Targeting the splicing factor SNRPB inhibits endometrial cancer progression by retaining the POLD1 intron by Yingwei Li, Zhongshao Chen, Huimin Xiao, Yanling Liu, Chen Zhao, Ning Yang, Cunzhong Yuan, Shi Yan, Peng Li

“…Mechanistically, we revealed that SNRPB knockdown decreased POLD1 expression and that POLD1 intron 22 was retained after SNRPB silencing in endometrial cancer cells, as determined via RNA sequencing data analysis. The retained intron 22 of POLD1 created a premature termination codon, leading to the absence of amino acids 941–1,107 and the loss of the site of interaction with PCNA, which is essential for POLD1 enzyme activity. …”
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Cuproptosis-related gene ACAD8 inhibits the metastatic ability of colorectal cancer by inducing cuproptosis by HuiE Zhuang, Yizhen Chen, Yizhen Chen, Sifu Huang

“…Small interfering RNA, immunohistochemistry, colony formation, wound-healing assays and so on were used to evaluate the biological functions of ACAD8. Bioinformatics was applied to investigate its relationships with immune infiltration, chemotherapy sensitivity, and signaling pathways.ResultsACAD8 expression was significantly reduced in mCRC and demonstrated excellent diagnostic performance. …”
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The Effect of Information Therapy Program of Quitting Smoking in Parents of Children with Asthma by Nicotine Replacement by Sedigheh Mohammadesmaeili, Nahid Ramzanghorbani, Shiba Kianmehr

“…Nicotine gum consumption can enhance certain aspects of health-related quality of life for both parents and children, as assessed by SF-12 and SGRQ, according to the results. Physical functioning (P=0.007) and school performance (P=0.002) were the two components most significantly affected. …”
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Study of Safety of Medicinal Products in Pregnant Women in Crimea by A. V. Matveev, E. A. Egorova, A. E. Krasheninnikov, E. I. Konyaeva

“…The most common reasons of ADRs in this category of patients were antibacterials for systemic use (130 cases, 48.5%), agents that have an effect on haematopoiesis and blood (54 cases, 20.15%), and agents that have an effect on the functions of the gastrointestinal tract (29 cases, 10.82%). …”
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Our Experiences and Learnings in Diagnosing MODY from Non-Institutional-Based Diabetes Care Clinics by Arunkumar R. Pande, Santosh Chaubey, Dinesh Kumar, Kumar P. Chandra, Thenral Geetha, Akshita Sharma

“…Methods: This study reports the retrospective analysis of data collected from four clinics between March 2016 and February 2023 from Lucknow, a city in northern India. …”
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Improving methods estimation of the investment climate of the country by E. V. Ryabinin, E. A. Hudorenko

“…The results articles as data and mathematical models will allow foreign investors to use the most objective assessment of the investment climate in the country in order to build their strategies market functioning. …”
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Family hardiness among primary caregivers of breast cancer patients in Hunan Province: a cross-sectional study exploring the relationship with attachment and caregiver preparedness by Xin Sun, Lili Xu, Lijuan Sheng

“…BackgroundFamily hardiness is a key variable contributing to positive family functioning, which has significant effects on the quality of life and the mental health of patientsand caregivers. …”
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A comprehensive crop suitability assessment under modern irrigation system in arid croplands. by Ahmed S Abuzaid, Hassan H Abbas, Mostafa A Mostafa, Yousif K El Ghonamy, Nazih Y Rebouh, Mohamed S Shokr

“…Agricultural suitability analysis using traditional methods is still arguable due to the uncertainty and subjectivity resulting from manual evaluations. …”
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Gustometry in various variants of bronchial asthma: Sensitivity thresholds for bitter and sweet tast by V. N. Mineev, M. A. Nyoma, L. N. Sorokina, P. V. Bryukhanova, D. E. Koksharova

“…The receptors for bitter and sweet taste, may, apparently, have opposite functions, but in available literature there is no data on the balance of sensitivity for bitter and sweet tastes in the same patients with bronchial asthma. …”
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The unseen struggle—depression and associated factors in geriatric cancer patients by Ozlem Dogan, Hayriye Sahinli, Dogan Yazilitas, Selen Kantarci

