Impact of microgravity on retinal neuroimmune responses and visual dysfunction in rats by Jin-Shuo Liu, Nai-Qin Yan, Ying-Yan Mao, Chen Xin, Da-Peng Mou, Xin-Xiao Gao, Jia Guo, Ning-Li Wang, Si-Quan Zhu

“…The number of retinal ganglion cells (RGCs) was quantified via immunofluorescence, the activation of astrocytes and microglial cells was determined, and Sholl analysis was conducted to assess the function and morphology of microglial cells. …”
Get full text

Centrifugation versus filtration-based cell salvage: impact on perioperative bleeding in cardiac surgery—the COLTRANE randomised clinical trial – study protocol by Christine Mouton, Nicolas Nesseler, Antoine Bénard, Mathieu Pernot, Alexandre Ouattara, Antoine Beurton, Alexandre Mansour, Victor-emmanuel Brett, Corinne Batsale, Anais Aitgougam, Anais Cordon, Aurelie Fresselinat, Geraldine Robert, Julien Imbault

“…Individual participant data will be made available on reasonable request to qualified researchers, following review and approval by the study sponsor and ethics committee.Trial registration number ClinicalTrials.gov, NCT06425614.…”
Get full text

Prognostic implications of the interaction between intratumoral microbiome and immune response in gastric cancer by Sifan Liu, Lingyu Qi, Lu Dong, Wenjing Sun, Siying Liu, Peng Li, Nan Zhang

“…The key genes were correlated with immune cells and suppressed the function of the host immune system. The intratumoral microbiomes were strongly associated with the hosts’ immune infiltration and significantly interacted with host immune genes to influence GC outcomes. …”
Get full text

Chronic exposure to polyethylene terephthalate microplastics induces gut microbiota dysbiosis and disordered hepatic lipid metabolism in mice by Tao Lu, Huan Liu, Xiaoqing Yuan, Desheng Li, Guanqing Zhang, Yue Wang, Qiqiang Xie, Xinhao Wang, Jingjian Chi, Zhenzhen Wang, Shaoping Wang, Yanling Gao, Ling Zhou, Maolei Xu

“…The results confirmed, for the first time, that PET MPs can induce oxidative stress, lipid accumulation, and apoptosis in liver cells, resulting in structural damage and functional abnormalities in the liver. Additionally, metabolomic analysis was combined with intestinal microbiota profiling to elucidate the potential toxicological mechanism. …”
Get full text

Repertoire-based mapping and time-tracking of T helper cell subsets in scRNA-Seq by Daniil K. Lukyanov, Daniil K. Lukyanov, Valeriia V. Kriukova, Kristin Ladell, Irina A. Shagina, Irina A. Shagina, Dmitry B. Staroverov, Dmitry B. Staroverov, Bella E. Minasian, Anna S. Fedosova, Pavel Shelyakin, Oleg N. Suchalko, Alexander Y. Komkov, Konstantin A. Blagodatskikh, Kelly L. Miners, Olga V. Britanova, Olga V. Britanova, Olga V. Britanova, Andre Franke, David A. Price, David A. Price, Dmitry M. Chudakov, Dmitry M. Chudakov, Dmitry M. Chudakov, Dmitry M. Chudakov, Dmitry M. Chudakov

“…IntroductionThe functional programs of CD4+ T helper (Th) cell clones play a central role in shaping immune responses to different challenges. …”
Get full text

Use of an extended KDIGO definition to diagnose acute kidney injury in patients with COVID-19: A multinational study using the ISARIC-WHO clinical characterisation protocol. by Marina Wainstein, Samual MacDonald, Daniel Fryer, Kyle Young, Valeria Balan, Husna Begum, Aidan Burrell, Barbara Wanjiru Citarella, J Perren Cobb, Sadie Kelly, Kalynn Kennon, James Lee, James Lee, Laura Merson, Srinivas Murthy, Alistair Nichol, Malcolm G Semple, Samantha Strudwick, Steven A Webb, Patrick Rossignol, Rolando Claure-Del Granado, Sally Shrapnel, ISARIC Clinical Characterisation Group

“…Compared to those without AKI, patients in the eKDIGO group had worse renal function on admission, more in-hospital complications, higher rates of ICU admission (54% versus 23%) invasive ventilation (45% versus 15%), and increased mortality (38% versus 19%). …”
Get full text

