A ROLE OF ARGININE DEIMINASE FROM STREPTOCOCCUS PYOGENES M49-16 IN PROMOTING INFECTION AND INHIBITION OF ENDOTHELIAL CELL PROLIFERATION by E. A. Starikova, A. B. Karaseva, L. A. Burova, A. N. Suvorov, A. V. Sokolov, V. B. Vasilyev, I. S. Freidlin

“…., inhibits proliferation and other endothelial cell functions related to angiogenesis. To confirm a leading role of arginine deiminase, as a factor responsible for the anti-proliferative effect, we have constructed an isogenic S. pyogenes M49-16 mutant unable to express arginine deiminase. …”
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The implementation, use and sustainability of a clinical decision support system for medication optimisation in primary care: A qualitative evaluation. by Mark Jeffries, Nde-Eshimuni Salema, Libby Laing, Azwa Shamsuddin, Aziz Sheikh, Anthony Avery, Antony Chuter, Justin Waring, Richard N Keers

“…Engagement between stakeholders was considered important for the intervention in ensuring prescribers continued to utilise its functionality. Sustained implementation might be enhanced by careful profile management of the suite of alerts in the system. …”
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Travel in Omani Maqamat Writings: A Textual Semiotic Study [In Arabic] by Saeed Al-Salti

“…According to Greimas, there are only six roles or functions underlying all narratives, which form three interconnected pairs: Sender + Receiver, Subject + Object, Helper + Opponent (Conflict). …”
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Diagnostic purposes of education: Problems, strategies and solutions by А. P. Usol’tsev, Т. N. Shamalo, Е. P. Аntipovа

“…The diagnostic purpose deformation is caused by dividing the functions between those who control education and those who perform it – teachers. …”
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Estimation of mangrove heights and aboveground biomass using UAV-LiDAR, Sentinel-1 and ZY-3 stereo images by Bolin Fu, Yingying Wei, Linhang Jiang, Hang Yao, Xiaomin Li, Yanli Yang, Mingming Jia, Weiwei Sun

“…We also estimated the aboveground biomass of different dominant mangrove species to better understand their ecological functions and health conditions. The results showed the following: (1) The canopy height model and height variables of the LiDAR point clouds, DVI and near-infrared bands of the ZY-3 stereo images, and polarimetric decomposition parameters of the Sentinel-1 SAR images were more sensitive to mangrove heights. (2) The LiDAR point clouds and Sentinel-1 SAR images achieved the highest inversion accuracy when using the RF algorithm, with R2 values of 0.875 and 0.685, respectively. …”
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Development and Characterization of CD44-Targeted X-Aptamers with Enhanced Binding Affinity for Cancer Therapeutics by Hongyu Wang, Weiguo He, Miguel-Angel Elizondo-Riojas, Xiaobo Zhou, Tae Jin Lee, David G. Gorenstein

“…CD44, a pivotal cell surface molecule, plays a crucial role in many cellular functions, including cell-cell interactions, adhesion, and migration. …”
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Uncovering the mechanism of resveratrol in the treatment of asthma: a network pharmacology approach with molecular docking and experimental validation by Li Chunxiao, Hou Xin, Liu Bowen, Sun Bingqing, Zhou Mengqi, Zhang Shuwen, Zhang Jingyuan, Lin Jiangtao

“…GO enrichment analysis identified 2,595 significant terms, associated with 2,402 biological processes, followed by 153 molecular functions and 40 cellular components. KEGG enrichment analysis identified 107 relevant pathways, including “apoptosis,” “TNF signaling pathway,” and “MAPK signaling pathway.” …”
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Pharmacological mechanisms of probenecid for SARS-CoV-2 and RSV co-infection: findings of system pharmacology, molecular docking, molecular dynamics simulation, and structure–activ... by Junbin Hong, Zhendong Guo, XiaoMei Huang, Peng Wu, Xinying Chen, Xiaoyi Liu, Jinghua Yang, Yanni Lai

“…Therefore, as one probable molecular candidate for the co-infection with SARS-CoV-2 and RSV, probenecid was researched in this exploration.MethodsUsing systems pharmacology and bioinformatics, we characterized the targets associated with probenecid for the treatment of SARS-CoV-2/RSV co-infection, focusing on their biological functions, mechanisms and binding activities. To further validate these findings, we conducted molecular docking, MD simulations, electrostatic potential mapping, and SAR analysis to explore the binding interactions between probenecid and the identified core targets.ResultsWe identified 141 targets that overlapped with the co-infection and probenecid, and used these shared targets to construct a protein-protein interaction (PPI) network. …”
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Biofilm matrix regulation by Candida glabrata Zap1 under acidic conditions: transcriptomic and proteomic analyses by Bruna Gonçalves, Diana Priscila Pires, Liliana Fernandes, Miguel Pacheco, Tiago Ferreira, Hugo Osório, Ana Raquel Soares, Mariana Henriques, Sónia Silva

“…Accordingly, various genes and matrix proteins with predicted functions in the regulation of carbohydrate metabolism, sugar binding, sugar transport, and adhesion (including Epa family) were repressed by Zap1. …”
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Numerical study of interstitial fluid flow behavior in osteons under dynamic loading by Tianyu Liu, Baochuan Xiong, Xin Cui, Chunqiu Zhang

“…Abstract Background The porous structure in bone tissue is essential for maintaining the physiological functions and overall health of intraosseous cells. …”
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Factors Influencing Telemedicine Adoption Among Health Care Professionals: Qualitative Interview Study by Fiona Schürmann, Daniel Westmattelmann, Gerhard Schewe

