Integrated multi-omics analysis and functional validation uncovers RPL26 roles in regulating growth traits of Asian water buffaloes (Bubalus bubalis) by Yangyang Shen, Zhenjiang An, Linna Gao, Mingfa Gu, Shuwen Xia, Qiang Ding, Yinxia Li, Shaoxian Cao, Jianbin Li, Jinming Huang, Jifeng Zhong, Kunlin Chen, Xiao Wang, Huili Wang

“…Conclusions Our study illustrates RPL26 roles in regulating growth traits via both integrated multi-omics analysis and functional validations that suggests the further applications of RPL26 for growth trait selection of water buffaloes.…”
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Clinical Proficiency of Low Hemoglobin Density and Microcyte Anemia Factor Parameters for the Diagnosis of Functional Iron Deficiency from Absolute Iron Deficiency in Chronic Infla... by Fatemeh Karamshahi, Ali Noori-Zadeh, Ali Seidkhani-Nahal, Abdollah Davodian, Gholam Basati, Iraj Alipourfard

“…Conclusion: Among the new red blood cell parameters, although both %LHD and Maf can be used to differentiate patients with absolute iron deficiency from those with functional iron deficiency, Maf demonstrated higher clinical sensitivity and specificity.…”
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Analysis of the impact of minimally invasive esophagectomy on quality of life and functional prognosis in patients with esophageal squamous cell carcinoma: A retrospective comparat... by Bo Liu, Kebing Wang, Wei Wang, Si Ye

“…Postoperative evaluation demonstrated significant improvements in quality of life scores across multiple dimensions, including physical symptoms (P = 0.006), emotional management (P = 0.013), role function (P = 0.013), cognitive function (P = 0.042), and social function (P = 0.021). …”
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Functional Study of the circRNA_0006393/miR-375/IGFBP4 Axis in Fracture Healing Associated with Male Idiopathic Osteoporosis by Xiaoyi Guo, Jie Xu, Lin Chen, He Huang, Zewei Gao, Xijia Jiang

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Functional dissection and assembly of a small, newly evolved, W chromosome-specific genomic region of the African clawed frog Xenopus laevis. by Caroline M S Cauret, Danielle C Jordan, Lindsey M Kukoly, Sarah R Burton, Emmanuela U Anele, Jacek M Kwiecien, Marie-Theres Gansauge, Sinthu Senthillmohan, Eli Greenbaum, Matthias Meyer, Marko E Horb, Ben J Evans

“…To better understand how sex-limited regions evolve and function, we studied a small W chromosome-specific region of the frog Xenopus laevis that contains only three genes (dm-w, scan-w, ccdc69-w) and that drives female differentiation. …”
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Structural and functional alterations of neurons derived from sporadic Alzheimer’s disease hiPSCs are associated with downregulation of the LIMK1-cofilin axis by Raimondo Sollazzo, Domenica Donatella Li Puma, Giuseppe Aceto, Fabiola Paciello, Claudia Colussi, Maria Gabriella Vita, Guido Maria Giuffrè, Francesco Pastore, Alessia Casamassa, Jessica Rosati, Agnese Novelli, Sabrina Maietta, Francesco Danilo Tiziano, Camillo Marra, Cristian Ripoli, Claudio Grassi

“…However, they differed in neuronal differentiation and function. sAD-derived neurons (sAD-hNs) displayed increased levels of AD-related proteins, including Aβ and phosphorylated tau. …”
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Reprogrammed human lateral ganglionic eminence precursors generate striatal neurons and restore motor function in a rat model of Huntington’s disease by Amy McCaughey-Chapman, Anne Lieke Burgers, Catharina Combrinck, Laura Marriott, David Gordon, Bronwen Connor

“…We investigated the ability for hiLGEPs to survive transplantation, differentiate to medium spiny-like striatal neurons and improve motor function in the QA lesion rat model of HD. …”
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ArfGAP3 Protects Mitochondrial Function and Promotes Autophagy Through Rab5a‐Mediated Signals in Ageing Skeletal Muscle by Mao Chen, Xiaoyu Huang, Bingshu Li, Ya Xiao, Liying Chen, Fangyi Zhu, Shasha Hong, Jianming Tang, Suting Li, Jie Min, Wenyi Jin, Yubiao Zhang, Lian Yang, Yang Li, Shufei Zhang, Li Hong

“…Knockdown of ArfGAP3 exacerbated impaired differentiation potential and induced aberrant mitochondrial morphology and functional dysfunction in ageing C2C12 myoblasts, whereas ArfGAP3 overexpression largely mitigated these effects. …”
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Stability for a Class of Differential Equations with Nonconstant Delay by Jin Liang, Tzon-Tzer Lu, Yashan Xu

