Quality of government for environmental wellbeing? Subnational evidence from European regions by Andrea Vaccaro, Carlotta Montorsi, Chiara Gigliarano

“…First, we find that subnational environmental data are spatially interdependent. Then, we construct a set of composite indicators of environmental wellbeing via Bayesian spatial factor analysis. …”
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A Multi‐Omics, Machine Learning‐Aware, Genome‐Wide Metabolic Model of Bacillus Subtilis Refines the Gene Expression and Cell Growth Prediction by Xinyu Bi, Yang Cheng, Xueqin Lv, Yanfeng Liu, Jianghua Li, Guocheng Du, Jian Chen, Long Liu

“…Abstract Given the extensive heterogeneity and variability, understanding cellular functions and regulatory mechanisms through the analysis of multi‐omics datasets becomes extremely challenging. …”
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Quantitative Characterization and Prediction of the Binding Determinants and Immune Escape Hotspots for Groups of Broadly Neutralizing Antibodies Against Omicron Variants: Atomisti... by Mohammed Alshahrani, Vedant Parikh, Brandon Foley, Nishank Raisinghani, Gennady Verkhivker

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Designing an educational model based on identity development with an Iranian-Islamic approach for primary school students. by Ali Oladhamzehzadeh, masoumeh oladiyan, Mahmoud Safari

“…The open, axial and selective coding and MAXQDA software was used in the data analysis of the qualitative part, and SPSS 16 and Smart PLS software were used in the quantitative part, and the data was analyzed in the inferential analysis using the factor analysis method. …”
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Baseline fibroblast growth factor 23 predicts incident heart failure and cardiovascular mortality in patients with chronic kidney disease: A 3-year follow-up study by Ying Wang, Dingxin Zhang, Runzhe Zhou, Xiangjie Yang, Xiaoxia Wang, Yuxin Jiang, Xinyuan Zhou, Dashan Li, Jin Zhang, Yonggui Wu

“…Background: Heart failure (HF) is a significant cause of death among patients with chronic kidney disease (CKD). Emerging data suggest a crucial role of fibroblast growth factor 23 (FGF23) in the pathogenesis of HF in CKD patients. …”
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A modified liver retraction method decreases liver dysfunction after laparoscopic gastrectomy by Hao-Jie Li, Lang Zhou, Wei-Han Zhang, Kai Liu, Kun Yang, Jian-Kun Hu, Xiao-Long Chen

“…This study aims to explore the effect of a modified liver retraction method (MLR) we designed on the postoperative liver function of patients receiving laparoscopic radical gastrectomy. …”
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A Bayesian Approach to Step-Stress Partially Accelerated Life Testing for a Novel Lifetime Distribution by Mervat K. Abd Elaal, Hebatalla H. Mohammad, Zakiah I. Kalantan, Abeer A. EL-Helbawy, Gannat R. AL-Dayian, Sara M. Behairy, Reda M. Refaey

“…Bayes estimators of the model parameters and acceleration factor are derived under both symmetric (balanced squared error) and asymmetric (balanced linear exponential) loss functions using informative priors. The novelty of this work lies in the integration of the Topp–Leone inverted Kumaraswamy distribution within the Bayesian step-stress partially accelerated life testing framework, which has not been explored previously, offering improved modeling capability for complex lifetime data. …”
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Serum extracellular vesicle microRNAs as potential biomarkers to predict pembrolizumab response and prognosis in metastatic non-small cell lung cancer patients by Daniela Lamorte, Luciana De Luca, Alfredo Tartarone, Stefania Trino, Irene Giulivo, Angelo De Stradis, Maddalena Maietti, Antonella Caivano, Ilaria Laurenzana

“…Through a functional analysis, these microRNAs are found to be connected to each other and involved in the pathology of NSCLC, particularly in IGF/P53/VEGF/NOTCH/PI3K pathways, in cytokine/interleukin signaling and in the immune system. …”
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Are Social Media-Based Marketing Strategies the New Mechanisms for Attracting Consumers? A Quantitative Method-Based Approach by Maidul Islam, Shabnam A. Sheikh

“…To understand the influence of social media marketing and the important role of influencer marketing in consumer purchase intention, a cross-sectional analysis was performed. Data from 210 participants were used for this study. …”
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MetaboLINK is a novel algorithm for unveiling cell-specific metabolic pathways in longitudinal datasets by Jared Lichtarge, Gerarda Cappuccio, Gerarda Cappuccio, Soumya Pati, Soumya Pati, Alfred Kwabena Dei-Ampeh, Alfred Kwabena Dei-Ampeh, Senghong Sing, Senghong Sing, Senghong Sing, LiHua Ma, Zhandong Liu, Zhandong Liu, Mirjana Maletic-Savatic, Mirjana Maletic-Savatic, Mirjana Maletic-Savatic

“…IntroductionIn the rapidly advancing field of ‘omics research, there is an increasing demand for sophisticated bioinformatic tools to enable efficient and consistent data analysis. As biological datasets, particularly metabolomics, become larger and more complex, innovative strategies are essential for deciphering the intricate molecular and cellular networks.MethodsWe introduce a pioneering analytical approach that combines Principal Component Analysis (PCA) with Graphical Lasso (GLASSO). …”
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High‐Frequency Mutations in TP53, AXIN1, CTNNB1, and KRAS, and Polymorphisms in JAK1 Genes Among Mongolian HCC Patients by Nomin Bold, Khurelsukh Buyanbat, Ariya Enkhtuya, Nomin Myagmar, Gerelsuren Batbayar, Zolzaya Sandag, Dolgion Damdinbazar, Nomuun Oyunbat, Tuul Boldbaatar, Ankhbayar Enkhbaatar, Gan‐Erdene Baatarjav, Taivan Nanzaddorj, Tsendsuren Oyunsuren, Gantulga Davaakhuu