Accelerometry-Assessed Physical Activity and Circadian Rhythm to Detect Clinical Disability Status in Multiple Sclerosis: Cross-Sectional Study by Nicole Bou Rjeily, Muraleetharan Sanjayan, Pratim Guha Niyogi, Blake E Dewey, Alexandra Zambriczki Lee, Christy Hulett, Gabriella Dagher, Chen Hu, Rafal D Mazur, Elena M Kenney, Erin Brennan, Anna DuVal, Peter A Calabresi, Vadim Zipunnikov, Kathryn C Fitzgerald, Ellen M Mowry

“…MethodsThis study represents an analysis of the baseline data from the prospective HEAL-MS (home-based evaluation of actigraphy to predict longitudinal function in multiple sclerosis) study. …”
Get full text

Effect of Clinic-Based and Asynchronous Video-Based Exercise on Clinic and Psychosocial Outcomes in Patients With Knee Osteoarthritis: Quasi-Experimental Study by Chidozie E Mbada, Henry Akintunji Awosika, Oluwatobi Ademola Sonuga, Micheal Akande, Tadesse Gebrye, Richard Woolf, Francis Fatoye

“…Eight out of 62 participants discontinued participation. Data collection and analysis have been completed. …”
Get full text

The Effect of Randomized Beta-Carotene Supplementation on CKD in Men by Api Chewcharat, Pol Chewcharat, Kathryn M. Rexrode, Robert J. Glynn, Julie E. Buring, John Michael Gaziano, Howard D. Sesso

“…Previous studies in animal models have demonstrated a potential protective effect of 30 mg/kg BC supplementation on renal ischemia or reperfusion injury and subsequently improved kidney function. The extension of these findings to humans, however, remains unclear. …”
Get full text

Cross-sectional study on exercise capacity in obese patients with severe obstructive sleep apnea syndrome by Shengrui Mei, Yue Zhou, Wenjun Wu, Xiaochuan Cui, Junyan Cai, Peng Yuan, Shukun Deng

“…After adjusting for confounding factors such as gender, age, exercise habits, smoking history, hypertension and diabetes, the multivariate model still maintained significant correlations.ConclusionSevere OSAS, as a severe complication of obesity, further exacerbates the decline in exercise capacity among obese patients, with the extent of impairment positively correlated with AHI values.CPET can be used to assess cardiopulmonary function in patients with obesity and OSAS. Early intervention can be carried out for obese patients with severe OSAS who show a downward trend in cardiopulmonary exercise indicators.…”
Get full text

Impact of Urban-Rural Integrated Development on Carbon Emission Intensity of Land Use: A Case Study of the Changsha–Zhuzhou–Xiangtan Urban Agglomeration by Li Xiaoqing, Zhou Guohua, Cui Shuqiang, Wang Hua, Liu Hui, Yu Xuexia

“…We found that 1) urban-rural integration accelerates the circulation of human, capital, technology, and other factors in urban and rural production and living activities, which affect the pattern and function of regional carbon sources and sinks by improving land-use efficiency, optimizing land allocation, and increasing energy consumption. …”
Get full text

Model for predicting risk of developing drug-induced liver injury during remdesivir therapy: observational prospective open case-control study by Yu. V. Shevchuk, A. V. Kryukov, I. I. Temirbulatov, I. V. Sychev, K. B. Mirzaev, N. P. Denisenko, Sh. P. Abdullaev, S. N. Tuchkova, V. I. Vechorko, O. V. Averkov, D. A. Sychev

“…The patients in both groups underwent a pharmacogenetic study, and a retrospective analysis of medical records was performed. Based on the data obtained, the association of clinical, laboratory, pharmacological and pharmacogenetic parameters with the development of drug-induced liver damage during remdesivir therapy was studied.Results. …”
Get full text

Trauma center vs. nearest non-trauma center: direct transport or bypass approach for out-of-hospital traumatic cardiac arrest by Ming-Fang Wang, Chen-Bin Chen, Chip-Jin Ng, Wei-Chen Chen, Shang-Li Tsai, Chien-Hsiung Huang, Chi-Yuan Chang, Li-Heng Tsai, Chi-Chun Lin, Cheng-Yu Chien

“…Abstract Background Out-of-hospital traumatic cardiac arrest (TCA), a sudden loss of heart function caused by severe trauma such as blunt, penetrating, or other injuries, presents significant public health challenges due to its high severity and extremely low survival rates. …”
Get full text

