A novel stemness-related lncRNA signature predicts prognosis, immune infiltration and drug sensitivity of clear cell renal cell carcinoma by Jia Liu, Lin Yao, Yong Yang, Jinchao Ma, Ruijian You, Ziyi Yu, Peng Du

“…Enrichment analysis was performed to explore the potential functions of SRmRNAs. Multiple machine learning algorithms were employed to construct a prognostic signature. …”
Get full text

Adipose-Derived Mesenchymal Stem Cells Accelerate Diabetic Foot Ulcer Healing by Promoting Macrophage M2 Polarization Through Downregulation of EREG and CSTA by Cao J, Zhang X, Li Z, Zhang S, Guo L, Liu Z, An W, Xu L, Li L, Long X, Yang Y

Get full text

Plasma microRNA signatures of aging and their links to health outcomes and mortality: findings from a population-based cohort study by Lieke M. Kuiper, Michelle M. J. Mens, Julia W. Wu, Jaap Goudsmit, Yuan Ma, Liming Liang, Albert Hofman, Trudy Voortman, M. Arfan Ikram, Jeroen G. J. van Rooij, Joyce B. J. van Meurs, Mohsen Ghanbari

“…Elevated scores on these microRNA-based aging biomarkers were associated with unfavorable health outcomes, including lower subjective physical functioning and self-reported health and increased mortality and frailty risk, but not with first- or multi-morbidity. …”
Get full text

CCL26 as a prognostic biomarker in hepatocellular carcinoma: integrating bioinformatics analysis, clinical validation, and radiomics score by Junjun Yan, Qiangming Liao, Yong Xie, Sihai Chen

“…Gene set variation and immune cell infiltration analyses were conducted to elucidate the biological functions of CCL26. Radiomic models for predicting CCL26 expression were constructed using CT images and genomic data from 34 TCGA patients. …”
Get full text

Multi-omics and experimental validation studies reveal key biomarkers of cellular senescence in diabetic retinopathy by Jinju Li, Hao Yang, Yixuan Lin, Zhaohui Fang

“…Single-cell sequencing and gene set enrichment analysis (GSEA) were employed to determine the cellular location and biological functions of DR-CS key biomarkers, and animal experiments further validated these biomarkers. …”
Get full text

How do strategic attributes of electronic commerce impel the perceived value and electronic loyalty of online food delivery applications (OFDAs) by Muhammad Asif Zaheer, Tanveer Muhammad Anwar, Zoia Khan, Muhammad Ali Raza, Hira Hafeez

“…In this globalized world and competitive environment, e-commerce demands have increased and organizations are giving special attention to web development, website design and functions to hold the current consumers with sustainable performance in the globalized and competitive environment. …”
Get full text

A novel bispecific aptamer targeting LAG3 and HER2 enhances T cell-mediated immunotherapy against HER2-positive cancer cells by Rui Guo, Xiaoyang Chen, Lu Ying, Wenjing Zhang, Zufa Sabeel, Lianhui Zhao, Jian Dong, Yiyang Dong, Zhao Yang

“…Herein, we developed a novel bispecific aptamer (HLB-apt) to investigate its dual-targeting therapeutic potential in regulating tumor-immune cell interactions.MethodFirstly, the Moe algorithm was used to simulate the docking results between the aptamer and the corresponding protein. Then, the constructed HLB-apt was validated. In addition, based on A549, HepG2 cells and Jurkat cells, the functions and mechanisms of HLB-apt acting simultaneously with A549, HepG2 cells and Jurkat cells were verified through in vivo and in vitro experiments.ResultsHLB-apt demonstrated specific binding capacity to both HER2-expressing tumor cells (A549 and HepG2) and LAG3-positive Jurkat cells. …”
Get full text

Identification of cell-type-specific, transcriptionally active transposable elements using long-read RNA-sequencing data-based comprehensive annotation by Chaemin Lim, Hyunsu An, Jihwan Park

“…Abstract Background The biological functions of transposable element (TE)-derived transcripts during physiological development, disease development, and progression have been previously reported. …”
Get full text

Soil Health Assessment in the Qinling Reclamation Area Based on Minimum Data Set and Risk Index by ZHANG Le, LI Chunyue, GAO Chuanyu, GUO Huan, LI Yifan

“…It is recommended to strengthen the diversity of herbaceous plants in future reclamation processes and increase fertilization to improve soil ecosystem functions and health levels.…”
Get full text

Simulation Analysis of Water Resource Scheduling in Nansu River Based on Coupled Water Quality-Quantity Model by HOU Xiang-dong, ZHAO Xiang-ling

“…Conducting research on water quality and quantity in rivers that flow through urban areas and serve functions such as water supply and irrigation, and implementing rational scheduling, is of significance for ensuring a healthy aquatic ecosystem and enhancing the well-being of local residents. …”
Get full text

