable of differentially caring every inch of skin as an on-body network. …”
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Effects of SNX9 on the structure and function of primary cilia in autosomal dominant polycystic kidney disease by Shen Ai-wen, Hu Wan-qian, Lin Lu, Yu Sheng-qiang

“…Objective To explore the effect and mechanism of SNX9 on primary cilia in autosomal dominant polycystic kidney disease（ADPKD）and provide theoretical rationales for seeking intervention targets.Methods The localization of SNX9 in cystic lining epithelium cell line（WT9-12）was observed by immunofluorescence.And the differential expression of SNX9 between normal renal tubular epithelial cell line（RCTEC）and WT9-12 was detected by Western blot.The expression of IFT88 was detected by Western blot and the change of cilia length examined by immunofluorescence.Results SNX9 existed in both cytoplasm and membrane of WT9-12 and its expression was lower than that in RCTEC（P<0.05）.When the expression of SNX9 was down-regulated,the expression of IFT88 declined and cilia became shorter（P<0.05）.Meanwhile,after the up-regulation of SNX9 by lentivirus,the expression of IFT88 increased and cilia became longer（P<0.01）.Conclusions In ADPKD,SNX9 exists in both membrane and cytoplasm of cyst epithelium and its expression is lower than that of normal renal tubular epithelial cell.As a result,the morphology and function of primary cilia become compromised.An up-regulation of SNX9 preserves the function of primary cilia and it may become a new target for ADPKD therapy.…”
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Discovering the interactome, functions, and clinical relevance of enhancer RNAs in kidney renal clear cell carcinoma by Zhaohui Sun, Haojie Du, Xudong Zheng, Hepeng Zhang, Huajie Hu

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Development and Functional Evaluation of an Upper Extremity Rehabilitation System Based on Inertial Sensors and Virtual Reality by Je-Nam Kim, Mun-Ho Ryu, Ho-Rim Choi, Yoon-Seok Yang, Tae-Koon Kim

“…The training contents, including various dynamic movements and static holds, were designed to evaluate the spatiotemporal aspects of the subject's functionality. The system was tested on a group of healthy subjects and a group with a simulated stiff elbow, allowing the evaluations to be quantitatively differentiated. …”
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Comparative acetylome analysis reveals the potential mechanism of high fat diet function in allergic disease by Yanan Sun, Ning Liu, Huihui Wang, Taiqi Qu, Fazheng Ren, Yixuan Li

“…These proteins were mainly involved in regulating energy metabolism and mitochondrial function. This study provides information regarding the underlying molecular mechanisms by which HFD promotes allergy.…”
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Systematic analysis and functional characterization of the chitinase gene family in Fagopyrum tataricum under salt stress by Qingqing Li, Yongyi Yang, Xue Bai, Lun Xie, Suzhen Niu, Biao Xiong

“…Results This study analyzed their phylogenetic relationships, conserved motifs, gene structures, syntenic relationships, physiological functions, and biochemical properties. This research identified 26 FtCHIs and examined their expression patterns under different salt stress conditions and across various tissues. …”
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Influence of siloxane content on the material performance and functional properties of polydimethylsiloxane copolymers containing naphthalene moieties by Kamble Riddhi, Ghanti Bholanath, Badri Rahul, Banerjee Susanta

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Comprehensive Weighted Newton Inequalities for Broad Function Classes via Generalized Proportional Fractional Operators by Mohamed A. Barakat

“…By integrating this identity with <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi mathvariant="double-struck">GPF</mi></semantics></math></inline-formula> operators, we derive various forms of <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mo>(</mo><mi mathvariant="script">WN</mi><mo>-</mo><mi mathvariant="script">TI</mi><mo>)</mo></mrow></semantics></math></inline-formula> suitable for several function types, including differentiable convex, bounded, and Lipschitz functions.…”
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The APOE–Microglia Axis in Alzheimer’s Disease: Functional Divergence and Therapeutic Perspectives—A Narrative Review by Aiwei Liu, Tingxu Wang, Liu Yang, Yu Zhou

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Management of liver metastases from non-functional gastroenteropancreatic neuroendocrine tumors: a systematic review by Jun-shuai Xue, Yi Yang, Zhen Huang, Hong Zhao, Xiao Chen, Jian-qiang Cai

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Ectopic Thyroid Tissue in the Mediastinum Characterized by Histology and Functional Imaging with I-123 SPECT/CT by Jed Hummel, Jason Wachsmann, Kelley Carrick, Orhan K. Oz, Dana Mathews, Fangyu Peng

