Impact of incremental versus conventional initiation of haemodialysis on residual kidney function: study protocol for a multicentre feasibility randomised controlled trial by Andrew Davenport, David Wellsted, Ken Farrington, Sivakumar Sridharan, Raja Mohammed Kaja Kamal, Bassam Alchi, James Burton, Enric Vilar

“…The study is designed also to provide pilot data to allow determination of effect size to power a definitive study.Methods and analysis After screening to ensure native renal urea clearance >3 mL/min/1.73 m2, the study will randomise 54 patients within 3 months of HD initiation to conventional in-centre thrice weekly dialysis or incremental in-centre HD commencing 2 days a week. …”
Get full text

Unlocking the biochemical and computational parameters of Ceropegia foetida: A scientific approach for functional bioactive compounds from a medicinal food plant by Fawaz Alheibshy, Abdulwahab Alamri, Saad Saeed Saad Alshahrani, Ahmed Awadh Saleh Alamri, Nasser A.Awadh Ali, Abdulwali Al-Khulaidi, Arshad Hussain, Sirajudheen Anwar

Get full text

A Cross-sectional Study to Assess the Association between the Cognitive Function with Severity of Dependence and Motivation to Quit in Patients with Substance Use Disorder by Shivani Dua, Ramchandra Das, Sudipta Kumar Das

“…Statistical Package for the Social Sciences(SPSS) v23 was used for data analysis. Results: All subjects included in the study were male. …”
Get full text

The effect of cognitive function and central nervous system depressant use on mortality-A prospective observational study of previously hospitalised older patients. by Tahreem Ghazal Siddiqui, Maria Torheim Bjelkarøy, Socheat Cheng, Espen Saxhaug Kristoffersen, Ramune Grambaite, Christofer Lundqvist

“…The long-term effects of CNSD use and reduced cognitive function in older patients are unclear. The aim of this study was to examine whether cognitive function and CNSD use at baseline hospitalisation were associated with all-cause mortality two years after discharge.…”
Get full text

Family function, coping style and well-being affect job burnout among telecommunication employees: a cross-sectional study in China by Jingjing Song, Xinqing Xu, Hanzhong Zhang, Zhenyu Pan, Jinghua Zhu, Jiangang Shao, Liping Jia

“…Using personal information forms and four scales. The collected data were processed and analyzed using SPSS 26.0.ResultsUsing partial correlation analysis, significant correlations (ps < 0.001) were found among family function, coping style, well-being, and job burnout. …”
Get full text

Combining Dielectric and Hyperspectral Data for Apple Core Browning Detection by Hanchi Liu, Jinrong He, Yanxin Shi, Yingzhou Bi

“…To reduce the computational complexity of high-dimensional multi-view data, canonical correlation analysis is employed for feature dimensionality reduction. …”
Get full text

Treatment decisions and surgery variables are predictors of better physical function after total hip and knee arthroplasty: a retrospective cohort study by Janis Nikkhah, Lukas Schöner, Carlos J. Marques, Christoph M. Pros, Reinhard Busse

“…Patients/methods We conducted a secondary, retrospective cohort analysis using longitudinal data from 6,144 THA and TKA patients who participated in the “PROMoting Quality Trial”. …”
Get full text

A comparison of three executive function interventions on direct and far transfer in Chilean school children: a cluster-randomized controlled protocol by Nicholas Napolitano, Cristian A. Rojas-Barahona, Jorge Gaete, Ricardo Araya

“…Secondary outcomes include literacy and mathematical skills. Data will be analyzed using Multivariate Analysis of Covariance (MANCOVA) and Linear Mixed Models (LMM) to examine main effects, interactions, and moderating roles of age and modality. …”
Get full text

Altered amplitude of low-frequency fluctuation and functional connectivity in patients with acute unilateral vestibulopathy: a resting-state fMRI study by Zhengwei Chen, Liangqun Rong, Lijie Xiao, Jie Rao, Haiyan Liu, Tengfei Liu, Fei Chen, Jun Zhang, Lu Wang, Xi Li, Xiue Wei