Internal Speech in Natural Discourse Communication: A Systematic Review and Modeling by Лариса Калмикова, Наталія Харченко, Георгій Калмиков, Інна Мисан, Віктор Коцур

“…This paper aims to discuss the results of the research related to the communicators’ inner speech functions; objectify the naturally existing connections between the internal speech and external components in the process of communication; present a specified model of the senders’ and addressees’ speech communication process. …”
Get full text

Potential Molecular Mechanisms of Paederia Foetida L. In Gout Treatment Through Network Pharmacology And Molecular Docking by Tuan Hoang Quoc, Vy Hoang Ngoc Phuong, Thu Nguyen Thi Anh, Quynh Phan Le Nhu

“…GO enrichment analysis revealed that P. foetida influenced multiple biological processes, cellular components, and molecular functions. KEGG analysis elucidated that the primary mechanism of P. foetida in gout treatment may be primarily related to the IL-17 signaling pathway and several other anti-inflammatories signaling pathways. …”
Get full text

deep-Sep: a deep learning-based method for fast and accurate prediction of selenoprotein genes in bacteria by Yao Xiao, Yan Zhang

“…Identification of all selenoproteins is of vital importance for investigating the functions of selenium in nature. Previous strategies for predicting selenoprotein genes mainly relied on the identification of a special cis-acting Sec insertion sequence (SECIS) element within mRNAs. …”
Get full text

Expression characteristics, molecular mechanisms, and clinical significance of DICER1 in breast cancer by Xi Zhang, Long Yu, Cuizhi Geng

“…A nomogram model was constructed based on clinical data to evaluate its prognostic value. …”
Get full text

The Role of the Arctic Economic Council in the International Legal Framework of the Arctic Ocean Environmental Governing by A. N. Vylegzhanin, N. V. Korchunov, A. R. Tevatrosyan

“…The status and the functioning of the said international forum, particularly with regard to the activities within its Working Groups, have been examined based on the analysis of the documents adopted by the forum since its establishment. …”
Get full text

Reasonable Support Parameters for Loess Tunnel Under Different Water Contents: A Case Study by Hao Chen, Yanbin Luo, Jianxun Chen, Hui Chen, Yanfeng Li, Pengkun Wang, Lele Guo

“…The research findings indicate that the strength of the surrounding rock is functionally related to its water content, with the cohesive force <i>c</i> exhibiting an exponential relationship and the angle of internal friction <i>φ</i> showing a linear relationship, and that the cohesive force <i>c</i> is more affected by changes in water content than the internal friction angle <i>φ</i>. …”
Get full text

Research on the Characteristics of Electrolytes in Integrated Carbon Capture and Utilization Systems: The Key to Promoting the Development of Green and Low-Carbon Technologies by Guoqing You, Yunzhi Li, Lihan Dong, Yichun Li, Yu Zhang

“…Ionic liquids (ILs) demonstrate unique advantages due to their tunability: imidazolium-based ILs improve formate selectivity to 85% via carboxylate intermediate formation, while amino-functionalized task-specific ILs (TSILs) achieve a 1:1 stoichiometric CO₂ absorption ratio. …”
Get full text

Integrative analysis of multi-omics data identified PLG as key gene related to Anoikis resistance and immune phenotypes in hepatocellular carcinoma by Xueyan Wang, Lei Gao, Haiyuan Li, Yanling Ma, Bofang Wang, Baohong Gu, Xuemei Li, Lin Xiang, Yuping Bai, Chenhui Ma, Hao Chen

“…Furthermore, we present compelling experimental evidence that PLG functions as a significant tumor promoter, suggesting its potential as a target for the formulation of tailored therapeutic strategies for HCC.…”
Get full text

Statistics on the Industry Structure of the Russian Economy and its Optimization Model by O. V. Morozov, M. A. Vasiliev

“…Optimization of the scale of industries is the formation of structural conditions for a more efficient functioning of the Russian economy; it can be recognized as a macroeconomic condition and a strategic reserve for the economic growth.…”
Get full text

The prevalence and long-term effects of PTSD and moral injury in Swedish military veterans by Sofia Nilsson, Alicia Ohlsson, Sofia Svensén, Gerry Larsson, Gerry Larsson

“…IntroductionIn the context of international military operations, officers and soldiers are exposed to various service-related stressors that may have long-lasting effects on their health and daily functioning. This study explored (1) the prevalence of symptoms indicative of both post-traumatic stress disorder (PTSD) and moral injury (MI), (2) the relationship between these conditions, and (3) the relationship between these conditions and a selection of background variables in Swedish military veterans who have previously been deployed in operations.MethodsThe study was a self-report survey. …”
Get full text