Identification of A1/A2 β-Casein Genotypes and Comparison of Their Digestive Properties by Shihang LI, Hongtao XU, Xiao LI, Meiling SUN, Xinyan YANG, Pengyu XIANG, Zhihao YANG, Chaoxin MAN, Yujun JIANG

“…To more comprehensively explore the possible biological activity effects on the human body, by analyzing and monitoring the changes of this protein during the digestion process, the exploration of the biological functions of A1/A2 β-casein is further achieved. In this study, allele-specific PCR was initially performed on milk samples collected from different cows in the pasture to identify A1 and A2 milk types. …”
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lncRNA Ubr5 promotes BMSCs apoptosis and inhibits their proliferation and osteogenic differentiation in weightless bone loss by Dong Wang, Yuan Gao, Yingjun Tan, Na Li, Xi Li, Jiaxiang Li, Yikai Pan, Xingcheng Zhao, Ming Yan, Yongchun Wang

“…Subsequently, the molecular functions and signaling pathways enriched by DEG were comprehensively analyzed by GO and KEGG. …”
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Single-nucleus RNA sequencing reveals the specific molecular signatures of myeloid cells responding to brain injury after microglial replacement by Xiao-Yi Xiong, Xiao-Yi Xiong, Xiao-Yi Xiong, Haicheng Yuan, Ying Mu, Yi He, Fang Xie, Xiao-Shuang Feng, Jia-Xin Xie, Xin-Ru Pan, Yu-Fei Wang, Jian Gong, Xiaoming Zheng, Peng-Fei Wang

“…Gene Ontology (GO) analysis showed that one term directly related to the “immune response” was shared between upregulated genes in Rep-MG and Rep-Mo/MΦ, while the other terms related to immune functions and other biofunctions were different between Rep-MG and Rep-Mo/MΦ, indicative of significantly different immune responses to brain injury between MG and MΦ. …”
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What is the relationship between exposure to environmental pollutants and severe mental disorders? A systematic review on shared biological pathways by Pierluigi Catapano, Mario Luciano, Salvatore Cipolla, Daniela D'Amico, Alessandra Cirino, Maria Chiara Della Corte, Gaia Sampogna, Andrea Fiorillo

“…Severe mental disorders are multi-dimensional constructs, resulting from the interaction of genetic, biological, psychosocial, and environmental factors. …”
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The readiness of future teachers to the implementation of system-activity approach as a pedagogical phenomenon by O. V. Tumasheva, N. A. Кirillova, E. A. Mikhalkina

“…It is necessary to reconsider widespread ideas about the role and functions of the teacher and to make serious corrections to the programmes of vocational training and all components of educational practice.The aim of the article was to study the pedagogical phenomenon “readiness of future teachers for implementation of system-activity approach” and the development of its science-based model.Methodology and research methods. …”
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Comprehensive analysis of long non-coding RNA and mRNA expression patterns during seminiferous tubules maturation in Guanzhong dairy goats by Fa Ren, Que Zhang, Yu Jiang, Wenling Xie, Pengyun Qiao, Jianhong Hu

“…However, the expression patterns and functions of these molecules across different developmental stages of dairy goat seminiferous tubules remain poorly understood. …”
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Bibliometric and Visualization Analysis of DprE1 Inhibitors to Combat Tuberculosis by Wang Q, Fu H, Zhang Y, Zhang M, Xu J, Fu J

