Mechanical control of the alternative splicing factor PTBP1 regulates extracellular matrix stiffness induced proliferation and cell spreading by Pei-Li Tseng, Weiwei Sun, Ahmed Salem, Mubarak Alaklobie, Sarah C. Macfarlane, Annica K.B. Gad, Mark O. Collins, Kai S. Erdmann

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MiRNA-mRNA network in osteoporotic fractures proposes the functional mechanism of hsa-miR-32-3p/TNFSF11 axis by Yukai Zeng, Bo Zhao, Jiawei Gong, Qingfeng Zhang, Fei Yang

“…Abstract Background and aims This study aimed to construct a miRNA-mRNA network in OF and explored the effect of the hsa-miR-32-3p/TNFSF11 axis on osteoclast function. Methods GSE70318 and GSE74209 datasets were used to filter the differentially expressed miRNAs in OF. …”
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Transcriptomic and metabolomic insights into the synergistic effects of resveratrol and β-hydroxy-β-methylbutyric acid on hepatic function under varying protein diets in Tibetan sh... by Yu Zhang, Kaina Zhu, Fengshuo Zhang, Zhenling Wu, Shengzhen Hou, Linsheng Gui

“…The 14% protein diet with RES and HMB improved the hepatic function through modulating the gene and metabolite in Tibetan sheep.…”
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Relationship Between Resting-State Functional Magnetic Resonance Imaging and Different Time in Target Glucose Range in Elderly Patients with Type 2 Diabetes Mellitus by Yang P, Liu S, Li L

“…Elderly T2DM patients in the low-TIR group were more susceptible to impaired brain function, which presented mainly as abnormal reduction in and activation of functional activity in some temporal lobes, frontal lobes, and occipital lobes in the resting state, and more significant when glycemic control is poorer.Keywords: type 2 diabetes mellitus, time in range, resting-state functional magnetic resonance imaging, low-frequency fluctuation, fractional low-frequency fluctuation, regional homogeneity…”
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konnect2prot 2.0: Integrating advanced analytical tools for deeper understanding of protein properties in a functional protein-protein interaction network by Shivam Kumar, Abhinav Agarwal, Dipanka Tanu Sarmah, Samrat Chatterjee

“…Proteins work in coordination to catalyze and regulate all biological activities and drive cellular functions. The collective behavior of proteins is studied through protein-protein interaction (PPI) networks, which provide a system-level understanding of their regulatory behavior. konnect2prot (k2p) is a web application that generates a context-specific directional PPI network from a list of proteins as input. …”
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Characterizing stochastic solitons behavior in (3+1)-dimensional Schrödinger equation with Cubic–Quintic nonlinearity using improved modified extended tanh-function scheme by Karim K. Ahmed, Hamdy M. Ahmed, Mohammed F. Shehab, Tarek A. Khalil, Homan Emadifar, Wafaa B. Rabie

“…Several stochastic exact solutions of this model is acquired through the application of the improved modified extended tanh-function scheme (IMETFS). This method offers a practical and effective approach to finding precise solutions to several kinds of nonlinear partial differential equations. …”
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The IG-DMR and the MEG3-DMR at human chromosome 14q32.2: hierarchical interaction and distinct functional properties as imprinting control centers. by Masayo Kagami, Maureen J O'Sullivan, Andrew J Green, Yoshiyuki Watabe, Osamu Arisaka, Nobuhide Masawa, Kentarou Matsuoka, Maki Fukami, Keiko Matsubara, Fumiko Kato, Anne C Ferguson-Smith, Tsutomu Ogata

“…To our knowledge, this is the first study demonstrating an essential long-range imprinting regulatory function for the secondary DMR.…”
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Microtubule Associated Protein 1b (MAP1B) Is a Marker of the Microtubular Cytoskeleton in Podocytes but Is Not Essential for the Function of the Kidney Filtration Barrier in Mice. by Markus Gödel, Dunja Temerinac, Florian Grahammer, Björn Hartleben, Oliver Kretz, Beat M Riederer, Friedrich Propst, Stefan Kohl, Tobias B Huber

“…Podocytes are essential for the function of the kidney glomerular filter. A highly differentiated cytoskeleton is requisite for their integrity. …”
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Metagenomic analysis reveals distinct patterns of gut microbiota features with diversified functions in C. difficile infection (CDI), asymptomatic carriage and non-CDI diarrhea by Lamei Wang, Xinhua Chen, Nira R. Pollock, Javier A. Villafuerte Gálvez, Carolyn D. Alonso, Dangdang Wang, Kaitlyn Daugherty, Hua Xu, Junhu Yao, Yulin Chen, Ciaran P. Kelly, Yangchun Cao

