Cerebrospinal fluid from patients with amyotrophic lateral sclerosis inhibits sonic hedgehog function. by Anna Drannik, Joan Martin, Randy Peterson, Xiaoxing Ma, Fan Jiang, John Turnbull

“…Since little is known about the functional status of Shh pathway in patients with ALS, we therefore sought to determine whether Shh protein levels or biological activity in cerebrospinal fluid (CSF) was less in ALS patients than controls, and whether these measures could be correlated with ALS disease severity and disease progression, and with other CSF analytes of biological interest in ALS. …”
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Heart Failure Impairs Bone Marrow Hematopoietic Stem Cell Function and Responses to Injury by Tina B. Marvasti, Faisal J. Alibhai, Grace J. Yang, Shu‐Hong Li, Jun Wu, Terrence Yau, Ren‐Ke Li

“…Background Heart failure (HF) is a clinical syndrome associated with a progressive decline in myocardial function and low‐grade systemic inflammation. Chronic inflammation can have lasting effects on the bone marrow (BM) stem cell pool by impacting cell renewal and lineage differentiation. …”
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Spatiotemporal regulation by downstream genes of Prok2 in the olfactory system: from development to function by Bo-Ra Kim, Min-Seok Rha, Min-Seok Rha, Hyung-Ju Cho, Hyung-Ju Cho, Joo-Heon Yoon, Joo-Heon Yoon, Chang-Hoon Kim, Chang-Hoon Kim, Chang-Hoon Kim, Chang-Hoon Kim

“…Mutations in PROK2, which encodes prokineticin-2, have been identified in approximately 9% of the KS patients with olfactory defects.MethodsWe examined olfactory function and analyzed the causes of olfactory dysfunction based on spatiotemporal development and gene expression changes in Prok2 knockout (KO) model mice with KS.ResultsThe ability of the OE to detect olfactory signals was diminished in adult Prok2 KO mice. …”
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Identification and Functional Validation of the <i>PeDHN</i> Gene Family in Moso Bamboo by Yaqin Ye, Yanting Chang, Wenbo Zhang, Tiankui Chu, Hanchen Tian, Yayun Deng, Zehui Jiang, Yanjun Ma, Tao Hu

“…Subcellular localization experiments showed that YK₂S-type dehydrins (PeDHN2/5/6) localized to both the nucleus and the plasma membrane, while K₂S-type dehydrins (<i>PeDHN4</i>/8) were exclusively localized to the plasma membrane, indicating functional differentiation. qRT-PCR analysis revealed that the expression of <i>PeDHN2/4/5/6/8</i> was significantly responsive to stress treatments with ABA, NaCl, and PEG. …”
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Bioinformatics-based prognostic value and in vitro functional validation of PTK6 in cutaneous melanoma by Yanyan Niu, Yanyan Niu, Xiaoyu Liu, Aixiu Shi, Danli Tang, Xiaodong Yao, Yan Lu

“…GO and KEGG analyses explored biological functions of PTK6-related differentially expressed genes (DEGs). …”
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METTL9 sustains vertebrate neural development primarily via non-catalytic functions by Azzurra Codino, Luca Spagnoletti, Claudia Olobardi, Alessandro Cuomo, Helena Santos-Rosa, Martina Palomba, Natasha Margaroli, Stefania Girotto, Rita Scarpelli, Shi-Lu Luan, Eleonora Crocco, Paolo Bianchini, Andrew J. Bannister, Stefano Gustincich, Tony Kouzarides, Riccardo Rizzo, Isaia Barbieri, Federico Cremisi, Robert Vignali, Luca Pandolfini

“…Overall, we demonstrate a developmental function of Mettl9 and link it to a 1MH-independent pathway, namely, the maintenance of the secretory system, which is essential throughout neural development.…”
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In-depth functional analysis of BRD9 in fetal hematopoiesis reveals context-dependent roles by Yifan Zhang, Masaki Nomura, Koutarou Nishimura, Weijia Zang, Yui Koike, Muran Xiao, Hiromi Ito, Miki Fukumoto, Atsushi Tanaka, Yumi Aoyama, Wataru Saika, Chihiro Hasegawa, Hiromi Yamazaki, Akifumi Takaori-Kondo, Daichi Inoue

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Outage Performance and Novel Loss Function for an ML-Assisted Resource Allocation: An Exact Analytical Framework by Nidhi Simmons, David E. Simmons, Michel Daoud Yacoub

