Deubiquitylase USP52 Promotes Bladder Cancer Progression by Modulating Ferroptosis through Stabilizing SLC7A11/xCT by Jianmin Liu, Yongwen Luo, Siming Chen, Gang Wang, Wan Jin, Wenyu Jiang, Mingxing Li, Yejinpeng Wang, Jingtian Yu, Houyi Wei, Renjie Zhang, Fenfang Zhou, Lingao Ju, Yi Zhang, Yu Xiao, Kaiyu Qian, Xinghuan Wang

“…Despite growing interest, the roles and vulnerabilities determining ferroptosis sensitivity in BLCA remain unclear. Re‐analysis of single‐cell RNA data reveals a decrease in high‐ferroptosis cancer cells as BLCA advances. …”
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Evaluating Long‐Term Outcomes of Children Undergoing Surgical Treatment for Congenital Heart Disease for National Audit in England and Wales by Kate L. Brown, Qi Huang, Ferran Espuny‐Pujol, Julie A. Taylor, Jo Wray, Carin van Doorn, Serban Stoica, Christina Pagel, Rodney C. G. Franklin, Sonya Crowe

“…Methods and Results Informed by user online discussion forums and scoping of national data, we selected sentinel CHDs and long‐term outcome metrics suitable for routine monitoring. …”
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Digital Transformation in Voluntary Sports Organizations: A Scoping Review on Multi-Level Drivers, Promoting Factors, Forms and Consequences by Pascal Stegmann, Grazia Lang

“…These organizations are central pillars of organized sports in Switzerland, playing a critical role in fulfilling the socio-political functions of sports, such as promoting public health, social integration, and civic engagement (Nagel et al., 2020). …”
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A Mobile App (Joint Effort) to Support Cannabis Use Self-Management and Reinforce the Use of Protective Behavioral Strategies: Development Process and Usability Testing by José Côté, Patricia Auger, Gabrielle Chicoine, Jinghui Cheng, Sylvie Cossette, Guillaume Fontaine, Christine Genest, Shalini Lal, Judith Lapierre, M Gabrielle Pagé, Marc-André Maheu-Cadotte, Geneviève Rouleau, Billy Vinette, Didier Jutras-Aswad

“…Usability was assessed through qualitative semistructured interviews and the User Version of the Mobile Application Rating Scale (uMARS), completed by a sample of 20 university students with a mean age of 21.8 (median 22) years, 14 (70%) of whom were women and 15 (75%) were undergraduates. Qualitative data were analyzed using thematic analysis. …”
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Impacts of loading thymoquinone to gold or silver nanoparticles on the efficacy of anti-tumor treatments in breast cancer with or without chemotherapeutic cisplatin by Soha Gomaa, Mohamed Nassef, Ahlam Abu-Shafey, Mona Elwan, Asmaa Adwey

“…Eleven days after EAC inoculations, assessments were conducted to evaluate the total number of tumor cells, splenocytes, white blood cells (WBCs), C-reactive protein (CRP) levels, flow cytometric analysis of apoptosis in EAC cells, as well as the functionality of the kidney and liver. …”
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The Structural Model of Happiness Based on Mindfulness with Mediator Role of Emotional Intelligence, Self-Compassion and Resilience by Mohammad Reza Tamannai far, Faezeh Taraffo

“…ConclusionThe purpose of this study was to investigate the mediating role of emotional intelligence, self-compassion and resilience in the relationship between mindfulness and happiness. The results of the data analysis showed that the conceptual model of the research had a good fit and mindfulness influenced resilience and happiness through emotional intelligence and self-compassion.  …”
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An exploratory study of the relevance of therapy format and therapist’ training in individual cognitive behavioral therapy for psychosis by Oda Skancke Gjerdalen, Manuela Zucknick, Manuela Zucknick, Ingvild Tvedt Westlie, Helen Bull, Stig Evensen, Erik Falkum, Marit Grande, Marit Grande, Roger Hagen, Roger Hagen, Roger Hagen, Kristin Lie Romm, Kristin Lie Romm, Lene Hunnicke Jensen, Petter Andreas Ringen, Petter Andreas Ringen, Olivia Schjøtt-Pedersen, Nasrettin Sönmez, Torill Ueland, Torill Ueland, Tiril Østefjells, Jan Ivar Røssberg, Jan Ivar Røssberg, June Ullevoldsæter Lystad, June Ullevoldsæter Lystad, June Ullevoldsæter Lystad

