Pathways between childhood trauma, clinical symptoms, and functioning in new-onset psychosis: novel insights from a network analysis approach by Dimitrios Kiakos, Luis Alameda, Ines Lepreux, Caroline Conchon, Livia Alerci, Marianna Gorgellino, Nadir Mebdouhi, Teya Petrova, Philippe Golay, Lilith Abrahamyan Empson, Philippe Conus, Sandra Vieira

“…Our results suggest that distinct disease phenotypes could be differentially associated with CT and functioning in individuals with new-onset psychosis. …”
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Proteogenomic reprogramming to a functional human blastomere-like stem cell state via a PARP-DUX4 regulatory axis by Ludovic Zimmerlin, Ariana Angarita, Tea Soon Park, Rebecca Evans-Moses, Justin Thomas, Sirui Yan, Isabel Uribe, Isabella Vegas, Clara Kochendoerfer, Willem Buys, Anthony K.L. Leung, Elias T. Zambidis

“…Summary: Here, we show that conventional human pluripotent stem cells cultured with non-specific tankyrase-PARP1-inhibited conditions underwent proteogenomic reprogramming to functional blastomere-like tankyrase/PARP inhibitor-regulated naive stem cells (TIRN-SC). …”
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Identification and expression analysis of cinnamyl CoA reductase gene family and function of StCCR6 in potato (Solanum tuberosum L.) by Chong Du, Yunzhu Che, Zengli Zhang, Fumeng He, Xinqi Zhang, Yujie Han, Zelin Yang, Jiaqi Wang, Tianshuai Qi, Ying Lan, Yingnan Wang, Fenglan Li

“…These findings establish a foundation for elucidating the functional roles of StCCRs in potato growth regulation and stress adaptation mechanisms.…”
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Comparative Transcriptome Analysis Reveals the Impact of a High-Fat Diet on Hepatic Metabolic Function in Tilapia (<i>Oreochromis niloticus</i>) by Rui Jia, Yiran Hou, Linjun Zhou, Liqiang Zhang, Bing Li, Jian Zhu

“…This study aimed to assess changes in hepatic metabolic function in tilapia and to explore the underlying molecular mechanisms through transcriptomic analyses. …”
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Genome-wide identification of glyoxalase (PbrGLY) gene family and functional analysis of PbrGLYI-28 in response to Botryosphaeria dothidea in pear by Fei Wang, Fengpei Sun, Zhaoyi Yu, Yue Zhang, Yuting Liu, Xiaolei Sun, Dan Li, Shaoling Zhang, Xun Sun

“…Conclusion This study speculates that the PbrGLY family may functionally differentiate and coordinately regulate pear resistance to ring rot disease, with the expression changes of PbrGLYI-28 potentially associated with B. dothidea infection and pear resistance.…”
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Na+/K+-ATPase is present in scrapie-associated fibrils, modulates PrP misfolding in vitro and links PrP function and dysfunction. by James F Graham, Dominic Kurian, Sonya Agarwal, Lorna Toovey, Lawrence Hunt, Louise Kirby, Teresa J T Pinheiro, Steven J Banner, Andrew C Gill

“…Consistent with previous results, the same protein inhibited fibrillisation kinetics of recombinant PrP. Since functional interactions between PrP(C) and Na(+)/K(+)-ATPase have previously been reported in astrocytes, our data highlight this molecule as a key link between PrP function, dysfunction and misfolding.…”
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RBM47 functions as an anti-oncogene by regulating expression and alternative splicing of cell proliferation and apoptosis associated genes in colorectal cancer cells by Guangshi Liu, Tao Li, Peng Li, Suyan Wei, Kamuran Abulizi

“…In summary, our results demonstrated the anti-tumor function and the globally downstream targets of RBM47 in CRC cells. …”
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Resting-state functional magnetic resonance imaging study on cerebrovascular reactivity changes in the precuneus of Alzheimer’s disease and mild cognitive impairment patients by Xue Tang, Luoyu Wang, Qi Feng, Hanjun Hu, Yidi Zhu, Zhengluan Liao, Zhongxiang Ding, Xiufang Xu

“…This study aims to evaluate cerebrovascular reactivity (CVR) and functional connectivity (FC) in patients with AD and mild cognitive impairment (MCI) using resting-state functional magnetic resonance imaging (rs-fMRI), bypassing the requirement for hypercapnia. …”
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Fibrocytes in early and long-standing rheumatoid arthritis: a 6-month trial with repeated synovial biopsy, imaging and lung function test by Søren Andreas Just, Frances Humby, Hanne Lindegaard, Pia Veldt Larsen, Christian Nielsen, Jens Christian Werlinrud, Henrik Daa Schrøder, Trine Torfing, Eva Kildall Hejbøl, Helene Broch Tenstad, Torben Barington

