Mass Spectrometry-Based Workflow for the Identification and Quantification of Alternative and Canonical Proteins in Pancreatic Cancer Cells by Clémence Guillon, Carole Pichereaux, Ikrame Lazar, Karima Chaoui, Emmanuelle Mouton-Barbosa, Mehdi Liauzun, Edith Gourbeyre, Pinar Altiner, David Bouyssié, Alexandre Stella, Odile Burlet-Schiltz, Serge Plaza, Yvan Martineau, Bertrand Fabre

“…Despite several studies investigating particular AltProts in diseases and demonstrating their importance in such context, we are still missing data on their expression and functions in many pathologies. Among these, pancreatic ductal adenocarcinoma (PDAC) is a particularly relevant case to study alternative proteins. …”
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Ephrin-B2 deletion in GABAergic neurons induces cognitive deficits associated with single-nucleus transcriptomic differences in the prefrontal cortex by Peijun Ju, Yu Fang, Siying Xiang, Weidi Wang, Ying Sun, Wei Wang, Yanli Ding, Chao Luo, Ping Jiang, Jianhua Chen

“…Comprehensive identification of cell-type-specific transcriptomic changes in EB2 knockout mice is expected to shed light on potential mechanisms associated with EB2 signaling in cognitive functions. Results Our study captures changes in cell populations in response to EB2 manipulation and reveals previously uncharacterized cell types (CPA6 + inhibitory neurons) in the mPFC. …”
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Silencing FGL1 promotes prostate cancer cell apoptosis and inhibits EMT progression by Shuaizhi Zhu, Zengshun Kou, Chengcheng Xiao, Lu Wang, Jiaxi Zhu, Yu Zheng, Hai Zhu

“…Abstract Emerging evidence from recent studies demonstrates that the FGL1/LAG-3 interaction axis plays a crucial role in mediating tumor immune evasion mechanisms, particularly through the suppression of T lymphocyte effector functions. However, the role of FGL1 in prostate cancer (PCa) remains unclear. …”
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Integrated metabolomics and transcriptomics analysis provides insights into biosynthesis and accumulation of flavonoids and glucosinolates in different radish varieties by Da Cai, Yanjie Dong, Lei Wang, Shancang Zhao

“…Radish is an important vegetable worldwide, with wide medicinal functions and health benefits. The quality of radish, strongly affected by phytochemicals like flavonoids and glucosinolates, are quite different depending on the radish varieties. …”
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Unveiling Ventilator-Associated Pneumonia: S100A8 as a Promising Biomarker Through Integrated RNA-Seq Analysis by Wang Q, Dong J, Jing X, Long Y, Jia H, Li Y, Wang J

“…The screen identified differentially expressed genes (DEGs) from the chemokine CC family, the S-100 family, and the α-defensin family, which are highly associated with immune-related antimicrobial functions. …”
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Expression of regulatory platelet microRNAs in patients with sickle cell disease. by Shilpa Jain, Maria G Kapetanaki, Nalini Raghavachari, Kimberly Woodhouse, Guoying Yu, Suchitra Barge, Claudia Coronnello, Panayiotis V Benos, Gregory J Kato, Naftali Kaminski, Mark T Gladwin

“…<h4>Conclusions</h4>We have identified significant differences in functionally active platelet miRNAs in patients with SCD as compared to controls. …”
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Quantitative evaluation of DNA damage repair dynamics to elucidate predictors of autism vs. cancer in individuals with germline PTEN variants. by Ruipeng Wei, Masahiro Hitomi, Tammy Sadler, Lamis Yehia, Daniela Calvetti, Jacob Scott, Charis Eng

“…The pleiotropy of the syndrome may, in part, be due to the alterations of the key multi-functions of PTEN. Maintenance of genome integrity is one of the key biological functions of PTEN, but no integrative studies have been conducted to quantify the DNA damage response (DDR) in individuals with PHTS and to relate to phenotypes and genotypes. …”
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Rural revitalization potential and pathway optimization in Qinling poverty-alleviation mountainous areas under community resilience framework by GUO Yuexi, CHEN Jia, YIN Sha, YANG Xinjun, XIAO Yang

“…Villages which focus on stability maintenance and decline prevention need to pay attention to farmers’ livelihood and implement differentiated planting. Villages of relocation and merger type should strengthen the ecological functions and values of the original villages, highlighting ecological restoration and conservation functions.…”
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A Rasch model based psychometric evaluation of different versions of the Minimal Insomnia Symptom Scale (MISS) among adults by Albert Westergren, Gita Hedin, Peter Hagell, Charlotte Bäccman, Annika Norell

