Thymidine phosphorylase in nucleotide metabolism: physiological functions and its implications in tumorigenesis and anti-cancer therapy by Bo Huang, Bo Huang, Qihang Yuan, Jiaao Sun, Chao Wang, Dong Yang

“…Recent research has increasingly illuminated the diverse functions of TYMP. It is known to facilitate platelet activation, osteoclast differentiation, and angiogenesis. …”
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Single-cell transcriptomics reveals metabolic remodeling and functional specialization in the immune microenvironment of bone tumors by Jun Chen, Na Cui, Shao-Hui He, Chun-Yan Xia, Wei-Qing Li

“…Methods Immune cells were isolated from 13 bone tumor samples and profiled via scRNA-seq to delineate cellular compositions, metabolic adaptations, and intercellular communication networks. Differential gene expression analysis, metabolic pathway enrichment, and pseudotime trajectory inference were employed to characterize functional states and differentiation processes of immune cell subsets. …”
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Genetic factors regulating lung vasculature and immune cell functions associate with resistance to pneumococcal infection. by Magda S Jonczyk, Michelle Simon, Saumya Kumar, Vitor E Fernandes, Nicolas Sylvius, Ann-Marie Mallon, Paul Denny, Peter W Andrew

“…Therefore we concluded that the cumulative effect of these candidate genes on vasculature and immune cells functions as contributory factors in the observed differences in susceptibility to pneumococcal infection. …”
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GDF-15 Levels in Gouty Arthritis and Correlations with Decreasing Renal Function: A Clinical Study by Osman Cure, Ertugrul Yigit, Merve Huner Yigit, Hakki Uzun

“…<b>Background/Objectives</b>: Gouty arthritis (GA) is a chronic inflammatory disorder frequently linked to systemic inflammation and impaired kidney function. Growth differentiation factor-15 (GDF-15) has been suggested as a potential biomarker involved in both inflammatory responses and renal dysfunction. …”
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Understanding the synthesis mechanism of arginine functionalized silver/silver chloride nanoparticles using sugar ligands by Şuheda Bolat, Suna Değirmenci, Abdurrahman Gümüş, Zafer Sancak, İdris Yazgan

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Neuro- and Cardiotoxins from Sea Anemones: Structure, Function and Potential of Application in Research and Medical Practice by R. S. Kalina, M. M. Monastyrnaya

“…Based on their toxic effect, the biologically active sea anemone peptides generally can be classified as neurotoxins due to their impact on the functioning of sodium channels in the cells of the nervous system of animals. …”
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Aspartate beta-hydroxylase is a prognostic factor in gallbladder cancer with the function of promoting tumorigenesis and chemoresistance by Luo Yuan, Huang Yunpeng, Li Xiong, Yu Wen, Wang Yongxiang

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Stem cell-derived pancreatic beta cells: a step closer to functional diabetes treatment? by Ikponmwosa Jude Ogieuhi, Chinonyelum Emmanuel Agbo, Victor Oluwatomiwa Ajekiigbe, Chidera Stanley Anthony, Jennifer Chinaecherem Onyehalu, Chinemelum Kingsley Nwankwo, Mercy Chisom Agu, Kaleb Lema, Olajumoke Adesola Adewole, Oluwatobi Asade, Simbiat Quadri Eniola, Ogochuku Elizabeth Obiaghanwa, Sheeba Abraham Jeyaraj, Ifeoluwa Sandra Bakare

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A Novel Case of Functional Gastric Neuroendocrine Carcinoma Occurred after Endoscopic Submucosal Dissection by Yoshiaki Shibata, Yuji Ito, Hiroko Fujita, Yume Okada, Toshihiko Nagai, Hirohito Sano, Kumiko Ito

“…This is the novel case of a functional gastric neuroendocrine carcinoma that occurred after ESD and induced a hypoglycemic attack associated with NICTH.…”
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Evaluation of the functional activity of CD39 ectonucleotidase in regulatory T cells in children with inflammatory bowel diseases by T. V. Radygina, E. G. Sorokina, S. V. Petrichuk, D. G. Kuptsova, O. V. Kurbatova, A. S. Potapov, S. A. Afanasyeva

“…Aim – evaluate the functional activity of CD39+ in Treg in children with IBD using the luciferin-luciferase method.68 children with IBD were examined. …”
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Biological function of RNA-binding proteins in myocardial infarction: a potential emerging therapeutic limelight by Chenyang Jin, Yutong Ye, Longzhe Gao, Zikan Zhong, Changzuan Zhou, Xiaoyu Wu, Xudong Li, Genqing Zhou, Songwen Chen, Yong Wei, Lidong Cai, Shaowen Liu, Juan Xu