“…Using a series of mixed effects models for repeated measurements, we examined differences between the groups in terms of general functioning and psychiatric symptom severity. Emphasis was placed on potential differences between the two groups receiving CBTp, considering both average differences across assessment points and trajectories over time.ResultsIn line with expectations, all groups demonstrated overall improvements in functioning and symptom levels. …”
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Epigenetic Drift Is Involved in the Efficacy of HBV Vaccination by Francesca Ferraresi, Simona Anticoli, Stefano Salvioli, Chiara Pirazzini, Luciano Calzari, Davide Gentilini, Christian Albano, Reparata Rosa Di Prinzio, Salvatore Zaffina, Rita Carsetti, Paolo Garagnani, Anna Ruggieri, Katarzyna Malgorzata Kwiatkowska

“…The literature search and pathway analysis indicate that such genes are involved in the correct functioning of the immune system. …”
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The potential habitat of Phlomoides rotata in Tibet was based on an optimized MaxEnt model by Jun-Wei Wang, Jun-Wei Wang, Min Xu, Norbu Ngawang, Yonghao Chen, Ngawang Bonjor, Xiaoyan Jia, Zhefei Zeng, Zhefei Zeng, La Qiong, La Qiong

“…IntroductionPhlomoides rotata, an important Tibetan medicinal plant, has garnered significant attention due to its remarkable medicinal value and ecological functions. However, overharvesting and climate change have progressively reduced its distribution range, threatening its survival.MethodsThis study employed an optimized MaxEnt model, integrating field survey data and multiple environmental variables, to predict and analyze the potential suitable distribution of P. rotata in Tibet.ResultsThe model achieved high predictive accuracy, with Ture skill statistic (TSS) = 0.87 and Cohen’s Kappa Coefficient (Kappa) = 0.81. …”
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Intelligent Environmental Health Risk Assessment System for the Elderly in Cold Regions Based on Artificial Intelligence Integrated Development Environment by Tianheng ZHANG, Yao FU, Jian GAO, Huanran XUE

“…Based on the collected data, a Bayesian probability model is constructed that transforms traditional Bayesian components into environment-specific parameters: Prior probabilities become baseline blood pressure values, likelihood functions become environmental adjustment effects, and posterior distributions become predictive blood pressure values with confidence intervals. …”
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Validation of Strategic Memory Advanced Reasoning Training as an efficient and effective approach to treating warfighters with persistent cognitive complaints associated with mild... by Andrew J. Darr, Andrew J. Darr, Andrew J. Darr, Angela Basham, Angela Basham, Angela Basham, Jessica L. Ryan, Melissa Caswell, Melissa Caswell, Melissa Caswell, Juan Lopez, Juan Lopez, Juan Lopez, Jennifer Zientz, Erin Venza, Ida Babakhanyan, Ida Babakhanyan, Ida Babakhanyan, Sandra Chapman, Jason M. Bailie, Jason M. Bailie, Jason M. Bailie

“…Additionally, treatment improved patient perceived functionality (KBCI) from T1 to T2 and these gains remained stable at T3 (p < 0.001, ηp2 = 0.377). …”
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Comparison of the Effect of Different Percentages of Sesame Oil and Soybean Oil on Growth Performance, the Weight of Internal Organs, and Serum Biochemical Parameters in Japanese q... by Maryam Karimi-Dehkordi, Forogh Mohammadi, Majid Gholami-Ahangaran

“…The concentrations of blood parameters were measured by colorimetry (photometry) using commercial kits available in the market and based on the provided instructions. The data were statistically analyzed by SPSS version 22 statistical software with the one-way analysis of variance (ANOVA) test. …”
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Acute cannabis intoxication among the paediatric population by Ginevra Malta, Giuseppe Davide Albano, Gianluca Lavanco, Anna Brancato, Carla Cannizzaro, Antonina Argo, Simona Contorno, Fulvio Plescia, Stefania Zerbo

“…During neurodevelopment, CB1 receptors exhibit unique expression patterns, including transient localization in brainstem regions critical for neurovegetative functions. These developmental dynamics likely explain children’s heightened sensitivity to THC’s neurological and neurovegetative effects, often resulting in more severe outcomes compared to adults. …”
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Neuropsychological outcome of indoor rehabilitation in post-COVID-19 condition—results of the PoCoRe study by Michael Jöbges, Melanie Tempfli, Melanie Tempfli, Christoph Kohl, Christoph Herrmann, Stefan Kelm, Alexa Kupferschmitt, Alexa Kupferschmitt, Alexa Kupferschmitt, Ida Montanari, Nike Walter, Gerhard Suetfels, Thomas Loew, Volker Köllner, Volker Köllner, Thilo Hinterberger

