Identifying Therapeutic Targets and Potential Drugs for Diabetic Retinopathy: Focus on Oxidative Stress and Immune Infiltration by Peng H, Hu Q, Zhang X, Huang J, Luo S, Zhang Y, Jiang B, Sun D

“…Single-gene Gene Set Enrichment Analysis (GSEA) identified biological functions, while nomograms and ROC curves assessed diagnostic potential. …”
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Exploring the Views of Dermatologists, General Practitioners, and Melanographers on the Use of AI Tools in the Context of Good Decision-Making When Detecting Melanoma: Qualitative... by Brad Partridge, Nicole Gillespie, H Peter Soyer, Victoria Mar, Monika Janda

“…However, AI-based support may entail a wide range of specific functions for AI. To appropriately integrate AI into decision-making processes, it is crucial to understand the precise role that clinicians see AI playing within their clinical deliberations. …”
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A New Mobile App to Train Attention Processes in People With Traumatic Brain Injury: Logical and Ecological Content Validation Study by Roxanne Laverdière, Philip L Jackson, Frédéric Banville

“…Another way to stimulate attention functions is to engage in the daily practice of mindfulness, a multicomponent concept that can be explained by the theoretical model of Baer and colleagues. …”
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Engineering safe anti-CD19-CD28ζ CAR T cells with CD8a hinge domain in serum-free media for adoptive immunotherapy by Muthuganesh Muthuvel, Muthuganesh Muthuvel, Thamizhselvi Ganapathy, Trent Spencer, Sunil S. Raikar, Saravanabhavan Thangavel, Alok Srivastava, Alok Srivastava, Alok Srivastava, Sunil Martin

“…The CAR-T cells expanded (148.4 ± 29 fold; n=7) in serum free media with very high viability (87.8 ± 2.2%; n=7) on day 12. The antitumor functions of CD19 CAR T cells as gauged against percentage lysis of NALM6 cells at a 1:1 ratio is 27.68 ± 6.87% drawing up to the release criteria. …”
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A new method for dealing with collider bias in the PWP model for recurrent events in randomized controlled trials by Chen Shi, Jia-Wei Wei, Zi-Shu Zhan, Xiao-Han Xu, Ze-Lin Yan, Chun-Quan Ou

“…This study aimed to propose a weighted PWP model, evaluate its statistical performance, and assess the potential consequences of using common practices when each recurrence has different baseline hazard functions. Methods We proposed adjusting the estimate of treatment effect through a weighting strategy that constructed a virtual population balanced between groups in each risk set. …”
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Cell-specific nanoengineering strategy to disrupt tolerogenic signaling from myeloid-derived suppressor cells and invigorate antitumor immunity in pancreatic cancer by Nilesh U. Deshpande, Anna Bianchi, Haleh Amirian, Iago De Castro Silva, Christine I. Rafie, Bapurao Surnar, Karthik Rajkumar, Akash Ashokan, Ifeanyichukwu C. Ogobuiro, Manan Patel, Erietta Stelekati, Shanta Dhar, Jashodeep Datta

“…Abstract Pancreatic ductal adenocarcinoma (PDAC) is characterized by intratumoral abundance of neutrophilic/polymorphonuclear myeloid-derived suppressor cells (PMN-MDSC) which exert anti-T-cell functions through multiple mechanisms, especially JAK2/STAT3-regulated arginase activity. …”
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Multi-omics identification of a polyamine metabolism related signature for hepatocellular carcinoma and revealing tumor microenvironment characteristics by Yuexi Yu, Huiru Liu, Kaipeng Liu, Meiqi Zhao, Yiyan Zhang, Runci Jiang, Fengmei Wang

“…Further analysis revealed significant differences in clinical features, biological functions, mutation profiles, and immune cell infiltration between high-risk and low-risk groups. …”
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Structural brain network organization in children with prenatal alcohol exposure by Xiaoyun Liang, Claire E. Kelly, Chun-Hung Yeh, Thijs Dhollander, Stephen Hearps, Peter J. Anderson, Deanne K. Thompson

