Annual cycle variations in the gut microbiota of migratory black-necked cranes by Yujia Zhang, Ruifeng Ma, Suolangduoerji, Shujuan Ma, Shujuan Ma, Akebota Nuertai, Ke He, Hongyi Liu, Ying Zhu

“…And the summer samples exhibited higher alpha (Simpson and Shannon), beta diversity (Bray-Curtis and UniFrac) and more diverse functions in gut microbiota compared to other seasons. …”
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Unveiling IRF4-steered regulation of context-dependent effector programs in CD4+ T cells under Th17- and Treg-skewing conditions by Anna Gabele, Maximilian Sprang, Mert Cihan, Mareen Welzel, Assel Nurbekova, Karolina Romaniuk, Sarah Dietzen, Matthias Klein, Georg Bündgen, Maxim Emelianov, Gregory Harms, Krishnaraj Rajalingam, Tanja Ziesmann, Katrin Pape, Beatrice Wasser, David Gomez-Zepeda, Kathrin Braband, Michael Delacher, Niels Lemmermann, Stefan Bittner, Miguel A. Andrade-Navarro, Stefan Tenzer, Katja Luck, Tobias Bopp, Ute Distler

“…However, the molecular mechanisms of how IRF4 steers diverse transcriptional programs in Th17 and Treg cells are far from being definitive. Here, we integrated data derived from affinity-purification and full mass-spectrometry-based proteome analysis with chromatin immunoprecipitation sequencing. …”
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Myths and misconceptions of intimate partner violence among sexual and gender minorities: a qualitative exploration by Stefan Kurbatfinski, Stefan Kurbatfinski, Nicole Letourneau, Nicole Letourneau, Nicole Letourneau, Nicole Letourneau, Nicole Letourneau, Susanne Marshall, Dawn McBride, Jason Novick, Keira Griggs, Arielle Perrotta, Arielle Perrotta, Morgan Daye, Carrie McManus, Kendra Nixon

“…BackgroundIntimate partner violence (IPV), referring to different forms of violence or abuse between two or more intimate partners, negatively impacts physical and mental health, performance in various settings, and familial functioning, leading to long-term adverse outcomes. …”
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Recognition and cleavage of human tRNA methyltransferase TRMT1 by the SARS-CoV-2 main protease by Angel D'Oliviera, Xuhang Dai, Saba Mottaghinia, Sophie Olson, Evan P Geissler, Lucie Etienne, Yingkai Zhang, Jeffrey S Mugridge

“…The SARS-CoV-2 main protease (Mpro or Nsp5) is critical for production of viral proteins during infection and, like many viral proteases, also targets host proteins to subvert their cellular functions. Here, we show that the human tRNA methyltransferase TRMT1 is recognized and cleaved by SARS-CoV-2 Mpro. …”
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TREM2 supports neuronal protection and microglial reactivity without an effect on misfolded protein deposition in chronic neurodegenerative prion disease by Sarah M. Carpanini, Barry M. Bradford, Alessio Alfieri, Pedro Piccardo, Jimena Monzón-Sandoval, Deborah Brown, Aileen Boyle, Aleksandra Pokrovskaya, Neil A. Mabbott, Jean Manson, Barry W. McColl, Barry W. McColl

“…TREM2 is a cell surface receptor on microglia that regulates homeostatic and immunomodulatory functions, including phagocytosis of apoptotic debris and the resolution of damage-associated inflammation. …”
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Mitochondrial dysfunction and fatigue in Sjögren’s disease by Astrid Rasmussen, Christopher J Lessard, A Darise Farris, Kristi A Koelsch, Biji T Kurien, Joshua Cavett, Kathy Sivilis, Robert Hal Scofield, John Aubrey Ice, Rebecca A Wood, Gavin Pharaoh, Valerie Lewis, Shylesh Bhaskaran, Holly Van Remmen

“…In healthy states, dysfunctional mitochondria are recycled by mitophagic processes; when impaired, poorly functioning mitochondria persist and produce inflammatory reactive oxygen species. …”
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A systematic review of fishing impacts on the trophic level of fish populations and assemblages in the Mediterranean Sea by Audrey Marguin, Audrey Marguin, Simona Bussotti, Simona Bussotti, Paolo Guidetti, Paolo Guidetti, Francesca Rossi, Francesca Rossi

