Clinical effect of Altemeier procedure on recurrent rectal prolapse by Zhai Yuze, Wang Benjun, Han Weiwei, Yu Bianfang, Gao Qianfu

“…[Methods] A retrospective analysis was conducted on the clinical data of 15 patients with recurrent rectal prolapse who were treated with Altemeier procedure from January 2019 to January 2022 in the Department of Anorectal surgery of the Affiliated Hospital of Shandong University of Traditional Chinese Medicine and Linyi People's Hospital. …”
Get full text

Involvement of M1 Macrophage Polarization in Endosomal Toll-Like Receptors Activated Psoriatic Inflammation by Chih-Hao Lu, Chao-Yang Lai, Da-Wei Yeh, Yi-Ling Liu, Yu-Wen Su, Li-Chung Hsu, Chung-Hsing Chang, S.-L. Catherine Jin, Tsung-Hsien Chuang

“…Analysis of clinical data in database revealed significantly increased expression of macrophage markers and inflammatory cytokines in psoriatic tissues over those in normal tissues. …”
Get full text

Profile of postpartum patients with urinary retention at Koja Regional Hospital, Jakarta, Indonesia by Suskhan Djusad, Alfa Putri Meutia, Surahman Hakim

“…Residual urine volume was measured by catheterization 6 hours after delivery. Data analysis, performed using SPSS version 22, included patient demographics and clinical factors such as maternal age, parity, gestational age, neonatal birth weight, and postvoid residual urine volume. …”
Get full text

Comparative evaluation of artificial intelligence models GPT-4 and GPT-3.5 in clinical decision-making in sports surgery and physiotherapy: a cross-sectional study by Sönmez Saglam, Veysel Uludag, Zekeriya Okan Karaduman, Mehmet Arıcan, Mücahid Osman Yücel, Raşit Emin Dalaslan

“…These findings suggest that advanced AI models can aid in diagnostic accuracy, treatment planning, and rehabilitation strategies. However, AI should function as a decision-support tool rather than a substitute for expert clinical judgment. …”
Get full text

The EQ-5D and EQ-HWB fit the perceptions of quality of life from a Chinese perspective: a concept mapping study by Yifan Ding, Zhuxin Mao, Zhihao Yang, Siliu Feng, Jan Busschbach

“…The Group Concept Mapping (GCM) method was used, with participants organizing the items to reflect their interrelationships. Data were analyzed via Groupwisdom™, an online tool supporting multidimensional scaling (MDS) and cluster analysis, culminating in visual cluster rating maps that highlighted the item associations and groupings. …”
Get full text

Impact of Obesity on Serum Levels of Neuropeptide –Y in Type 2 Diabetics in Relation to Glycemic Status by Nada T Hasan, Shatha Ali

“…Eighty-seven T2DM patients attending the clinic of The National Center of Diabetes Treatment & Research/Baghdad, were included in this study, had been categorized into; Group (1): 45 patients (19 male, 26 female) obese T2DM patients with BMI (30.5- 44) kg/m2 and age range (31-59) years, and Group (2): Normal body weight T2DM patients with BMI (18.6-24.9) kg/m2, included 42 patients (20 male, 22 female), with age range of (33-60) years .Fasting blood specimens were utilized to measure serum NPY and glycemic markers. Data analysis revealed that fasting serum glucose, HbA1c, homeostatic model assessment of insulin resistance (HOMA-IR) and neuropeptide Y values were significantly elevated (P˂0.001) in group-1 in comparison with group-2, however fasting insulin level and homeostasis model assessment of beta-cell function (HOMA-B) were significantly elevated (P˂0.001) in group-2 compared to group-1. …”
Get full text

The Relationship between Systemic Expression Levels of Immune Cells and Tumor Markers and High-Risk HPV Infection in Patients with Cervical Cancer, Cervical Intraepithelial Neoplas... by Guo P, Wu L, Wang H, Wang L, Li H, Wang H, Wang Y, Shao S, Chen S