“…Complex structural network analyses can provide insight into the neurobiological underpinnings of these functions, as they may be sensitive for characterizing the effects of PAE on the brain. …”
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An Integrated Approach Utilizing Single-Cell and Bulk RNA-Sequencing for the Identification of a Mitophagy-Associated Genes Signature: Implications for Prognostication and Therapeu... by Yuke Zhang, Li Ding, Zhijin Zhang, Liliang Shen, Yadong Guo, Wentao Zhang, Yang Yu, Zhuoran Gu, Ji Liu, Aimaitiaji Kadier, Jiang Geng, Shiyu Mao, Xudong Yao

“…Furthermore, the cellular functions of the genes of interest were verified in vitro. …”
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Exploring radiation resistance-related genes in pancreatic cancer and their impact on patient prognosis and treatment by Dong Dai, Dong Dai, Sen Wang, Jiaze Li, Yu Zhao

“…The obtained differentially expressed genes were enriched by GO and KEGG to reveal their biological functions. Key genes were screened by univariate and multivariate Cox regression analysis, and a risk scoring model was constructed, and patients were divided into high-risk group and low-risk group. …”
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Acousto-Electric Conversion Fiber Networks via Regional Activation of Schwann Cell-Derived Exosomes for Neurogenic Bone Regeneration by Weiwei Yi, Xiaoyu Han, Fan Wang, Qiuyu Tang, Huzhe Liu, Bo Liao, Jieliang Shen, Juan Wang, Wenguo Cui, Dingqun Bai

“…Neurogenic bone regeneration is essential for the effective restoration of bone tissue functionality, with exosomes derived from Schwann cells regionalized in bone injury tissue playing a crucial role in this process. …”
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Novel HSA-PMEMA Nanomicelles Prepared via Site-Specific In Situ Polymerization-Induced Self-Assembly for Improved Intracellular Delivery of Paclitaxel by Yang Chen, Shuang Liang, Binglin Chen, Fei Jiao, Xuliang Deng, Xinyu Liu

“…Moreover, compared to traditional methods of creating protein–hydrophobic polymer conjugates, SI-PISA demonstrates higher reaction efficiency and better preservation of protein functionality. <b>Methods</b>: We synthesized HSA-PMEMA nanomicelles via SI-PISA using HSA and methoxyethyl methacrylate (MEMA)—a novel hydrophobic monomer with a well-defined and stable chemical structure. …”
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Isolation and molecular characterization of the FLOWERING LOCUS C gene promoter sequence in radish (Raphanus sativus L.) by Yuan-yuan XU, Jing WANG, Shan-shan NIE, Dan-qiong HUANG, Yan WANG, Liang XU, Rong-hua WANG, Xiao-bo LUO, Li-wang LIU

“…FLOWERING LOCUS C (FLC) plays a key role in plant flowering by functioning as a repressor. Two genomic DNA sequences, a 3 046-bp from an early- and a 2 959-bp from a late-bolting radish line were isolated and named as RsFLC1 and RsFLC2, respectively, for they share approximately 87.03% sequence identity to the FLC cDNA sequences. …”
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Bioinformatics methods for identifying differentially expressed genes and signaling pathways in nano-silica stimulated macrophages by Lin Zhang, Changfu Hao, Juan Li, Yaqian Qu, Lei Bao, Yiping Li, Zhongzheng Yue, Miao Zhang, Xinghao Yu, Huiting Chen, Jianhui Zhang, Di Wang, Wu Yao

“…To identify the differentially expressed genes and explore their potential functions, we adopted the gene ontology analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis and also constructed protein–protein interaction network. …”
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Validation of the European Oncology toolkit for the self-assessment of Quality of Life (EUonQoL-Kit) in cancer patients and survivors: study protocol of a pan European survey by G. Apolone, M. Costantini, L. Caselli, N. Bos, A. Caraceni, G. Ciliberto, N. Couespel, M. Ferrer, M. Groenvold, S. Kaasa, C. Lombardo, R. Pietrobon, G. Pravettoni, A. Sirven, H. Vachon, G. Velikova, O. Garin, A. Gilbert, A. Machiavelli, C. Marzorati, R. Miceli, M. Pe, MA. Petersen, A. Tanzilli, F. van Schelven, C. Dantas, I Minnée-van Braak, L. Pinnavaia, C. Brunelli

