Neuroligin-3 R451C induces gain-of-function gene expression in astroglia in an astroglia-enriched brain organoid model by Rui Dang, Mridul Dalmia, Ziyuan Ma, Mengmeng Jin, Kushal Aluru, Vincent R. Mirabella, Ava V. Papetti, Li Cai, Peng Jiang

“…Interestingly, our RNA sequencing data suggest that these mutant astroglia significantly upregulate pathways that support neural functions when compared to isogenic wild-type astroglia. …”
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ID1 and ID3 functions in the modulation of the tumour immune microenvironment in adult patients with B-cell acute lymphoblastic leukaemia by Nathaly Poveda-Garavito, Nathaly Poveda-Garavito, Nathaly Poveda-Garavito, Carlos A. Orozco Castaño, Carlos A. Orozco Castaño, Yulieth Torres-Llanos, Yulieth Torres-Llanos, Yulieth Torres-Llanos, Nataly Cruz-Rodriguez, Rafael Parra-Medina, Rafael Parra-Medina, Sandra Quijano, Jovanny Zabaleta, Alba Lucia Combita, Alba Lucia Combita, Alba Lucia Combita

“…RNA-seq evaluated immune genes associatedwith B-ALL immune response, while xCell and CytoSig analysed TIME cell profiles and cytokines. Pathway analysis, gene ontology, and differential gene expression (DEGs) were examined, with functional enrichment analysis performed using KEGG ontology.ResultsPatients were divided into two groups based on ID1 and ID3 expression, namely basal and overexpression. …”
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APOL1 High-Risk Genotype is Not Associated With New or Worsening of Proteinuria or Kidney Function Decline Following COVID-19 Vaccination by Sarah E. Nystrom, Karen L. Soldano, Micki Rockett, Somenath Datta, Guojie Li, Daniel Silas, Melanie E. Garrett, Allison E. Ashley-Koch, Opeyemi A. Olabisi

“…Paired data were stratified by number of APOL1 risk alleles (RAs) and compared within groups using Wilcoxon signed rank test and across groups by analysis of variance. …”
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GPD2 inhibition impairs coagulation function via ROS/NF-κB/P2Y12 pathway by Jiajie Chen, Guifeng Xu, Zhipeng Xie, Shaoxia Xie, Wenwei Luo, Shilong Zhong, Weihua Lai

“…Subsequently, epigenome-wide association study (EWAS), summary data-based Mendelian randomization (SMR), and heterogeneity in dependent instruments (HEIDI) analyses were applied to pinpoint critical methylation sites that influence gene expression, platelet function recovery, and bleeding risk. …”
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Predictive utility of nomogram based on serum glucose-regulated protein 78 and kidney function for long-term kidney graft survival by Keiji Fujimoto, Hiroki Adachi, Serina Kita, Megumi Sakuma, Hirotaka Yamanouchi, Sho Kumano, Ai Fujii, Keita Yamazaki, Keiichiro Okada, Norifumi Hayashi, Kengo Furuichi

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Efficient removal of tetracycline from wastewater using chitosan-based aerogels functionalized with natural zeolite, Fe₃O₄, and MOF-808 by Fatemeh Babaei, Rauf Foroutan, Abolfazl Tutunchi, Mehrshad Ahmadi, Bahman Ramavandi

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The Effect of Recombinant Human Brain Natriuretic Peptide Combined with Xinmailong on Heart Failure and Its Impact on Cardiac Function and Inflammatory Response by Ge Z, Li C, Liu Y, Sun X