“…Stability is investigated for the following differential equations with nonconstant delay x't=qtFxt-ptfxt-τt, where p:[0,+∞)→[0,+∞), q:[0,+∞)→R, τ:[0,+∞)→[0,r], and F and f:R→R with xfx>0   for   x≠0   and   x≤a (a is a positive constant) are continuous functions. …”
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Interplay between ALK2R206H mutant receptor and autophagy signaling regulates receptor stability and its chondrogenic functions by Laura Coculo, Marius Wits, Irene Mariani, Giulia Fianco, Serena Cappato, Renata Bocciardi, Nicoletta Pedemonte, Elisabetta Volpe, Serena Ciolfi, Rosario Luigi Sessa, Serena Rinaldo, Francesca Cutruzzolà, Daniela Trisciuoglio, Marie-Josè Goumans, Gonzalo Sanchez-Duffhues, Venturina Stagni

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Klf5-adjacent super-enhancer functions as a 3D genome structure-dependent transcriptional driver to safeguard ESC identity by Guangsong Su, Bohan Chen, Yingjie Song, Qingqing Yin, Wenbin Wang, Xueyuan Zhao, Sibo Fan, Jie Lian, Dongqing Li, Jinfang Bi, Peng Li, Zhongfang Zhao, Lei Zhang, Jiandang Shi, Wange Lu

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Generation of functional neutrophils from a mouse model of X-linked chronic granulomatous disorder using induced pluripotent stem cells. by Sayandip Mukherjee, Giorgia Santilli, Michael P Blundell, Susana Navarro, Juan A Bueren, Adrian J Thrasher

“…In the longer term, correction of iPSC from human patients with CGD has therapeutic potential not only through generation of transplantable haematopoietic stem cells, but also through production of large numbers of autologous functional neutrophils.…”
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A new family of q-Bernstein polynomials: probabilistic viewpoint by Ayse Karagenc, Mehmet Acikgoz, Serkan Araci

“…In this paper, we introduce a new class of polynomials, called probabilistic q-Bernstein polynomials, alongside their generating function. Assuming [Formula: see text] is a random variable satisfying moment conditions, we use the generating function of these polynomials to establish new relations. …”
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Stability Analysis of a Mathematical Model for Infection Diseases with Stochastic Perturbations by Marina Bershadsky, Leonid Shaikhet

Subjects: “…the general method of constructing Lyapunov functionals…”
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Crohn’s Disease-associated variant in laccase domain containing 1 (LACC1) modulates T cell gene expression, metabolism and T cell function by Yingcong Li, Gabriel Ascui, Martina Dicker, Thomas Riffelmacher, Vivek Chandra, Benjamin Schmiedel, Ting-Fang Chou, Pandurangan Vijayanand, Mitchell Kronenberg

“…Human CD4+ T cells with LACC1 gene knockdown show altered metabolism, including reduced oxygen consumption rate, and reduced in vitro regulatory T cell differentiation. Therefore, our study provides a mechanism linking these specific LACC1 variants to colitis by attributing promoter region variants to changes in T cell metabolism and function.…”
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Prediction of the time course of callus stiffness as a function of mechanical parameters in experimental rat fracture healing studies--a numerical study. by Tim Wehner, Malte Steiner, Anita Ignatius, Lutz Claes

“…Based on this corroborated model, a fit curve function was derived which predicts the increase of callus stiffness dependent on bodyweight, fixation stiffness, and fracture gap size. …”
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Stem cell-derived exosomes: a potential therapeutic strategy for enhancing tendon stem/progenitor cells function in tendon-bone healing by Junjie Tang, Peng Shen, Xinyuan Wu, Minhao Chen, Hua Xu

“…This review provides an overview of the mechanisms and functions of stem cell-derived exosomes in altering the properties of TSPCs and facilitating tendon-bone healing. …”
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Engineering 3D Scaffold‐Free Nanoparticle‐Laden Stem Cell Constructs for Piezoelectric Enhancement of Human Neural Tissue Formation and Function by Emma Claire James, Eva Tomaskovic‐Crook, Jeremy Micah Crook

“…Here engineering novel 3D scaffold‐free human neural stem cell constructs with integrated piezoelectric nanoparticles for enhanced neural tissue induction and function is described. Tetragonal barium titanate (BaTi03) nanoparticles are employed as piezoelectric stimulators prepared as cytocompatible dispersions, incorporated into 3D self‐organizing neural spheroids, and activated wirelessly by ultrasound. …”
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The Role of Brain-Derived Neurotrophic Factor as an Essential Mediator in Neuronal Functions and the Therapeutic Potential of Its Mimetics for Neuroprotection in Neurologic and Psy... by Tadahiro Numakawa, Ryutaro Kajihara

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GB18-06, a nanobody targeting GDF15, effectively alleviates weight loss and restores physical function in cachexia models by Yu Huang, Jinyong Wang, Xiling Wei, Hui Zhang, Wei Shang, Xiangling Zhang, Lanjiao Zhai, Xi Chen, Huiming Li, Suofu Qin

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