“…Psychometric analyses will encompass exploratory and confirmatory factor analyses (measurement model and structural validity), Cronbach's alpha (internal consistency), intraclass correlation coefficient (test–retest reliability), Pearson/Spearman correlation (concurrent validity), comparison of group scores (construct validity), and Differential Item Functioning (cross-country item equivalence). …”
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Decoding dengue’s neurological assault: insights from single-cell CNS analysis in an immunocompromised mouse model by Minyue Qiu, Lixin Zhao, Xiaojia Li, Yipei Fan, Minchi Liu, Dong Hua, Yunkai Zhu, Yinyin Liang, Yu Zhang, Wen Xiao, Xiaofeng Xu, Jintao Li

“…Finally, motor and sensory functions of mice were detected by open field test and hot plate test, respectively. …”
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The essence and structure of the scientific outlook of future teachers of natural and mathematical specialties by Zelinha Yulia, Halitsan Olha

“…The scientific outlook of the future teacher of natural and mathematical specialties is represented by a multicomponent synthetic construct, that reproduces its essential features at the intersection of the coordinates of the “personal / professional” dichotomy; assumes the presence of a methodological and innovative professional culture, systematic and logical scientific thinking, reflectiveness of the individual and the teacher’s desire for self-development, self-realization and selfimprovement in professional and pedagogical activities; functions as a dynamic synthesis of scientific-researchanalytical and pedagogical-methodical skills, which allow to overcoming discreteness in the formation of specialized (science-mathematical) and general-specialist competences (pedagogical, didactic, methodologicalresearch) of a science-mathematics teacher; provides comprehensive updating of scientific information in pedagogy, mathematics, physics, natural science, biology and physiology, teaching methods of professional disciplines, which leads to the student’s awareness of the holistic nature of natural and mathematical sciences as a scientific and socio-cultural phenomenon; records the deployment of a multi-vector research search with the aim of developing an individual scientific strategy for teaching natural and mathematical disciplines; produces the teacher’s ability to actualize interdisciplinary connections in the system of natural and mathematical sciences; provides an adequate selection of personalized methods of teaching science and mathematics disciplines, developed on the basis of the activation of cognitive self-projection of the future science and mathematics teacher as a scientist and researcher. …”
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ARID1A deficiency attenuates the response to EGFR-TKI treatment in lung adenocarcinoma by Fangfang Yang, Fangfang Yang, Helei Hou, Guanqun Wang, Guangming Fu, Xingfa Huo, Xueqin Duan, Na Zhou, Xiaochun Zhang

“…AT-rich interactive domain 1A (ARID1A), which is a key subunit of SWI/SNF complexes, demonstrates critical regulatory functions as a tumour suppressor gene in cancer. The aim of this study is to determine the role of ARID1A deficiency in the therapeutic efficacy of EGFR-TKIs in LUAD.MethodsWe identified the ARID1A mutation as a potential prognostic marker in EGFR-mutant LUAD by analysing data from cBioPortal. …”
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Immune status changes in patients with phlegmon in the maxillofacial region relation with purulent process prevalence by N. G. Barannik, S. D. Varzhapetyan, A. V. Sidoryako, Yu. S. Karabinova

“…One manifestation of violation of protective functions in this group of patients are changes in the synthesis of interleukin blood. …”
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Simulation and Test of Key Decorticating Components of Spiral Ramie Decorticator by Wenlong Zheng, Lan Ma, Jiajie Liu, Bo Yan, Yiping Duan, Sixun Chen, Jiangnan Lyu, Wei Xiang

“…To address the production challenges posed by high labor intensity and the scarcity of small, direct-feeding ramie decorticators in hilly and mountainous regions, this study designed and optimized a spiral ramie decortication component that integrated functions of ramie stalk crushing, xylem removal, outer shell scraping, and phloem separating and throwing. …”
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