“…Trust referents played a pivotal role; trust in technology was linked to functionality (6/14, 43%) and reliability (5/14, 36%), while trust in treatment depended on effective collaboration (9/14, 64%). …”
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Computational modeling of superparamagnetic nanoparticle-based (affinity) diagnostics by Loïc Van Dieren, Loïc Van Dieren, Loïc Van Dieren, Loïc Van Dieren, Loïc Van Dieren, Antoine A. Ruzette, Vlad Tereshenko, Haïzam Oubari, Haïzam Oubari, Haïzam Oubari, Yanis Berkane, Yanis Berkane, Jonathan Cornacchini, Jonathan Cornacchini, Filip Thiessen EF, Filip Thiessen EF, Filip Thiessen EF, Filip Thiessen EF, Curtis L. Cetrulo, Curtis L. Cetrulo, Curtis L. Cetrulo, Curtis L. Cetrulo, Korkut Uygun, Korkut Uygun, Alexandre G. Lellouch, Alexandre G. Lellouch, Alexandre G. Lellouch, Alexandre G. Lellouch, Alexandre G. Lellouch, Alexandre G. Lellouch

“…Superparamagnetic IONPs, which exhibit magnetization only in the presence of an external field, can be functionalized with ligands for targeted affinity diagnostics. …”
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Development and validation of a fluency rating scale for Swiss German Sign Language by Tobias Haug, Nivja H. de Jong, Franz Holzknecht, Katja Tissi, Sandra Sidler-Miserez, Alessia Battisti, Regula Perrollaz, Sarah Ebling, Sabine Reinhard, Sarah Caminada

“…Overall, the rating scale functioned well, with each score category being modal at some point on the continuum. …”
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Finite element model-based evaluation of the effectiveness of the incisional skinbridge procedure for posterior horseshoe perianal abscess by Shi Rong, Wang Jing, Ke Minhui, Chen Zuqing, Huang Juan, Chen Riqi, Wang Zhaochu

“…Tailoring the skin-bridge design might be crucial in preserving postoperative anal integrity and functionality following perianal abscess surgery.…”
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Targeting IL-33 reprograms the tumor microenvironment and potentiates antitumor response to anti-PD-L1 immunotherapy by Yu Bai, Tao Wu, Jun Lin, Shuwen Xu, Xian Zeng, Xuyao Zhang, Jiajun Fan, Dianwen Ju, Mengyang Li, Yanyang Nan, Xiaozhi Hu, Kaicheng Zhou, An Zhu, Zihan Dou, Zhonglian Cao, Xumeng Zhang, Yuanzhen Zhang, Xuebin Wang

“…Background The main challenge against patients with cancer to derive benefits from immune checkpoint inhibitors targeting PD-1/PD-L1 appears to be the immunosuppressive tumor microenvironment (TME), in which IL-33/ST2 signal fulfills critical functions. However, whether IL-33 limits the therapeutic efficacy of anti-PD-L1 remains uncertain.Methods Molecular mechanisms of IL-33/ST2 signal on anti-PD-L1 treatment lewis lung carcinoma tumor model were assessed by RNA-seq, ELISA, WB and immunofluorescence (IF). …”
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Genome-Wide Identification and Expression Analysis of <i>NAC</i> Gene Family Members in Seashore Paspalum Under Salt Stress by Xuanyang Wu, Xiaochen Hu, Qinyan Bao, Qi Sun, Pan Yu, Junxiang Qi, Zixuan Zhang, Chunrong Luo, Yuzhu Wang, Wenjie Lu, Xueli Wu

“…This study established a theoretical basis for understanding the molecular functions and regulatory mechanisms of the <i>NAC</i> gene family in seashore paspalum under salt stress.…”
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Exploration of M2 macrophage-related biomarkers and a candidate drug for glioblastoma using high-dimensional weighted gene co-expression network analysis by Suyin Feng, Suyin Feng, Suyin Feng, Long Zhu, Long Zhu, Long Zhu, Jinyuan Gu, Kun Kou, Yongtai Liu, Guangmin Zhang, Hua Lu, Honglai Zhang, Runfeng Sun, Runfeng Sun

“…Subsequently, the clusterProfiler package was employed to functionally annotate the genes specifically highly expressed in the cells. …”
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Optimal control for high-precision repeat ground-track orbits via convex optimization by Yanchao HE, Lei ZHANG, Yijun YANG, Qian CHEN

“…By formulating the optimization problem with multiple objective functions for RGT orbits, the proposed method allows one to compute the initial conditions, thus guaranteeing the repetition of ground tracks with high accuracy and low time consumption via nonlinear optimization techniques. …”
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Toward a sustained recovery of the lodging sector: a management path to lessen the Corona Variants upshots by Ola Abdel Moneim Emara, Hazem Tawfik Halim, Mohamed Samy El-Deeb, Yasser Tawfik Halim

“…Henceforward, the study constructs a frame for sustained lodging sector recovery. …”
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Statistics on Differences in the Institutional Composition of the National Economy and Issues Related to its Harmonization by O. V. Morozov, A. G. Biryukov, M. A. Vasiliev

“…At the same time, it is obvious that the ratio between the public and other (non-state) sectors refers to the issue of strategic importance, to the issue of the effectiveness of the country's economic system in its integrity, and therefore requires theoretical, methodological and practical resolution.The objectives of the research are: (1) to determine the relative scale and efficiency of the public sector functioning in the national economy, to establish minimum necessary and maximum possible values of its scale; (2) to determine the size and establish a measure of harmonious combination of institutional components of the domestic economy aimed at maximizing its efficiency.Materials and methods. …”
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