Tumor Morphology for Prediction of Poor Responses Early in Neoadjuvant Chemotherapy for Breast Cancer: A Multicenter Retrospective Study by Wen Li, Nu N. Le, Rohan Nadkarni, Natsuko Onishi, Lisa J. Wilmes, Jessica E. Gibbs, Elissa R. Price, Bonnie N. Joe, Rita A. Mukhtar, Efstathios D. Gennatas, John Kornak, Mark Jesus M. Magbanua, Laura J. van’t Veer, Barbara LeStage, Laura J. Esserman, Nola M. Hylton

“…Background: This multicenter and retrospective study investigated the additive value of tumor morphologic features derived from the functional tumor volume (FTV) tumor mask at pre-treatment (T0) and the early treatment time point (T1) in the prediction of pathologic outcomes for breast cancer patients undergoing neoadjuvant chemotherapy. …”
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Optimisation of the performance and structure of soluble ball seat metal sealing rings based on response surface by CHEN Zhen, RAN Qingjie, CHEN Nengpeng, WANG Qiaomu

“…On this basis, the Box-Behnken design is used to construct a four-factor and three-level experimental scheme, and a second-order response surface agent model is established by 25 sets of simulation data, with the dual optimization objectives of minimizing the equivalent force and maximizing the contact pressure, and the relationship between the structural parameters and the equivalent force and the contact pressure as the optimization function, and the range of geometrical parameters as the boundary conditions. …”
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Reconstruction of a lncRNA-Associated ceRNA Network in Endothelial Cells under Circumferential Stress by Zhuhui Huang, William Adiwignya Winata, Kui Zhang, Yang Zhao, Yang Li, Ning Zhou, Shaoyou Zhou, Wei Fu, Bokang Qiao, Guoqi Li, Yihui Shao, Jubing Zheng, Ran Dong

“…The nodes with most degrees in three kinds of RNAs are hsa-miR-4739, NEAT1, and MAP3K2. Functional analysis showed that different biological processes enriched in biological regulation, response to stimulus and cell communication. …”
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Genetic evolution, epidemic trends, and recombination dynamics of PRRSV-1 in China by Chengzhen Weng, Chengzhen Weng, Chengzhen Weng, Xinxin Huang, Xinxin Huang, Xinxin Huang, Zhian Chen, Zhian Chen, Minjia He, Minjia He, Minjia He, Beiwen Zhang, Beiwen Zhang, Beiwen Zhang, Hongxi Li, Hongxi Li, Hongxi Li, Jingrui Xie, Jingrui Xie, Meichun Chen, Meichun Chen, Meichun Chen, Longxin Qiu, Longxin Qiu, Xiaobing Li, Xiaobing Li, Chong Cao, Chong Cao, Hongbo Chen, Hongbo Chen

“…In summary, whole-genome studies of PRRSV-1 demonstrated that major recombinant subgroups and genetic evolution align with the current prevalence of BJEU06-1-like strains in China. Analysis of GP5 encoded by ORF5 confirmed the presence of differences between whole-genome and ORF5 data, exhibiting minor discrepancies in both the phylogenetic trees and the level of genetic diversity. …”
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The Impact of Audit Quality on Organizational Capital and Financing Capacity by Somaye Fathi, Mahdi Bahar Moghadam, Kazem Shamsadini

“…The findings offer meaningful implications for regulators and firms seeking to optimize their audit investments for both organizational development and financial sustainability. Metod and dataThis study employs panel data analysis of 1,776 firm-year observations (148 companies) from Tehran Stock Exchange-listed firms between 2011-2022, sourced from the Codal database and the Management Research, Development, and Islamic Studies Library. …”
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‘High hopes for treatment’: Australian stakeholder perspectives of the clinical translation of advanced neurotherapeutics for rare neurological diseases by Christina Q. Nguyen, Didu S. T. Kariyawasam, Tsz Shun Jason Ngai, James Nguyen, Kristine Alba‐Concepcion, Sarah E. Grattan, Elizabeth E. Palmer, Kate Hetherington, Claire E. Wakefield, Russell C. Dale, Sue Woolfenden, Shekeeb Mohammad, Michelle A. Farrar

“…Thematic and quantitative data analysis followed. Results Participants described high positive interest in advanced therapies, but low knowledge of, and access to, reliable information. …”
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geodl: An R package for geospatial deep learning semantic segmentation using torch and terra. by Aaron E Maxwell, Sarah Farhadpour, Srinjoy Das, Yalin Yang

“…Convolutional neural network (CNN)-based deep learning (DL) methods have transformed the analysis of geospatial, Earth observation, and geophysical data due to their ability to model spatial context information at multiple scales. …”
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POT1 genetic testing in melanoma-prone families in Sweden: germline variant prevalence and tumor spectrum in identified carriers by Konstantinos Papadakis, Francesca Portelli, Karina Schultz, Hedvig Olsson Sterky, Ismini Vassilaki, Jan Lapins, Michael R. Sargen, Sofia Obolenski, David J. Adams, Muyi Yang, Veronica Höiom, Hildur Helgadottir

“…The population frequency of pathogenic variants (PVs) was assessed using the SweGen and the gnomAD databases. Functional evaluation was performed using a saturation genome editing (SGE) assay. …”
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Investigation of DC-Biased Optical OFDM With Precoding Matrix for Visible Light Communications: Theory, Simulations, and Experiments by Tao Jiang, Ming Tang, Rui Lin, Zhenhua Feng, Xi Chen, Lei Deng, Songnian Fu, Xiang Li, Wu Liu, Deming Liu