“…Patients receiving only oral therapy, those under palliative care, those with brain metastases, or those with insufficient cognitive functionality were excluded. Demographic and clinical data were collected from medical records. …”
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Digiwork: how agriculture 4.0 is changing work for farm advisers by Ruth Nettle, Julie Ingram, Margaret Ayre

“…These changes have implications for the functioning of the advisory system which, without collective support from government or industry, will privilege technology-centric, commercial and privatised advisory efforts.…”
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ProbC: joint modeling of epigenome and transcriptome effects in 3D genome by Emre Sefer

“…An emerging question is whether it is possible to deduce 3D genome characteristics and interactions by integrative analysis of multiple chromatin marks and associate interactions to functionality of the interacting loci. …”
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DIGITAL ECONOMY AND RECRUITMENT POTENTIAL: STRATEGICAL INTERCONNECTION AND PROSPECTS by G. Yu. Peshkova, А. Yu. Samarina

“…On the example of activity of separate higher education institutions, the ways and models of functioning of the higher school are shown according to economic tendencies.…”
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A novel HVEM-Fc recombinant protein for lung cancer immunotherapy by Yuanshan Yao, Bin Li, Jing Wang, Chunji Chen, Wen Gao, Chunguang Li

“…Abstract Background The ubiquitously expressed transmembrane protein, Herpesvirus Entry Mediator (HVEM), functions as a molecular switch, capable of both activating and inhibiting the immune response depending on its interacting ligands. …”
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Prevention of school bullying as a factor in the safety of the educational environment by O.B. Krushelnitskaya, T.Y. Marinova, V.A. Orlov, V.B. Slastina

“…<strong>Theoretical basis.</strong> The analysis presented in the article is based on foreign data published from 2021 to 2025 on the development and application of school bullying prevention programs as a means of improving the safety of the educational environment. …”
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An Adaptive PSO Approach with Modified Position Equation for Optimizing Critical Node Detection in Large-Scale Networks: Application to Wireless Sensor Networks by Abdelmoujib Megzari, Walid Osamy, Bader Alwasel, Ahmed M. Khedr

“…The critical node detection problem (CNDP) focuses on determining the set of nodes whose removal most significantly affects the network’s connectivity, stability, functionality, robustness, and resilience. CNDP is a significant challenge in network analysis that involves identifying the nodes that have a significant influence on connectivity or centrality measures within a network. …”
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Addressing genome scale design tradeoffs in Pseudomonas putida for bioconversion of an aromatic carbon source by Deepanwita Banerjee, Javier Menasalvas, Yan Chen, Jennifer W. Gin, Edward E. K. Baidoo, Christopher J. Petzold, Thomas Eng, Aindrila Mukhopadhyay

“…However, sustainable feedstocks pose a challenge due to incomplete high-resolution metabolic data for non-canonical carbon sources required to curate GSMM and identify implementable designs. …”
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Decoding mitochondrial stress genes in DCM: towards precision diagnosis and therapy by Bingbing Zhu, Hai Cheng, Jiawei Li, Yangyang Hu, Xiaoning Ge

“…These genes were analyzed for functions related to immunity, drug sensitivity, and single-cell localization. …”
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From seagrass roots to saline soils: discovery of two new genera in Lulworthiales (Sordariomycetes) from osmotically stressed habitats by Martina Réblová, Jana Nekvindová, Ondřej Hynar, Martin Vohník

“…Thalassodendromyces clustered in a strongly supported clade with Spathulospora, a parasitic genus of the red macroalga Ballia, while the closest relatives of Halomyrma were identified as the asexual genera Halazoon and Halophilomyces (nom. inval. Art. 40.7). An analysis of published metabarcoding ITS rDNA data from environmental samples in the GlobalFungi database indicated that H. pluriseptata is widely distributed across temperate, subtropical, and tropical regions in the Northern and Southern Hemispheres. …”
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Differentiating healthy orthorexia from orthorexia nervosa: sociodemographic, psychological and dietary characteristics in a French sample by Eva Hanras, Emilie Boujut, Juan Ramón Barrada, Géraldine Dorard

“…Setting: Data were collected between May 2021 and September 2022. …”
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