Epigenetic Regulation of IFI44L Expression in Monocytes Affects the Functions of Monocyte-Derived Dendritic Cells in Systemic Lupus Erythematosus by Shuaihantian Luo, Ruifang Wu, Qianwen Li, Guiying Zhang

“…However, little is known about the mechanism and function of IFI44L overexpression in SLE. In this study, we aimed to investigate the epigenetic mechanism of IFI44L overexpression in SLE monocyte and its potential functions contributing to the pathogenesis of SLE. …”
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Função interpretativa, alopoiese do direito e hermenêutica da cordialidade / Function of legal interpretation, allopoietical law and cordiality hermeneutics by Guilherme Leite Gonçalves

“…</p> <p class="Standard"><strong> Abstract</strong></p> <p class="Standard">This article seeks to analyze the function of the legal interpretation in the differentiation process of Law in modern society and to question the universalizability of this premise in light of the Brazilian case. …”
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Ultrasound-driven wireless piezoelectric hydrogel synergizes with cotransplantation of NSCs–hUCMSCs for structural and functional recovery in spinal cord injury by Hao Zhong, Mi Zhou, Junrui Guo, Danyang Chen, Cong Xing, Song Liu, Hongjiang Yang, Hongpeng Ma, Qi Zhang, Jianhai Yang, Shiqing Feng, Guangzhi Ning

“…Neural stem cells (NSCs) have the potential to promote functional recovery after SCI; however, their therapeutic potential is limited by poor survival, restricted proliferation, and suboptimal differentiation. …”
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Comparative non-targeted metabolomics reveals distinct metabolic profiles and functional traits in six mung bean (Vigna radiata) varieties. by Xinting Shen, Huifang Shen, Fei Wang, Yao Wang, Rui Zhao, Zhebin Li, Ye Zhou, Xinmiao Yao

“…The study also offers a scientific basis for the development of functional mung bean products and future breeding strategies focused on metabolic traits.…”
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Dual-functional titanium implants via polydopamine-mediated lithium and copper co-incorporation: synergistic enhancement of osseointegration and antibacterial efficacy by Jun Li, Bo Jiang, Liu Yang, Pu Zhang, Jingwen Wu, Yalan Yang, Yan Yang, Guiling Wang, Jie Chen, Ling Zhang, Shiqin Huang, Lingli Zhang, En Zhang

“…In vivo efficacy was evaluated in a rat femoral defect model via micro-CT and histology.Results and discussionLi+-functionalized surfaces (PDA@Li 800) enhanced osteoblast proliferation and osteogenesis via Wnt/β-catenin activation. …”
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Integrated and Functional Genomics Analysis Validates the Relevance of the Nuclear Variant ErbB380kDa in Prostate Cancer Progression. by Mahmoud El Maassarani, Alice Barbarin, Gaëlle Fromont, Ouafae Kaissi, Margot Lebbe, Brigitte Vannier, Ahmed Moussa, Paule Séité

“…The nuclear localization of ErbB3 has been reported in various cancer tissues and cell lines but the nuclear functions and the putative correlation with tumour progression and resistance to therapy remain unclear. …”
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Comparison of 4-Weeks Motor Relearning Programme and Mirror Therapy in Improving Upper Limb Motor Function In Stroke Patients - RCT by Zujaja Ashraf, Aqsa Naveed, Nimra Sultan, Nimra Rafaqat, Maham Nasir, Wardah Zafar, Gaber S Soliman

“…Conclusion: It is determined that Motor Relearning Programme and Mirror Therapy did not show any significant improvement in upper limb motor function among the two groups while on differentiation within the groups Motor Relearning Programme results were more remarkable that of Mirror Therapy. …”
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Neuroligin-3 R451C induces gain-of-function gene expression in astroglia in an astroglia-enriched brain organoid model by Rui Dang, Mridul Dalmia, Ziyuan Ma, Mengmeng Jin, Kushal Aluru, Vincent R. Mirabella, Ava V. Papetti, Li Cai, Peng Jiang

“…In this study, we introduce a robust method for generating astroglia-enriched organoids through BMP4 treatment during the neural differentiation phase of organoid development. Our RNA sequencing analysis reveals that astroglia developed within these organoids exhibit advanced developmental characteristics and enhanced synaptic functions compared to those grown under traditional two-dimensional conditions, particularly highlighted by increased neurexin (NRXN)-neuroligin (NLGN) signaling. …”
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Regulation of immune responses by a tumor necrosis factor in pearl oysters: insights from PmTNF gene expression and function by Wu Yifan, Liang Bidan, Liang Haiying

“…Tumor necrosis factor (TNF) is a multifunctional cytokine that regulates cellular processes such as inflammation, apoptosis, differentiation, and proliferation and activates various functions of the immune system. …”
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Characterizing the Endophytic Microbiome and Microbial Functional Assemblages Associated with Fengtang Plum (<i>Prunus salicina</i> Lindl.) Development and Resistance by Jiqing Lei, Yinna Shi, Hong Li, Rui Wang

