Intrinsic immunosuppressive features of monocytes suppress CAR-T19 through IL-1 pathway modulation in mantle cell lymphoma by Kun Yun, R. Leo Sakemura, Ismail Can, Omar Gutierrez Ruiz, Ekene J. Ogbodo, Shuwen Zhang, Ateka Saleh, Truc N. Huynh, Claudia Manriquez Roman, Olivia L. Sirpilla, Carli M. Stewart, James H. Girsch, Jennifer M. Feigin, Long Mai, Hong Xia, Brooke Kimball, Lionel A. Kankeu Fonkoua, Mehrdad Hefazi, Michael W. Ruff, Fariborz Rakhshan Rohakhtar, Vernadette Simon, Elizabeth L. Siegler, Mike Mattie, Sao-Mai Nguyen-Mau, Simone Filosto, Saad S. Kenderian

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Individual Pharmacotherapy Management (IPM-II) for Patient and Drug Safety in Polypharmacy via Clinical Electronic Health Record Is Associated with Significant Fall Prevention by Ursula Wolf, Luise Drewas, Hassan Ghadir, Christian Bauer, Lars Becherer, Karl-Stefan Delank, Rüdiger Neef

“…A retrospective pre-post intervention study in geriatric traumatology on ≥70 years old patients compared 200 patients before IPM implementation (CG) with 204 patients from the IPM intervention period (IG) for the entire medication list, organ, cardiovascular and vital functions and fall risk parameters. Results: Statistically similar baseline data allowed a comparison of the average 80-year-old patient with a mean of 11.1 ± 4.9 (CG) versus 10.4 ± 3.6 (IG) medications. …”
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Extensive modulation of the circulating blood proteome by hormonal contraceptive use across two population studies by Nikola Dordevic, Clemens Dierks, Essi Hantikainen, Vadim Farztdinov, Fatma Amari, Vinicius Verri Hernandes, Alessandro De Grandi, Francisco S. Domingues, Orr Shomroni, Kathrin Textoris-Taube, Vivien Bahr, Hannah Schmid, Ilja Demuth, Florian Kurth, Michael Mülleder, Peter Paul Pramstaller, Johannes Rainer, Markus Ralser

“…Methods Utilizing high-throughput mass spectrometry, we quantified 148 highly abundant proteins, functioning in the innate and adaptive immune system, coagulation and nutrient transport in 3632 blood plasma, and 500 serum samples from the CHRIS and BASE-II cross-sectional population studies, respectively. …”
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Community-based exercise for health promotion and secondary cancer prevention in Canada: protocol for a hybrid effectiveness-implementation study by Margaret L McNeely, Christopher Sellar, Tanya Williamson, Melissa Shea-Budgell, Anil Abraham Joy, Harold Y Lau, Jacob C Easaw, Albert D Murtha, Jeffrey Vallance, Kerry Courneya, John R Mackey, Matthew Parliament, Nicole Culos-Reed

“…To move this efficacy evidence into practice, we designed and launched a 5-year study to evaluate the relative benefit from implementing a clinic-to-community-based cancer and exercise model of care.Methods and analysis A hybrid effectiveness and implementation trial design is being used to evaluate the effectiveness of delivery of community-based exercise and to collect data on implementation of the programme. …”
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Optimizing the Construction Supply Chain Network Considering the Flow of Materials, Equipment, Manpower, Drawings and Technical Documents by Seyed Saeid Helli, Hadi Mokhtari, Saeed Dehnavi

“…All indices, parameters, decision variables, objective functions and constraints have been introduced and presented in the proposed model. …”
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Correlations of Cancer-Related Fatigue with Clinicopathological Features and Quality of Life in Gastric Cancer by Dong Liu, A-Dong Xia, Yue-Long Xing, Kai Zhang, Dan Chen

“…Pearson’s correlation analysis revealed a positive correlation between patient emotions and the CRF BFI score (r=0.443, P=0.001). …”
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Influence of pyridyl nitrogen’s position and hydrogen bonding interactions on antibacterial activities investigated by in vitro and in silico by Suma Ramachandra Gopady, Thripthi Nagesh Shenoy, Abdul Ajees Abdul Salam, Srikrishna Herga Damodar Kedlaya, Shashanka Puranika Kota, Anusha Prabhu, Yegneswaran Prakash Peralam, Srinivasulu Maddasani

“…The experimental results were supported by molecular docking, molecular dynamics simulation and ADME/T analysis. The findings are consistent with experimental data, demonstrating that Schiff base 4Py exhibits greater inhibitory efficacy against S.aureus, while 3Py shows superior activity agains E. coli, compared to their respective HB complexes.…”
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Prognostic changes in lymphocyte subpopulations during the development of autoimmune complications in patients with DiGeorge syndrome by N. V. Davydova, N. V. Zinovieva, S. B. Zimin, O. V. Shvez, E. V. Galeeva, Yu. E. Konoplyannikova, O. V. Molochnikova, Yu. V. Petrova, G. N. Gildeeva, I. G. Kozlov

