Integrative analysis of cell state changes in lung fibrosis with peripheral protein biomarkers by Christoph H Mayr, Lukas M Simon, Gabriela Leuschner, Meshal Ansari, Janine Schniering, Philipp E Geyer, Ilias Angelidis, Maximilian Strunz, Pawandeep Singh, Nikolaus Kneidinger, Frank Reichenberger, Edith Silbernagel, Stephan Böhm, Heiko Adler, Michael Lindner, Britta Maurer, Anne Hilgendorff, Antje Prasse, Jürgen Behr, Matthias Mann, Oliver Eickelberg, Fabian J Theis, Herbert B Schiller

“…Integration of 233,638 single‐cell transcriptomes (n = 61) across three independent cohorts enabled us to derive shifts in cell type proportions and a robust core set of genes altered in lung fibrosis for 45 cell types. Mass spectrometry analysis of lung lavage fluid (n = 124) and plasma (n = 141) proteomes identified distinct protein signatures correlated with diagnosis, lung function, and injury status. …”
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Effectiveness of Xiakucao Oral Liquid combined with methimazole on early thyroid function recovery and treatment compliance in Graves’ disease: a real-world retrospective cohort st... by Dong Lin, Lina Zhang, Lu Zhang, Jialu Zhu, Houcheng Li, Bichai Yuan

“…The association between XKC+MMI and early thyroid function recovery was analyzed using multiple linear regression in the subgroup of patients with post-treatment data available at 3 months.ResultsA total of 441 patients were enrolled, among whom 113 (25.6%) patients received XKC+MMI. …”
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Comparison of the effectiveness of mindfulness-based stress reduction versus cognitive-behavioral therapy on emotion regulation, mindfulness, and cognitive-executive functions in f... by Emad Alkasir, Abbas Masjedi-Arani, Fatemeh Jafarian Dehkordi, Amir Sam Kianimoghadam, Behrooz Afshari, Shafigheh Yousefi

“…In this study, the Difficulties in Emotion Regulation Scale, Five-Facet Mindfulness Questionnaire, Stroop task, Tower of London task, and Wisconsin Card Sorting Task were used at baseline, posttest, and follow-up. Data were analyzed by SPSS22 using analysis of variance (ANOVA) with repeated measurements. …”
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Correlation between conventional and unconventional lipid parameters with the risk of progression of renal function decline: insights from the China Health and Retirement Longitudi... by Yijing Xin, Yimeng Wang, Yuyuan Shu, Hanyang Liang, Yanmin Yang

“…Background This study aimed to evaluate the association between conventional and unconventional lipid parameters and the risk of future chronic kidney disease (CKD) and progression of renal function decline.Methods Data from 4,542 participants who were free of CKD at baseline were analyzed using information from the China Health and Retirement Longitudinal Study (2011–2015). …”
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CD8+ regulatory T cells, and not CD4+ T cells, dominate suppressive phenotype and function after in vitro live Mycobacterium bovis-BCG activation of human cells. by Mardi C Boer, Krista E van Meijgaarden, Simone A Joosten, Tom H M Ottenhoff

“…Here, we present a comparative analysis of the suppressive phenotype and function of CD4+ versus CD8+ T cells after in vitro live BCG activation of human cells. …”
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Effects of traditional Chinese medicine massage therapy on pain, functional activity, muscle activation patterns and proprioception in knee osteoarthritis: a randomised controlled... by Xin Zhou, Cheng Tang, Bowen Zhu, Yangyang Fu, Min Fang, Sitong Fang, Qingguang Zhu, Yuen Yee Janice Hiew

“…Therefore, we hypothesised that exercise therapy in conjunction with TCM massage may lead to more satisfactory results in terms of pain management, active functional muscle activation patterns and proprioception in patients with KOA.Methods and analysis A parallel, single-centre, randomised controlled trial involving 106 patients will be conducted at Shuguang Hospital, Shanghai University of Traditional Chinese Medicine. …”
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Effectiveness of total hip arthroplasty versus non-surgery on patient-reported hip function at 3 months: a target trial emulation study of patients with osteoarthritis by Amanda D Klaassen, Wiard Jorritsma, Nienke W Willigenburg, Carina L E Gerritsma, Bas L E F Ten Have, Dirk Jan F Moojen, Maaike G J Gademan, Rolf H H Groenwold, Rudolf W Poolman

“…We aimed to assess the causal effects of total hip arthroplasty (THA) compared with nonoperative treatment in reducing patient-reported hip disability at 3 months in patients with osteoarthritis, using real-world data. Methods: We emulated a target trial using real-world data of 2 Dutch hospitals between April 2020 and January 2022. …”
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Longitudinal Reciprocal Effects of Physical Exercise, Executive Function, and Subjective Well-Being: A Three-Wave Random-Intercept Cross-Lagged Panel Model in Chinese Minority Coll... by Xueyan Bai, Lin Yang

“…Data were analyzed using a random-intercept cross-lagged panel model (RI-CLPM), and multigroup analysis (MGA) was used to examine the moderating effects of gender, family ethnic composition, and residential area. …”
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The Predictive Role of StrainParameters in Predicting All-Cause Mortality in Diabetic Hypertensive Patients with Normal Left Ventricular Systolic Function in Long-Term Follow-up by Mustafa Çetin, Turhan Turan, Müjdat Aktaş, Tayyar Gökdeniz, Murat Gökhan Yerlikaya, Ezgi Kalaycıoğlu, Ender Emre, Ahmet Özderya