“…RBPs, as key regulators coordinating cell differentiation and tissue homeostasis, exhibit specific functions in gene transcription, RNA modification and processing, and post-transcriptional gene expression. …”
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Features of the functioning of the hypothalamic-pituitary-thyroid axis in mice with Lewis carcinoma on the background of induced hyperthyroidism by E. M. Frantsiyants, V. A. Bandovkina, I. V. Kaplieva, I. V. Neskubina, E. I. Surikova, A. I. Shikhlyarova, L. K. Trepitaki, M. A. Gusareva, I. A. Udalenkova, E. O. Vasilieva, N. D. Cheryarina, V. V. Pozdnyakova

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BMSCs-targeting piezoelectric stimulation and immunomodulatory dual-functional hydrogel for promoting diabetic bone regeneration by Jintao Dong, Wengang Dong, Huijie Ran, Dongxu Wu, Xinli Wang, Hongli Chen, Jiahao Cao, Xu Wang, Xinsen Lin, Wei Lei, Tianji Wang, Yafei Feng

“…This resulted in a dual-functional B-TNs@CMS composite hydrogel designed to combine targeted BMSC stimulation with immunomodulatory properties. …”
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Differential item functioning analysis on a measure of mindfulness (MAP) = Análise do funcionamento diferencial de uma medida de atenção plena (MAP) = Análisis del funcionamiento diferencial de una medida de atención plena (MAP) by Pires, Jeferson Gervasio, Nunes, Carlos Henrique Sancineto da Silva

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Natural potential difference induced functional optimization mechanism for Zn-based multimetal bone implants by Jing Xu, Zhenbao Zhang, Jianhui Wang, Yuhan Qi, Xiaohong Qi, Yijie Liang, Manxi Li, Haixia Li, Yantao Zhao, Zhuangzhuang Liu, Yanfeng Li

“…The excess release of Zn2+ induced by accelerated degradation enhanced the antibacterial function. A voltage signal generated by the natural potential difference also promoted in vitro osteogenic differentiation through activating the PI3K-Akt signaling pathway, and inhibited the toxicity of overdose Zn2+ in vivo, significantly improving bone regeneration. …”
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Ferroportin 1 depletion in neural stem cells promotes hippocampal neurogenesis and cognitive function in mice by Yiqian Ding, Shanshan Yao, Shuxin Guo, Wei Meng, Jie Li, Fudi Wang, Jianhua Zhang, Yan-Zhong Chang, Guofen Gao

“…In the adult brain, newborn granule cells continuously integrate into the hippocampal circuits, and fine-tuning the regulation of this process is crucial for improving hippocampal function. Iron is an essential element for the development and functionality of the brain. …”
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bFGF-Chitosan “brain glue” promotes functional recovery after cortical ischemic stroke by Jiao Mu, Xiang Zou, Xinjie Bao, Zhaoyang Yang, Peng Hao, Hongmei Duan, Wen Zhao, Yudan Gao, Jinting Wu, Kun Miao, Kwok-Fai So, Liang Chen, Ying Mao, Xiaoguang Li

“…The mammalian brain has an extremely limited ability to regenerate lost neurons and to recover function following ischemic stroke. A biomaterial strategy of slowly-releasing various regeneration-promoting factors to activate endogenous neurogenesis represents a safe and practical neuronal replacement therapy. …”
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Decellularized liver scaffolds for constructing drug-metabolically functional ex vivo human liver models by Juan Liu, Ariel Hanson, Wenzhen Yin, Qiao Wu, Eliane Wauthier, Jinmei Diao, Timothy Dinh, Jeff Macdonald, Ruihong Li, Masahiko Terajima, Mitsuo Yamauchi, Ziye Chen, Praveen Sethupathy, Jiahong Dong, Lola M. Reid, Yunfang Wang

“…We have developed a bioengineered, perfused, organ-level human liver model that accurately replicates key liver functions, including metabolic activities, and protein synthesis, thus addressing some of the limitations associated with traditional liver monolayers, organoids, and matrix-embedded liver cells. …”
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Feasibility of simplified Patlak parametric imaging with scaled population-based input function on pancreatic cancer by Zhixin Hao, Haiqiong Zhang, Yonghong Dang, Jiangdong Qiu, Mengshi Yan, Xinchun Yan, Zhenghai Huang, Chao Ren, Taiping Zhang, Wenming Wu, Li Huo

“…Patlak parametric images were generated from the dynamic PET series using both the image-derived input function (IDIF) and the sPBIF. The consistency between IDIF and sPBIF was evaluated by comparing the area under the curve (AUC) and Patlak parameters derived from both input functions. …”
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Sufficient Conditions for the Non-Existence of Global Solutions to Fractional Systems with Lower-Order Hadamard-Type Fractional Derivatives by Saeed M. Ali, Mohammed D. Kassim

Subjects: “…method of test function…”
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