“…For the field studies, only 6 estimated TLs of species and used stable isotope analysis. Most modelling studies used data from other models, online databases or large-scale monitoring of commercial catches and research surveys, whereas the field studies collected fish locally. …”
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Systematic protein–protein interaction mapping for clinically relevant human GPCRs by Kate Sokolina, Saranya Kittanakom, Jamie Snider, Max Kotlyar, Pascal Maurice, Jorge Gandía, Abla Benleulmi‐Chaachoua, Kenjiro Tadagaki, Atsuro Oishi, Victoria Wong, Ramy H Malty, Viktor Deineko, Hiroyuki Aoki, Shahreen Amin, Zhong Yao, Xavier Morató, David Otasek, Hiroyuki Kobayashi, Javier Menendez, Daniel Auerbach, Stephane Angers, Natasa Pržulj, Michel Bouvier, Mohan Babu, Francisco Ciruela, Ralf Jockers, Igor Jurisica, Igor Stagljar

“…Our data represent the first large‐scale interactome mapping for human GPCRs and provide a valuable resource for the analysis of signaling pathways involving this druggable family of integral membrane proteins.…”
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The Ethical Significance of Brain-Computer Interfaces as Enablers of Communication by Toma Gruica

“…The first treats them as medical devices warranting standard risk-benefit analysis, assessing safety, efficacy, and clinical outcomes.[2] The second framework situates BCIs within the emerging field of neuroethics, emphasizing concerns about privacy, cognitive liberty, data security, and the potential for manipulation.[3] Although previous work has already emphasized the ethical importance of BCIs in restoring communicative capacities, this paper develops the claim further by foregrounding what may be termed the ethical function of BCIs.[4] Their significance lies not just in enhancing particular interactions or reducing barriers, but in re-establishing the very possibility of communication, through which individuals assert their will, can participate in community, and be recognized as interlocutors. …”
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Feeding Behavior and Ecological Significance of <i>Craspedacusta sowerbii</i> in a Freshwater Reservoir: Insights from Prey Composition and Trophic Interactions by Hailong Yan, Yu Wang, Mengyao Wu, Yuying Li, Wanping Wang, Dongliang Zhang, Jingjing Guo, Nicola Fohrer, Bailian Larry Li

“…Through in situ cultivation, microscopic examination, and amplicon sequencing analysis, we identified the primary food sources of <i>C. sowerbii</i> within the reservoir’s aquatic food web. …”
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A Quantitative Risk Assessment Model for <i>Listeria monocytogenes</i> in Non-Ready-to-Eat Frozen Vegetables by Ursula Gonzales-Barron, Régis Pouillot, Juliana De Oliveira Mota, Akio Hasegawa, Ana Allende, Qingli Dong, Matthew J. Stasiewicz, Jovana Kovacevic, Vasco Cadavez, Laurent Guillier, Moez Sanaa

“…Based on available published data, the model was coded in nine sequential R functions designed to assess the effectiveness of blanching, the improvement in processing environment hygiene, the implementation of sampling schemes at the end of processing, and improved consumer instructions on the product’s package. …”
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CD38 Deficiency Promotes Inflammatory Response through Activating Sirt1/NF-κB-Mediated Inhibition of TLR2 Expression in Macrophages by Yisong Qian, Chuqiao Chen, Leliang Ma, Ziwei Wang, Ling-Fang Wang, Li Zuo, Yaqin Yang, Xiang Huang, Meixiu Jiang, Xiaolei Wang, Huidong Shi, Mingui Fu, Ke-Yu Deng, Hong-Bo Xin

“…CD38 was first identified as a lymphocyte-specific antigen and then has been found to be widely expressed in a variety of cell types. The functions of CD38 are involved in numerous biological processes including immune responses. …”
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Glycopattern comparison of sperm and exosomes from conventional in vitro fertilization and rescue intracytoplasmic sperm injection: Enhancing sperm motility through exosome‐mediate... by Muhammad Anas Ramzan, Zhedong Yang, Li Cao, Jinyuan Zhang, Fei Wu, Miaomiao Xin, Bo Guo, Lumin Wang, Lingyu Zhao, Yannan Qin, Chengcheng Liu

