Identification of ZNF652 as a Diagnostic and Therapeutic Target in Osteoarthritis Using Machine Learning by Chen Y, Liang R, Zheng X, Fang D, Lu WW, Chen Y

“…Nevertheless, its role in OA has not been elucidated.Methods: The search term “osteoarthritis” was utilized to procure transcriptome data relating to OA patients and healthy people from the Gene Expression Omnibus (GEO) database. …”
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A usability evaluation framework for a mobile application in supporting home-based rehabilitation for stroke patients: A qualitative study by Shih-Ying Chien

“…Conclusions Satisfaction and performance surveys and qualitative data analysis revealed that most participants described the interface design of the app as intuitive and easy to use. …”
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Use of modern family planning methods and its association with quality of life among Rwandan women: a multi-center cross-sectional study by Uwineza Mireille Aimee, Diomède Ntasumbumuyange, Polyphile Ntihinyurwa, Izere Salomon, Aurore Nishimwe, Stephen Rulisa

“…The Short-Form 36 (SF-36) Health Survey was used to evaluate the QoL. Data analysis was performed using the R programming version 4.0.2. …”
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Clinical Prediction of Secondary Bloodstream Infections in Patients with Cerebral Infarction: A Nomogram-Driven Risk Assessment Model Based on LASSO Regression by Zhang L, Li X, Cai D, Mei C, Lu L

“…The LASSO analysis identified four predictors: The following variables were found to have a statistically significant relationship to the occurrence of the primary complication: peripherally inserted central venous catheters (PICC) (odds ratio [OR] = 2.791, 95% confidence interval [CI] =1.514– 5.148), use of ventilators(VA) (OR = 2.771, 95% CI=1.410– 5.443), Indwelling urinary catheters(CAU) (OR = 1.800, 95% CI= 0.990– 3.276), and hypoalbuminemia (OR = 3.643, 95% CI=2.195– 6.046).The nomogram demonstrated an AUC of 0.789 in the training set and 0.778 in the test set, indicating a satisfactory model fit across data sets. …”
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The association of visceral and subcutaneous fat areas with phenotypic age in non-elderly adults, mediated by HOMA-IR and HDL-C by Yuanhong Liu, Min Xu, Liqing Wang, Linyun Meng, Mengran Li, Shumin Mu

“…Abstract Background Ageing results in diminished adaptability, as well as declines in physiological and psychological functions and resilience. The epigenetic clock ‘Phenotypic Age’ (PhenoAge) represents ‘preclinical ageing’. …”
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Who’s Who & Whereabouts by Petter Granli, Joyce Poole

“…The main components of the system are: a searchable database (Who’s Who) of registered adult elephants with admin and user interfaces; a searchable database of observations (Whereabouts) including elephant sightings, signs, sick and wounded individuals, and mortalities, with admin and user interfaces; a user interface (My Observations) for entering and edit of data; a Smartphone application (EleApp) permitting collection and upload of data; a searchable Google-Earth-based Mapping interface with export functionality; a Features Guide (photographs and text describing how to identify elephants); a User Info. …”
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Circular RNA profiling identifies circ_0001522, circ_0001278, and circ_0001801 as predictors of unfavorable prognosis and drivers of triple-negative breast cancer hallmarks by Dania Awata, Vishnubalaji Radhakrishnan, Hibah Shaath, Ramesh Elango, Sameera Rashid, Mohammed Akhtar, Thasni Karedath Abdul Azis, Ikhlak Ahmed, Khalid Ouararhni, Ammira S. Al-Shabeeb Akil, Nehad M. Alajez

“…Among these, the expression of circ_0001522, circ_0001278, and circ_0001801 was validated using divergent primers, and their backsplice junctions were confirmed using Sanger sequencing. Functionally, siRNA-mediated knockdown of these circRNAs significantly suppressed cell proliferation, colony formation, three-dimensional organoid growth, and cell migration in TNBC models. …”
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The application of One Health concept in China and its practice and innovation in cross-sector cooperation by Yang Gao, Chengyue Li, Qingyu Zhou, Mo Hao

