Network based approach for drug target identification in early onset Parkinson’s disease by Ashmita Dey, Mrittika Chakraborty, Ujjwal Maulik, Sanghamitra Bandyopadhyay

“…Notably, shared pathway analysis shows that prioritized drugs such as Amantadine, Apomorphine, Atropine, Benztropine, Biperiden, Bromocriptine, Cabergoline, Carbidopa, and Citalopram, currently used for other conditions, interact with key EOPD-associated diagnostic markers, suggesting their potential for drug repurposing. The constructed functional network’s validity is reinforced by statistically significant drug-target pairs. …”
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Open-World Semi-Supervised Learning for fMRI Analysis to Diagnose Psychiatric Disease by Chang Hu, Yihong Dong, Shoubo Peng, Yuehan Wu

“…Due to the incomplete nature of cognitive testing data and human subjective biases, accurately diagnosing mental disease using functional magnetic resonance imaging (fMRI) data poses a challenging task. …”
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Fast prediction method for fatigue life of pump truck boom structure based on ensemble learning model by DONG Qing, SU Youcheng, XU Gening, SHE Lingjuan, CHANG Yibin

“…ObjectiveTo rapidly and accurately assess the fatigue life of in-service concrete pump truck boom structures, a fatigue life prediction method based on an ensemble learning model is proposed, utilizing monitoring data and machine learning techniques.MethodsFirstly, a concrete pump truck information acquisition system was employed to obtain functional and performance characteristics during the operational phase of the pump truck. …”
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Resilience and its relationship with disability in persons with bipolar disorder and schizophrenia: A comparative study by Arnab Datta, Dhrubajyoti Chetia

“…Severe mental illnesses are associated with poor and heterogeneous functional outcomes. Symptom remission is inadequate to achieve patient-oriented outcome, and positive psychopathology constructs like resilience have emerged as possible mediators. …”
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The urban lighting in the rehabilitation of the minor historical centre. The design scenarios for the architectural valorisation and the energy efficiency improvement of the urban... by Pierluigi De Berardinis, Chiara Marchionni, Luisa Capannolo

“…The latter, which had a purely functional role in the past, has recently taken a figurative and emotional role, associated with the vision of the urban light scene during the night and its valorization. …”
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GENERAL SCHEME OF DECISION SUPPORT SYSTEM FOR OPTIMIZATION OF CONDUCT MOBILE ROBOTIC MANIPULATOR by Fariza Bilyalovna Tebueva, Vladislav Borisovich Sychkov, Maxim Gennadievich Ogur

“…This article presents an overview of intelligent decision making capability automated architecture for robotic systems. he proposed architecture is a two-level structure, where the level of solutions provides methods of constructing a plan of autonomous operation, and functional level provides interaction with the hardware of the robot means.…”
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The passive voice in the Holy Quran: an exploratory study by Abdallah Abu Qub’a, Mohammed Nour Abu Guba, Shehdeh Fareh, Ghaleb Rabab’ah

“…The findings suggest that the passive voice in the Quran serves multiple functions, often operating simultaneously. The primary functions of passive constructions include brevity and conciseness, emphasizing the action or object, and expanding meaning.…”
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Chebyshev-Fourier Spectral Methods for Nonperiodic Boundary Value Problems by Bojan Orel, Andrej Perne

“…Instead of using basis functions periodic on a given interval −1,1, we use functions periodic on a wider interval. …”
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Large-scale genomic analysis reveals significant role of insertion sequences in antimicrobial resistance of Acinetobacter baumannii by Fei Xie, Lifeng Wang, Song Li, Long Hu, Yanhua Wen, Xuming Li, Kun Ye, Zhimei Duan, Qi Wang, Yuanlin Guan, Ye Zhang, Qiqi Shi, Jiyong Yang, Han Xia, Lixin Xie

“…This significantly enhances the accuracy of AMR prediction, emphasizing the pivotal function of IS elements in antibiotic resistance. Notably, we uncover a series of conserved sequence patterns linking IS elements and ARGs, which outperform ARGs alone in phenotypic prediction. …”
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Analysis and Prediction of the Dynamic Antiplane Characteristics of an Elastic Wedge-Shaped Quarter-Space Containing a Circular Hole by Shen Liu, Jie Yang, Yue Liu, Qin Liu

“…The scattering wave field in subregion I is constructed by the mirror method, and the standing wave field in region II is constructed by the fractional Bessel function. …”
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3D WSN clustering routing algorithm based on IHBA optimized fuzzy C-means by Jing YANG, Biyang XU, Weizheng LI, Wei LI, Zhaoqiang ZHU, Tao QIN

