OPEN DUCTUS ARTERIOSUS IN PREMATURE INFANTS WITH EXTREMELY LOW AND VERY LOW BODY WEIGHT by Людмила Николаевна Игишева, Жанна Анатольевна Звягина, Елена Глебовна Цой, Андрей Владимирович Шабалдин, Тамара Михайловна Вакулова

“…The aim of the research – to identify significant factors affecting the postnatal functioning of PDA in premature infants with extremely low and very low body weight and to evaluate them from a manageability perspective. …”
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Screening of the key genes and signaling pathways for schizophrenia using bioinformatics and next generation sequencing data analysis by Iranna Kotturshetti, Basavaraj Vastrad, Veena Kori, Chanabasayya Vastrad, Shivakumar Kotrashetti

“…Gene ontology (GO) enrichment analysis and REACTOME pathway enrichment analysis were carried out to identify potential biological functions and pathways of the DEGs. Protein-protein interaction network, module, micro-RNA (miRNA)-hub gene regulatory network, transcription factor (TF)-hub gene regulatory network, and drug-hub gene interaction network analysis were performed to identify the hub genes, miRNA, TFs, and drug molecules. …”
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Brake rigging dynamic simulation under braking on a track section with irregularities (the case of a passenger car) by I. A. Yaitskov, V. V. Kosarevskii

“…In addition, under the superposition of the bogie-frame pitching and bouncing oscillations, when moving along an uneven track, the rigging block can move up and down the wheel-working surface within a range of up to 50 mm. The simulation functionality of the dynamic processes of the brake system of a passenger car was expanded in the “UM-Loko” software package.Discussion and Conclusions. …”
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Analysis of the Transition from Representation to Aesthetics in Photography Based on Rancière's Views by Khalil Pourkhatami, Ramtin Shahbazi

“…A technical image, such as a photograph, is produced by a device, which is an entity designed for specific functions, having supplanted and emulated human manual labor. …”
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Multi-Domain Environmental Quality of Indoor Mixed-Use Open Spaces and Insights into Healthy Living—A Quarantine Hotel Case Study by Han Wang, Wenjian Pan

“…Many hotels adopt mixed-use and open room spatial layouts, integrating diverse daily functions into a single tiny space, fostering flexible utilization and micro-scale space sharing; however, these also introduce potential health risks. …”
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Psychological capital mediates the relationship between medication adherence and cancer-related fatigue in breast cancer patients undergoing long-term treatment by Chunli Yan, Chunli Yan, Yane Chu

“…CRF is a pervasive and debilitating symptom that adversely affects physical functioning and emotional well-being. Psychological capital (PsyCap), a construct encompassing self-efficacy, hope, optimism, and resilience, has been shown to enhance treatment engagement and promote mental health. …”
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Metabolic pathway activation and immune microenvironment features in non-small cell lung cancer: insights from single-cell transcriptomics by Yanru Liu, Yanru Liu, Yanru Liu, Hanmin Liu, Hanmin Liu, Ying Xiong, Ying Xiong

“…Wet lab experiments validated the role of KRT6B in NSCLC, demonstrating that KRT6B expression is elevated and it stimulates the proliferation of cancer cells.DiscussionThese observations not only enhance our understanding of metabolic reprogramming and its biological functions in NSCLC but also provide new perspectives for early detection, prognostic evaluation, and targeted therapy. …”
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Identification and attribution analysis of integrated ecological zones based on the XGBoost-SHAP model: A case study of Chengdu, China by Xiaobin Huang, Xiaosheng Liu, Yuanhang Jin, Xue Gao, Youliang Chen

“…The framework integrates Ecosystem Service Value (ESV) and Landscape Ecological Risk (LER) as core indicators, applies Z-score standardization and quadrant classification to delineate four ecological zone types with distinct ecological functions, and further employs the XGBoost-SHAP model to identify key natural and anthropogenic drivers and explain their roles in spatial environmental evolution. …”
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The protective role and mechanism of ginkgolide B in regulating mTOR signalling pathway involved in Manganese-induced apoptosis and autophagy in N27 cells by Liyu Su, Shunyu Xiang, Huan Mao, Jiayu Fu, Hongwei Ding, Feng Wang, Lan Zhao, Jianwei Bai, Yuyan Cen, Deyu Zhu, Meng Deng, Yan Li

“…Ginkgolide B (GB) is a diterpenoid compound found in the leaves of the traditional Chinese medicine plant Ginkgo biloba, which has been shown to have a variety of pharmacological functions. However, the role of GB in Manganese(Mn)-induced apoptosis and autophagy in neuronal cells remains poorly understood. …”
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Single-cell sequencing uncovers a high ESM1-expression endothelial cell subpopulation associated with bladder cancer progression and the immunosuppressive microenvironment by Yifeng Qiu, Yuhan Wang, Jiahe Liu, Baohua Liu, Kai Sun, Qi Hou

“…The heterogeneity and biological functions of tumor endothelial cells (ECs) during BC progression remain poorly understood. …”
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Immune Evasion Mechanism Mediated by ITPRIPL1 and Its Prognostic Implications in Glioma by Zou Xiaoyun, Ye Wenhao, Wu Huan, Yang Yuanyuan, Liu Changqing, Wen Hebao, Ma Caiyun

