Increased BNIP3-mediated mitophagy attenuates GDAP1 loss of function - implications for Charcot-Marie-Tooth disease 4A by Li Zhang, Alireza Pouya, Janina Kopetzky, Sara Bitar, Christina Wolf, Federica Dal Bello, David Gomez-Zepeda, Stefan Tenzer, Axel Methner

“…Charcot-Marie-Tooth disease type 4 A ((CMT4A), an autosomal recessive neuropathy, is caused by mutations in ganglioside-induced differentiation-associated protein 1 (GDAP1). GDAP1 resides in the outer mitochondrial membrane facing the cytosol and is involved in mitochondrial dynamics and function. …”
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Identification and functional characterization of key biomarkers in diffuse large B-cell lymphoma: emphasis on STYX as a prognostic marker and therapeutic target by Junaid Abid, Mahmood Basil A. Al-Rawi, Ahmad Mahmood, An Li, Tiemin Jiang

“…Methylation analysis highlighted a negative correlation between DEGs methylation levels and mRNA expression, while survival analysis identified high STYX expression as significantly associated with poorer overall survival in DLBC patients. Functional assays demonstrated that STYX knockdown in U2932 cells led to reduced cell proliferation, colony formation, and enhanced wound healing, indicating STYX’s pivotal role in DLBC cell survival and migration. …”
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Stage-specific transcriptomic analysis reveals insights into the development, reproduction and biological function of allergens in the European house dust mite Dermatophagoides pte... by José Cristian Vidal-Quist, Félix Ortego, Bart N. Lambrecht, Stephane Rombauts, Pedro Hernández-Crespo

“…Herein, we report a comprehensive RNAseq analysis of larvae, nymphs, and adult males and females, mapped to a recently published high-quality genome with extended functional annotations. Results Analysis of differentially expressed genes (DEG) revealed that female-biased expression was the most prevalent profile (16% of genes), while males exhibited the highest fold-change differences. …”
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Scaffolds functionalized with matrix metalloproteinase-responsive release of miRNA for synergistic magnetic hyperthermia and sensitizing chemotherapy of drug-tolerant breast cancer by Rui Sun, Man Wang, Tianjiao Zeng, Huajian Chen, Toru Yoshitomi, Masaki Takeguchi, Naoki Kawazoe, Yingnan Yang, Guoping Chen

“…These composite scaffolds offer an innovative strategy for treating breast cancer, with synergistic anticancer effects and regenerative functions.…”
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Characterization of feline nonsteroidal anti-inflammatory drug activated gene-1 (fNAG-1) and its protective function in kidney cells by Pattawika Lertpatipanpong, Hyunjin Moon, Jung Eun Seo, Minsu Kim, Seung Joon Baek

“…Nonsteroidal anti-inflammatory drug-activated gene (NAG-1), also known as growth differentiation factor 15 (GDF15), is a member of the transforming growth factor-β superfamily and has been associated with anti-obesity properties and preservation of kidney function. …”
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Disentangling the Switching Behavior in Functional Connectivity Dynamics in Autism Spectrum Disorder: Insights from Developmental Cohort Analysis and Molecular‐Cellular Association... by Wei Li, Xia Qiu, Jin Chen, Kexuan Chen, Meiling Chen, Yinyan Wang, Wenjie Sun, Jing Su, Yongchang Chen, Xiaobao Liu, Congying Chu, Jiaojian Wang

“…Abstract Characterizing the transition or switching behavior between multistable brain states in functional connectivity dynamics (FCD) holds promise for uncovering the underlying neuropathology of Autism Spectrum Disorder (ASD). …”
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IL-15 functionalized biomimetic hybrid mRNA vaccine for enhanced NSCLC immunotherapy via synergistic activation of T cells and NK cells by Jueshuo Guo, Li Peng, Penglong Ma, Yaping Mai, Ting Gao, Na Yu, Wenbao Zuo, Jianhong Yang

“…Herein, we developed an IL-15 functionalized biomimetic hybrid mRNA vaccine (LMPR) that activates NK cells in collaboration with CD8+T cells, compensating the MHC-dependent limitation to boost antitumor therapy. …”
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Genome-Wide Identification of the Shaker Potassium Channel Family in Chinese Cabbage and Functional Studies of <i>BrKAT1</i> in Yeast by Jin-Yan Zhou, Ze-Chen Gu, Dong-Li Hao

“…The difference between <i>BrKAT1.1</i> and <i>BrKAT1.2</i> lay in their promoter regulatory elements, suggesting that differences in transcriptional regulation contributed to the functional differentiation of <i>BrKAT1.1</i> and <i>BrKAT1.2</i>. …”
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Restoration of Miro1’s N-terminal GTPase function alleviates prenatal stress-induced mitochondrial fission via Drp1 modulation by Gee Euhn Choi, Ji Yong Park, Mo Ran Park, Chang Woo Chae, Young Hyun Jung, Jae Ryong Lim, Jee Hyeon Yoon, Ji Hyeon Cho, Ho Jae Han

