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14921
Gfi1 controls the formation of effector-like CD8+ T cells during chronic infection and cancer
Published 2025-05-01“…Abstract During chronic infection and tumor progression, CD8+ T cells lose their effector functions and become exhausted. These exhausted CD8+ T cells are heterogeneous and comprised of progenitors that give rise to effector-like or terminally-exhausted cells. …”
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14922
Four genes shared between rheumatoid arthritis and cervical cancer are associated with cervical cancer prognosis
Published 2025-05-01“…We started by identifying differentially expressed genes in RA and CC and then applied WGCNA to detect functionally related gene clusters using gene expression data from the GEO database. …”
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14923
Targeting MDM2 homodimer and heterodimer disruption with DRx-098D in TP53 wild-type and mutant cancer cells
Published 2025-09-01“…Novel pharmacological strategies capable of inhibiting pro-oncogenic MDM2 beyond its p53-dependent functions represent increasingly attractive therapeutic strategies to treat solid and hematological cancers that are dependent upon MDM2/MDMX, regardless of TP53 mutational status. …”
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14924
Activation of AMPK in platelets promotes the production of offspring
Published 2024-12-01“…Platelets are terminally differentiated anucleated cells, but they still have cell-like functions and can even produce progeny platelets. …”
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14925
Multi-exit Kolmogorov–Arnold networks: enhancing accuracy and parsimony
Published 2025-01-01“…Multi-exit KANs consistently outperform standard, single-exit versions on synthetic functions, dynamical systems, and real-world datasets. …”
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14926
Frizzled1 and Frizzled2 are not redundant for competitive survival under low-Wingless levels in the developing Drosophila wing epithelium
Published 2025-01-01“…While sharing overlapping functions, these receptors also have distinct non-canonical roles and exhibit differential expression patterns along the Wingless gradient. …”
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14927
First observation of strange baryon enhancement with effective energy in pp collisions at the LHC
Published 2025-03-01“…Abstract The production of (multi-)strange hadrons is measured at midrapidity in proton-proton collisions at s $$ \sqrt{s} $$ = 13 TeV as a function of the local charged-particle multiplicity in the pseudorapidity interval |η| < 0.5 and of the very-forward energy measured by the ALICE Zero-Degree Calorimeters. …”
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14928
Proteomics‐Empowered Microfluidic‐SERS Immunoassay for Identifying and Detecting Biomarkers of Micropapillary Lung Adenocarcinoma
Published 2025-07-01“…To enable sensitive, multiplex detection of 4 upregulated DEPs, the nanomixing effect is leveraged to enhance target protein‐SERS barcode interactions while minimizing nonspecific binding to antibody‐functionalized gold electrodes. The SERS barcode cocktail allows simultaneous detection of the 4 selected DEPs. …”
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14929
An islanding detection method for grid-connect inverter based on parameter optimized variational mode decomposition and deep learning
Published 2025-04-01“…Firstly, the proposed adaptive variational mode decomposition (AVMD) strategy improves the optimal mode number and penalty term of VMD by utilizing the relative entropy between the original signal and the intrinsic mode functions (IMFs). Then, the Teager energy operator (TEO) further extracts sequence features to track the instantaneous energy of the IMFs. …”
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14930
Elucidating linear programs by neural encodings
Published 2025-06-01“…To mitigate this rather non-explainability of LPs we show how to adapt attribution methods by encoding LPs in a neural fashion. The encoding functions consider aspects such as the feasibility of the decision space, the cost attached to each input, and the distance to special points of interest. …”
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14931
Culture of memory: Prof. Edmund Balgač and his (un)forgotten building opus
Published 2025-01-01“…Even today, many buildings utilizing this structural system continue to fascinate with their appearance and functionality. This paper analyzes the theoretical contributions of Prof. …”
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14932
Clinical and morphological analysis of the case of lethal outcome in a patient with Binswanger’s disease
Published 2017-04-01“…At the last stage of the disease, clinical picture is presented by dementia, disorders of the self-service and the pelvic organs functions. The article presents a 42 years-old patient with the terminal stage of the BD’s type vascular dementia verified by postmortem histological examination. …”
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14933
Electrospinning of Cellulose Acetate Propionate: Optimization of Processing Parameters for Advanced Applications
Published 2025-07-01“…This study investigates the electrospinning of cellulose acetate propionate (CAP) and the optimization of processing parameters to produce nanofibrous membranes with advanced functionality. CAP, a biodegradable and semi-synthetic polymer, offers exceptional thermal and mechanical properties, making it a promising material for applications in filtration, wound dressing, and containment membranes. …”
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14934
Molecular and Physiological Responses of <i>Litopenaeus vannamei</i> to Nitrogen and Phosphorus Stress
Published 2025-02-01“…Environmental stressors such as nitrogen and phosphorus play a critical role in regulating the growth and physiological functions of <i>Litopenaeus vannamei</i>, a key species in aquaculture. …”
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14935
Integrating advanced neural network architectures with privacy enhanced encryption for secure and intelligent healthcare analytics
Published 2025-08-01“…Depending on the Kaggle healthcare dataset, the model receives an accuracy of 98.73%, which is better than the current functioning. “NeuroShield” includes characteristic-based access control (ABAC), Advanced Encryption Standard (AES), Multi-Factor Authentication (MFA) and differential privacy-based optimizations that provide strong protection. …”
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14936
Service Composition and Optimal Selection for Industrial Software Integration with QoS and Availability
Published 2025-07-01“…This algorithm integrated Tent chaotic mapping and a Levy flight-enhanced differential evolution (DE) strategy. Extensive experiments were conducted, including performance evaluation on 17 benchmark functions and case studies involving nine industrial software integration scenarios of varying scales. …”
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14937
Does side matter? Deciphering mechanisms that underpin side-dependent pathogenesis and therapy response in colorectal cancer
Published 2025-05-01“…In response, recent analyzes, including those utilizing whole genome sequencing, transcriptional profiling, and single-cell analyses, have demonstrated that key molecular differences exist between disease sites, with differentially expressed genes spanning a diverse range of cellular functions. …”
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14938
The ideals of student youth in relation to the present, possible and anti-ideal
Published 2022-04-01“…However, there is still no research of these categories as a single functioning system when studying the image of the social world of young people.Aim. …”
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14939
Cutting-Edge Stochastic Approach: Efficient Monte Carlo Algorithms with Applications to Sensitivity Analysis
Published 2025-04-01“…The theoretical proof demonstrates that these algorithms exhibit an optimal rate of convergence for functions with continuous and bounded first derivatives and for functions with continuous and bounded second derivatives, respectively, both in terms of probability and mean square error. …”
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14940
Single-cell and bulk transcriptome analyses reveal elevated amino acid metabolism promoting tumor-directed immune evasion in colorectal cancer
Published 2025-05-01“…This score was applied to a separate single-cell RNA sequencing (scRNA-seq) dataset from 23 CRC patients to investigate cell-cell interactions and functions of tumor-infiltrating immune cells, revealing distinct immune TME landscapes shaped by tumor metabolism. …”
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