“…Results of correlation analysis indicated that ALFF value (z-value) in left insular was negatively correlated with the canal paresis value (p = 0.005, r = −0.483), and the FC (z-value) between left insular and left precuneus was negatively correlated with dizziness handicap inventory score (p = 0.012, r = −0.438) in patients with AUVP.ConclusionPatients with AUVP during acute period showed altered functional activity and connectivity in brain regions mainly involved in motor control and vestibular information processing. …”
Get full text

New insights into radioresistance in breast cancer identify a dual function of miR‐122 as a tumor suppressor and oncomiR by Isidro X. Perez‐Añorve, Claudia H. Gonzalez‐De la Rosa, Ernesto Soto‐Reyes, Fredy O. Beltran‐Anaya, Oscar Del Moral‐Hernandez, Marisol Salgado‐Albarran, Oscar Angeles‐Zaragoza, Juan A. Gonzalez‐Barrios, Daniel A. Landero‐Huerta, Margarita Chavez‐Saldaña, Alejandro Garcia‐Carranca, Nicolas Villegas‐Sepulveda, Elena Arechaga‐Ocampo

“…In the present study, differential expression profiling assays identified 16 deregulated miRNAs in acquired radioresistant breast cancer cells, of which miR‐122 was observed to be up‐regulated. Functional analysis revealed that miR‐122 has a role as a tumor suppressor in parental cells by decreasing survival and promoting radiosensitivity. …”
Get full text

Parallels of structural-functional parameters the myocardium, C-type natriuretic peptide and endothelin-1 plasma concentrations in women with uncomplicated essential hypertension by V. V. Petrovska, B. M. Zhebel

“…In addition, the rate of SNP / ET-1 is higher in GC II. In the analysis of structural and functional changes of the myocardium in patients with essential hypertension it has been found that higher plasma concentration of SNP as ET-1 in patients with essential hypertension stage II is associated with registration of pronounced degree of hypertrophy and the presence of DD. …”
Get full text

Brain functional alterations in early stage of coal workers’ pneumoconiosis with alcoholism: insights from a resting-state fMRI investigation by Boting Xue, Gang Cao, Lingling Ren, Yuxiang Zhao, Xuecong Lv, Yong’ai Li, Hagiwara Akifumi, Hagiwara Akifumi, Yongbo Liu, Xiaowei Han

“…Functional connectivity analysis revealed increased connectivity from the right orbitofrontal cortex to the right pars triangularis of the inferior frontal gyrus and from the right precuneus cortex to the right lingual gyrus in both CWP groups. …”
Get full text

Unresponsiveness induced by sevoflurane and propofol is associated with reduced basal forebrain cholinergic nuclei functional connectivity in humans, a pilot exploratory study by Juliana Zimmermann, Rachel Nuttall, Daniel Golkowski, Gerhard Schneider, Andreas Ranft, Rüdiger Ilg, Afra Wohlschlaeger, Christian Sorg, Marlene Tahedl

“…A significant source of cholinergic innervation comes from basal forebrain cholinergic nuclei (BFCN), with bi-directional connections between anterior BFCN and the default mode network (DMN). Since DMN functional connectivity (FC) is consistently reduced during anesthesia-induced unresponsiveness in humans, we hypothesized that BFCN-FC during anesthesia-induced unresponsiveness is reduced and particularly, anterior BFCN-FC reductions might be related to DMN-FC reductions. …”
Get full text

The effects of maternal health literacy, family functioning and self-efficacy on antepartum depression in pregnant women in China: a moderated mediation model by Ling Zhang, Li Ren, Hongyu Li, Haiyan Qiu, Hong Yang, Xiaolan Shi, Honghui Rong, Chuanfen Zheng, Fengju Li, Ting Luo, Lu Lu, Enyu Lei, Dali Yi, Ji-an Chen

“…Maternal health literacy (MHL), family functioning (FF), and self-efficacy (SE) are important factors affecting antepartum depression (AD) in pregnant women. …”
Get full text