“…DBA is primarily bound to the neck, acrosomal region, plasma membrane, and tail of IVF sperm, but its binding was significantly reduced in RICSI sperm. Functionally, IVF exosomes enhanced RICSI sperm motility in a dose‐dependent manner by upregulating DBA‐recognized glycans. …”
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Health-related quality of life with bemarituzumab plus mFOLFOX6 in patients with FGFR2b-overexpressing, advanced gastric or gastroesophageal junction cancer by Z.A. Wainberg, P.C. Enzinger, S. Qin, K. Yamaguchi, J. Wang, X. Zhou, A. Gnanasakthy, K. Taylor, A. Yusuf, I. Majer, A. Jamotte, Y.-K. Kang

“…Background: In the phase II, randomized, double-blind FIGHT trial (NCT03694522), treatment with bemarituzumab plus mFOLFOX6 resulted in improvements in progression-free survival and overall survival relative to mFOLFOX6 alone in previously untreated locally advanced or metastatic gastric or gastroesophageal junction cancer with fibroblast growth factor receptor 2b overexpression. Using data from the final analysis, we analyzed patient-reported outcomes (PROs) to evaluate the impact of adding bemarituzumab to mFOLFOX6 on health-related quality of life (HRQoL). …”
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Research on screening key proteins related to the pathogenesis of sepsis associated encephalopathy based on DIA proteomics technology by Wu Shuhui, Hu Hongjie, Lu Yuru, Zhu Wei

“…Objective To explore the key proteins in plasma of patients with sepsis associated encephalopathy (SAE) through data-independent acquisition(DIA) quantitative proteomics and machine learning techniques, with the aim of guiding research on SAE pathogenesis and aiding early diagnosis. …”
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IMPACT-ICU feasibility study: pragmatic mixed-methods randomised controlled trial of a follow-up care intervention for survivors of critical illness and caregivers by Sunita Mathur, John Muscedere, David M Maslove, Miranda Hunt, John Gordon Boyd, Stephanie Sibley, Tracy Boyd, Michelle Tryon, Natasha Arianne Jawa, Michaela Hanley, Robin Westphal, Afolasade Fakolade

“…Tertiary outcomes will be a battery of cognitive, physical functioning and psychiatric outcomes.Implications Survivorship from critical illness extends beyond surviving an ICU stay. …”
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Constructing a novel mitochondrial metabolism-related genes signature to evaluate tumor immune microenvironment and predict survival of colorectal cancer by Hou Wang, Hou Wang, Kai Zhang, Guang Ning, Guang Ning

“…Core mitochondrial metabolism-related gene, TMEM86B was identified and its functions validated through cell-based assays and in vivo mouse models.ResultsFifteen mitochondrial metabolism-related genes were identified, including HSD3B7, ORC1, GPSM2, NDUFA4L2, CHDH, LARS2, TMEM86B, FABP4, TNFAIP8L3, HMGCL, GDE1, ACOX1, ARV1, HDC, and GSR. …”
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Intratracheal Administration of Itraconazole-Loaded Hyaluronated Glycerosomes as a Promising Nanoplatform for the Treatment of Lung Cancer: Formulation, Physiochemical, and In Vivo... by Sultan Aati, Hanan O. Farouk, Marwa H. Elkarmalawy, Hanan Y. Aati, Nahla Sameh Tolba, Hossam M. Hassan, Mostafa E. Rateb, Doaa S. Hamad

“…Methods: The glycerosomes were functionalized with hyaluronic acid (HA-GLY) to potentiate the anticancer efficacy of ITZ and extend its local bio-fate. …”
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The association of internet use and cognition among older adults: mediating roles of social networks and depressive symptoms by Xiuyuan Zhu, Zihan Ni, Xiaoying Zhu, Xiaoying Zhu, Yi Yang, Shiyu Xie, Xinguo Wang, Xiaoguang Yang

“…Enhancements in internet literacy and optimization of age-appropriate product designs are recommended to improve cognitive functions in older populations.…”
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Cognitive deficits in patients with obsessive&amp;ndash;compulsive disorder &amp;ndash; electroencephalography correlates by Kamaradova D, Hajda M, Prasko J, Taborsky J, Grambal A, Latalova K, Ociskova M, Brunovsky M, Hlustik P

“…The subgroup of patients with normal cognitive functions (N=9) did not differ in cortical EEG sources from healthy controls.Conclusion: The present results suggest that frontal low-frequency cortical sources of resting-state EEG rhythms can distinguish groups of cognitively impaired and cognitively intact patients with OCD. …”
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