“…Defects are characterized by T cell lymphopenia, changes in the functions and subpopulation composition of T and B lymphocytes. …”
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Evaluation of drug release from topical dosage forms and permeability prediction through the skin barrier (review) by N. B. Melnikova, I. A. Sheferov, A. A. Emasheva, A. A. Sheferova, D. A. Panteleev, A. I. Slivkin

“…The paper showed statistical methods of data analysis (MANOVA, ANOVA) and model-dependent methods (zero order, first order, Higuchi model, Korsmeyer – Peppas model, Hixson – Crowell model, etc.). …”
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Quantitative and structural features of the SMN1 and SMN2 genes in patients with spinal muscular atrophy 5q by A. I. Vlasenko, V. D. Nazarov, S. V. Lapin, A. V. Mazing, E. A. Surkova, T. V. Blinova, T. M. Alekseeva

“…We assessed an indirect parameter of aggressiveness (the age of the patient’s visit to the laboratory) to assess the severity of clinical manifestations of SMA. Statistical analysis was carried out using the statistical data processing program GraphPad Prism9.Results. …”
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CHANGES IN THE DENTAL STATUS OF PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE by D.V. Emelyanov, T.O. Petrushanko

“…Against this background, it is clear that the functions of a dentist include not only restoring or whitening teeth. …”
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Development of a Serious Game to Simulate Neonatal Intensive Care Unit Experiences: Collaborative Quasi-Experimental Study by Yukihide Miyosawa, Koichi Hirabayashi, Kodai Yamada, Fumiya Kobayashi, Nanami Ogihara, Noa Takeda, Eri Okamura, Shogo Matsumura

“…Descriptive and inferential statistics were used for data analysis. ResultsThe game, titled First Steps in the NICU, was released for iOS, Android, and Steam. …”
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Real-world experience of diagnosis, disability, and daily management in parents of children with different genetic developmental and epileptic encephalopathies: a qualitative study by Cristina Garcia-Bravo, Domingo Palacios-Ceña, Ángel Aledo-Serrano, Javier Güeita-Rodríguez, Juan Francisco Velarde-García, Juan Nicolas Cuenca-Zaldivar, Romain Marconnot, María Cristina Alonso-Blanco, Jorge Pérez-Corrales, Carmen Jimenez-Antona

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On-Demand Gait-Synchronous Electrical Cueing in Parkinson's Disease Using Machine Learning and Edge Computing: A Pilot Study by Ardit Dvorani, Constantin Wiesener, Christina Salchow-Hommen, Magdalena Jochner, Lotta Spieker, Matej Skrobot, Hanno Voigt, Andrea Kuhn, Nikolaus Wenger, Thomas Schauer

“…We demonstrate the system's functionality and safety during on-demand gait-synchronous electrical cueing in two patients, performing freezing of gait assessments. …”
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Non-invasive biopsy diagnosis of diabetic kidney disease via deep learning applied to retinal images: a population-based study by Ziyao Meng, MEng, Zhouyu Guan, MD, Shujie Yu, MBBS, Yilan Wu, BSc, Yaoning Zhao, BSc, Jie Shen, PhD, Cynthia Ciwei Lim, MMed, Tingli Chen, MD, Dawei Yang, PhD, An Ran Ran, PhD, Feng He, MSc, Haslina Hamzah, BSc, Sarkaaj Singh, MSc, Anis Syazwani Abd Raof, MSc, Jian Wen Samuel Lee-Boey, MBBS, ProfMBBS Soo-Kun Lim, MBBS, ProfMD Xufang Sun, MBBS, Shuwang Ge, MD, ProfMD Gang Xu, MD, Prof Hua Su, MD, Yang Cheng, MD, Feng Lu, PhD, ProfPhD Xiaofei Liao, PhD, ProfPhD Hai Jin, PhD, Chenxin Deng, MMed, Lei Ruan, MD, ProfMD Cuntai Zhang, MD, Chan Wu, MD, ProfMD Rongping Dai, MD, Yixiao Jin, MSc, Wenxiao Wang, PhD, Tingyao Li, BSc, Ruhan Liu, PhD, Jiajia Li, PhD, Jia Shu, BEng, Yuwei Lu, MBBS, Xiangning Wang, MD, Qiang Wu, MD, Yiming Qin, BEng, Jin Tang, MD, Xiaohua Sheng, MD, Qiong Jiao, MD, ProfPhD Xiaokang Yang, MD, ProfPhD Minyi Guo, MD, Gareth J McKay, PhD, ProfPhD Ruth E Hogg, PhD, Gerald Liew, MBBS, Evelyn Yi Lyn Chee, PhD, ProfPhD Wynne Hsu, PhD, ProfPhD Mong Li Lee, PhD, Simon Szeto, MBChB, ProfMD Andrea O Y Luk, MBChB, ProfMD Juliana C N Chan, MBChB, Carol Y Cheung, PhD, Gavin Siew Wei Tan, FRCSEd, Yih-Chung Tham, PhD, ProfMD PhD Ching-Yu Cheng, PhD, Charumathi Sabanayagam, MD PhD, ProfPhD Lee-Ling Lim, MD PhD, ProfMD PhD Weiping Jia, MD PhD, ProfMD PhD Huating Li, MD PhD, Bin Sheng, Prof, Tien Yin Wong, Prof