“…Rasch model analyses focused on targeting, reliability, response category functioning, model fit, differential item functioning (DIF) and score transformation. …”
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Serine Hydroxymethyltransferase Modulates Midgut Physiology in <i>Aedes aegypti</i> Through miRNA Regulation: Insights from Small RNA Sequencing and Gene Expression Analysis by Qian Pu, Yujiao Han, Zhuanzhuan Su, Houming Ren, Qingshan Ou, Symphony Kashyap, Shiping Liu

“…This study provides new insights into the molecular mechanisms through which <i>SHMT</i> influences the biological functions and nutritional metabolism of the mosquito midgut. …”
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Modeling and Control of a Permanent Magnet <i>DC</i> Motor: A Case Study for a Bidirectional Conveyor Belt’s Application by Ernesto Molina-Santana, Luis Angel Iturralde Carrera, José M. Álvarez-Alvarado, Marcos Aviles, Juvenal Rodríguez-Resendiz

“…Simulation tests validated the proposed control scheme, highlighting the functionality and tradeoffs of its internal components.…”
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Spatial cell graph analysis reveals skin tissue organization characteristic for cutaneous T cell lymphoma by Suryadipto Sarkar, Anna Möller, Anne Hartebrodt, Michael Erdmann, Christian Ostalecki, Andreas Baur, David B. Blumenthal

“…The resulting protein abundance maps were then analyzed via scoring functions to quantify the heterogeneity of the individual cells’ neighborhoods within spatial graphs inferred from the cells’ positions in the tissue samples. …”
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Periurban Agriculture and Organic Farming: Investigating Synergies and Policy Implications by Orlando Cimino, Francesca Giarè, Roberto Henke

“…This, in turn, activates other on-farm functions such as the supply of public goods and services. …”
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Validation of the Arabic eHealth literacy questionnaire: a factor and Rasch analysis study by Walid Al-Qerem, Osama N. Fadhil, Anan Jarab, Anan Jarab, Alaa Hammad, Fawaz Al-Asmari, Rahaf Zidan, Judith Eberhardt

“…The findings revealed good internal consistency with Cronbach’s α ranging between ranging between 0.71 to 0.84. Differential Item Functioning analysis indicated no gender-specific variations.DiscussionThe validated Arabic eHLQ is a reliable tool that can help in supporting the development of tailored interventions to improve healthcare delivery in Arabic-speaking regions.…”
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A variable metric proximal stochastic gradient method: An application to classification problems by Pasquale Cascarano, Giorgia Franchini, Erich Kobler, Federica Porta, Andrea Sebastiani

“…Convergence results are provided for both convex and non-convex objective functions. Extensive numerical experiments verify that the suggested approach performs on par with state-of-the-art methods for training both statistical models for binary classification and artificial neural networks for multi-class image classification. …”
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Circular thin plates buckling analysis with HRPIM method by Baid Sokayna, Hilali Youssef, Mesmoudi Saïd, Bourihane Oussama

“…This paper aims to introduce a new approach to simulate geometrically nonlinear problems that require shape functions with higher order continuity such as the buckling analysis of circular thin and thick plates based on two theories; Classical plate theory (CPT) and Third order Shear Deformation Theory (TSDT). …”
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AI-assisted discovery of quantitative and formal models in social science by Julia Balla, Sihao Huang, Owen Dugan, Rumen Dangovski, Marin Soljačić

“…By extending neuro-symbolic methods to find compact functions and differential equations in noisy and longitudinal data, we show that our system can be used to discover interpretable models from real-world data in economics and sociology. …”
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Influences of dwell time and cursor control on the performance in gaze driven typing by Jens R. Helmert, Sebastian Pannasch, Boris M. Velichkovsky

“…Our results indicate that smoothing raw eye position and temporal delays in visual feedback enhance the system's functionality and usability. Best overall performance was obtained with a dwell time of 500 ms.…”
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DeepSeek vs. ChatGPT vs. Claude: A comparative study for scientific computing and scientific machine learning tasks by Qile Jiang, Zhiwei Gao, George Em Karniadakis

“…We designed all our experiments so that a nontrivial decision is required, e.g, defining the proper space of input functions for neural operator learning. Our findings show that reasoning and hybrid-reasoning models consistently and significantly outperform non-reasoning ones in solving challenging problems, with ChatGPT o3-mini-high generally offering the fastest reasoning speed.…”
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De Novo Assembly and Comparative Transcriptome Analysis Provide Insight into Lysine Biosynthesis in Toona sinensis Roem by Xia Zhang, Zhenqiao Song, Tian Liu, Linlin Guo, Xingfeng Li

“…A total of 25,570 could be annotated with known biological functions, which indicated that the T. sinensis leaves and shoots were undergoing multiple developmental processes especially for active metabolic processes. …”
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