“…Qingqing Wang,1 Huixiao Fu,2 Yining Zhang,3 Man Zhang,1 Jian Xu,1 Jian Fu1,4 1College of Pharmacy, Guizhou University of Traditional Chinese Medicine/National Engineering Technology Research Center for Miao Medicine/Guizhou Engineering Technology Research Center for Processing and Preparation of Traditional Chinese Medicine and Ethnic Medicine, Guiyang, People’s Republic of China; 2Department of Science and Education, The First People’s Hospital of Guiyang, Guiyang, People’s Republic of China; 3College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, People’s Republic of China; 4State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, People’s Republic of ChinaCorrespondence: Huixiao Fu, Email fuhuixiao@126.com Jian Fu, Email fu_jian2008@163.comBackground: Tuberculosis (TB) poses a serious threat to public health, particularly owing to the increase in multidrug-resistant tuberculosis (MDR-TB) and extremely drug-resistant tuberculosis (XDR-TB); thus, there is an imperative need for novel treatments to tackle this issue. …”
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Oxygenated VOC Detection Using SnO₂ Nanoparticles with Uniformly Dispersed Bi₂O₃ by Haoyue Yang, Koichi Suematsu, Felipe Hiroshi Mashiba, Ken Watanabe, Kengo Shimanoe

“…The results confirm the significant role of surface functionalization for sensing materials. The obtained outstanding sensing performance provides the potential application for the simultaneous detection of total oxygenated VOCs in practice.…”
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Research on the Stability Prediction and Optimization of CNC Milling Based on Bagging–NSGAⅡ Under the Influence of Multiple Factors by Congying DENG, Qian YOU, Yang ZHAO, Lijun LIN, Guofu YIN

“…Under each position, impact testing is then carried out at the tool tip for different tool-overhang lengths to obtain the corresponding frequency response functions (FRFs). Then, limiting axial cutting depth <italic>a</italic>_plim values are theoretically predicted using the tool-tip FRFs and machining parameters. …”
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Analysis of the atomization performance of hydrodynamic rotating spray dust suppression device with setting fan by Hui XU, Qinghua CHEN, Dejun WANG

“…At the same time, the fan blade is set on the water shaft, so that the device has both rotating spray and negative pressure suction dust reduction functions; we build a coal mine dust experimental system, collect coal dust samples from Inner Mongolia 5013 excavation face, and measure the total dust and respiratory dust concentrations of three dust reduction schemes through CCZ-20A dust sampler. …”
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A Novel Triptolide Nano-Liposome with Mitochondrial Targeting for Treatment of Hepatocellular Carcinoma by Zhou L, Du Y, Shang Y, Xiang D, Xia X

“…In this study, we used triptolide (TP), a bioactive constituent in Tripterygium wilfordii Hook F, as a model drug to develop a novel nano-liposome drug delivery system for the treatment of liver tumours.Methods: We constructed a functionally-modified triptolide liposome (FA+TPP-TP-Lips) using the film-dispersion method and investigated its physicochemical properties, mitochondrial targeting of hepatic tumour cells, in vitro and in vivo anti-hepatic tumour activity and its mechanism.Results: The prepared FA+TPP-TP-Lips had a particle size of 99.28 ± 5.7 nm, a PDI of 0.20 ± 0.02, a zeta potential of 1.2 ± 0.08 mV, and an encapsulation rate of 74.37% ± 1.07%.FA+TPP-TP-Lips facilitates the cellular uptake of drug delivery systems and improves their targeted delivery to mitochondria. …”
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Screening of novel β-carotene hydroxylases for the production of β-cryptoxanthin and zeaxanthin and the impact of enzyme localization and crowding on their production in Yarrowia l... by Mladen Soldat, Tadej Markuš, Vasilka Magdevska, Martin Kavšček, Aleksander Johannes Kruis, Jaka Horvat, Gregor Kosec, Štefan Fujs, Uroš Petrovič

“…An intermediate between β-carotene and zeaxanthin, β-cryptoxanthin, is found only in specific fruits and vegetables and has several important functions for human health. The low concentration of β-cryptoxanthin in these sources results in low extraction yields, making biotechnological production a promising alternative for achieving higher yields. …”
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The Use of Economic and Mathematical Modeling in Assessing the Competitiveness of Tourism Industry Enterprises by S. N. Medvedeva, V. P. Pavlyuk