“…Our findings showed p53 overexpression in tumors with TP53 mutations (F270I and S362S), while mutations such as R213* and a short‐sequence deletion upstream of intron 7 produced premature stop codons, resulting in truncated p53 and loss of tumor suppressor function. β‐catenin accumulation was observed in tumors with CTNNB1 mutations (D32N/Y, S33C/Y, S34V, S37P, T41A, and S45P). …”
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MISAO: A Multi-Strategy Improved Snow Ablation Optimizer for Unmanned Aerial Vehicle Path Planning by Cuiping Zhou, Shaobo Li, Cankun Xie, Panliang Yuan, Xiangfu Long

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Digitalization of the Financial Activities of Platform Companies: Competitive Potential and social Impact by V. P. Bauer, V. V. Eremin, M. V. Ryzhkova

“…The authors apply methods such as theoretical analysis of scientific publications (analysis, synthesis, generalization); deduction as a procedure for the transition from the general to the particular; analysis of the structure of the influence of platform companies on the strategies of competition, highlighting the differences between the platform and linear business models; determining the influence of platform companies on competition among offline partners; identification of competition between platform companies and within them; highlighting aspects of the social impact of the functioning of platforms and platform companies. …”
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Monocyte-derived APCs are central to the response of PD1 checkpoint blockade and provide a therapeutic target for combination therapy by Louis Boon, Matheus H W Crommentuijn, Sjoerd T T Schetters, Laura J W Kruijssen, Yvette van Kooyk, Ernesto Rodriguez, Jan Van den Bossche, Joke M M Den Haan

“…It is still unclear how these APCs develop and function before and during αPD1 ICB or how they are associated with tumor rejection.Methods Here, we used B16 mouse melanoma and MC38 colorectal carcinoma tumor models, which show differential responses to αPD1 ICB. …”
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Cross-sectional and longitudinal association of seven DNAm-based predictors with metabolic syndrome and type 2 diabetes by Suet Mei Chew, Alexander Teumer, Pamela R. Matías‑García, Christian Gieger, Juliane Winckelmann, Karsten Suhre, Christian Herder, Wolfgang Rathmann, Annette Peters, Melanie Waldenberger

“…Therefore, we examined the cross-sectional associations between seven DNAm-based predictors and prevalent metabolic conditions in participants with methylation data from the KORA study. We also analyzed the longitudinal association with time-to-incident T2D and the relative prognostic value compared to clinical predictors from the Framingham 8-year T2D risk function in predicting incident disease over eight years. …”
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Manganese mitigates atrazine-induced oxidative stress and hepatorenal toxicity: insights from network pharmacology and in vivo experimentation by Solomon E. Owumi, Tella T. Adedayo, Joseph Chimezie, Bayode Oluwawibe, Harieme Agbarogie, Jesutosin O. Babalola, Oludare M. Ogunyemi, Uche O. Arunsi, Moses T. Otunla, Chioma E. Irozuru, Ahmad Altayyar, Eziuche A. Ugbogu

“…Abstract Network analysis has provided valuable insights into the mechanisms underlying the hepatoprotective effects of manganese (Mn) in rats subjected to atrazine (ATZ) intoxication. …”
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Clinical utility of novel diabetes subgroups in predicting vascular complications and mortality: up to 25 years of follow-up of the HUNT Study by Bjørn Olav Åsvold, Elin Pettersen Sørgjerd, Arnulf Langhammer, Kare I Birkeland, Paz Lopez-Doriga Ruiz, Tore Julsrud Berg, Eirin Beate Haug, Vera Vik Bjarkø, Sofia Carlsson, Valeriya Lyssenko

“…To identify diabetes subgroups, we used the same variables (age at diagnosis, body mass index, HbA1c, homeostasis model assessment estimates of beta cell function and insulin resistance, and glutamic acid decarboxylase antibodies) and the same data-driven clustering technique as in previous studies. …”
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Treatment goals indicate palliative care hospital costs: a longitudinal economic study by Monika Hagemann, Barbara Janina Kidszun, Matthias Schwenkglenks, Odile Stalder, Steffen Eychmüller, Maud Maessen

“…METHODS: We performed a retrospective, observational analysis of hospital costs using administrative data from a Swiss university hospital of all specialist palliative care inpatients in the period 2016–2022. …”
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Time Trends and Causes of Infection-Related Mortality Among Patients Starting Dialysis in Finland: A Nationwide Cohort Study by Susanna Kinnunen, Ilkka Helanterä, Auni Juutilainen, Wisam Bitar, Jaakko Helve, Patrik Finne

“…Follow-up continued until death of any cause, kidney transplantation, moving abroad, recovery of kidney function, loss of follow-up, or end of study. Exposure: Long-term kidney replacement therapy. …”
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Potential role of Amyloid-β on the association between Orexin-A and blood-brain barrier leakage of globus pallidus in Alzheimer’s disease and dementia with lewy bodies by Jinghuan Gan, Ziming Xu, Chen Wen, Hao Wu, Zhichao Chen, Zhihong Shi, Hao Lu, Yajie Wang, Shuai Liu, Yong Ji

“…Demographic, clinical, and neuropsychological data were collected. The mediation analysis models were used to calculate the mediating effect of Aβ on the associations between orexin-A and BBB permeability in GP (reflected by K trans or Vp values). …”
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