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Development of a PROM to measure patient-centredness in chronic care consultations in primary care by Anne Holm, Anna Bernhardt Lyhnebeck, Sussi Friis Buhl, Kristine Bissenbakker, Jette Kolding Kristensen, Anne Møller, Anders Prior, Zaza Kamper-Jørgensen, Sidsel Böcher, Mads Aage Toft Kristensen, Asger Waagepetersen, Anders Hye Dalsgaard, Volkert Siersma, Ann Dorrit Guassora, John Brandt Brodersen, on behalf MM600 trial group

“…Psychometric validation showed high internal consistency, overall high reliability, and moderate fit indices in the confirmatory factor analysis for all five domains. Few items demonstrated differential item functioning concerning variables such as age, sex, and education. …”
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Gut dysbiosis is associated with difficult-to-treat rheumatoid arthritis by Patricia Ruiz-Limón, Patricia Ruiz-Limón, Patricia Ruiz-Limón, Natalia Mena-Vázquez, Natalia Mena-Vázquez, Isabel Moreno-Indias, Isabel Moreno-Indias, Isabel Moreno-Indias, Jose Manuel Lisbona-Montañez, Jose Manuel Lisbona-Montañez, Jose Manuel Lisbona-Montañez, Arkaitz Mucientes, Arkaitz Mucientes, Sara Manrique-Arija, Sara Manrique-Arija, Sara Manrique-Arija, Rocío Redondo-Rodriguez, Rocío Redondo-Rodriguez, Laura Cano-García, Laura Cano-García, Francisco J. Tinahones, Francisco J. Tinahones, Francisco J. Tinahones, Francisco J. Tinahones, Antonio Fernández-Nebro, Antonio Fernández-Nebro, Antonio Fernández-Nebro

“…The gut microbiota was analyzed using 16S rRNA gene sequencing; bioinformatics analysis was performed using QIIME2, and its functionality was inferred through PICRUSt. …”
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Hybrid closed-loop systems for managing blood glucose levels in type 1 diabetes: a systematic review and economic modelling by Asra Asgharzadeh, Mubarak Patel, Martin Connock, Sara Damery, Iman Ghosh, Mary Jordan, Karoline Freeman, Anna Brown, Rachel Court, Sharin Baldwin, Fatai Ogunlayi, Chris Stinton, Ewen Cummins, Lena Al-Khudairy

“…Two reviewers extracted data independently using a piloted data extraction form. …”
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Developing a multivariate drought index to assess drought characteristics based on the SWAT-Copula method in the Poyang Lake basin, China by Liping Guo, Fusheng Chen, Bin Wang, De Li Liu, Xiulong Chen, Hongsheng Huang, Hua Bai, Kaitao Liao, Zhiming Xia, Keyu Xiang, Linchao Li, Taihui Zheng, Qiang Yu

“…A Multivariate Standardized Drought Index (MSDI) was then developed with simulated Standardized Soil Moisture Index (SSI) and Standardized Precipitation Index (SPI) based on copula functions. We found that (1) The SWAT can simulate monthly streamflow well with NS being 0.76–0.92 for validation data over the sub-basins in the PLB. (2) The MSDI index indicated that there were more drought events during 1960–1979 and 2000–2019, highlighting a cyclical pattern of drought events in the PLB. (3) The Xiushui River Basin encountered the most extreme drought conditions since 2000, indicating the basin faced a high risk of dry conditions. …”
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Impairment in work and activities of daily life in patients with psoriasis: results of the prospective BioCAPTURE registry by Tamara W. van Hal, Juul M. P. A. van den Reek, Mark H. Wenink, Marisol E. Otero, Paul M. Ossenkoppele, Marcellus D. Njoo, Annet Oostveen, Bas Peters, Milan Tjioe, Else N. Kop, John E. M. Körver, Sharon R. P. Dodemont, Marloes M. Kleinpenning, Maartje A. M. Berends, Wendelien R. Veldkamp, Martijn B. A. van Doorn, Johannes M. Mommers, Robert-Jan Lindhout, Astrid L. A. Kuijpers, Paula P. van Lümig, C. (Els) J. de Jonge, Ron A. Tupker, Judith Hendricksen, Romy R. Keijsers, Frank H. J. van den Hoogen, Johanna E. Vriezekolk, Elke M. G. J. de Jong

“…Associations between impairments and contextual factors varied, but all impairments were associated with worse mental/physical general functioning.Conclusion: Patients with psoriasis using biologicals are less likely to have work-for-pay. …”
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