“…This study elucidates microbial community succession patterns during Fengtang plum development; notably, functional predictions were inferred from 16S/ITS sequencing data rather than direct metagenomic or metatranscriptomic analyses, thus limiting mechanistic interpretations, though future work integrating multi-omics approaches would strengthen functional insights.…”
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Interpenetrating network hydrogel-loaded embryonic stem cell-derived endocardial cells improves cardiac function after myocardial infarction by Boshi Liu, Laiping Zhang, Xiao Guan, Jie Liu, Weinian Shou, Xin Chen, Xiaohui Li, Dayan Cao

“…Abstract Background With an in-depth understanding of cardiac cell differentiation, cell therapy derived from stem cells has shown promising therapeutic effects in the treatment of myocardial infarction (MI). …”
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The Important Role of Dendritic Cell (DC) in iNKT-Mediated Modulation of NK Cell Function in Chlamydia pneumoniae Lung Infection by Lei Zhao, Xiaoling Gao, Hong Bai, Antony George Joyee, Shuhe Wang, Jie Yang, Weiming Zhao, Xi Yang

“…In this study, we investigated the influence and mechanism of iNKT cell on the differentiation and function of NK cell in Cpn lung infection and the role played by DCs in this process. …”
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Dual-transcriptomics on microdissected cells reveals functional specialisation of symbiont-bearing-cells and contrasted responses to nutritional stress in the cereal weevil by Nikoletta Galambos, Nicolas Parisot, Agnès Vallier, Claudia Bevilacqua, Séverine Balmand, Carole Vincent-Monégat, Rita Rebollo, Benjamin Gillet, Sandrine Hughes, Abdelaziz Heddi, Anna Zaidman-Rémy

“…We found that central bacteriocytes overexpress transport and G-protein signalling-related genes when compared to peripheral bacteriocytes, indicating a signalling and/or transport function of these cells. Diet composition strongly impacts host and endosymbiont gene expression and reveals a molecular trade-off among metabolic pathways. …”
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Selective Modulation of Osteoclast Function by <i>Bothrops moojeni</i> Venom and Its Fractions: Implications for Therapeutic Targeting in Bone Diseases by Fernanda D’Amélio, Hugo Vigerelli, Isabel de Fátima Correia Batista, Rodrigo Pinheiro Araldi, Álvaro R. B. Prieto-da-Silva, Daniel Carvalho Pimenta, Irina Kerkis

“…Our study explores the differential effects of <i>Bothrops moojeni</i> venom and its fractions on osteoclast (OC) morphology, function, and osteoclastogenesis. …”
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<i>Andrographis paniculata</i> Extract Supports Skin Homeostasis by Enhancing Epidermal Stem Cell Function and Reinforcing Their Extracellular Niche by Roberta Lotti, Laetitia Cattuzzato, Xuefeng Huang, David Garandeau, Elisabetta Palazzo, Marika Quadri, Cécile Delluc, Eddy Magdeleine, Xiaojing Li, Mathilde Frechet, Alessandra Marconi

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The Correlation Between DRD2 and COMT Gene Polymorphisms, HPT and HPG Axes Functions, and Antipsychotic Drug-Induced Hyperprolactinemia and Macroprolactinemia by Wang Z, Li J, Chen H, Jin H, Wang S, Hu X

“…The polymorphisms of DRD2 Taq1A and COMT Val158Met were analyzed using RFLP-PCR at baseline, and the levels of total prolactin (T-PRL), macroprolactin, C peptide (C-P), estradiol (E2), cholesterol (TC), low density lipoprotein (LDL), insulin, cortisol, thyroid function, and reproductive hormone were measured at baseline and the end of the fourth week of treatment. …”
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Frog‐Derived Neuroregenerative‐Peptide‐Reinforced Bioactive Hydrogels with Injectability, Thermosensitivity, and Enhanced Neurotrophic Function for Repairing Central Nervous Injuri... by Zhengang Sun, Zhenjuan Sun, Chenxi Du, Hongyu Chen, Xingchao Zhang, Yuanyuan Liu, Fang Dong, Xuexiao Ma, Gang Wei, Haiyuan Yue

“…Furthermore, PCV hydrogels reduce immune responses and limit excessive astrocyte proliferation, significantly improving motor function recovery in rats with spinal cord injuries. …”
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Chicken GLUT4 function via enhancing mitochondrial oxidative phosphorylation and inhibiting ribosome pathway in skeletal muscle satellite cells by Lin Zhang, Pengna Luo, Huihong Li, Yuxian Pan, Huaiyong Zhang, Xuemeng Si, Wen Chen, Yanqun Huang

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The interaction networks of small rubber particle proteins in the latex of Taraxacum koksaghyz reveal diverse functions in stress responses and secondary metabolism by Silva Melissa Wolters, Natalie Laibach, Jenny Riekötter, Kai-Uwe Roelfs, Boje Müller, Jürgen Eirich, Richard M. Twyman, Iris Finkemeier, Dirk Prüfer, Dirk Prüfer, Christian Schulze Gronover

“…Our data contribute to the functional differentiation between TkSRPP paralogs and demonstrate unexpected interactions that will help to further elucidate the network of proteins linking TkSRPPs, stress responses and NR biosynthesis within the cellular complexity of latex.…”
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Operators of potential type in problems of applied analysis by Igor Eduardovich Naats, Victoria Igorevna Naats, Roman Andreevich Riskalenko, Elena Pavlovna Yartseva

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