ADRB2 inhibition suppresses cancer immune evasion by regulating tumor SOX10-PD-L1 axis and T cell function by Yang Wang, Wei Zhang, Yu Zhang, Ling Chen, Shiyu Wang, Kun Song, Feng Yu, Jing Ouyang, Shan Cao, Cong Peng, Dongbo Liu, Yingying Dai, Wenwu Pei, Ziyang Hong, Weihua Huang, Yijing He, Panpan Liu, Hanying Yi, Gan Zhou, Howard McLeod

“…Additionally, similar studies in colorectal cancer (CRC) models confirmed the conserved function of the ADRB2-SOX10-PD-L1 axis.Results This study explores the role of ADRB2 in regulating tumor PD-L1 expression and T cell functionality, offering insights for cancer immunotherapy. …”
Get full text

Proinflammatory macrophages release CXCL5 to regulate T cell function and limit effects of αPD-1 in steatosis-driven liver cancer by Taojian Tu, Handan Hong, Diala Alhousari, Lina He, Mario Alba, Yiwei Gu, Brittney Hua, Phillip Nguyen, Qi Tang, Tianyi Xia, Karam Ashouri, Anastasia Martynova, Christina Nakhoul, Whitaker Cohn, Genshu Wang, Geyang Xu, Zhang-Xu Liu, Curtis Okamoto, Enrique Cadenas, Julian Whitelegge, Weiming Yuan, Shefali Chopra, Keigo Machida, Liyun Yuan, Anthony El-Khoueiry, Bangyan L. Stiles

“…ANOVA/t tests were used for data analysis. Results: Using LiPten steatosis-tumor mice, we identified CXCL5 as the NAC most robustly upregulated as steatosis progresses to cancer (>100 fold, n = 6–11). …”
Get full text

Beginning and Completion of Events in the Russian and English Language Picture of the World and Features of their Perception in the National Language Consciousness by T. N. Osintseva

“…The analysis of linguistic means was carried out on the basis of the functional-semantic approach. …”
Get full text

Brain connectivity disruptions in PTSD related to early adversity: a multimodal neuroimaging study by Richard O. Nkrumah, Traute Demirakca, Claudius von Schröder, Lemye Zehirlioglu, Noel Valencia, Yasmin Grauduszus, Sabine Vollstädt-Klein, Christian Schmahl, Gabriele Ende

“…However, the underlying neurobiology of ACE-related PTSD remains unclear.Objective: The present study investigated the brain connectivity in ACE-related PTSD using multimodal neuroimaging data.Methods: Using a total of 119 participants with ACE (70 with ACE-related PTSD and 49 ACE-exposed controls), this study acquired T1-weighted MRI, diffusion-weighted MRI, and resting-state fMRI data to examine structural and functional connectivity between groups. …”
Get full text

Assessment of pulmonary function in COPD patients using dynamic digital radiography: A novel approach utilizing lung signal intensity changes during forced breathing by Noriaki Wada, Akinori Tsunomori, Takeshi Kubo, Takuya Hino, Akinori Hata, Yoshitake Yamada, Masako Ueyama, Mizuki Nishino, Atsuko Kurosaki, Kousei Ishigami, Shoji Kudoh, Hiroto Hatabu

“…Objectives: To investigate the association of lung signal intensity changes during forced breathing using dynamic digital radiography (DDR) with pulmonary function and disease severity in patients with chronic obstructive pulmonary disease (COPD). …”
Get full text

The Effects of 8 weeks of high intensity interval training and high intensity functional training on physical performance and volume of firefighters' self-contained breathing appar... by Afshin Seraji, Sajad Ahmadizad, David Cornell

“…Two days before training and 48 hours after the last training session the VO2max test (Bruce’s protocol) and simulated firefighting test were carried out.Results: The statistical analysis of the data showed that HIFT and HIIT caused a significant increase in maximal oxygen uptake (VO2max) and performance, and a significant decrease in the volume of SCBA used in firefighters (p<0.05), though, these changes were not significantly different between HIIT and HIFT groups (p<0.05). …”
Get full text