“…Similarly, prenatal corticosterone exposure led to impaired neuropsychiatric and cognitive function in the offspring by affecting mitochondrial distribution and synaptogenesis, rescued by Miro1WT, but not N-terminal GTPase active form Miro1P26V, expression. …”
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Dual-functional injectable adhesive hydrogel delivering ginger-derived doxorubicin vesicles for osteosarcoma recurrence suppression and post-resection wound healing by Qiang Zhang, Qiang Zhang, Qiang Zhang, Qiang Zhang, Yu Zhang, Yu Zhang, Yu Zhang, Yu Zhang, Hui Chen, Hui Chen, Hui Chen, Hui Chen, Lei-Na Sun, Lei-Na Sun, Lei-Na Sun, Lei-Na Sun, Bin Zhang, Bin Zhang, Bin Zhang, Bin Zhang, Dong-Sheng Yue, Dong-Sheng Yue, Dong-Sheng Yue, Dong-Sheng Yue, Chang-Li Wang, Chang-Li Wang, Chang-Li Wang, Chang-Li Wang, Zhen-Fa Zhang, Zhen-Fa Zhang, Zhen-Fa Zhang, Zhen-Fa Zhang

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Integrated Jacobi elliptic function solutions to the (3+1)-dimensional generalized Kadomtsev–Petviashvili equation by utilizing new solutions of the elliptic equation of order six... by Ahmad H. Alkasasbeh, Belal Al-Khamaiseh, Ahmad T. Ali

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A method integrating a non-stationary random field for constrained inversion of CSAMT data by Qianwei DAI, Luyao GUO, Yun WU, Zhexian XIONG, Dan DUAN, Zhonglin BAO, Hongfei WU, Fengyun HAO

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Immunohistochemical Expression of Differentiated Embryonic Chondrocyte 1 and Cluster of Differentiation 44 in Oral Potentially Malignant Disorders by Bianca-Andreea Onofrei, Delia Gabriela Ciobanu Apostol, Mădălina-Gabriela Tanasă, Elena-Raluca Baciu, Cristina Popa, Ana Maria Sciuca, Mihaela Paula Toader, Victor-Vlad Costan

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Preventing White Adipocyte Browning during Differentiation In Vitro: The Effect of Differentiation Protocols on Metabolic and Mitochondrial Phenotypes by Elena Herbers, Mimmi Patrikoski, Anita Wagner, Riikka Jokinen, Antti Hassinen, Sini Heinonen, Susanna Miettinen, Hilkka Peltoniemi, Eija Pirinen, Kirsi H. Pietiläinen

“…We developed a workflow that included functional assays and morphological analysis of mitochondria and lipid droplets. …”
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Ultrasound-Assisted Extraction and Microencapsulation of <i>Durvillaea incurvata</i> Polyphenols: Toward a Stable Anti-Inflammatory Ingredient for Functional Foods by Nicolás Muñoz-Molina, Javier Parada, Angara Zambrano, Carina Chipon, Paz Robert, María Salomé Mariotti-Celis

“…These findings support the potential of microencapsulated <i>Durvillaea incurvata</i> extract as an anti-inflammatory ingredient for functional food development.…”
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A Novel Liquid Chromatographic Time-of-Flight Tandem Mass Spectrometric Method for the Determination of Secondary Metabolites in Functional Flours Produced from Grape Seed and Oliv... by Achilleas Panagiotis Zalidis, Natasa P. Kalogiouri, Ioannis Mourtzinos, Dimitris Sarris, Konstantinos Gkatzionis

“…This study introduces a liquid chromatographic time-of-flight tandem mass spectrometric method (LC-QTOF-MS/MS) to assess the phenolic profiles of functional flours from different origins and evaluate their potential use within the frame of a circular economy. …”
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Method for numerical solution of boundary value problems for equations in partial proizvodnyh with empirical functions on the basis of the integral Fredholm equation of the first k... by Igor Eduardovich Naats, Victoria Igorevna Naats, Roman Andreevich Ryskalenko

“…In this paper we describe a method of constructing approximate solutions to boundary value problems for differential equations in partial derivatives with the original data obtained in the experiment (empirical functions). …”
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Identification of prognostic hub genes and functional role of BAIAP2L2 in prostate cancer progression: a transcriptomic and experimental study by Xiangyang Zhan, Xiangyang Zhan, Xiangyang Zhan, Xiangyang Zhan, Wenkai Wang, Jie Lian, Yichun Li, Jianyi Gu, Jianyi Gu, Jianyi Gu, Jianyi Gu, Dongdong Guo, Dongdong Guo, Dongdong Guo, Dongdong Guo, Dongliang Xu, Dongliang Xu, Dongliang Xu, Dongliang Xu, Guanqun Ju, Guanqun Ju, Guanqun Ju, Guanqun Ju

“…BackgroundProstate cancer (PCa) is a prevalent malignancy in men, and understanding its molecular mechanisms is crucial for identifying therapeutic targets.MethodsTranscriptomic data from prostate tumors and matched healthy tissues were obtained from The Cancer Genome Atlas (TCGA). Differential expression analysis using the DESeq2 algorithm identified differentially expressed genes (DEGs). …”
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Combined proteomics and metabolomics analysis reveal the effect of a training course on the immune function of Chinese elite short‐track speed skaters by Tieying Li, Jing Shao, Nan An, Yashan Chang, Yishi Xia, Qi Han, Fenglin Zhu

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Comprehensive prognostic gene identification and functional characterization of GRAMD1A in Wilms tumor: development of risk prediction models and therapeutic implications by Qiang Zeng, Junfeng Tao, Lilu Qin, Yong Zeng, Zhong Liu, Mingxian Xu, Linshan Zeng

“…Identified differentially expressed genes (DEGs) underwent Gene Ontology (GO) and KEGG pathway enrichment analysis to explore biological functions and pathways associated with WT progression. …”
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