“…The simulation results demonstrate the complementary cumulative distribution function of PAPR can be reduced ∼3 dB, while the performance of clipping distortion power and clipping error probability are significantly improved. …”
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Higher vasoactive usage despite hemodynamic goals is associated with higher mortality in acute myocardial infarction-related cardiogenic shock by Jorge A. Ortega-Hernández, Héctor González-Pacheco, Diego Araiza-Garaygordobil, Rodrigo Gopar-Nieto, Daniel Sierra-Lara-Martínez, Daniel Manzur-Sandoval, José Luis Briseño-De-La-Cruz, Salvador Mendoza-García, Álvaro Montañez-Orozco, Arturo Arzate-Ramírez, José Omar Arenas-Díaz, César A. Gómez-Rodríguez, Hector Antonio Santos-Alfaro, Jaime Hernández-Montfort, Alexandra Arias-Mendoza

“…The median age was 61 years; most were men (82%), and 82.8% had ST-segment elevation myocardial infarction. End-organ function showed progressive deterioration with escalating vasoactive use. …”
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Early rehabilitation challenges of surgical patients with COVID-19 infection - a single-arm study by Simić-Panić Dušica, Bošković Ksenija, Pantelinac Slobodan, Knežević Aleksandar, Jovićević Predrag, Kozios Apostolos, Janjić Nataša, Nikolić Nikola, Vojnović Larisa, Tomašević-Todorović Snežana

“…A very limited amount of data regarding the rehabilitation outcome of surgical patients with COVID-19 is available in the current literature. …”
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Defects in the necroptosis machinery are a cancer resistance mechanism to checkpoint inhibitor immunotherapy by Katja Steiger, Peter May, Florian Bassermann, Anna Sax, Stefan Enssle, Nardine Soliman, Tatiana Nedelko, Giada Mandracci, Fabian Stögbauer, Laura Joachim, Christof Winter, Nadia El Khawanky, Hendrik Poeck, Simon Heidegger

“…However, it is unclear to which extent functional necroptosis in tumor cells contributes to ICI immunotherapy.Methods With genetically engineered tumor cell lines that lack specific components of the necroptosis machinery (mixed lineage kinase domain-like pseudokinase (MLKL), receptor interacting protein kinase 3 (RIPK3)), we addressed the importance of necroptotic tumor cell death for the efficacy of ICI immunotherapy in murine models. …”
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What patients with lung cancer with comorbidity tell us about interprofessional collaborative care across healthcare sectors: qualitative interview study by Michel Wensing, Johanna Forstner, Michael Thomas, Jasmin Bossert, Matthias Villalobos, Anja Siegle, Corinna Jung, Nicole Deis, Katja Krug

“…Data analysis was performed using qualitative content analysis to structure data into themes and subthemes. …”
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Tracing Eponymous Word Combinations in Education and Pedagogy by Vera Budykina, Oksana Polyakova

“…The study was conducted following dictionary criticism principles and tackled the analysis of quantitative and qualitative data on eponymous phrases found in three English-language special dictionaries. …”
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Combination of glycin and thiotriazolin in a single medicinal form by O. V. Khromylova

“…According to the obtained data of thermogravimetric analysis of glycine substance, thiotriazoline, mixtures of glycine-thiotriazolin should be noted. …”
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Assessment of the Economic Efficiency of Long-Term Care System in the Stavropol Territory by I. I. Deren, K. A. Samofatova

“…The purpose of the article is to economically substantiate the effectiveness of a long-term care system functioning in the form of social services at home, compared with stationary social services for people with limited mobility and non-mobile citizens to determine the most optimal and profitable form of providing social services for the state.Materials and methods. …”
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Social and communicative adaptation of first-year students at a medical university by V. I. Chumakov, E. V. Shishkina, I. V. Chumakov

“…The use of methods for studying scientific and methodological literature, evaluating information obtained during theoretical analysis, comparison, grouping of data, generalization, made it possible to form the original questionnaire "Assessment of socio-communicative adaptation of first-year students in a medical university." …”
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HOTSED: A new integrated model for assessing potential hotspots of sediment sources and related sediment dynamics at watershed scale by Manuel La Licata, Alberto Bosino, Seyed Hamidreza Sadeghi, Mattia De Amicis, Andrea Mandarino, Andrea Terret, Michael Maerker

“…HOTSED integrates geomorphic spatial information with both structural and functional properties of connectivity. HOTSED provides a single and intuitive output that depicts the location of sediment source hotspots. …”
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Significant differences in knee kinematics of healthy subjects with high and low anterior tibial laxity by Shiyang Chen, Shaohua Chen, Qingyang Kang, Fangzheng Lin, Fangzheng Lin, Fangzheng Lin, Shuting Zheng, Xixi Liu, Chunhong Guo, Chunhong Guo, Yongjin Li, Yongjin Li, Dingkun Lin, Dingkun Lin, Xiaolong Zeng

“…However, further research is needed to explore the clinical functional effects of knee laxity.…”
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Persistence of activated anti‐mesothelin hYP218 chimeric antigen receptor T cells in the tumour is associated with efficacy in gastric and colorectal carcinomas by Sameer Mir, Abhilash Venugopalan, Jingli Zhang, Nishanth Ulhas Nair, Manjistha Sengupta, Manakamana Khanal, Chaido Stathopoulou, Qun Jiang, Raffit Hassan

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