“…Pengfei Guo,1 Lirui Wu,1 Huiying Wang,1 Lanpeng Wang,2 Hongxia Li,1 Hongli Wang,1 Yajuan Wang,1 Shujuan Shao,1 Suning Chen1 1Hebei Central Hospital of Petroleum Gynecology, Langfang, Hebei, 065000, People’s Republic of China; 2Langfang People’s Hospital, Langfang, Hebei, 065000, People’s Republic of ChinaCorrespondence: Lirui Wu, Email arvb800@163.comObjective: To analyze the relationship and clinical significance between systemic expression levels of immune cells and tumor markers and high-risk human papillomavirus (HPV) infection in patients with cervical cancer, cervical intraepithelial neoplasia, and chronic cervicitis.Methods: A retrospective analysis was conducted on the clinical data of 69 patients with cervical cancer infected with HPV (Group A), 78 patients with CIN (Group B), and 52 patients with chronic cervicitis (Group C) treated at Hebei Central Hospital of petroleum gynecology from April 2021 to April 2023. …”
Get full text

Bioestabilização anaeróbia de resíduos sólidos orgânicos em reatores de batelada Anaerobic biostabilization of organic solid waste in batch reactors by Valderi D. Leite, Wilton S. Lopes, Shiva Prasad

“…It may be pointed out that this treatment process biostabilizes the putrescible organic waste, making it available for application in the soils as well as producing of methane, which can be used as a source of alternative energy for domestic and industrial purposes. The analysis of the data shows that the performance of the biostabilization process is a function of the percentage of rumen used.…”
Get full text

Development and validation of a predictive model for frailty risk in older adults with cardiovascular-metabolic comorbidities by Lulu Yan, Lulu Yan, Entong Ren, Chenjiao Guo, Yuanyuan Peng, Hao Chen, Weihua Li

“…Binary logistic regression analyses revealed that depression, social activity, history of falls, life satisfaction, ADL scores, cognitive function, age and the number of CMDs were significantly associated with frailty. …”
Get full text

Immune responses and recovery from spotty liver disease in layer birds by Sarah Eastwood, Timothy B. Wilson, Jiongrui Huang, Bronwyn E. Campbell, Peter C. Scott, Robert J. Moore, Thi Thu Hao Van

“…Altogether, the results indicate that over time, immune memory, enhanced barrier function, and a balanced immune response developed, resulting in reduced impact of infection on the birds. …”
Get full text

A Transformer-LSTM-SVR hybrid model for AI-driven emotional optimization in NEV embedded interior systems by Zongming Liu, Xuhui Chen, Xinan Liang, Zhicheng Sun, Fengqi Yang, Wenwen Ou, Linwei Li, Xiayan Qin

“…Abstract With the rapid expansion of the new energy vehicle (NEV) market, a shift from function-oriented toward emotion-oriented interior design has emerged as a key factor in enhancing user experience and brand differentiation. …”
Get full text

Mir-199a-3p aggravates neuroinflammation in an Alzheimer’s disease transgenic mouse model by promoting M1-polarization microglia by Chenyang Wang, Xiaolu Bu, Mengyao Cao, Yunyu Lian, Haocong Ling, Mo You, Junfei Yi, Xiaoya Gao, Duobin Wu, Yang Li

“…Results Intracerebroventricular administration of miR-199a-3p agomir exacerbated amyloid deposition and impaired cognitive function in AD mice, and promoted microglial polarization toward the M1 phenotype. …”
Get full text