“…I-123 SPECT/CT is useful for guiding tissue biopsy of ectopic thyroid tissue distant from orthotopic thyroid gland and functional and anatomic characterization of mediastinal ectopic thyroid tissue for surgical resection when it is medically necessary.…”
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Analyzing longitudinal trait trajectories using GWAS identifies genetic variants for kidney function decline by Simon Wiegrebe, Mathias Gorski, Janina M. Herold, Klaus J. Stark, Barbara Thorand, Christian Gieger, Carsten A. Böger, Johannes Schödel, Florian Hartig, Han Chen, Thomas W. Winkler, Helmut Küchenhoff, Iris M. Heid

“…Abstract Understanding the genetics of kidney function decline, or trait change in general, is hampered by scarce longitudinal data for GWAS (longGWAS) and uncertainty about how to analyze such data. …”
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Origins of lithium inventory reversibility with an alloying functional layer in anode-free lithium metal batteries by Lennart Wichmann, Shi-Kai Jiang, Johannes Helmut Thienenkamp, Marvin Mohrhardt, Bing Joe Hwang, Martin Winter, Gunther Brunklaus

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The effects of restraint stress and orthodontic tooth movements on the intestinal epithelial structure and metabolic function in rats. by Ye Cheng, Yue Li, Ziqing Fan, Nannan Wang, Min Wang, Yanfen Li, Chao Liu, Huang Li, Fuhua Yan

“…This study aimed to investigate the effects of restraint stress and orthodontic treatment on the intestinal epithelial structure, barrier function, flora, and metabolism in rats. Twenty 8-week-old male Wistar rats were randomly divided into four groups: sham-stressed non-orthodontic (CC), sham-stressed orthodontic (CO), stressed non-orthodontic (SC), and stressed orthodontic (SO). …”
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Patellofemoral Pain (Ⅱ): Clinical Practice Guidelines Linked to the International Classification of Functioning, Disability and Health by The Academy of Orthopaedic Physical Therapy of the American Physical Therapy Association

“…The Academy of Orthopaedic Physical Therapy of the American Physical Therapy Association(APTA)created clinical practice guidelines on patellofemoral pain(PFP)based on the International Classification of Functioning, Disability and Health(ICF).Firstly, the guidelined describes the formulation method, International Classification of Diseases(ICD)-10 codes and ICF codes corresponding to PFP.In addition, the guidelines reviewed the latest peer-review literature to grade different levels of evidence, and provided recommendations on assessment and physical therapy for patellofemoral pain with recommendation grades, which were divided into three parts:1)Impairment/function-based diagnosis: prevalence and incidence, pathoanatomical features, risk factors, diagnosis and classifications(overuse/overload without other impairment, muscle performance deficits, movement coordination deficits, and/or mobility impairments)and differential diagnosis.2)Examination: outcome measures, activity limitations, physical impairment. …”
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Evaluation of phenotypic and functional stability of RAW 264.7 cell line through serial passages. by Bartłomiej Taciak, Maciej Białasek, Agata Braniewska, Zuzanna Sas, Paulina Sawicka, Łukasz Kiraga, Tomasz Rygiel, Magdalena Król

“…So far, only a few functional features of these cells have been studied, for example their ability to differentiate into osteoclasts. …”
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Probing Wnt pathway and functional signal in equine melanocytic neoplasms through quantitative proteomics and immunohistochemistry by Parichart Tesena, Ruethaiwan Vinijkumthorn, Amornthep Kingkaw, Petchpailin Yanyongsirikarn, Khajornpol Phasuk, Sekkarin Ploypetch, Narumon Phaonakrop, Sittiruk Roytrakul, Wanwipa Vongsangnak, Nawarus Prapaiwan

“…Results Using proteomic analysis of 19 tissue samples (normal: n = 6, early EMN: n = 7, severe EMN: n = 6) through LC–MS/MS, 12,310 proteins were identified. Differentially expressed proteins (DEPs) and functional interaction analysis revealed significant overexpression of Wnt signature proteins, e.g., canonical (Wnt2B) and non-canonical (Wnt5B) Wnt signaling in early EMN stages. …”
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Functional Reproductive and Developmental Traits Differences Between Two Macrocystis Ecomorphs: Importance of Neutral Lipids by Camilo Rodríguez‐Villegas, Alejandro H. Buschmann, Mayra A. Barrios, Sandra Pereda, Carolina Camus, Pamela Fernández, María C. Hérnandez‐González, Ángela M. Baldrich, Cynthia Urrutia, Ailen M. Poza, Karina Villegas, Camila Martínez, Jaime Vargas

“…Hence, both ecomorphs show, in addition to genetic and morphological differences, differential reproductive functional traits consistent in time and space that further support the hypothesis of an ongoing separation of these two Macrocystis ecomorphs.…”
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