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Effects of Five-Element Music-Based Psychological Intervention Combined with Respiratory Specialty Care on Negative Emotions and Lung Function in Patients with Chronic Obstructive... by Yanqiu Jiang, Yang Chen, Hanhan Hong

“…Methods: A retrospective analysis was conducted on the clinical data of 170 COPD patients admitted to Second Affiliated Hospital of Naval Medical University (Shanghai Changzheng Hospital) from February 2022 to February 2023. …”
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Differences in fatty infiltration in thigh muscles and physical function between people with and without knee osteoarthritis and similar body mass index: a cross-sectional study by Jessica B. Aily, Marcos de Noronha, Ricardo J. Ferrari, Stela M. Mattiello

“…No participants were lost to assessment, ensuring complete data analysis for all participants. We used independent t-test and mean difference (95% CI) to compare thigh intraMAT and interMAT volume, self-reported measures (WOMAC questionnaire), physical function measures, and knee extension strength between groups. …”
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Static stability of functionally graded porous nanoplates under uniform and non-uniform in-plane loads and various boundary conditions based on the nonlocal strain gradient theory by Ihab Omar, Thamer Marhoon, Shahram Babadoust, Akram Shakir Najm, Mostafa Pirmoradian, Soheil Salahshour, S. Mohammad Sajadi

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Comparison of clinical outcomes between flexible antagonist protocol and long luteal phase protocol in patients with normal ovarian reserve function: a prospective cohort study by Ying Tian, Jing Hao, Xueliang Tu, Shaobin Feng, Mingtao Li, Yang Chen, Zelei Cao

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Dual functions of the ΔNp63-miR-141-3p-YAP1 regulatory axis in cervical cancer progression are dependent on histological subtype by Somayeh Panahi-Moghadam, Majid Sadeghizadeh, Shirin Farivar, Faezeh Vakhshiteh

“…The results were confirmed by western blot analysis. The ΔNp63-miR-141-3p-YAP1 axis exhibited distinct, cell-line-specific functions. …”
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Family function and health self-management ability among older adults from mountainous areas in China: moderated mediation model in a cross-sectional study by Jian-Hua Chen, Mei-Fen Chen, Norhasmah Mohd Zain, Chee-Yeong Yap, Azlina Yusuf, Bi-He Ying

“…The survey included questions on sociodemographic characteristics, the Adult Health Self-Management Skills (Ability) Rating scale, family APGAR scale and General Self-Efficacy (GSE) scale. Data were analysed using descriptive statistics, Spearman’s correlation, and multiple regression analysis with mediation and moderated mediation models. …”
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Rapid Screening of Illegal Addition of Compounds Regulating Sexual Function in Traditional Chinese Medicine Based on UPLC-Q-TOF MS Technique Combined with UNIFI Software by Min LIAO, Ying-chao WANG, Qi CHEN, Lian JIANG, Hai-ning WANG

“…In recent years, the illegal addition of male sexual function-regulating compounds in traditional Chinese medicine (TCM) has attracted widespread attention. …”
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Impact of Cognitive VR vs. Traditional Training on Emotional Self-Efficacy and Cognitive Function in Patients with Multiple Sclerosis: A Retrospective Study Focusing on Gender Diff... by Maria Grazia Maggio, Alessandra Benenati, Federica Impellizzeri, Amelia Rizzo, Martina Barbera, Antonino Cannavò, Vera Gregoli, Giovanni Morone, Francesco Chirico, Angelo Quartarone, Rocco Salvatore Calabrò

“…Emotional self-efficacy, depression, and anxiety were assessed, alongside cognitive function pre- and post-intervention. Results: Findings indicate that the VR-G showed significant improvements in managing negative emotions, reduced depressive and anxiety symptoms, and enhanced cognitive performance, particularly in verbal learning and working memory. …”
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Acute Care Rehabilitation Services Utilization and Post-Acute Discharge Destination among Adults with Traumatic Brain Injury: The Moderating Effect of Functional and Physical Perfo... by Rayyan A. Bukhari, Jennifer A. Weaver, Julia Sharp, Amanda Hoffman, Deana Davalos, Matt P. Malcolm, James E. Graham

“…Design: In a secondary analysis of de-identified electronic health record (EHR) data, multivariable moderation logistic regression models were performed to calculate odds ratios (ORs) for the likelihood of community discharge among patients who utilized OT/PT services. …”
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Impact of Fecal Microbiota Transplant Formulations, Storage Conditions, and Duration on Bacterial Viability, Functionality, and Clinical Outcomes in Patients with Recurrent <i>Clos... by Mohamed Shaheen, Chelsea McDougall, Leona Chan, Rose Franz, Karen Wong, Ryland T. Giebelhaus, Gwen Nguyen, Seo Lin Nam, A. Paulina de la Mata, Sam Yeo, James J. Harynuk, Sepideh Pakpour, Huiping Xu, Dina Kao

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Comparison of right ventricular function and clinical outcomes in type 2 diabetes patients with and without obstructive coronary artery disease: insights from a CMR study by Jin Wang, Wei-Feng Yan, Ke Shi, Hua-Yan Xu, Shi-Qin Yu, Ying-Kun Guo, Li Jiang, Yue Gao, Yu-Jiang, Xue-Ming Li, Yuan Li, Zhi-Gang Yang

“…Abstract Background Obstructive coronary artery disease (OCAD) marks a high-risk group within patients with type 2 diabetes mellitus (T2DM), underscoring the need for tailored prevention and management strategies. However, limited data exist on right ventricular (RV) function and clinical outcomes in T2DM patients with versus without OCAD. …”
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