Revitalizing Ukrainian Cities: The Role of Public-Private Partnerships in Smart Urban Development by Vitalii Kruhlov, Jaroslav Dvorak, Volodymyr Moroz, Dina Tereshchenko

“…The study explores key aspects of smart cities development, including the integration of digital technologies, the use of data, and innovative business models aimed at optimizing city functions. …”
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Physical Activity as a Factor to Improve the Quality of Student Life by M. M. Kolokoltsev, S. S. Iermakov, N. V. Tretyakova, V. L. Kraynik, E. V. Romanova

“…The comparison of the obtained data on the physical condition of students of different generations was carried out through comparative analysis. …”
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GPR65 is a novel immune biomarker and regulates the immune microenvironment in lung adenocarcinoma by Hanxu Zhou, Zhi Chen, Shuang Gao, Chaoqun Lian, Junjie Hu, Jin Lu, Lei Zhang

“…GPR65 is an extracellular pH-sensing G protein-coupled receptor and a glycosphingolipid receptor, which is engaged in the functions of regulating tumor immunity. However, the prognostic value of GPR65 and its relevance to immune infiltration in LUAD are unknown.MethodsThe proportion of immune, stromal and tumor cells in LUAD samples was assessed by ESTIMATE algorithm scores with RNA sequence data and clinical information from LUAD patients downloaded from The Cancer Genome Atlas (TCGA) database. …”
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Toxoplasma calcium-dependent protein kinases 3 mediates M1 macrophage polarization by targeting host Arginase-1 by Ran An, Fang Liu, Niuniu Dai, Fangmin Li, Xingyun Liu, Haijian Cai, Lijian Chen, Jian Du

“…Results The interaction between TgCDPK3 and Arginase-1 is functionally correlated and leads to a reduction in Arginase-1 activity, ultimately, contributing to the M1-biased phenotype of the host macrophages, which is related to restraining the proliferation of parasites. …”
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Establishing a community advisory board to align harm reduction research with the unique needs of Black and Latine communities by Simon Kapler, Hira Hassan, Alexander Jeremiah, Katurah Bryant, Presto Crespo, Nesta Felix, Sónyi Elena Lopez, Antonio Morales, Sean Reeves, Ayana Jordan

“…In the future, the CAB will also guide data analysis and research publications. Other areas of emphasis have included straightforward language in study materials, balanced messaging about harm reduction recommendations, and specific community outreach opportunities. …”
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THE PLACE OF PROFESSIONAL EDUCATION SYSTEM IN FORMATION OF GRADUATES’ COMPETITIVENESS by G. F. Shafranov-Kutsev, G. Z. Efimova

“…In the course of empirical stage, social questionnaire survey was conducted among the working youth (N=956). Acquired data were processed using the license version of the SPSS programme. …”
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Genicular nerve radiofrequency ablation, phenol neurolysis or conservative medical management in patients with knee osteoarthritis: protocol for the RADIOPHENOL randomised controll... by Markus W Hollmann, Johan Haumann, Bram Thiel, Marc B Godfried, Jan-Willem Kallewaard, Paul R de Wit, Rienk van Beek, Monique Schokker, Carin Wensing, Gezina Oei, Derk A van Kampen, Lars Elzinga, Gijs Hendriks, Jeroen van de Heiden, Jan Willem Coumou

“…We aim to publish our results in international peer-reviewed journals.Trial registration details ClinicalTrials.gov NCT06094660, including the WHO Trial Registration data set items. Registered on 20 October 2023, first patient enrolled on 27 November 2023.…”
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High expression of G-protein signaling modulator 2 in hepatocellular carcinoma facilitates tumor growth and metastasis by activating the PI3K/AKT signaling pathway by Xiao-Qin He, Yue-Feng Zhang, Jia-Jun Yu, Yuan-Yuan Gan, Na-Na Han, Mei-Xia Zhang, Wei Ge, Jun-Jian Deng, Yong-Fa Zheng, Xi-Ming Xu

“…We previously showed that G-protein signaling modulator 2 was upregulated in hepatitis B virus-related hepatocellular carcinoma tissues through a hierarchical clustering analysis. With this study, we first assessed the expression pattern of G-protein signaling modulator 2 in hepatocellular carcinoma specimens and adjacent noncancerous tissues; clinical data were analyzed, along survival times, utilizing the Kaplan–Meier method. …”
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Health effects and mediating mechanisms of smart wearable devices on older people: evidence from China by Enkai Guo, Enkai Guo, Enkai Guo, Shiyi He, Shiyi He, Shiyi He, Lan Zheng, Lan Zheng, Lan Zheng

“…To maximize benefits, we propose a dual-path optimization strategy: (1) Develop age-appropriate functions and use methods to improve device accessibility among older adult people, and (2) Generate a personalized exercise prescription for the older people to promote regular physical activity and exercise habits to improve their health level.…”
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Optimization of PLGA-Doxorubicin Hybrid Nanoparticles using Design of Experiments: Synthesis, Characterization, and Applications by Adina TURCU-STIOLICA, Andrei BITA, Maria Viorica CIOCILTEU

“… Background and Aim: Poly (lactic-co-glycolic acid) (PLGA) exhibits a range of advantageous properties, including tunable particle sizes, stability, biodegradability, and the potential for surface functionalization. These characteristics have established PLGA as a widely utilized material in drug delivery systems. …”
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Effect of diet combined with exercise intervention on tumor necrosis factor α in overweight or obese groups: Based on the exercise dose-response relationship by Chuan qiu shui Wang, Kun Wang, Shi qi Liu, Liang Sun, Jiong Luo