“…This included evaluating ITPRIPL1 expression levels in glioma, its association with clinicopathological features, prognostic significance, immune landscape, targeted drug sensitivity, and underlying biological functions. Ninety‐eight machine learning algorithm combinations were screened to identify the optimal predictive model. …”
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Exploring ENPP5 as a diagnostic biomarker for sepsis: a comprehensive bioinformatics analysis by Jiamin Gao, Yanjun Li, Jinping Huang, Cailing Wei, Jieling Chen, Aichun Huang, Ningmei Liu, Yibo Lu, Shixiong Yang

“…This study aims to identify markers associated with biological functions to offer new strategies for sepsis diagnosis. …”
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Berberine in the treatment of radiation-induced skin injury: insights from proteomics and network pharmacology by Jie Zou, Jie Zou, Xia-Juan Xiao, Ping Zhang, Xing-Zi Huang, Jing Wang, Chun-Qin Tao, Xiao-Lan Ou, Gong Chen, Ting-Hao He, Long Yang, Biao Huang, Dao-Jiang Yu, Dao-Jiang Yu, Yu Zhao

“…Molecular functions and pathways were analyzed through GO and KEGG pathway enrichment analyses. …”
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Exploring the multi-targeted mechanism of Saikosaponin A in prostate cancer treatment: a network pharmacology and molecular docking approach by Genbao Zhu, Genbao Zhu, Genbao Zhu, Zhiming Jiang, Niuping Zhu, Niuping Zhu, Donghui Wang, Donghui Wang, Tianpeng Guo, Tianpeng Guo, Yiqing Meng, Yiqing Meng, Yi Zhu, Yi Zhu, Kemeng Tan, Mengxue Hu, Heng Tang, Xuannian Wang, Xuannian Wang

“…Next, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed to elucidate associated biological functions and signaling pathways. Meanwhile, molecular docking between core targets and SSA was performed using Autodock software. …”
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Live attenuated coronavirus vaccines deficient in N7-Methyltransferase activity induce both humoral and cellular immune responses in mice by Zhen Zhang, Qianyun Liu, Ying Sun, Jiali Li, Jiejie Liu, Ruangang Pan, Liu Cao, Xianying Chen, Yingjian Li, Yuzhen Zhang, Ke Xu, Deyin Guo, Li Zhou, Ke Lan, Yu Chen

“…Our previous work showed that CoV nonstuctural protein 14 (nsp14) functions as (guanine-N7)-methyltransferase (N7-MTase), which is involved in RNA cap formation. …”
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Development of a PROM to measure patient-centredness in chronic care consultations in primary care by Anne Holm, Anna Bernhardt Lyhnebeck, Sussi Friis Buhl, Kristine Bissenbakker, Jette Kolding Kristensen, Anne Møller, Anders Prior, Zaza Kamper-Jørgensen, Sidsel Böcher, Mads Aage Toft Kristensen, Asger Waagepetersen, Anders Hye Dalsgaard, Volkert Siersma, Ann Dorrit Guassora, John Brandt Brodersen, on behalf MM600 trial group

“…Few items demonstrated differential item functioning concerning variables such as age, sex, and education. …”
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Targeting the major pro-inflammatory interleukin-6-type cytokine receptor gp130 by antagonistic single domain antibodies by Silke Pudewell, Julia Heuser, Inna Dorogobed, Britta Lipinski, Thi Hong Hue Tran, Pia Metzenmacher, Richard Kunze, Felix Geyer, Stefan Zielonka, Doreen M. Floss, Harald Kolmar, Jens M. Moll, Jürgen Scheller

“…Furthermore, we functionally demonstrate the inhibitory effect of the selected nanobodies in cell-based transmigration assays of the human colorectal cancer cell line HT-29.DiscussionIn summary, our study has identified and characterized four novel inhibitory high-affinity gp130 nanobodies with potential for use in cytokine-dependent autoimmunity or cancer therapy.…”
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Multi-omics dissection of MAPK-driven senescence unveils therapeutic vulnerabilities in KIAA1549::BRAF-fusion pediatric low-grade glioma models by Romain Sigaud, Anja Stefanski, Florian Selt, Daniela Kocher, Diren Usta, Daniel Picard, Isabel Büdenbender, Marc Remke, Stefan M. Pfister, David T. W. Jones, Tilman Brummer, Olaf Witt, Till Milde

“…Trametinib treatment inhibited MAPK activity, OIS and SASP signatures across all omics levels, functionally underscored by reduced sensitivity towards senolytic drugs. …”
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Tongue squamous cell carcinoma-derived exosomes miR-21-5p affect tumor progression via promoting M2 macrophage polarization by Zixian Xu, Xin Fang, Shan Wang, Jiabei Mu, Qixian Gai, Yantong Chen, Zheyi Sun, Jiemei Zhai

“…Further investigation demonstrated a significant association between exosomal miR-21-5p and M2 polarization of tumor-associated macrophages (TAMs). Functionally, TSCC-derived exosomes promoted the polarization of M0 macrophages towards the M2 phenotype. …”
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Pseudogene BNIP3P1 Regulates H. pylori–Induced Apoptosis in Gastric Mucosal by Acting on the miR-411-5p/BNIP3 Axis by Andong Zhang, Xin Yan, Ningzhe Li, Shiying Yan, Shu Li, Hua Yang, Yimeng Liu, Jian Zhang, Jia Wang, Jian Zhao, Mei Cao

“…Our findings suggest that BNIP3P1 functions as a competing endogenous RNA (ceRNA) within the BNIP3/miR-411-5p axis during H. pylori infection, which ultimately hinders cell proliferation and promotes apoptosis in GES-1 cells. …”
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