“…The implementation of such a system is directly related to the analysis and assessment of the whole variety of conditions and factors for the functioning of the subjects of the tourism industry.…”
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Exploring the Anti-depression Mechanism of Polygonatum ordoratum Based on GEO Database Combined with Network Pharmacology and Molecular Docking Technology by Zhenxu JIANG, Chaoxing WANG, Yuliang WANG, Hong ZHAO, Yu SHEN, Shiqing SUN, Yongzhe MA, Mingming SONG, Yu ZHANG

“…A total of 209 GO entries were obtained through GO enrichment analysis, including 149 biological processes (BP), 23 cellular components (CC), and 37 molecular functions (MF), primarily involving the Chemical carcinogenesis-receptor activation, Small cell lung cancer, and Adipocytokine signaling pathway. …”
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Beyond the SAFE strategy: Systematic review and meta-analysis of prevalence and associated factors of active trachoma among children in Ethiopia. by Zufan Alamrie Asmare, Denekew Tenaw Anley, Melaku Ashagrie Belete, Anteneh Mengist Dessie, Melkamu Aderajew Zemene, Ermiyas Alemayehu, Natnael Moges, Natnael Kebede, Sintayehu Simie Tsega, Asaye Alamneh Gebeyehu, Rahel Mulatie Anteneh, Ermias Sisay Chanie

“…Therefore, it is imperative to fine-tune the intervention focus on personal hygiene-related activities in removing dirt, fly-eye contact, and a well-structured approach for both constructing and ensuring the functionality of household taps and latrines. …”
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Translation, cultural adaptation and validation of the Danish version of the haematological malignancy patient-reported outcome measure (HM-PRO) by Sam Salek, Sören Möller, Niels Abildgaard, Tine Rosenberg, Maria Torp Larsen, Peter Asdahl, Kasper Kofod Pedersen, Marie Therese Lassen, Christen Lykkegaard Andersen, Lene Kongsgaard Nielsen

“…After cognitive debriefing interviews, it underwent psychometric testing with a variety of hematologic malignancies. Construct validity, internal consistency, dimensionality, item response theory (IRT) and differential item functioning were investigated. …”
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Support of individual educational trajectories based on the concept of explainable artificial intelligence by I. G. Zakharova, M. S. Vorobeva, Yu. V. Boganyuk

“…The algorithm for constructing recommendations is divided into stages and provides for variability in decision making.Scientific novelty. …”
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Effect of Human Resource Interventions on Innovation Performance The Mediating Role of Innovative Work Behavior by Abbas M.M Al Hawamdeh *, Manal Mohammed Mahmoud Al Hawamdah, Hamzeh Mohammad AL-Hawamdeh, Mahd Eid Alhawamdeh, Tharwat Alhawamdeh

“…The primary goal was to analyse the influence of interventions in human resources on performance in innovation, with innovative work behaviours functioning as a mediator in corporations in Jordan. …”
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Machine learning identification of key genes in cardioembolic stroke and atherosclerosis: their association with pan-cancer and immune cells by Tianxiang Zhang, Chunhui Yuan, Mo Chen, Jinjiang Liu, Wei Shao, Ning Cheng

“…Gene ontology and Kyoto encyclopedia of genes and genomes analyses were performed to explore the functions of common FR-related DEGs (FRDEGs). Two machine learning algorithms, Least Absolute Shrinkage and Selection Operator (LASSO) regression and Support Vector Machine Recursive Feature Elimination (SVM-RFE), were used to screen for overlapping FRDEGs in CS and AS. …”
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Network Pharmacology and Metabolomics Reveal Anti-Ferroptotic Effects of Curcumin in Acute Kidney Injury by Liu X, Zhou Y, Lu Z, Yang F, Wang Y, Zhang S, Zhang J, Zou H, Lin M

“…Molecular docking and enzyme activity assay was carried out to evaluate the effects of Cur on MAOA.Results: Our results showed that in vivo Cur preserved renal functions in AKI mice by lowering levels of serum creatinine, blood urea nitrogen, while in vitro ameliorated the cell viability of HK-2 cells damaged by ferroptosis. …”
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