“…Tumor necrosis factor α (TNF-α) is a key inflammatory factor that significantly impacts various body functions. Objective: 1) To assess whether combined interventions are more effective than single interventions in combining diet and exercise. 2) To assess the effectiveness of exercise dose in different interventions on tumor necrosis factor (TNF-α) levels in obese or overweight patients. …”
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Optimizing Energy and Spectral Efficiency in Mobile Networks: A Comprehensive Energy Sustainability Framework for Network Operators by Luis Mata, Marco Sousa, Pedro Vieira, Maria Paula Queluz, Antonio Rodrigues

“…Notably, the implemented ML and XAI model achieved an F1-Score of 0.78 for 5G scenarios and 0.83 for 4G scenarios in predicting the Energy Sustainability Class, relying on a reduced set of indicators encompassing the most influential factors. An additional analysis, based on domain expertise, provided evidence of potential causal relationships between the class and observed variables involving channel quality, Multiple Input Multiple Output (MIMO) utilisation, network topology and energy-saving functionalities. …”
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NRF2 maintains redox balance via ME1 and NRF2 inhibitor synergizes with venetoclax in NPM1-mutated acute myeloid leukemia by Jiayuan Hu, Zihao Yuan, Yan Shu, Jun Ren, Jing Yang, Lisha Tang, Xingyu Wei, Yongcan Liu, Fangfang Jin, Qiaoling Xiao, Xinyi Chen, Nan Wu, Wen Zhao, Ziwei Li, Ling Zhang

“…The high NRF2 expression levels were at least partially induced by fat mass and obesity-associated protein (FTO) via m6A modification. Functionally, NRF2 exerts its antioxidant effects by transcriptionally upregulating malic enzyme 1 (ME1) expression and enhancing its activity. …”
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Herpesviruses mimic zygotic genome activation to promote viral replication by Eva Neugebauer, Stephanie Walter, Jiang Tan, Nir Drayman, Vedran Franke, Michiel van Gent, Sandra Pennisi, Pia Veratti, Karla S. Stein, Isabelle Welker, Savaş Tay, Georges M. G. M. Verjans, H. T. Marc Timmers, Altuna Akalin, Markus Landthaler, Armin Ensser, Emanuel Wyler, Florian Full

“…Here we show that herpesviruses from all subfamilies, papillomaviruses and Merkel cell polyomavirus actively induce DUX4 expression to promote viral transcription and replication. Analysis of single-cell sequencing data sets from patients shows that viral DUX4 activation is of relevance in vivo. …”
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Mitochondria-derived nuclear ATP surge protects against confinement-induced proliferation defects by Ritobrata Ghose, Fabio Pezzano, Rémi Badia, Savvas Kourtis, Ilir Sheraj, Shubhamay Das, Antoni Gañez Zapater, Upamanyu Ghose, Sara Musa-Afaneh, Lorena Espinar, Albert Coll-Manzano, Katja Parapatics, Saška Ivanova, Paula Sànchez-Fernàndez-de-Landa, Dragana Radivojevikj, Valeria Venturini, Stefan Wieser, Antonio Zorzano, André C. Müller, Verena Ruprecht, Sara Sdelci

“…In this study, proteomics analysis revealed that cellular confinement induced a strong enrichment of mitochondrial proteins in the nuclear fraction. …”
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Factors affecting the design of the management dashboard framework with an emphasis on the components of human resources productivity by Hassan Barmaki, Farshad Faezy Razi, Ehtesham Rashidi

“…Delphi method was used to analyze the data. The findings of the research showed that after collecting data and conducting interviews and conducting the Delphi method, 15 dimensions and 53 indicators were counted in the final model in 4 main components. …”
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Single-cell RNA sequencing provides new insights into the interaction between astrocytes and neurons after spinal cord injury in mice by Zhi Tang, Hengyang Lu, Xiao Yang, Mao Wu, Junfeng Yang, Shaoshuo Li, Heng Liu, Junkang Zhou, Bin Tang, Xinyao Du, Fei Xu, Yang Shao, Jianwei Wang

“…Different subtypes of astrocytes and neuronal cells were identified and their dynamic changes and functionalities during the development of SCI. An intriguing discovery was the identification of a specific subtype of astrocytes characterized by unique expression of Gap43, Vim, Aldoc, and Mt1. …”
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Analyzing the Impact of the Presence of Foreign Tourists in Religious Places on Their Attitude Towards Shiism by Marziyeh Farshiddost, Behrooz Badkoo, Mohamad Ghasemisiani

“…These people have been selected by the purposeful sampling method of 15 people and a semi-structured interview has been conducted using the qualitative method. Data analysis has been done in the form of open, central and selective coding using the grounded theory method. …”
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Development of an AI model for DILI-level prediction using liver organoid brightfield images by Shiyi Tan, Yan Ding, Wei Wang, Jianhua Rao, Feng Cheng, Qiuyin Zhang, Tingting Xu, Tianmu Hu, Qinyi Hu, Ziliang Ye, Xiaopeng Yan, Xiaowei Wang, Mingyue Li, Peng Xie, Zaozao Chen, Geyu Liang, Yuepu Pu, Juan Zhang, Zhongze Gu

“…Abstract AI image processing techniques hold promise for clinical applications by enabling analysis of complex status information from cells. …”
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Ecological health assessment of Tibetan alpine grasslands in Gannan using remote sensed ecological indicators by Zeyu Du, Xibin Ji, Jane Liu, Wenyue Zhao, Zhibin He, Jiachang Jiang, Qiyue Yang, Liwen Zhao, Jinlong Gao

“…Ecosystem health assessments are crucial to protect the ecological environment and ensure the sustainable ecological functions of alpine ecoregions. At present, few studies evaluating the ecosystem health of the Gannan alpine grassland, China, an ecologically fragile area, based on a remote sensing theoretical framework exist. …”
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