The systemic lupus erythematosus IRF5 risk haplotype is associated with systemic sclerosis. by F David Carmona, Jose-Ezequiel Martin, Lorenzo Beretta, Carmen P Simeón, Patricia E Carreira, José Luis Callejas, Mónica Fernández-Castro, Luis Sáez-Comet, Emma Beltrán, María Teresa Camps, María Victoria Egurbide, Spanish Scleroderma Group, Paolo Airó, Raffaella Scorza, Claudio Lunardi, Nicolas Hunzelmann, Gabriela Riemekasten, Torsten Witte, Alexander Kreuter, Jörg H W Distler, Rajan Madhok, Paul Shiels, Jacob M van Laar, Carmen Fonseca, Christopher Denton, Ariane Herrick, Jane Worthington, Annemie J Schuerwegh, Madelon C Vonk, Alexandre E Voskuyl, Timothy R D J Radstake, Javier Martín

“…In this study we aimed to evaluate whether three different haplotypic blocks within this locus, which have been shown to alter the protein function influencing systemic lupus erythematosus (SLE) susceptibility, are involved in SSc susceptibility and clinical phenotypes. …”
Get full text

SUMO modified ETV1 promotes M2-polarized tumor-associated macrophage infiltration and cancer progression by facilitating CCL2 transcription in esophageal squamous cell carcinoma ce... by Tianci Han, Xiaoqi Guo, Junwei Xie, Wei Tong, Liang Zhang

“…ETS variant transcription factor 1 (ETV1) plays an important role in multiple malignancies. However, its function in ESCC progression and tumor microenvironment (TME) remains to be explored. …”
Get full text

Fixation Time for Competing Beneficial Mutations and Their Genomic Footprint by Wolfgang Stephan

“…Using published simulation data, we also describe the genomic footprint of competing beneficial mutations. …”
Get full text

Modeling future sediment retention service in the Bagh-e-Shadi Forest protected area using InVEST and the ACCESS-ESM1-5 climate model by Sharif Joorabian Shooshtari, Tahereh Ardakani, Hadise Beik Khormizi

“…IC0 and kb are calibration factors that shape the sigmoid function in the SDR–IC relationship. From 1997 to 2021, our findings indicated that the study area experienced an average annual soil loss of 77.1 t ha−1 year−1. …”
Get full text

Ailanthone disturbs cross-talk between cancer cells and tumor-associated macrophages via HIF1-α/LINC01956/FUS/β-catenin signaling pathway in glioblastoma by Xubin Deng, Qianbing Zhang, Fa Jin, Fengfei Lu, Guosheng Duan, Luwei Han, Meiling Zhu, Zhengyan Yang, Gong Zhang

“…This study aims to explore the biological function and the underlying mechanism of ailanthone in GBM. …”
Get full text

Comparing the efficacy of ankle arthrodesis performed through anterior or lateral approaches in end-stage ankle arthritis treatment by Hongbin Cao, Nan Li, Guixin Wang, Jun Liang, Haijing Huang, Jinquan He

“…Methods A retrospective analysis of the clinical data of 86 patients with ankle arthritis treated with ankle arthrodesis between January 2019 and December 2022 was conducted. …”
Get full text

Association between obstructive sleep apnea and quality of life in Korean middle-aged people: a cross-sectional study by Jiwon Kim, Min Jeong Joo, Jae Yong Shin, Chung-Mo Nam, Eun-Cheol Park

“…Poor sleep quality from OSA affects concentration, cognitive function, and mental health, contributing to conditions such as depression and anxiety. …”
Get full text

Robotic versus laparoscopic surgery for severe deep endometriosis: protocol for a randomised controlled trial (ROBEndo trial) by Tero Rautio, Pasi Ohtonen, Outi Uimari, Anna Maria Terho, Johanna Mäkelä-Kaikkonen, Terhi Puhto, Sari Koivurova

“…The superiority of robotic surgery has not, however, been provedin randomised controlled studies, and there is a lack of long-term outcome data. Advanced endometriosis surgery offers an excellent platform to study the feasibility and long-term outcomes of robotic surgery compared with conventional laparoscopy.Methods and analysis ROBEndo is a prospective, randomised, controlled clinical trial in a single-centre setting. …”
Get full text