“…Objectives To correlate the level of fibrocytes in peripheral blood, synovial tissue and in vitro culture in rheumatoid arthritis (RA) with changes in disease activity, imaging and pulmonary function.Methods Twenty patients with early RA (ERA) and 20 patients with long-standing RA (LRA) were enrolled in a 6-month prospective study. …”
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Automated Detection of Schizophrenia Based on Retinal Measures and Neurological Soft Signs: Applications of Interpretable Classification Methods and the Choquet Integral Aggregatio... by Pawel Krukow, Steven M. Silverstein, Pawel Karczmarek, Adam Domagala, Adam Kiersztyn, Malgorzata Plechawska-Wojcik, Maria Garcia Gadanon, Kamil Jonak

“…Background: Schizophrenia is a psychiatric illness with a significant functional impairment. Its diagnosis is based on clinical observation, despite much evidence for its neurobiological basis. …”
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MicroRNA-486: a dual-function biomarker for diagnosis and tumor immune microenvironment characterization in non-small cell lung cancer by Jun Yu, Yi Shen, Yao Xu, Zhengyang Feng, Yuntian Shen, Yaqun Zhu, Jian Huan, Qiliang Peng

“…Conclusions This dual-modality investigation establishes miR-486 as a multi-functional biomarker in NSCLC, demonstrating both diagnostic utility and immunoregulatory potential through tumor microenvironment modulation.…”
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Genome-wide identification of APX genes in flax (Linum usitatissimum) and functional characterization of LuAPX12 in osmotic and salinity stress responses by Yuan-Dong Li, Rong Ma, Yu-Xi Zheng, Li-Qiong Xie

“…Conclusions A comprehensive genome-wide characterization of the flax APX gene family was conducted, and the function of the APX-R gene LuAPX12 under osmotic and salt stress was preliminarily validated. …”
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The downregulation of hormone-sensitive lipase and dysregulation of cholesterol receptors/transporter affect testicular lipid homeostasis and function in HFD-induced oligoasthenosp... by Min Pan, Jingya Li, Yujia Wang, Ziao Liu, Li Li, Tongsheng Wang

“…Conclusion The down-regulation of HSL and dysregulation of cholesterol receptors/transporter may affect lipid homeostasis, thereby damaging testicular function.…”
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Association of functional health literacy and cognitive ability with self-reported diabetes in the English Longitudinal Study of Ageing: a prospective cohort study by Ian J Deary, Chloe Fawns-Ritchie, Jackie Price

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Research on the Coordination Relationship and Zoning Optimization of Territorial Spatial Functions in Southern Karst Regions Based on a Multi-Scale Fusion Model by Ting Feng, Xiaodong Yu, Yan Zhou, Renling Dong, Dong Wu, Meilin Zhang

“…The identification and management of Territorial Spatial Functions (TSFs) across multi-scale is crucial for achieving the SDGs. …”
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The expression of liver–gonadal axis genes reveals the long–term effects of exogenous estradiol on gonad development and liver function in GIFT tilapia by Ye Yuan, Zexun Zhou, Shandong Chen, Yunyun Liu, Yongchun Li, Yan Miao, Shi Wang, Zhongyuan Shen, Lei Zeng, Jun Xiao, Qinbo Qin, Wuhui Li

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Analysis of the expression profile and biological function of plasma miRNAs in chronic lymphocytic leukemia and multiple myeloma patients occupationally exposed to pesticides by Luiza Flavia Veiga Francisco, Willian Garcia Birolli, Welinton Hirai, Caroline Rocha Nunes, Iara Zapparoli Gonçalves, Fabiana de Lima Vazquez, Álvaro José dos Santos Neto, Fernando Barbosa Junior, Márcia Maria Chiquitelli Marques, Henrique C.S. Silveira

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The combined effect of Pdx1 overexpression and Shh manipulation on the function of insulin‐producing cells derived from adipose‐tissue stem cells by Mahmoud Hashemi Tabar, Mohammad Reza Tabandeh, Eskandar Moghimipour, Dian Dayer, Ata A. Ghadiri, Elham Allah Bakhshi, Mahmoud Orazizadeh, Mohammad Ali Ghafari

“…Pancreatic and duodenal homeobox 1 (Pdx1) and Sonic hedgehog (Shh) are the key regulators of beta‐cell function. In vitro experiments have shown that there is significant cooperation between Pdx1 and Shh with regard to the production and maintenance of insulin‐producing cells (IPCs). …”
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Does endoscopic sclerotherapy in filarial chyluria affect renal function and morphology? A prospective study using dimercaptosuccinic acid renal scan by Bimalesh Purkait, Apul Goel, Satyawati Deswal, Monica Agrawal, BhupendraPal Singh, Manoj Kumar

“…The relative renal function did not change >5% from the baseline value in any patient except one (in which the differential function increased paradoxically by 12%). …”
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High throughput morphological screening identifies chemically defined media for mesenchymal stromal cells that enhances proliferation and supports maintenance of immunomodulatory f... by Thomas M. Spoerer, Andrew M. Larey, Winifred Asigri, Kanupriya R. Daga, Ross A. Marklein

“…Expansion using undefined fetal bovine serum (FBS) or human platelet lysate contributes to MSC functional heterogeneity and limits control of product quality. …”
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