“…Zhaorui Ge,1,* Chunyan Li,2,* Yanling Liu,3 Xiujuan Sun4 1Department of Internal Medicine, Xianxian Hospital of Traditional Chinese Medicine, Xianxian, 062250, People’s Republic of China; 2Department of Cardiology, The Second Affiliated Hospital of Hebei North University, Baoding, People’s Republic of China; 3Wuqiao County Hospital of Traditional Chinese and Western Medicine Internal medicine, Wuqiao County, People’s Republic of China; 4Department of Cardiology, Wuqiao County Hospital of Integrated Chinese and Western Medicine, Wuqiao County, People’s Republic of China*These authors contributed equally to this workCorrespondence: Chunyan Li, Email yds734@126.comObjective: To analyze the effect of recombinant human brain natriuretic peptide (rhBNP) combined with Xinmailong on heart failure and its impact on cardiac function and inflammatory response.Methods: A retrospective analysis was conducted on the clinical data of 60 heart failure patients treated in our hospital from January 2023 to March 2024. …”
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Biological Activity and Structure–Activity Relationship of Functionalized Thiols Against <i>Leishmania major</i>, the Agent of Human Cutaneous Leishmaniasis by Taylor Henne, Linsey Curry, Kenlei Gunther, Cameron Smith, Hannah Braunstein, Abdikani Omar Farah, Timothy K. Beng, Blaise Dondji

“…Together, our data demonstrate that functionalized thiols have an in vivo anti-<i>Leishmania</i> activity that is directly linked to their chemical structure.…”
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Effects of Ankle Proprioceptive Training on Ankle Functionality and Performance of Recreational Badminton Players with Pronated Feet: A Quasi-experimental Study by Shivani Vyas, S Sudhakar

“…The data analysis was done using Statistical Package of Social Sciences (SPSS) version 29.0 for Windows. …”
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Association of workplace support for health with occupational health literacy and illness avoidance: moderated mediation by functioning through a salutogenic lens by Nestor Asiamah, Isaac Aidoo, Etornam Doamekpor, Emelia Sarpong, Emelia Danquah, Cosmos Yarfi, Eric Eku, Usman Yaw Baidoo, Christiana Afriyie Manu, Rita Sarkodie Baffoe

“…Common health behaviours are healthy diet and physical activity, both of which protect physical functioning and well-being. Employees are more likely to avoid illness and maintain physical functioning if they receive enough WSH and improve their OHL. …”
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Vitamin C intake and cognitive function in older U.S. adults: nonlinear dose–response associations and effect modification by smoking status by Xingchen He, Yijia Lin, Xinyi Wu, Min Li, Tianyu Zhong, Yanhong Zhang, Yanhong Zhang, Xuliang Weng, Xuliang Weng

“…ObjectiveTo investigate the association between vitamin C intake and cognitive function in U.S. older adults, focusing on dose–response characteristics and effect modification of key subgroups.MethodsUtilizing data from the 2011–2014 National Health and Nutrition Examination Survey (NHANES), this cross-sectional study included 2,801 adults aged ≥ 60 years. …”
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The Impact of Inorganic Nitrate-Rich Beetroot Juice on Microvascular Blood Flow, Cognitive Function, and Other Hemodynamic Outcomes in Postmenopausal Women by Begum Celik, Jeremy Spencer, Daniel Lamport, Noa Argomaniz, Charlotte Mills

“…Early results indicated no significant difference between the groups with respect to SBP or DBP. A statistical analysis of the full data set, including endothelium-dependent and -independent microvascular function and cognitive tests, will be presented. …”
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The Effects of SGLT2 Inhibitors on Lipid Profile and Kidney Function in Patients with Chronic Kidney Disease Regardless of Diabetes and Hypertension Status by Selena Gajić, Stefan Janković, Milorad Stojadinović, Kristina Filić, Ana Bontić, Jelena Pavlović, Ivana Mrđa, Kristina Petrović, Lara Hadži-Tanović, Jelena Žunić, Mihajlo Kostić, Aleksandra Kezić, Marko Baralić

“…Methods: This study was a retrospective data analysis of 75 patients with CKD on SGLT2i treatment. …”
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Changes in Respiratory Function Before and After Cardiopulmonary Bypass in Children with Congenital Heart Disease with Increased or Decreased Pulmonary Blood Flow by Liang L, Hou A, Xi H, Yang J, Liu C