“…With our result, we formulate a theoretically optimal, differentiable loss function to train our predictor. We then compare predictors trained using this and traditional loss functions namely, binary cross-entropy (BCE), mean squared error (MSE), and mean absolute error (MAE). …”
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Trait-mediated insect colonization of newly established grassland strips in agricultural landscapes by Maria Peer, Sophie Kratschmer, Raja Imran Hussain, Manuela Bürgler, Bea Maas, Dominik Rabl, Ronnie Walcher, Tobias Schernhammer, Norbert Schuller, Nora Vogel, Matthias Heer, Simon Zwatz, Bernhard Krautzer, Dietmar Moser, Thomas Frank

“…However, the development of the functional composition of insect assemblages in newly established grassland, which determine how species contribute to key ecosystem processes such as pollination, nutrient cycling, and pest control, are less understood. …”
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Towards Nonlinearity: The <i>p</i>-Regularity Theory by Ewa Bednarczuk, Olga Brezhneva, Krzysztof Leśniewski, Agnieszka Prusińska, Alexey A. Tret’yakov

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Tuning method of automatic controllers to object models with second order advance-delay and dead time by Dumitru Moraru

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Birnbaum's models for the assessment of quality of dough «linear algebra, analytical geometry» by Lidia A. Muratova

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Particularities in the “Oldie but Goldie” Tc-99m DMSA Renography: A Retrospective Reference Centre Overview of 931 Children by Irena Cristina Grierosu, Iuliana Magdalena Starcea, Wael Jalloul, Maria Adriana Mocanu, Roxana Alexandra Bogos, Tudor Ilie Lazaruc, Madalina Andreea Beldie, Ruxandra Tibu, Teodor Marian Ionescu, Cati Raluca Stolniceanu, Brindusa Casiana Acsinte, Cipriana Stefanescu, Alexandra Saviuc, Vlad Ghizdovat

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Analyzing the impact of white noise on optical solitons and various wave solutions in the stochastic fourth-order nonlinear Schrödinger equation by Mohammed F. Shehab, Hamdy M. Ahmed, Salah Boulaaras, M.S. Osman, Karim K. Ahmed

Subjects: “…Improved modified extended tanh-function method…”
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Prenatal stress increases corticosterone levels in offspring by impairing placental glucocorticoid barrier function. by Can Liu, Hongya Liu, Hongyu Li, Deguang Yang, Ye Li, Rui Wang, Jiashu Zhu, Shuqin Ma, Suzhen Guan

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Study on the mechanisms and functions of lncRNAs in regulating carboplatin resistance in ovarian cancer cells by HONG Yi, CHEN Cuilan, YIN Fuqiang, LIU Xia

“…Objective To screen for differentially expressed long non-coding RNAs (lncRNAs) in carboplatinresistant ovarian cancer (OC) based on expression profiling microarrays and conduct functional enrichment analysis to comprehensively understand the signaling pathways of lncRNAs in response to carboplatin resistance in OC. …”
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Vaginal metatranscriptome meta-analysis reveals functional BV subgroups and novel colonisation strategies by Scott J. Dos Santos, Clara Copeland, Jean M. Macklaim, Gregor Reid, Gregory B. Gloor

“…Compared to amplicon sequencing and shotgun metagenomic approaches focusing on a single or few species, investigating the transcriptome of the vaginal microbiome at a system-wide level can provide insight into the functions which are actively expressed and differential between states of health and disease. …”
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Direction-aware functional class scoring enrichment analysis of infinium DNA methylation data by Mark Ziemann, Mandhri Abeysooriya, Anusuiya Bora, Séverine Lamon, Mary Sravya Kasu, Mitchell W. Norris, Yen Ting Wong, Jeffrey M. Craig

“…First, we examine the differential pathway methylation associated with chronological age. …”
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Green’s Function and Positive Solutions of a Third-Order Equation with Periodic Boundary Conditions by Nickolai Kosmatov

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Angiogenesis-related genes and immune microenvironment in moyamoya disease: a transcriptomic and functional analysis by Zhenyu Zhou, Hongchuan Niu, Shaoqi Xu, Junze Zhang, Yutong Liu, Chengxu Lei, Shihao He, Yuanli Zhao

“…Functional enrichment, immune infiltration, and metabolic pathway analyses and drug prediction mapping (Connectivity Map [CMap]) were performed. …”
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