“…Methods: From June to August 2023, 30 semi-structured interviews were conducted with experts from the Health Commission, Centre for Disease Control and Prevention, Department of Ecology and Environment, Ministry of Agriculture and Rural Affairs, Department of Transportation, Administration for Market Regulation, and other departments. Qualitative analysis of the interview data was performed using NVivo12. …”
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Interleukin‐11 promotes lung adenocarcinoma tumourigenesis and immune evasion by Cristina Cirauqui, Laura Ojeda, Itziar Otano, Irene Pazos, Alba Santos, Eva M. Garrido‐Martín, Patricia Yagüe, Javier Ramos‐Paradas, Sonia Molina‐Pinelo, Giovanna Roncador, José Luis Solórzano, M. Teresa Muñoz, Patricia Cozar, Patricia Plaza, Rocío Suárez, Marta Jiménez, Roberto Moreno, Arantxa Rosado, Pablo Gámez, Ricardo García‐Luján, Jon Zugazagoitia, E. Alejandro Sweet‐Cordero, Mariano Barbacid, Amancio Carnero, Irene Ferrer, Luis Paz‐Ares

“…LUAD cell lines genetically engineered to overexpress or to silence IL‐11 or its receptor (IL‐11RA) were used for in vitro functional analysis and for in vivo experiments. Additionally, we used three different in vivo models: patient‐derived xenografts (PDXs), tobacco‐exposed mice and genetically engineered mouse models. …”
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Fecal Metabolome and Bacterial Composition in Severe Obesity: Impact of Diet and Bariatric Surgery by Nuria Salazar, Manuel Ponce-Alonso, María Garriga, Sergio Sanchez-Carrillo, Ana María Hernández-Barranco, Begoña Redruello, María Fernández, José Ignacio Botella-Carretero, Belén Vega-Piñero, Javier Galeano, Javier Zamora, Manuel Ferrer, Clara G de Los Reyes-Gavilán, Rosa Del Campo

“…The study also aimed to incorporate big data analysis for the omics results and machine learning by a Lasso-based analysis to detect the potential markers for excess weight loss. …”
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Structure–property models of organic compounds based on molecular graphs with elements of the spatial structures of the molecules by N. A. Shulaeva, M. I. Skvortsova, N. A. Mikhailova

“…First, it is assumed that the required structure–property equation has a definite form and depends on several adjusted numerical parameters and two changeable functions of one variable. In this step, from some set of functions, the pair of functions that provide the best model is selected. …”
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Digital cognitive training in children with attention-deficit/hyperactivity disorder: a study protocol of a randomised controlled trial by Sally Richmond, Hannah Kirk, Kim Cornish, Mark A Bellgrove, Tori Gaunson, Meg Bennett

“…Introduction Attention-deficit/hyperactivity disorder (ADHD) is one of the most prevalent neurodevelopmental disorders and is a persistent pattern of inattention and/or hyperactivity-impulsivity that interferes with daily functioning. Children with ADHD are developmentally vulnerable, with the disorder linked to emotional regulation difficulties, behavioural disturbances, as well as academic challenges. …”
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PSYCHOLOGICAL ASPECTS OF QUALITY OF LIFE AND PROGNOSIS OF REHABILITATION IN PATIENTS WITH ULCERATIVE COLITIS by T. E. Chernyshova, O. A. Neganova, S. N. Styazhkina, A. A. Valinurov

“…UC patients are characterized by a significant decrease in physical and emotional functioning. The analysis of personal and situational anxiety demonstrated an association between psychological health and social functioning. …”
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High-Frequency Cognitive Control Training for Depression: Case Report by Yannick Vander Zwalmen, Kristof Hoorelbeke, David Demeester, Ernst H W Koster

“…Reliable change indices were calculated for several self-report questionnaires, measuring cognitive and affective functioning. ResultsCognitive task performance suggests improved cognitive functioning after training (accuracy scores increased from 43/181, 24% at baseline to 110/181, 61% shortly after training), which was maintained at follow-up (accuracy scores around 50%). …”
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Tongue squamous cell carcinoma-derived exosomes miR-21-5p affect tumor progression via promoting M2 macrophage polarization by Zixian Xu, Xin Fang, Shan Wang, Jiabei Mu, Qixian Gai, Yantong Chen, Zheyi Sun, Jiemei Zhai