“…This study aims to examine the changes in respiratory function before and after CPB in children under 12 years diagnosed with CHD with different types of shunts.Methods: A retrospective analysis was conducted on the clinical data of 60 pediatric patients with CHD admitted to the hospital between January 2022 and December 2023. …”
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Influence of matrix nature on the functional efficacy of biomedical cell product for the regeneration of damaged liver (experimental model of acute liver failure) by S. V. Gautier, M. Yu. Shagidulin, N. A. Onishchenko, I. M. Iljinsky, V. I. Sevastianov

“…Aim. A comparative analysis of the functional efficacy of biomedical cell products (BMCP) for the regeneration of damaged liver based on biopolymer scaffolded porous and hydrogel matrices was performed on the experimental model of acute liver failure. …”
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Ammonifying and phosphorus-solubilizing function of Aliikangiella maris sp. nov. isolated from Phaeocystis globosa bloom and algal–bacterial interactions by Fei Li, Fei Li, Ming-Ben Xu, Liang-Hao Pan, Jie Li, Cai-Bi Lan, Zhe Li, Shan Lu, Jun-Xiang Lai, Jun-Xiang Lai, Peng-Fu Li

“…Genomic analysis revealed that strain GXAS 306T had many potential functions favorable for interacting with algae, and further experimental evidence confirmed the ammonifying and phosphorus-solubilizing function. …”
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EXPERIMENTAL EVALUATION OF LONG-TERM ADVERSE SIDE EFFECTS OF CYTOSTATIC DRUGS ON FEMALE REPRODUCTIVE FUNCTION AND PHARMACOLOGICAL WAYS TO REDUCE THEM by T. G. Borovskaya, V. E. Goldberg, M. E. Poluektova, A. V. Vychuzhanina, Yu. A. Shchemerovа, V. A. Grigoreva, A. A. Ligacheva, E. A. Bokhan

“…The purpose of the study was a comparative experimental assessment of long-term toxic effects of cytostatic drugs (epirubicin, etoposide, platidiam, carboplatin, paclitaxel) on the female reproductive function and search for pharmacological ways to reduce them.Material and Methods. …”
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Respiratory function and respiratory complications in spinal cord injury: protocol for a prospective, multicentre cohort study in high-income countries by David J Berlowitz, Maria T E Hopman, Martin Schubert, Gabi Mueller, Martin W G Brinkhof, Xavier Jordan, Anja M Raab, Karin Postma, David Gobets, Sven Hirschfeld, Burkhart Huber, Margret Hund-Georgiadis, Renate Wildburger

“…This paper details the protocol for a large-scale, multicentre research project that aims to evaluate the ability of parameters of respiratory function to predict and understand variation in inpatient risk of pneumonia in SCI.Methods and analysis RESCOM, a prospective cohort study, began recruitment in October 2016 across 10 SCI rehabilitation centres from Australia, Austria, Germany, the Netherlands and Switzerland. …”
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Detection of structural-functional coupling abnormalities using multimodal brain networks in Alzheimer’s disease: A comparison of three computational models by Yinping Lu, Luyao Wang, Toshiya Murai, Jinglong Wu, Dong Liang, Zhilin Zhang

“…Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by the disconnection of white matter fibers and disrupted functional connectivity of gray matter; however, the pathological mechanisms linking structural and functional changes remain unclear. …”
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Efficacy and Safety of Recombinant Human Thrombopoietin (rhTPO) on Coagulation Function and Inflammatory Factors in the Treatment of Patients with Sepsis-Related Thrombocytopenia by Huijuan Wang MD, Dong Chen MD, Ming He MD

“…Background this study aimed to investigate the efficacy of recombinant human thrombopoietin (rhTPO) in the treatment of sepsis-associated thrombocytopenia, and to evaluate its impact on coagulation function, inflammatory markers, platelet (Plt) count, and patient prognosis. …”
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