“…Various measures were employed, including the fatigue scale for motor functioning and cognition (FSMC), the Test Battery for Attention (TAP) and the Montreal Cognitive Assessment (MoCA).ResultsOut of the 1,086 recruited participants, a total of N = 701 participants were included in the main data analysis. …”
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Climate, soil and management factors drive the quantitative relationships between soil fertility and spring maize water productivity in northern China by Jiao Shi, Minggang Xu, Xinhua He, Huaiping Zhou, Jianhua Li

“…The potential QRs determined by boundary functions were reached up to 6.2, 5.26 and 6.12 kg m−3 in NW, at dry years and under NPK, respectively. …”
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HSP90AA1 is an unfavorable prognostic factor for hepatocellular carcinoma and contributes to tumorigenesis and chemotherapy resistance by Zhaoying Wang, Longfei Fan, Heng Xu, Zhongqiang Qin, Ziyi Zhu, Di Wu, Yigang Zhang, Ruoyu Liu, Jianzhu Wei, Zhen Qian, Peipei Yang, Bo Xie, Mu Yuan, Jingyu Qian

“…Cell viability assay, Clonal formation assay, and Live/dead staining assay were employed to determine the gene functions. After cross-analysis of differentially expressed genes (DEGs) and ICD-related genes (ICDRGs), 7 differentially expressed ICDRGs were identified in HCC. …”
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Impact of gut microbial diversity on egg production performance in chickens by Liping Wu, Tao Zhang, Zhihua Luo, Huiyuan Xiao, Di Wang, Cailong Wu, Xinyan Fang, Jiawei Li, Jing Zhou, Junjie Miao, Hongli Tan, Yanan Wang, Qing Liu, Jianhua Huang

“…These differences in gut microbiota influence key physiological functions, including nutrient absorption and hormone regulation through metabolic pathways, and directly affect egg production performance. …”
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Insights into high-altitude adaptation and meat quality regulation by gastrointestinal metabolites in Tibetan and black pigs by Xue Bai, Xue Bai, Zhiying Huang, Helin Tan, Yiren Gu, Xun Wang, Long Jin, Peng Shang, Keren Long, Diyan Li, Mingzhou Li

“…Integrated multi-omics approaches linked stomach metabolism, particularly through bile secretion pathways influenced by acetylcholine, to muscle functionality, highlighting the important role played by the ATP1B4 gene in enabling muscle physiology in Tibetan pigs.DiscussionThis study highlights the importance of targeted dietary interventions in improving meat quality for specific pig breeds. …”
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Altered expression and potential role of N6-methyladenosine mRNA methylation in abdominal aortic aneurysm mouse model by Julin Wang, Tianyu Miao, Yanyun Wang, Tiehao Wang, Zhangyu He, Fei Xiong, Ding Yuan, Qiang Guo, Yi Yang, Zhichen Tang, Bin Huang, Jichun Zhao

“…This study aimed to explore the expression profile, potential functions and regulated mechanism of m6A RNA methylation in the abdominal aortic aneurysm mice model. …”
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Molecular landscape of sex- and modality-specific exercise adaptation in human skeletal muscle through large-scale multi-omics integration by Macsue Jacques, Shanie Landen, Adam P. Sharples, Andrew Garnham, Ralf Schittenhelm, Joel Steele, Aino Heikkinen, Elina Sillanpää, Miina Ollikainen, James Broatch, Navabeh Zarekookandeh, Ola Hanson, Ola Ekström, Olof Asplund, Séverine Lamon, Sarah E. Alexander, Cassandra Smith, Carlie Bauer, Mary N. Woessner, Itamar Levinger, Andrew E. Teschendorff, Linn Gillberg, Ida Blom, Jørn Wulff Helge, Nicholas R. Harvey, Larisa M. Haupt, Lyn R. Griffiths, Atul S. Deshmukh, Kirsi H. Pietiläinen, Päivi Piirilä, Robert A.E. Seaborne, Marie Klevjer, Anja Bye, Ulrik Wisløff, Bernadette Jones-Freeman, Nir Eynon

“…Summary: We investigated the molecular mechanisms of exercise adaptations in human muscle by integrating genome, methylome, transcriptome, and proteome data from over 1,000 participants (2,340 muscle samples). …”
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