“…Additionally, we performed single-sample gene set enrichment analysis (ssGSEA), constructed a multivariate Cox regression model, and performed survival analysis using paired RNA transcriptome and clinical data from TSCC patients. …”
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Prevalence and Factors Associated with Self-Reported Vision Disability among the Elderly in Malaysia: Findings from National Health and Morbidity Survey (NHMS) 2018 by Muhammad Solihin Rezali, Nor’ Ain Ab Wahab, Norhafizah Sahril, Muhd Hafizuddin Taufik Ramli, Nik Adilah Shahein, Ying Ying Chan, Nur Liana Ab Majid, Mohd Hasnan Ahmad, Mohd Shaiful Azlan Kassim

“…The data were analyzed using SPSS version 21.0 utilizing a complex sample design with multivariable logistic regression analysis to determine the prevalence and associated factors to vision disability. …”
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Smart CAR-T Nanosymbionts: archetypes and proto-models by Juan C. Baena, Juan C. Baena, Juan Sebastián Victoria, Juan Sebastián Victoria, Alejandro Toro-Pedroza, Alejandro Toro-Pedroza, Cristian C. Aragón, Cristian C. Aragón, Joshua Ortiz-Guzman, Joshua Ortiz-Guzman, Joshua Ortiz-Guzman, Juan Esteban Garcia-Robledo, Juan Esteban Garcia-Robledo, David Torres, Lady J. Rios-Serna, Lady J. Rios-Serna, Ludwig Albornoz, Joaquin D. Rosales, Joaquin D. Rosales, Carlos A. Cañas, Carlos A. Cañas, Carlos A. Cañas, Gustavo Adolfo Cruz-Suarez, Gustavo Adolfo Cruz-Suarez, Gustavo Adolfo Cruz-Suarez, Gustavo Adolfo Cruz-Suarez, Felipe Ocampo Osorio, Felipe Ocampo Osorio, Felipe Ocampo Osorio, Tania Fleitas, Ivan Laponogov, Alexandre Loukanov, Alexandre Loukanov, Alexandre Loukanov, Kirill Veselkov, Kirill Veselkov

“…At the same time, artificial intelligence (AI), with its powerful algorithms for data analysis and predictive modeling, is transforming how we design, evaluate, and monitor advanced therapies, including the optimization of manufacturing processes. …”
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A new method for dealing with collider bias in the PWP model for recurrent events in randomized controlled trials by Chen Shi, Jia-Wei Wei, Zi-Shu Zhan, Xiao-Han Xu, Ze-Lin Yan, Chun-Quan Ou

“…The characteristic of the simulation data was the baseline hazard changed with the number of events. …”
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Sewage sludge-derived biochar modified with MgCl2: Used as adsorbent material for phosphorus removal from aqueous medium by Valber Georgio de Oliveira Duarte, Jader Alves Ferreira, Denise Eulálio, Guilherme Max Dias Ferreira, Vera Regina Leopoldo Constantino, Gustavo Franco de Castro, Jairo Tronto

“…Additionally, the kinetic data showed that the pseudo-second-order model better fitted the experimental data. …”
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ARID1A deficiency attenuates the response to EGFR-TKI treatment in lung adenocarcinoma by Fangfang Yang, Fangfang Yang, Helei Hou, Guanqun Wang, Guangming Fu, Xingfa Huo, Xueqin Duan, Na Zhou, Xiaochun Zhang

“…AT-rich interactive domain 1A (ARID1A), which is a key subunit of SWI/SNF complexes, demonstrates critical regulatory functions as a tumour suppressor gene in cancer. The aim of this study is to determine the role of ARID1A deficiency in the therapeutic efficacy of EGFR-TKIs in LUAD.MethodsWe identified the ARID1A mutation as a potential prognostic marker in EGFR-mutant LUAD by analysing data from cBioPortal. …”
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