Serum sPD-1 as a marker of T cell exhaustion in ART-naïve, ART-experienced, and intestinal parasite co-infected HIV-positive adults at the university of Gondar comprehensive specia... by Tadelo Wondmagegn, Wubet Birhan, Eseye Derb, Mulualem Lemma, Hana Yohannes, Degsew Ewunetie Anteneh, Alembante Bazezew, Kebebe Tadesse, Bewuketu Belete Alemu

“…Abstract Background Human Immunodeficiency Virus (HIV) remains a significant global health challenge despite advancements in prevention and treatment. It impairs immune function and leads to T-cell exhaustion, driven by sustained expression of the immune checkpoint receptor PD-1, which exists in membrane-bound and soluble forms. …”
Get full text

Pre-sleep casein ingestion with probiotic strains improves anaerobic power and lower-body-specific strength and power performance in soccer players by Reza Sadeghi, Mohammad Hemmatinafar, Fereshteh Eftekhari, Babak Imanian, Negar Koureshfard

“…Additionally, isokinetic strength parameters, including absolute peak torque (APT) and average rate of force development (AvRFD), were measured for the knee extensors (ext) and flexors (flx) muscles (concentric phase at angular velocities of 60°/s and 180°/s, using the dominant leg). One-way analysis of covariance (ANCOVA) or Quade tests with a significance level of p < 0.05 was used to analyze the collected data.Result The current study’s findings indicated that APT-180°/s (ext) significantly increased in CAS (p = 0.008) and PRO+CAS (p = 0.003) compared to PLA. …”
Get full text

The effect of dexmedetomidine on acute kidney injury after elective major abdominal surgery : a retrospective single-center propensity score matched study by Haibei Liu, Rong Luo, Liu Qian, Yujun Zhang, Wensheng Zhang, Juan Tan, Ling Ye

“…Secondary outcomes included intraopertive average urine output, renal function on the first day after surgery, incidence of postoperative dialysis, postoperative intensive care unit (ICU) admission, in-hospital mortality, length of hospital stay, incidence of intraoperative hypotension and bradycardia, and intraoperative use of inotropes and vasopressors. …”
Get full text

Using five exposure metrics to explore the association between ambient PM2.5 and the hospital admissions for COPD in Tianshui city, China by Deshun Li, Jiyuan Dong, Xiaoju Liu, Juan Shu, Lisha Zhu, Hairong Bao

“…We collected daily records of COPD admission and hourly data on air pollutants and meteorological factors from Tianshui, China, 2018–2019. …”
Get full text

INVESTIGATION OF THE GENETIC ALTERATIONS IN CDKN2A/B AND IL7R IN T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA by RMB Lemos, ES Costa, T Ferraz, MT Schramm, MM Lins, MCN Fagundes, ALT Maciel, M Emerenciano

“…The activation of IL7R, either due to the presence of gain-of-function mutations (̃10% of cases) or its upregulation, is a recurrent event in T-ALL associated with disease relapse. …”
Get full text

The Paleochrono-1.1 probabilistic model to derive a common age model for several paleoclimatic sites using absolute and relative dating constraints by F. Parrenin, M. Bouchet, C. Buizert, E. Capron, E. Corrick, R. Drysdale, K. Kawamura, A. Landais, R. Mulvaney, I. Oyabu, S. O. Rasmussen

“…We demonstrate the ability of Paleochrono-1.1 in an experiment involving only the MSL speleothem in Hulu Cave (China), and we compare the resulting age model with the Speleothem Isotope Synthesis and Analysis version 2 (SISALv2) age models. We then demonstrate the multi-archive capabilities of Paleochrono in a new ice-core–speleothem dating experiment, which combines the Antarctic Ice Core Chronology 2023 dating experiment, based on records from five polar ice cores, with data from two speleothems from Hulu Cave, dated<span id="page8736"/> using uranium / thorium radiometric techniques. …”
Get full text

Comparative Effectiveness of Midazolam-Based Sedation on the Need for Intracranial Pressure Lowering Therapies in Traumatic Brain Injury by Rianne G.F. Dolmans, Giovanni Russo, James Anstey, Ewout W. Steyerberg, Fabio S. Taccone, Andrew Udy, Giuseppe Citerio, Carole Ichai, Rafael Badenes, John Prowle, Ari Ercole, Mauro Oddo, Antoine Schneider, Stefan Wolf, Raimund Helbok, David Nelson, D. Jamie Cooper, Mathieu van der Jagt

Get full text