“…Downstream statistical analyses (including alpha and beta diversity analysis, differential abundance analysis, correlation network analysis, and potential functional analysis) were then performed. …”
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iTRAQ-based quantitative proteomic profiling of the regulatory mechanisms on immune functions and blood lipids in aged mice fed with Lentinula edodes-derived polysaccharides by Xiaofei Xu, Xiaofei Liu, Jin Chen, Jingjing Guan, Donghui Luo

“…The mechanisms of mushroom polysaccharides on immune functions and lipid metabolism of aged mammals have not been fully elucidated. …”
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Resveratrol and β-hydroxy-β-methylbutyric acid supplementation promotes ileal development and digestive function by altering microbial community abundance and metabolites in Tibeta... by Jiacheng Gan, Qiurong Ji, Quyangangmao Su, Shengzhen Hou, Linsheng Gui

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Tooth loss and physical function among older adults related to race and ethnicity in Hawai‘i: A cross-sectional study from 2014 to 2020 by Wei Zhang, Yan Yan Wu, Fran C. Woodworth, Deborah J. Mattheus

“…Background: Oral health and functional limitations are major health concerns among aging populations in the U.S. and globally. …”
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A Multidisciplinary Approach to Unplanned Conversion from Off-Pump to On-Pump Beating Heart Coronary Artery Revascularization in Patients with Compromised Left Ventricular Function by Georgia Tsaousi, Antonis A. Pitsis, George D. Ioannidis, Dimitrios G. Vasilakos

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Acute effect of low-intensity aerobic exercise on eliciting enhanced parietal activation and promoting executive function performance more than moderate-intensity exercise by Shen Lingling, Chen Huaqing, Li Xuan, Cai Jichen, Li Chenxi, Wang Chuhuai

“…IntroductionAerobic exercise intensity differentially impacts cognitive function and brain activity, but the optimal intensity for enhancing cognitive function and cortical activity remains unclear. …”
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A Novel Synonymous Variant in SQSTM1 Causes Neurodegeneration With Ataxia, Dystonia, and Gaze Palsy Revealed by Urine‐Derived Cells‐Based Functional Analysis by Shinji Masuko, Mitsuto Sato, Katsuya Nakamura, Kohei Hamanaka, Satoko Miyatake, Yuji Inaba, Tomoki Kosho, Naomichi Matsumoto, Yoshiki Sekijima

“…Conclusions Only a few reports have highlighted the presence of chorea; however, our findings suggest that NADGP should be considered as a differential diagnosis of hereditary chorea. This study also demonstrates the utility of UDCs, obtained using noninvasive approaches, in functionally analyzing genetic diseases.…”
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Kidney Tissue Proteome Profiles in Short Versus Long Duration of Delayed Graft Function - A Pilot Study in Donation After Circulatory Death Donors by M. Letizia Lo Faro, Kaithlyn Rozenberg, Honglei Huang, Sergei Maslau, Sarah Bonham, Roman Fischer, Benedikt Kessler, Henri Leuvenink, Edward Sharples, Jan H. Lindeman, Rutger Ploeg

“…Introduction: Delayed graft function (DGF) is often defined as the need for dialysis treatment in the first week after a kidney transplantation. …”
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A Systems Biology Approach to Elucidating Functional and Genomic Signatures in Host-Pathogen Interactions of Triple Infections: Tuberculosis, HIV, and SARS-CoV-2 by Mohd. Imran, Hayat Ali Alzahrani, Ranya Mohammed Elmagzoub, Zia Ur Rehman, Khadiga G. Abd Elaleem, Ahlam S. Mohamed, Aida A. Elsharief, Hayaa M. Alhuthali

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Methods for deriving the law of radioactive decay and the law of radiation absorption using the property of the exponent function when studying Physics in the system of secondary v... by D. B. Siyukhova, T. I. Demina

“…It seems that this is caused by two reasons: firstly, when writing the exponent function, the base of natural logarithms is used – the number e, which is unknown to intermediate students; secondly, the above laws are usually derived by solving differential equations, which is far beyond the scope of the mathematics curriculum. …”
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Three-Dimensional Left Atrial Reservoir Function During Sinus Rhythm Can Discriminate Between a History of Paroxysmal Atrial Fibrillation and its Absence by Jiří Plášek, Valeria Skopelidou, Jan Strakoš, Diana Drieniková, Martin Ráchela, Jiří Pudich, Jiří Vrtal, Miroslav Homza, Jan Václavík

“…Conclusions: Three-dimensional left atrial reservoir function can differentiate patients with paroxysmal AF from patients without a history of this arrhythmia.…”
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Exosomal miR-122-5p for regulation of secretory functions of fibroblasts and promotion of breast cancer metastasis by targeting MKP-2: an experimental study by Yun Lv, Yue Li, Jie Zhou, Xin Liu, Dandan Wang, Dongmei Wang, Dandan Tong, Shuhuai Wang, Hanxiang An, Xinmei Kang

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