“…Aiming at the problem that clustering routing algorithm in a three-dimensional (3D) scene has high energy consumption and short network lifetime, a clustering routing algorithm IFCRA for 3D wireless sensor networks based on improved honey badger algorithm optimized fuzzy C-means was proposed.The network clustering, cluster head election, and data transmission stages were optimized respectively.Firstly, the improved honey badger algorithm was used to optimize the fuzzy C-means algorithm, solving the problem of fuzzy C-means easily falling into local optima, and the topological structure was divided based on the distance and energy characteristics of nodes.Secondly, the optimal cluster head function was constructed by combining the energy and relative distance of nodes within the cluster to balance the cluster head load.Finally, an adaptive transmission mechanism was used to search for relay nodes, and the optimal transmission path function was constructed by combining node distance and energy.The improved honey badger algorithm was used to optimize the data transmission energy consumption.Simulation results show that IFCRA has reasonable clustering, balanced energy consumption, and long lifespan in a 3D heterogeneous scene.…”
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A comparison of viral strategies and model systems to target norepinephrine neurons in the locus coeruleus reveals high variability in transgene expression patterns. by Chantal Wissing, Lena S Eschholz, Maxime Maheu, Kathrin Sauter, Fabio Morellini, J Simon Wiegert, Alexander Dieter

“…Finally, to further facilitate the investigation of LC-NE function, we created a suite of constructs, including a reporter protein, a calcium indicator, and a light-driven cation channel, whose expression is mediated by the previously described PRS×8 promoter. …”
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Aplicativo móvel Nursing Alert® para apoio ao enfermeiro na identificação da deterioração clínica do paciente [Nursing Alert® mobile app to support nurses in identifying patient cl... by Lidiane Soares de Andrade, Renata Flavia Abreu da Silva, Teresa Tonini

“…Results: the name and logo of the Nursing Alert® application associate it with its function as an Android® and iOS® version mobile application registered with Brazil’s National Industrial Property Institute. …”
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Spatiotemporal Variation Characteristics and Influencing Factors of Water Transparency in the Pilot Zone of Yangtze River Delta by WANG Yu, ZHOU Wei-qi, BAI Meng-yu, SU Han, HU Wei

“…[Conclusion] Recommendations are proposed for future transparency enhancement projects in the pilot zone: for lakes, control land-based phosphorus input; for river channels outside embankments, enhance bottom sediment stabilization under navigation disturbances; for river channels within embankments, emphasize the algae-suppressing function of submerged vegetation, highlighting the synergistic effect of ecological restoration on transparency management.…”
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Impact of seasons on industrial grounding resistance by Roman Sikora, Adrian Wilk, Przemysław Markiewicz, Ewa Korzeniewska

“…Abstract A properly designed and constructed ground electrode should perform well for many years. …”
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An Efficient Method for Immortalizing Mouse Embryonic Fibroblasts by CRISPR-mediated Deletion of the Tp53 Gene by Srisathya Srinivasan, Hsin-Yi Ho

“…Mouse embryonic fibroblasts (MEFs) derived from genetically modified mice are a valuable resource for studying gene function and regulation. The MEF system can also be combined with rescue studies to characterize the function of mutant genes/proteins, such as disease-causing variants. …”
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Handmade as a resource of social and cultural development of modern society by Aminet Magametovna Siyukhova, Elena Nikolaevna Bazalina, Angela Askerovna Kubova

“…The main conclusions of the research are the following: the possibilities of handicraft work in the utilitarian-applied and artistic-aesthetic fields of activity are most clearly manifested; handmade is a significant element for a large number of people in the organization of a positive communication space; in a mass society, needlework is a way of constructing and representing personal identity. The most significant function of handmade is the function of changing the type of activity in order to prevent emotional burnout in the conditions of concentrated information flows and the rapid pace of production and economic life.…”
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Multi-omics data reveal that SAA1 + fibroblasts exacerbate periodontitis by regulating macrophage inflammation and chemotaxis by Li Li, Yuting Yang, Fang Dai, Libin Deng, Meixiu Jiang, Chenjiang He, Ting Long, Kaiqiang Yang, Xinbo Yang, Li Song

“…Results This study successfully constructed a single-cell transcriptome atlas comprising 65,979 periodontal tissue cells and identified an SAA1 + fibroblast subpopulation with key functions. …”
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Understanding the regulation of aspartate metabolism using a model based on measured kinetic parameters by Gilles Curien, Olivier Bastien, Mylène Robert‐Genthon, Athel Cornish‐Bowden, María Luz Cárdenas, Renaud Dumas

“…Abstract The aspartate‐derived amino‐acid pathway from plants is well suited for analysing the function of the allosteric network of interactions in branched pathways. …”
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Quantum-data-driven dynamical transition in quantum learning by Bingzhi Zhang, Junyu Liu, Liang Jiang, Quntao Zhuang

“…Our findings provide guidance on constructing the cost function to accelerate convergence in QNN training.…”
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